A .Every year this last complex hosts an important international sculpture show.o.head..TherOf the numerous Rupestrian churches in Matera that combine the charm of the stark rock with the refinement and elegance of their interior decorations, the imposing Church of San Pietro Barisano is definitely worth a visit.So are the Church of Santa Lucia delle Malve, the Rupestrian Complex of Convicinio di Sant’Antonio, the Churches of Santa Maria de Idris and San Giovanni, the Church of Santa Barbara with its splendid frescoes and, finally, the, between Sasso Caveoso and Sasso Barisano.
Mind Geek responded with a statement that: "The best solution lies in a multi-layered approach in which the parent assumes the central role." The UK's Conservative Party won the country's 2015 general election with a pledge to obligate UK internet service providers to block access to hardcore pornographic websites that did not implement age restrictions by using verifiable age checks.


Tags: 1990s, 90210, A Different World, abortion, adolescence, AIDS, Beverly Hills 90210, Bikini Kill, Buffy the Vampire Slayer, City of Angels, Dawson’s Creek, Degrassi, Degrassi: Next Class, Diane Shipley, HIV, Ian Ziering, Kathy Molter, Left Eye, Luke Perry, Meg Ryan, Michelle Williams, Monica Keena, Monica Lewinsky, morality, MTV, Neve Campbell, Nicolas Cage, nineties, Party of Five, Philadelphia, pregnancy, repressed, Rookie, Sassy Magazine, Sex, sexuality, Shannon Doherty, single mother, slut shaming, teenagers, television, The Golden Girls, TLC, Tom Hanks, Tori Spelling, Tumblr, virginity, zines
The Slut-Shaming of Anthony Weiner
What would it look like to slut shame a middle-aged, heterosexual man? The Anthony Weiner scandal is giving us a clue.
Tags: anthony weiner, feminism, gender, politicians, Sex, sex scandals, sexism, sexting, slut shaming, sluts


or early college years. I’ve gotten to know them a bit as individuals too. What I have learned is this group of young men are incredibly caring and sensitive to their fans. Their tweets and posts can be a bit off-color and not what I’d want my young daughter to read. A few bands look a bit scary with their dramatic make up, but they also post incredibly caring pieces. Brady Szuhaj of Late Nite Reading posted a very encouraging video to his MILC site about not giving up called For Those Struggling. When they meet their fans each member takes time to talk to them, give them a hug and sign what ever they’ve been asked to sign.
On the surface this all looks like fluff. Dig a little deeper and you learn that these young musicians also save lives.
To celebrate the end of the school year this past weekend we saw the Bryan Stars Tour in Marietta, GA then again in Jacksonville, Florida. For a few days the fun of following this group of bands from Georgia to Florida kept us from being preoccupied with where our deployed soldier is serving. As an added bonus we even heard from our soldier while on the beach in Jacksonville!
photo by Stanley Leary </s> We were all woken up around 8:30 or 9:00 by the phone. According to Athena and Celeste, it rang about fourteen times, but I only heard about three. Usually by the time you wake up enough to realize the phone is ringing, the person calling is tired of waiting for you to pick up and hangs up about the time you get to the phone. This is why neither Athena nor Celeste got up to get the phone. But it kept ringing until I was awake, and I have a conditioned response to jump out of bed and answer the phone, which did me no good, because in my case, it was actually true that the caller was tired of letting the phone ring.
By this time, everyone was awake, and Celeste came into our room, probably to find out what the call was about, especially because her boyfriend's out of town and she wanted to hear from him. So after I hung up, the very first thing she said was, "Let's watch Angelic Layer." And that's when I realized we wouldn't get any work done today.
Celeste says some crazy things. Last night we were playing Kingdom Hearts, which everyone, including Celeste, knows to be our favorite pastime, and she walks into the living room and says, "We can do what K5 does when they're bored!" I was like, "Hello? We're playing Kingdom Hearts. Obviously, not bored." But that's okay, because Athena was just doing tournament stuff, and her suggestion was to read Trivial Pursuit questions, which doesn't really disrupt tournaments.
And then Celeste went swimming, and instead of working we watched Host Club. And I'm proud of myself for correctly identifying Daisuke Namikawa's voice before the end sequence started. As soon as the name popped into my head it was so obvious.
I think the Kingdom Hearts review will have to wait again. Celeste's boyfriend will be back this evening, and he can take her away to do fun things while we get back to this new seriesHost Club after having it for two whole days, boxes full of Mimsy, Celeste having a digital camera, people watching the anime we like, and Willy's freedom. </s> Super Graphics: The Works of Yuki Kikutake
How
According to Yuki Kikutake, “supergraphics”gs.
With an innovative but simultaneously subtle viewpoint fostered by her global experiences, Japanese graphic designer Kikutake focuses not only on attractive, comfortable spaces but also on places and objects that give a negative impression.
This book features around twenty of Kikutake's works and cross-genre designs that can serve as a guideline for future projects, from landmarks and trains to product and book design.
Published by Seigensha, 2018
Hardcover with jacket, 192 pages, color and b&w images, 5.9 × 8.7 inches
ISBN: 978-4-86-152677-0 </s> Dr. Clare Larkin has been a healthcare practitioner for over 20 years. Over the last 12+ years, Dr. Larkin has studied and focused on the body’s energy and its role in health and healing. This interest, combined with her background as a chiropractic physician lead to her instant connection with Matrix Repatterning therapy.
“As a chiropractor. I often had satisfactory results, but there always seemed to be a few patients whose conditions did not resolve completely and I knew there was something more I could do for them. I had heard of a patient’s remarkable success after treatment with Matrix Repatterning for severe post-concussion symptoms. I researched the technique and it was clear to me that this was the missing link that I had been searching for. I then decide so I could get to the root cause of my patients’ problems and enable their bodies to heal on a much deeper level. I am happy that I am able to offer such a life-changing therapy to so many people.” </s> Transfer Photos from iPod touch to PC Easily
The instructions for transfer from iPod to the computer, iPod Touch to iPhone, and iPod to iMac/ Mac Book Pro (Air) are explained below, step by step, for each kind of transfer. The first shows how to transfer photos from an


Some of the projects include a 15,000 square foot indoor riding arena, two guest houses, an orangery, the complete renovation of several other buildings and the complete renovation of the grounds. Larry has demonstrated he has both the knowledge and the capable manpower to complete all of the projects we have undertaken. Larry has made the projects an enjoyable experience by being available to us whenever and for whatever we request of him. Their subcontractors are extremely trustworthy, responsible and constantly aware of the needs and privacy of our family. We very much look forward to our continued friendship with Larry as we work on our various properties and would enthusiastically recommend his firm for whatever projects they felt capable of undertaking.”


Discussion of a number of top veterinary issues with links to resources for discovering state laws governing those topics. Chapter of the FDA's Compliance Policy Guides dealing with veterinary medicine. Explains how to follow FDA regulations related to veterinary medicine.
Website by the Center for Veterinary Medicine (CVM) on the practices and procedures of the FDA regarding veterinary medicine. Includes drug approval, classification, and reporting guidelines.
Map of the United States with detailed information on veterinary laws in each state. Can also search for laws by topic and species and find specific cases. MaintainLegal information about veterinary practices in Massachusetts.


Meanwhile, the Dutch newspaper De Volkskrant has quoted van der Sloot's lawyer in the Netherlands as saying his confession was "possibly fake" and may have been coerced. "Joran told his mother crying Monday that he was being interrogated under reasonably barbaric conditions," the paper quoted Bert de Rooij as saying. "He said the police were trying to force him to confess." In a second interview with CBS News, de Rooij said van der Sloot also told his mother that he was being interrogated in a "very rude way" and that he thought the Peruvian authorities were "aiming at a coerced confession."


No chance they might deal the more expensive Hanrahan and pony up to keep Grilli for another season or two?$5 million for Grilli, at least the version of him we've had for the past two seasons, is not unreasonable for one more year. He could act as the primary closer and help coach Morris and/or Wilson to succeed him. This would be cheaper than Hanrahan, we'd still get a major league ready player in the process by trading Hanrahan, and our 'pen would still have a back-end hammer. Why aren't they thinking of pursuing this strategy?


Maxi flower print crêpe de Chine flared dress, rolled shoulder straps, V-neck.
Catch all the eyes with the maxi floral print crêpe de Chine dress with contrasting lining, rolled shoulder straps, V-neck, flared line, invisible side zipperGet ready to become the protagonist of a garden party when wearing it with a timeless clutch bag and jewelry sandals.


With another year of Tokyo Game Show underway, Square Enix is flexing its action-RPG muscles with a fresh look at Kingdom Hearts HD 2.8 Final Chapter Prologue. Like other trailers before it, the TGS trailer showcases snippets from all of the titles that make up 2.8, but places the biggest emphasis on Aqua’s journey in Kingdom Hearts Birth By Sleep 0.2.
Kingdom Hearts HD 2.8 Final Chapter Prologue hits the PlayStation 4 Jan. 24, 2017, while a Kingdom Hearts event announcing more information is expected this December.


This part of the Philippine Navy.
The infant Philippine Navy was established during the Philippine Revolution (1896-1898),y. It then consisted of the pinnace Magdalo and several steam launches captured from the Spanish. The Navy refitted these for war and moved troops, arms, and supplies to the provinces. The Navy played a major role during the raid against the Spanish garrison and magazine on Bacoor Bay, which was the first amphibious assault by elements of the Revolutionary Navy.
The Corps was expanded to batallion strength on November 7, 1955, with two rifle companies and a Headquarters and Service Company under Lieutenant Commander Gregorio L. Lim, PN as its Battalion Commander. The 3rd Marine Company was activated on November 7, 1961. To provide the fire and anti-tank support for the Philippine Marine Battalion, as well as to provide ceremonial guard and security for VIP's, a weapons company was activated on April 10, 1966. The battalion was expanded to a force of nine rifle companies two years later.
OnThe Corps has evolved from a company of volunteers to three Marine Brigades and one Marine Reserve Brigade, ten Battalion Landing Teams, a Combat Support Brigade, one Reconnaissance Battalion, a Training Center, Headquarters Battalion and Marine Security Escort Group.
The nit'he unit also fills most of the PMC's ceremonial duties.
^ "The Philippine Marine Corps:History". http://www.philippinemarinecorps.mil.ph/fhistory.html. Retrieved 2008-06-06.


The sound and quality of one's speech is the most important factor in spoken communication. Whatever an individual's position in life, speaking Chinese clearly and phonetically correctly will make one better understood. This course helps students reduce common pronunciation errors and develop more natural intonation and stress patterns. The course covers all the main aspects of Chinese phonetics: Phonemic system (vowels and consonants), an introduction to pinyin, the Chinese phonetic alphabets, the four tones of intonation as well as the cultural background of some pronunciation of the characters.
Contact teaching, pronunciation and listening practices in pairs and in language laboratory.
The students learn the Chinese consonant and vowel sounds, intonation, word stress, word reductions, sentence rhythm and blending words in conversation.


in Muscle Building by Get Holistic Health If you are hungry to increase your muscle mass without gaining fat, adopt a disciplined approach to bodybuilding. Lose the idea of eating anything in sight or spending 20 hours at the gym each week. Engage in short, intense workouts of 30 to 45 minutes to see optimal results and eat a high protein, fiber-rich…
Peak Performance: The Ins And Outs Of A Protein Diet
Diet guides have been around for as long as people started being concerned with their bodies and since whenever thatleft palate and cleft lip
Four Ways To Stay Healthy And Prevent Cancer
in Overall Health by Get Holisticcancer is about to become the leading cause of death in the world, with deaths standing at more than 7 million each year. This accounts for over 13% of all the world deaths each year. WTO postulates that at least 33% of those deaths could have been prevented.…


Influence of Cyclosporin A, Dexamethasone, and Benzalkonium Chloride (BAK) on Corneal Epithelial Wound Healing in the Rabbit and Guinea Pig Eye
D. Kössendrup, M. Wiederholt, F. Hoffmann
Corneal erosions were produced by iodine vapor application in rabbit and guinea pig eyes. The corneal erosion of each eye was… Expand
[Spersadex and Spersadex with chloramphenicol eyedrops].


The previous sections have discussed the syntactic classification of verbs with nominal arguments. We argued that the traditional classification, which takes the adicity of the verb as its point of departure, results in grouping verbs together which actually have very little in common, and that it is better to base the classification on the type of arguments the verb takes. This has led to the classification in Table 6. The unaccusative verbs in this table can be subdivided further into verbs selecting the perfect auxiliary hebben and verbs selecting the perfect auxiliary zijn. The class of undative verbs is normally not distinguished, but we have given some arguments in favor of its existence. Observe that Table 6 is virtually identical to the one given as Table 1 in the introduction to Section 2.1, the only difference being that the latter refers to thematic roles instead of (derived) syntactic functions.


Now I look around, more than twenty years after my parents separated, and see that the original framework did, indeed, fall apart. But rather than stay in pieces on the ground, God provided more people to build it into a sort of Jerry-rigged family system. It looks really funny but it works!
Over the last twenty years God has brought strangers into my life who became family. I have step-parents I think of as another mom and dad. I have half-brothers but they've always been simply brothers. I can't imagine my life without them. Then there are the people God brought to me who aren't married or born into my family. Each has taught me something and helped me to be the woman God intended for me to be. Whether white, brown, black, pink or a blend of all of the above... love we receive from Jesus when he becomes the most important person in our lives, in turn, pours out onto others. What's most amazing to me about this, is that when we receive Jesus' love and love him more deeply, we end up loving others better!
Could I have understood the concept of a kingdom family without my parents getting a divorce?Certainly. Could I have grasped it as easily?Probably. Would the kingdom family mean as much to me if my family had never been broken in the first place?


Training and Human Resources Development in Networked Organisations
The Changing Environment of Companies
Training Suppliers and Middlemen
Training Your Suppliers
Training Your Middlemen
Training and HRD Changes in Companies
The way how many companies operate today is in rapid changes; many new developments such as "virtual company", "modular company", "co-makership" and "networking" are having a crucial impact to every field of life in the companies. It is widely recognized that organizations are moving away from centrally coordinated, multi-level hierarchies and toward a variety of more flexible structures - like the networked mode to work (see e.g. Miles and Snow 1992).
These altering operative modes will have in the near future also an important effect to training and human resources development. Not only do the new operational modes change the conventional functions and operations of the training and HRD departments - in addition the role of training and HRD in companies widens from internal function for training and developing also in much a wider extent also the suppliers, middlemen and customers of the company.
The quickly changing operating environment of the companies is in the following described only few developmentstraining and human resources development.
The mode of the "virtual corporation" quotes to a situation in which the basic business entity is not anymore a single company but rather a temporary network of independent companies - suppliers, customers, even rivals - and access to one another´s markets (see e.g. Business Week, February 8, 1993, pp. 36 - 40). Davidow and Malone (1992) stress that the virtual corporation will appear edgeless, with perm.
The other important aspect has been addressed with the term "modular corporation". In brief, the idea of a modular corporation is to nurture a few core activities and let outside specialists make the parts, handle deliverers, or do the accounting (see e.g. FORTUNE, February 8, 1993, pp. 52 - 56, see also Peters 1992). This development in the companies dictates that many operations are subcontracted and the company itself focuses strongly on the "core competences" to build its competitive advantage.
The destiny of the company is not only decisive anymore by and large of its own operations, but it shares its destiny with a number of actors. The relationships between the company (and its different entities), its suppliers and its middlemen and especially its customers change. Many writers, for instance Davidow and Uttal, argue that growing interdependence with suppliers urges also that companies realize their duties towards their suppliers. Davidow and Uttal (1989) call this interdependence sharing the same co-destiny. The role of the middlemen is changing as well - the middlemen can be independent service producers and the same company might have different middlemen competing with its products and services on the same market. It is obvious that the trust of the middlemen must be high middlemen/distributors long-lasting (see e.g. Peters 1988; Davidow and Malone 1992). The customers of the company are taking more responsibility (and should be more prepared to do so) of different activities, such as product and system design, which previously have been belonging to the domain of the company itself.
In all tclear distinctions between firms and markets, between the company and its external environment have disappeared (see e.g. Webster 1992). In my understanding the new organizational modes lead to three major changes nt. These developments can be described as follows:
1. training and HRD responsibility is widening to suppliers and middlemen
2. training and HRD must focus more on joint values and processes as well as on core competences
3. training and HRD must take responsibility also of the training and development of the customers.
The training responsibility of the companies is changing with the quick change of the business environment (see Figure 1 - in the visualization of Figure 1 basic sources have been Kotler 1988 and Miles and Snow 1992). Many companies recognize that for the smooth running of their activities, the training of their suppliers and middlemen is urged.
Figure 1 Training responsibility in conventional business
Figure 2 New "networked" organisation and altering training responsibility
Some advanced companies have recognized that the entire production chain of the company must be trained according to company standards and company practices. Such new practices as ISO 9000 quality system, statistical process control (SPC), just-in-time (JIT) manufacturing require that the suppliers, the producers and the middlemen are all sharing the same way of thinking and share equally the same dedication to quality. Many companies - like Xerox Corp., Motorola Inc., Ford Motor Co. - have realized that suppliers are a crucial part of the quality improvement and that the quality of suppliers can be assured by providing access to their own training and HRD programmes, consultancy help and training (see e.g. U.S. Congress, OTA 1990; Geber 1989). However, as yeto the training level of their suppliers, and the smaller suppliers in particular are facing trouble in meeting the different new requirements.
It should be recognized that there are also remarkable threats is linking the suppliers too closely to all the practices and requirements of the companies. Miles and Snow stress that continued, step-by-step customization of a supplier´s processes can ultimately result in the inability of the supplier to compete in other markets and an obligation on the part of the company to use all of the supplier´s output.
The case of the use of interactive video in the training of SPC by the Ford Motor Company illustrates how a major manufacturer is contributing to the training of its suppliers by offering a critical resource.
Ford Motor Company developed together with Futuremedia in the United Kingdom an interactive video package of about SPC. The training package consisted of five video disks devoted to quality questions, including themes like an introduction to SPC, SPC in production, SPC in service etc. The interactive video disks contain also additional information which can be accessed by the students, summaries of the content of each module, and questions for students.
Ford has been devoting much effort to quality and especially to the quality improvement of its suppliers. Today Ford Motor Company strongly recommends that all its suppliers use this training tool as a part of their employee training (see e.g. Rushby 1988).
If the role of suppliers is a critical one to the company, so is the role of the middlemen as well. The marketing middlemen are in many industries forming an important interface to the customers. The middleman should be a part of the same value and quality system as the company itself.
The training of marketing middlemen is often the key to success in many sectors of industrial marketing. Some companies operate a strict policy of never introducing a new product to the market until the sales literature has been printed and every distributor has been properly trained (Nickolaus 1990). However, the different opportunities offered by TBT have not been widely utilized in the training of marketing middlemen.
The caillustrates that TBT can be a valuable addition to the support services which a company offers for its middlemen.
Massachusetts Mutual Life Insurance Company has over 4600 agents housed in 100 agencies and approximately 200 districtsupporting its agents in various ways. It recognized, however, that although the conventional support services and the different financial incentives were still important, the support services offered had to be developed in various new ways.
The company produced an interactive video (IV) training program called Mass Mutual Selling Skills to be used by its agents. This program allows the agents to respond to various sales situations and learn the essentials in the selling of insurances. The agents have also been asked to participate in the cost of the courseware development.
The company has listed the greatest benefits as the potential for agents to learn at their own pace and the drastically reduced (30%) training time with increased quality compared with old training systems (Curtis 1991; Razza 1988).
The location of the companies and their operations have been in quick changes as well. The concept of value chain (developed by Michael E. Porter, see figure 3) is helping to define how a company can spread its activities. Porter suggests that the company must examine each activity in the value chain to see if there is a competitive advantage to concentrating and/or coordinating the activity globally in various ways (Porter 1986). Although this is usually understood to be most effective in upstream value activities, it is obvious that there is great potential also in downstream value activities. Takeuchi and Porter have already discussed thoroughly the possibilities of international marketing in global strategy (Takeuchi and Porter 1986). However, the recent developments in computers and electronic networks open new options for the operations of the companies. Porter distinguishes the downstream and upstream activities in value chain. He argues that by and large the downstream activities are more related to the customer and thus they are more usually tied to where the buyer is located.
Figure 3 The Value Chain (Porter)
Porter goes on to argue that the downstream activities which create competitive advantage are largely country specific and that in those activities it is likely that the multidomestic pattern of international competition is more dominant than the global pattern However, many recent developments espdecreased the importance of performing at a given location. For instance reliable and fast transport systems offer as well new options for the companlocation of the customer service expertise.
The operations of the companies will be more geographically dispersed in the future, but so will also be the case in many industries concerning suppliers, subcontractors, middlemen and especially customers. To enable effective running of the companies, the companies must not only deliver their usual training more widely, but also take a new approach the training and human resources development. The three new main denominators are sharing through the networks, promoting throughout the networked organization also joint values and processes, and gaining commitment. The task of training and human resources development is to promote new themes such as joint values and procedures throughout the company´s environment - as discussed earlier also including suppliers, middlemen and customers. The goal of training and human resources development is not only to sharpen the core competences of the work force but also to build new types of commitments between the company and its suppliers, middlemen and customers.
Porter has described the forces driving companies to high coordination of activities and to a geographically dispersed configuration of activities. As Lei and Scolum stress in many global undertakings done by the Japanese and Korean companies and networks the single most important task facing human resources development is the constant training, development, and socialization of manager´s in organization´s values, mission, and philosophies.
As the Figures 3 and 4 show, the companies need not only coordination as such, but also joint values, joint procedures and joint processes throughout their operations. It should be stressed that these joint values and procedures are even more needed with suppliers and middlemen than ever before.
Figure 4 Coordination and configuration according to Porter
Figure 5 Requirements for highly coordinated and geographically dispersed activities
It seems to be important that in the new organizational modes the companies stress also "core competences" - in other words such competences of the companies which are unique and crucial for their success. However, it is likely that in the companies there are needed joint values, processes and procedures as a basis for these core competences (see Figure 6).
Although all the major companiesdifferences in training and human resources development are great on a practical level. The strategic emphasis on training differs greatly in different companies. Carnevale, Gainer, and Villet discuss the strategic importance of training for the company. The role of the trainers is too often outside the strategic core of the company. They argue as well that the trainers do not often think strategically and have by and large the role of fire-fighters (see Carnevale 1990). However, like many other writers they also stress that training can have an important strategic role for the company when the competition is moving more clearly into new areas and when the decisive factor in competition is to a wide extent the competence of the workforce (see e.g. U.S. Congress, OTA 1990; IRDAC 1990).
Companies use a wide variety of different training providers and settings in their training and human resources development. These include for instanceetc.); training industry; private training consultants; professional, trade, and labour organizations; OEMs; governmental bodies. The importance of these depends on the general training setting of the company.
Increasing demand and the cost pressure have been driving company traine training needed. Streamlining of the training and adoption of technology-based training (TBT) methods in training delivery can give good results. Due to the flexibility, and savings in time and money TBT is quickly increasing in major companies. U.S. based large companies like IBM, Ford Motor Company, and Motorola expect that by the late 1990s over half of their company training will be delivered outside the traditional classroom using some form of instructional technology (see U.S. Congress OTA 1990). At IBM, for instance, the development has been very fast. In the early 1980s only about 5 per cent of the company´s training was delivered by technology. In the year 1990 the figure had grown to 30 per cent (Geber 1990). However, while big organizations have been using different training methodquite reluctant to invest in training even by new methods.
The case of Abbey National illustrates how a company with widely dispersed activities can effectively use computer-based training (CBT) in its employee development.
Abbey National is a U.K. based building society with 15,000 employees. The company felt that it was difficult to reach all its 680 branch offices effectively for training. Training by conventional means was felt to be insufficient for the quickly altering business environment of banking services. The number of different services provided had been rising fast.
The company chose to deliver one part of its training by CBT. Abbey National designed and provided the programs themselves. Major benefits of the scheme were the potential to deliver “off-the-shelf” routine-like training courses and also to focus, by the extensive use of CBT, the face-to-face tuition better than before in the training activities of the company. (Auvinen 1992).
Customers are the basis of success for every company. Thus it has been understood in all major companies that the different ties and interactions with the customers must be increased. Companies serve their customers in the training area by different means. Some use short-term educational conferences in new product education See Bertrand and Stumping 1990). Some companies, like Control Data, let the customers use their training centres and study there together with the company´s own employees (Normann 1991). Digital provides its customers distance learning packages and CBT courses (see Kearsley 1985; Blackburn 1991).
Ulrich stresses that companies should alter their thinking and concentrate on creating customer commitment instead of creating customer satisfaction. He urges that the human resource management (HRM) activities of the company should be directed outside the company instead of only serving the internal company functions. According to him customers could be involved in differenties, like in designing and structuring the technical and management training and as participants in internal training. These kinds of actions build strategic unity between the company and its customers (Ulrich 1989).
The potential of customer training can be regarded by the concept of the “company´s training interface”. In short, the concepta part of the services offered by companies. Customer training can answer the growing training needs of the customers, as discussed below in more detail. For clarification, it is important to stress that customer training, of course, is only one element in the “service-mix” of the company. However, well-designed and well-organized customer training can offer customers both direct benefits (savings in human resource development (HRD) costs, short lead-times in equipment utilization) and potential benefits (access to expertise, networking with other customers). Proper performance in customer training can contribute to both financial incentives (mainly by) and strategic incentives (increasing customer commitment to the company).
The case of IBM illustrates the effort of a global company to serve its customers in a quickly changing area of technology. Caron from IBM argues that the company feels it must offer the customers the same training as they provide for their employees. This sharing is laying the groundwork for long-term partnerships (Caron 1991).
In 1983 IBM installed a satellite-based training system called ISEN (Interactive Satellite Education Network) in the United States to deliver customer training. By late 1990 it consisted of four studios and 116 remote classrooms in 20 receiving sites all over the U.S. ISEN broadcasts five to six hours daily and is available 245 days per year.
ISEN is based on a one-way digital video system (two images are sent in parallel on a 1.5 Mbits/second band) and two-way audio by terrestrial telephone lines.offered via a Student Response Unit (SRU) which consists of a microphone and a numeric pad. With the help of this numeric pad the students can either call the teacher asking for the floor for a question or can comment or answer a multiple choice question presented by the teacher.
Partly as a result of active cooperation with customers, IBM in the United Kingdom found the need for high-quality interactive training programs. Thus a terrestrial distance learning system was implemented in the United Kingdom in 1989. The ETVN (Education TeleVision Network) uses 384 Kbits/second terrestrial lines and offers students the chance to work on a PS/2 workstation. Some customers of IBM have already expressed a wish to install a remote classroom utilizing this educational layout on their own premises (Scott 1990 and Herremans 1990).
The changing operational scene of the companies and their changing environment of business sets new challenges for training and human resources development. My strong understanding is that in many companies the new preconditions of business should favor the use of the methods of distance learning, as distance education will offer radical, new potential to undertake training and human resources development despite constraints of time and space. In many cases programmes delivered by these methods are suiting the new operational environments if the business but are also opening new avenues to build up new types of relationships (by sharing more easily the training and human resources development efforts) withAuvinen, A-M, Miksi organisaatiot käyttävät etäopetusta?, in Lähellä, kaukana, yksin yhdessä. Helsingin yliopisto 1992.
Blackburn, L N, Open Learning Application of Collaborative Learning Technology, in in le Fèvre, F, and van Muylwijk, B, editors, Training for Competitiveness. Bussum 1991.
Carnevale, A P, Gainer, L J, and Villet J,Jossey-Bass Publishers 1990.
Caron, H, Progress in Business Today depend on Education,urtis, J C, Training as a major business strategyDavidow, W H, and Malone M S, The Virtual Corporation. HarperCollinsPublishers 1992.
Davidow, W H, and Uttal, B, Total Customer Service. HarperPerennial 1989.
Herremans, A, Corporate Training for the Business World, conference presentation at VSAT´90 and European Satellite Users´ Conference in Luxemburg, 1990.
IRDAC, IRDAC Report on Skills Shortages 1990.
Kearsley, G, Training for tomorrow. Addison-Wesley 1985.
Kotler, P Prentice-Hall International 1988.
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Nickolaus, N, Marketing New Products With Industrial Distributors. Industrial Marketing Management, Vol 19, 1990.
Normann, R, Second Edition. Tiptree 1991.
Peters, T, Thriving on Chaos. Perennial Library 1988.
Peters, T, Liberation Management. Alfred A. Knopf 1992.
Porter, M, , in Porter, M, editor, Competition in Global Industries. Harvard Business School Press 1986.
Scott, B, The Possibilities of Videoconferencing in the Internal Training at Multidomestic Enterprises, in Keiper Associates International Oy, editors, EUROCON 90 Proceedings.
Takeuchi, H, and Porter, M E, TgiesWy. Washington 1990.
Webster, F E, Journal of Marketing, October 1992.
Bertrand, K, Stumping for New Technology Products. Business Marketing, April 1990.
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Geber, B, Keeping Your Suppliers in Step. Training, July 1989.
Geber, B, Goodbye Classrooms. Training, January 1990.
Lei, D, and Scolum, J W, Global Strategic Alliances: Payoffs and Pitfalls, Organizational Dynamics.
Razza, J C Jr, Are Companies Trimming Agent Support. Life Association News, October 1988.
Rushby, N, A Praiseworthy Application of Interactive Video. Personnel Management, May 1988.
Ulrich, D, . Sloan Management Review, Summer 1989.


rules in place. My number one favorite being? We always got to skip the front of the line. A very handy thing at a place like this.


Home›Jazz concerts›Bill O’Connell’s Hope for Change
By Ted PankenIMay. 9, 2022
O’’Connellized covers that make up the proceedings. “Steve is a very broad guy,” said O’Connell, who harnesses Jordan’s“perfect tempo.”
Opening the “Moment’s Notice” set, Jordan establishes a thematically cohesive mix of backbeats and swing, allowing O’Connell – his flowing chops and personal refraction of Hancock-Tyner-Evans-Corea vocabulary on full display – to allow the flow to breathe. Jordan personalizes the feel of Elvin Jones 3 on “Enough Is Enough,” soulful blues underscored by Craig Handy’s moaning tenor solo; funks on a stop-time treatment of “My Foolish Heart”; and switches seamlessly with Martinez between Afro-Latin and swing on “Chaos,” a rambunctious 5/4 theme with Eddie Palmieri-esque overtones.
“Chaos” evokes O’Connell’ged O’Connell to write, and he placed O’Connell’s “Little T” Hancockish on the Grammy-winning Amanecer. “” O’Connell said. “”
Throughout the 1980s, O’Connell shied away from leading sideman gig security ambitions with, among others, Jon Lucien, Toshiko Akiyoshi, Astrud Gilberto, Gato Barbieri and Dave Valentin (an employer and colleague until his died in 2017). “I wanted a balanced life, between family and children, and the New York side worked for me,” said O’Connell, who has raised four children with his wife of 33 years. “I’ve conducted gigs occasionally, but not out of necessity. I’m a writer. Ideas for new projects and new music are always in my head, and to do what I wanted I had to throw myself more by myself From 2000, I constantly expressed what I was thinking. comicsth a loyal jazz host and carved out a successful solo career,…
Ron Miles: 1963–202eader, and simpatico sideman who shared the stages and…
Randy Brecker performed four blind tests, according to DownBeat records. This was his first in a long time…
April 26, 2022 1:31 p.m.
Half ang you (also his first recording…


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Surf and sustainability at Soneva resorts
Luxurious experiences define Soneva resorts, like 3D astronomy and rainforest-friendly Chocolate Rooms, says founder Sonu Shivdasani
When I meet Shivdasani on his recent trip to Mumbai, I realise that like most people who have studied in the UK (he is a graduate of Eton and Oxford), the founder-CEO still holds on to the accent. The address on his business card, though, lists Bangkok, where his sustainable luxury resort brand, Soneva, is headquartered. With two island properties in the Maldives — Soneva Fushi and Soneva Jani — a private island in Thailand, Soneva Kiri, and, most recently a yacht, Soneva in Aqua, his company is niche, but has become a favourite of celebrities like Gwyneth Paltrow.
Celebrating the uncommon
Intelligent luxury is what the duo practise — where the emphasis is not on objects, but on what is not commonplace. So for their guests who already enjoy the high life, Soneva is about space, privacy, fresh air and unique experiences. Their massive properties (Soneva Kiri is located on 400 hectares) come with desalination plants — where drinking water is processed to the sounds of classical music. At makers programmes, guests can use the plastic that washes up to create souvenirs, and the popular Chocolate Room has a changing selection of delicacies. He is especially proud of the resorts’ use of non-tropical timbers, which “grow rapidly in plantations and are great carbon sinks”.
Shivdasani’s focus is on creating concepts that reinforce their sustainable culture, like Glasscycle, the glass studio at Soneva Fushi. What started out as a way for the property to recycle its glass bottles, has now become a revenue earner. “I was reading about the Murano glass industry and its decline,” he says, explaining how he bought a glass furnace in Italy. “Now we have three talented glass blowers, and four to five times a year we invite artists.” Designer Manish Arora made four pieces on a recent visit. “One sold immediately, we’ve kept another and he has the third. The last work is up for sale.”
Printable version | Sep 23, 2020 1:33:38urf-and-sustainability-at-soneva-resorts/article24291545.ece


Here we are at day 23, only seven more to go and I would have achieved my goal of writing for thirty days.
After my haircut, my daughter and I hit Starbucks and then started to do some birthday shopping for my gorgeous wife. We have three birthdays in rather quick succession in our family and one of them isn’t mine. I love spending time with her, she is an amazing kid.


Whilstbased on my appearance and their clearly advanced awareness of popular culture, the wording of the latter made it seem as though I was a meal or an exotic cuisine. The retorts of ‘Hi Gandalf’ or ‘I’ve never tried jerk before’ never hit in the same way. What was most shocking to me at the time was the sheer volume of identical messages, so much so that I was addressed more as Jackie Chan or an exotic product than a simple, ‘Hi’.
Almost every time I have been alone in the city of London on the way to visit a friend, I have been met by men who unwarrantedly come up to me – especially at night – saying (*painfully slowly and over-enunciated*): ‘Where are YOU from?’, ‘Niii haooo maaaa’, ‘You speak English?’, ‘You pretty’, ‘Are. You. Lost?’. No look of absolute shock on their faces when I answered the first question in a thickly coated Aussie accent I put on, ‘Straya, MATE’, as I stormed off.
They’re the model minority; they put their heads down, work hard, and don’t complain.
What I was witnessing, in all these messages and interactions, was a pattern of male societal behaviour – a deeply rooted cultural consciousness – that continues to reduce Asians through painfully limited stereotypes, that continues to exoticise them as the oriental ‘other’, and that is haunted by histories of systematic racism, colonialism and hyper-sexualisation. One that thinks it’s funny to ask if my white boyfriend is ‘charged by the hour’, or ask for my passport instead of my driver’s licence for proof of identity, or glare and cough on me for being a walking virus or alien in my own home.
Too often, these incidents, this behaviour, is normalised and swept under the rug. It is funny to make fun of Asians, to sexualise them because they don’t care, they don’t FEEL.  They’re submissive in bed; don’t worry, they won’t argue or fight back. They’re small and cute, almost invisible.
It is such behaviour, such stereotyping, hyper-sexualising and infantilising of Asian women, that is all the more painful in light of the recent rise in hate crimes against Asians around the Western world, epitomised in the brutal shooting of the Asian-American women in Atlanta.
So where does this deeply embedded and terrifyingly normalised consciousness come from?
In one sense, it is very much historical. Like many parts of the world, many parts of Asia were subject to Western Imperialism: its desire to conquer and rule, its paternalistic perception of inferior colonial subjects, its desire for the exotic goods of the East. From the British Empire’s territories in Myanmar, India, Sri Lankaand Hong King, France’s colonies in present-day Vietnam, Laos and Cambodia, the Spanish territories in the Philippines, even to the intervention of Western countries such as America in parts of Asia during the Cold War, the impact of colonialism is widespread.
Indeed, it was the Western world and these Empires that constructed the prevailing myth of East Asian peoples as ‘The Yellow Peril’: faceless, primitive humans. Almost ironically, this myth originated from the immigration of Asian ‘aliens’ to the very countries that had themselves invaded parts of Asia and continued well into the 20th-century. In Cll Chinese immigration, with few exceptions, and was repealed in 1947. In America, along with the Chinese Massacre of 1871 – in which 500 white individuals stormed Old Chinatown in Los Angeles, killing and hanging Chinese immigrants – racist political pressure prompted the Immigration Act of 1917 and Asian Exclusion Act of 1924, barring immigration from the Asia-Pacific zone, altered in 1952 by an immigration quota scheme with preference determined by desirable ethnic groups. proliferation In Australia, the Yellow Peril novels, such as White of Yellow? (1927) and The Yellow Wave (1895) expressed not only the fear of racial invasion but also the fear of Asian sexual voraciousness and immorality, echoed in Britain. This facilitated the White Australia Policy that sought to legally ban or limit non-white immigration from 1901 to as recent as 1975, with current senator Pauline Hanson famously asserting in her Maiden Speech in 1996 that Australia was being ‘swamped by Asians’.
Although we speak of the ‘rise’ in Asian Hate Crimes in the past year, this issue is nothing new. It is shocking, but not surprising. It is embedded in the very fabric of our inherently racist, patriarchal societies that have been founded on white supremacy. It is time for all of us, especially those who continue to enjoy aspects of Asian cultures that they pick and choose, to stand up to such a normalised, racist consciousness that has led to this violence. To speak out against those little comments, those off-handed remarks and ‘jokes’, because it is a fundamental issue that is ingrained in all our psyches.
Here is a poem I’d like to leave you with, written following an incident of racial and sexual harassment.
To let me echo you.
But then, the silence.
Her voice is stolen.
Her tongue is dead.
Are trapped, are gone.
Sold in the west.
It has none!


Curious and Eclectic Fused Glass,
Made on Vancouver Island.
A little bit about my process: The local wildlife and landscapes I photograph on Vancouver Island inspire most of my glass work, basically I am a bit of a gardening and bird nerd.
I have a rather short attention span so using my own photography as inspiration gives me plenty of opportunity to change up the focus of my work. Nature, gardening and pets are the most common themes you will see in my fused glass.
Everything I create is unique and handcrafted, even small items such as magnets or ornaments have variations in them and each piece of my glass artwork has its own distinct character.
Even my frames are made locally by my talented friend Peter Cooke.
My history working with glass:
I have worked with glass for more than 22 years (yes I am that old), I learned to work with stained glass in the late 1990’s and then in 2006 I was introduced to fused glass while working in a commercial stained glass shop. For now I have hung up my soldering iron and I work strictly with fused glass but I am sure one day I will pick up my soldering iron again return to making some stained glass.


ally sprinkled with gorgeous little flourishes, from its interactive environments to the numerous little residents of each stage who react to you in different ways.
<br /).

 Go to the cave stage and you'll be able to explore its near darkness by allowing a little man with a lantern to sit atop you as you plough through treasure.

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This stage is also the most obvious example of the actual game tucked away underneath Hohokum's stylised worlds, and therefore the area where it becomes clear that despite its aesthetic beauty its gameplay feels too basic.

 It's clear that Hohokum is about style first and foremost, but once that style's initial welcome eventually wears off you're left looking for substance, and it's here where Hohokum's shortcomings come to the fore.
 As a game, it's left wanting. A lack of signposting makes for trial-and-error experiments which can be frustrating, and the confusing stage layout means you'll get lost unless you can memorise increasingly labyrinthian world maps.

.

 MovieStarPlanet Hack Tool. Using MovieStarPlanet cheats takes time and effort only to get limited number of resources. With Msp Hack Tool we are talking unlimited resources like Diamonds, Star Coins, Fame and VIP.

 In its defense, it does its best to ensure you explore the game world with the addition of hidden eyes, which are located around each stage and have to be collected by flying past them and making them open up.
.

But this is only a nudge in the right direction, leaving us with a game that frustrates as often as it fascinates and nullifies many of the positive vibes it initially sends out.

 Hohokum is love at first sight - it will have you captivated for its opening hours. And if you believe charm is more important than challenge, you'll be enthralled throughout.

.

.imajinasi tak bertepi Street Fighter IV rewrites the formul />.
<br /.) The new stages, meanwhile, are bursting with personality and colour, though their more fantastical, over-the-top settings and design can feel at odds with the rest of the game. Duking it out in a cosmic space elevator isn't technically street fighting.

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USE YOUR SURVIVAL INSTINCTSSNEAK TO GAIN AN EDGE
A

.

.

FIND EVERY COLLECTIBLE
Throughout.

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Coastal Forest (Complete map) - On a platform up a tree northeast of the Forest Ruins base camp

Mountain Temple (Complete map) camp

Mountain Village (Relic map) - Tomb of the Unworthy reward

Mountain Village (GPS map) - Tomb of Ascension reward

Mountain Base/Base Exterior (Complete map) - Down the zip line directly above the Radio Tower base camp

Shanty Town (Relic map) - Well of Tears reward

Shanty Town (GPS map) - Hall of Judgment reward

Geothermal Caverns (Complete map)

Summit Forest (Relic map) - Stormguard Sanctum reward

Shipwreck Beach (Relic map) - The Flooded Vault reward

Shipwreck Beach (GPS map) - Temple of the Handmaidens reward

Cliffside Bunker (Complete map) - Next

Research Base (Complete map) - In the corridor after beating the lift puzzle

Chasm Shrine (Complete map) - On a raised platform above the winch puzzle

Be aware that some collectibles are found in the Cliffside Bunker area on the southern tip of the island which doesn't have a fast travel base camp, and once you've completed the game it can only be accessed via Shipwreck Beach.

EXAMINE RELICS TO REVEAL SECRETS
Once.

!

TRAVERSE AREAS SAFELY
There.

.

KNOW YOUR LIMITS WHEN EXPLORING</h3.

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UPG


convulsions, when Ignatia is the remedy, you will find the face pale, or else at times flushed up, but usually deathly pale. There is twitching of individual muscles, those about the eyelids or the mouth, and the child stiffens out. Especially is Ignatia the remedy when the convulsions have appeared after grief, fright, or some violent emotion.
GLONOIN produces sudden violent congestions to the head as does Opium. Like Opium and Ignatia, it may be used for the sudden effects of violent emotions. In the convulsions, the fingers are spread asunder and extended, a symptom which you also find under SECALE.
VERATRUM ALBUM also suits for convulsions after sudden violent emotions. But you find the face cold and blue, with cold sweat on the forehead.
BELLADONNA remedy for convulsions following violent emotions, anger, etc., with bright red face, wild straining eyes, hot head, and spasms of the glottis.
OPIUM is probably the best remedy when, from fright of the wet-nurse, the child gets retention of urine.
CUPRUM is indicated in convulsions where the fingers are clenched. There is marked blueness of the face and mouth. Any attempt to swallow fluids causes gurgling in the throat.
IGNATIA may be used in chills and fever when there is thirst during the chill and when the warmth of the stove or artificial heat relieves the chill. That is not a common symptom. This is very diiFerent from NUX VOMICA, which finds no relief from covering up or from the heat of the stove.
The action of Ignatia on the genital organs must also be mentioned, as we find it indicated in dysmenorrhoea, associated with what is termed menstrua) colic, that is when there is a great deal of bearing down in the hypogastric region. The patient exhibits hysterical symptoms. The pains are of labor-like character, and are seemingly relieved by pressure, by lying down, and by change of position. The menses are dark.
The nearest remedies here are, first, COCCULUS INDICUS. This has uterine spasms and dark menstrual flow ; but the backache always enables you to differentiate this drug from others. It has a weak, lame feeling in the small of the back, as though the patient were about to be paralyzed. The limbs tremble when the patient begins to walk. In addition to this, she often complains of a feeling of emptiness, or hollowness in various cavities of the body, especially in the chest and abdomen.
PULSATILLA is at times to be us; and the more severe are the pains, the more chilly does the patient become.
CHAMOMILLA is a third drug similar to Ignatia in uterine spasms. It is indicated by the mental symptoms. The patient is very cross, can scarcely answer any one civilly.
ACTEA RACEMOSA is called for in uterine spasms when the pains fly across the hypogastrium from side to side.
STRAMONIUM and VERATRUM ALBUM for hiccough after hot drinks, and ARSENICUM and PULSATILLA after cold drinks.
TEUCRIUM MARUM VERUM is useful in hiccough after nursing.
ZINCUM holds a very peculiar relation to Ignatia and Nux vomica. It follows Ignatia well while it is inimical to Nux vomica. </s> >>.
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ALBION midfielder Ronnie Wallwork has again urged patience as the Baggies prepare for another difficult test against Southend tomorrow.
Although boasting an impressive 100 per cent record from their Championship programme to date, the Baggies haven't had it all their own way at The Hawthorns this season as less-fancied teams pitch up to try and stifle and frustrate.
"After being unfortunate not to win at Preston, we are all looking forward to going out against Southend and are desperate for three points," he said.
Albion's impeccable points haul at home this season is in contrast to their failure to yet win on their travels, but Wallwork insists that will all be sorted in time.
"We just need to get the three points tomorrow and then address our away form, simple as that," he added.


PHNOM PENH (FN), Feb. 22 — Arriving this morning, Feb.22, visiting Thai princess Maha Chakri Sirindhorn met with Prime Minister Hun Sen later of the day at Peace Palace, Phnom Penh, hailing Cambodian students as being “smart and hard-working”.
The Thai princess is on a three-day visit Cambodia from Feb. 22, through Feb. 24, during which she will preside over a number of projec
Prime Minister Hun Sen saidwould be further strengthened through this important visit by the princess and that a lot of benefits would be therefore generated and in the interest of the two countries and people.


wins in his home state of Vermont. According to early results...
Acl...


I remember well the path from which I came, but I know that if I spend too much time dwelling on how I got here, I will be paralyzed and unable to proceed. Absence of progress does not progress make, so I know I must push on. It's difficult to make a decision, but I know I have to make a choice.
As new information becomes available, it's important to constantly re-evaluate the choices that available based on the information that is known. But it doesn't mean that the original decision isn't valid… it just means it's important to continue to evaluate and adjust as you get more information.


Bike-riding bureaucracy may threaten the classic 'obāchan dismount'
I can understand this new law to a point. But after that point, I wonder if there aren’t huge advantages to riding against the flow of traffic so you can see what is coming and avoid an accident (the very reason it is recommended you walk against the traffic). There are few bicycle lanes in Japan and most people ride slow-moving mama-chari clunkers intended as people-movers. Thus they are ill- equipped for road riding, with few reflectors and no mirrors to give you warning of what is coming up behind you. Riding against the traffic serves as the largest rear-view mirror you could ever wish for. And the Japanese have always ridden this way. They’re quite used to it.
Furthermore, the Japanese people are quite deft at cycling with a child in a seat on the front handlebars and another in the seat over the back wheel. Some riders even bring their dog along on a lead so he can get some exercise. In Japan, cycling is truly a family affair.
While I agree with jurisprudence that will make society safer and more orderly, wouldn’t having bicycle lanes do far more to protect us than denying us the world’s largest rear-view mirror?
You are also not allowed to hold an open umbrella, ride next to another cyclist or carry more than one child (up to 6 years old) on the bicycle at a time. And, believe it or not, it’s an infraction to cross the road while the traffic light is still red, even when there is no one around to see you do it.
But this is what rattles my chain: Why make new laws that may have little effect?
Rather than aim for extreme bicycle harmony, perhaps we should teach critical thinking skills that promote bicycle safety (helmets, anyone?). Then we would be more prepared to deal with those inclement occasions when people do break the rules (because people like us will always break the rules). After all, it would be sad to see the extinction of the “obāchan dismount” — the ability to jump off your bike (and land squarely on two feet) when things get the slightest bit dicey.
If we always rely on rules to tell us what to do and what not to do, then I wonder what will be next. “No kayaking on the highway,” perhaps?
transportation, cycling, road traffic law


On January 27th, 2007, in a splendid evening of entertainment, novelist James Conroyd Martin was awarded a gold medal by The American Institute of Polish Culture. Martin was honored "for promotion of Polish history and culture." In the presentation of the medal, Lady Blanka Rosenstiel, founder and president of the institute, cited Martin's books as "extraordinarily beautiful and insightful."


Students Association pleads with ASUU to resolve dispute with FG

 on, would “definitely portend ill for the education sector’’ and the country in general.
“We are trying to meet with education stakeholders as well as ASUU to put the agitating issues on the table to see which ones we can plead with ASUU to suspend for now and the ones we can engage the Federal Government on.
“As much as we are not in support of the strike, we are not telling ASUU out-rightly that it is wrong for them to go on strike. You don’t flog a man and tell him not to cry.
“We are also pleading with the Federal Gme since 2009.
“We are planning to engage them on Monday, Aug. 21. Let us sit down collectively and find a way out,’’ Okereafor said.
“If ASUU cannot go on research to get the desire.


So often we speak as if like feedback, we value feedback, we even welcome feedback. I worked with a client a number of years ago who's mantra was "We are a feedback-rich environment!"
Do we have the same reactions however when the feedback we receive is more critical?Is there a best way to respond when you are given feedback that your performance is not up to standard or that your behaviors are not valued by others?
I had a client call me a few weeks ago and he was audibly frustrated when I answered the phone. We really didn't even exchange any pleasantries like, "How are you doing?
"Scott, you would not believe my boss and what she just did!We on a really important project for one of our top internal customers. The project has gone well overall, the client has been very pleased and there have been zero complaints, and we are even under budget. When I sat down to review the project as part of my performance review, my boss acknowledged my hard work and then said I would be getting an average performance rating. Average!I can tell you my performance was anything but average!"
He said that he just sat there just stunned and ask himself, "How could anything on the project went any better?Average performance?What do you have to do to get a top performance recognition around here?"
He told me that he was so emotional that he couldn't even hear anything else his boss was saying to him. All he wanted to know was WHY she felt this way. Was she paying attention at all?
I said to the young man on the phone, "It sounds to me like what your boss is saying is that your performance is like that of most people in the organization and that means that it is good enough that they want you to stick around for the near future."
"Scott, you have no idea how hard I worked, how many hours, what we did to make that project happen on time and under budget."
"I am sure I don't understand the details, but I am wondering if you are hearing the message your boss is trying to send. She is saying well done, but since you are expecting to hear 'excellent,' and you are not, what you are hearing is 'bad.'"
Then I said, "Are you sure her message to you is BAD?"
I don't think he heard my question because he was still so fired up that he said to me, "All I want to know is WHY she feels this way."
"That may be the wrong question," I said, "I think what you want to really know is HOW you could do better next time to get the rating you are expecting."
Have you ever experienced this?I mean, worked really hard on something, poured your life into it, thought you were doing really well, and then suddenly you are confronted with the feeling that what you are doing isn't really good enough?
Next week I will continue on the topic of critical feedback, and offer more ideas on how to respond in this kind of situation. Have you experienced a situation like this before?


Andrew Bosworth, now in an internal memo published December 30 and obtained by The New York Times, that while he felt Facebook was “responsible” for Trump’s election, it was not due to Russian meddling.
“,” he wrote.
Bosworth closed his post by endorsing Facebook CEO Mark Zuckerberg’s defense of political advertising on the platform, after hundreds of employees criticized the decision.


The puzzles belonging to this category are usually solved by opening or dividing them into pieces, including those puzzles with secret opening mechanisms, which must be opened by repeated approximations.
Even those puzzles consisting of several metal parts, connected together in a certain way, belong to this category.
The two puzzles of the image on the right are particularly fun to play during meetings between friends or in family evenings, since they seem to be easily resolvable but, in reality, a lot of people cannot solve them. In this case the problem is represented by the connecting parts that have a conical part that can only be removed with the movement in one way direction. However, each piece has a blocked side so that it could be fitted into the groove of the adjacent part due to its shape. As a result, the other direction is also blocked, so that its groove remains stuck in the side of the next adjacent part.
The so called "secret boxes" or "puzzle boxes with secret opening mechanisms" are extremely popular in Japan and belong to this category. These boxes contain, usually invisible, more or less complex mechanisms that reveal a small gap in the opening. There is a wide variety of opening mechanisms: the barely visible panels that need to be moved, tilt mechanisms, magnetic locks, movable pins that need to be turned to a certain position up and even the time locks where an object must be kept in a precise position until the liquid fills a container.


I am an ATT customer and don't have time to go stand in line. Therefore, I was wondering at what time would I be able to check either ATT or Apple online to see if the pick up instore is available?
I wonder is it better to look for an iPhone at malls...
I've read that malls don't let customers in early compared to standalone stores. Anyone ever experienced success at malls compared to standalone stores?
But do they have any stock?


Ministry of Infrastructure and Watermanagement. including 6  implementing bodies: Dutch Customs, Rijkswaterstaat, Rijksdienst Wegvervoer, Cargonaut, Portbase, and Connekt
Ministry for Transport, Mobility & Urban Agenda
The project is open to observer organisations that would like to contribute and join efforts to realize a sustainable data sharing. The German Ministry of Transport and Digital infrastructure participates as an observer in the FEDeRATED projects.
Within the context of testing data sharing opportunities on their feasibility  business and public authorities are invited to participate in a multitude of national and cross-bordering pilots and living labs.


Pyridoxine hydrochloride is an essential vitamin (vitamin B6) required for healthy body function. In cases of deficiency, it can be taken as an oral dietary supplement. Pyridoxine is a vitaminm and specifically the manufacture of antibodies, the maintenance of nerve function, the making red blood cells and hemoglobin, and the maintenance of blood.


or out of range, setting to INVALID_GENID, jn=18446744073709551616.000000
1. The same indexer node indexes the data pushed to it, and it is searchable in Splunk Web by browsing to http://{indexer_host}:8000
Before the issue appeared, no configuration changes were done.
If you are seeing errror in your Clustered Indexers splunkd.log:
INFO CMMaster - event=commitGenerationFailure pendingGen=13 requesterReason=addPeerSuccess guid= <GUID> failureReason='Cluster has only 'x' peers (waiting for 'y' peers to join the cluster).
The errors will stop appearing when the required number of peers to meet Replication factor is online
also haven't hear about this ClusterMaster (CM) error Message. Could it be a Custom one from a 3rd party App?
But for the additional 2. 😞 The Indexers in a indexing Cluster typically can only search on own data... maybe Its changeable when you connect the cluster as search peer : But I'm pretty sure you should not do this
Hi SierraX,
One or more replicated indexes may not be fully searchable. Some search results may be incomplete or duplicated as we try to fix up your cluster. For more information, check the cluster manager page on the master - splunkd URI: https://{splunk_master_node}:8089.
What resulted the above message? and what should I look for in the "https://{splunkmasternode}:8089" URL?
A bit confused.. </s> Ken of N9000+
There will only be one live recording this Saturday, 7/20/19 at 11 AM instead of two: N9000+'s Stranger Things: Season 3 spoiler review with special guest, Todd of Todd Foolery. CLICK HERE TO GO TO THE LIVE EVENT:View: </s> Well, this is the last time i’m saying “i don’t wanna do lessons today, i’ll do them later”
 Install this userscript KunOn script
Read the Textfugu explanation of onyomi / kunyomi
On ’.
General rule of thumb I use is:
- Kanji by itself like 月 = kun reading
- Kanji with hirgana (okurigana) like 長い or 着く = kun reading
- Kanji with other kanji like 漢字 = on readingd to find the answer myself but to no avail–
Is there a script that shows all possible meanings after a correct answer during review?
It really help in situations when there are words having overlapping meanings such as:
実 - 「じつ」 ---------> Reality; Truth
事実 -「じじつ」 ----> Reality; Truth; Fact
Much Appreciated! </s> It’s a bit hard to see where it fits, because the radical is never used anywhere
For the mythical update it would the good the clean up the radicals used 0–1 times a bit (looks at raptor cage).
Wow, your memory is something else! I had no recollection of this thread at all, and I was the one who wrote it
that looks radically different from what I remember.
“We’re making some huge radical changes soon


GLOBAL EDITION BENCHMARKER Auto Retail Best Practices from Across the Globe "...dealers who relentlessly manage these components will set themselves up for considerable benefits...
Tony Noland Owner, Tony Noland & Associates Tony Noland started as a salesperson and served in most of the traditional management positions in the retail dealership structures, including Dealer Principal ultimately becoming President and CEO of a major U.S. 20 Group company with more than 3,000 automotive clients. His regular BenchMarker International column records and reviews the U.S. retail motor business. He can be reached at tonynoland@me.com New Vehicle Sales Recovery Continues; But Look How Bad It Really Was…
any fancy programming stuff, and you can make all the necessary changes and adjustments yourself as you go along....
Why would you do that then?And, certainly, why would you do it now?"The answer is of course that each department should and must be a profit center. If that is not the case there is an issue. If you then apply focus, structure and management, somewhere in there is a weakness that is failing to produce profitability for all departments." The message: Go out there and fix it. With direction from Paddy O'Brien, global chairman of Sewells Group, we followed with a series of questions to which Mark gives his insightful responses: What sets Gaukroger Holden apart from the other Australian dealers?"I'm not sure what other dealers do – and that has never been my focus. I only concern myself with what we do and how we can do it better. "Are we perfect?No, absolutely not. Are we driven to succeed?Absolutely. Maintaining that level of drive month in and month out and refusing to be anything but the best you can be, seems to produce consistent results." Are you doing anything special to motivate and retain your key staff?"The people working on your staff are the key to any business or organization and dealership success is usually directly contributable to its people. We continually pose the following to ourselves: • How well are our people trained, rewarded and appreciated?• Do we have the right people in the right roles?Edition: September 2014 | sewellsgroup.com 22 In-Depth with Benchmarker "At our dealership, all staff have incentives in place linked to some form of KPI performance measurement. This ensures all staff feel they are an integral part of the team." What ingredients to success do you put into the mix to ensure that your people get the most out of every opportunity?"The term 'ingredients to success' is quite appropriate because – just as in cooking – you may have all the ingredients but if you fail to measure them the pie is going to taste and look like a mess!It's the same with dealershipfellow dealer principals I know that look at the month's results only at the END of the month!That's like a pilot looking at his instruments or flight path just five minutes from arrival time. That's TOO LATE!Any dealer that has a decent DMS, has good people and has a remote interest in what they do, can and does measure dealership performance on a daily basis. "In no particular order of priority, focus should be on prospect management, PDS/SSS, workshop control, daily sales, daily gross measurement, expense management…to name but a few. It becomes a daily habit – just like any other habit: it is simply what you do as part of the daily routine." Do you differentiate between the customer experience and customer retention in your business?"No. I don't see how they are not interconnected anyway. We also don't differentiate between our customers. If you buy a $1,000 runner, you get the same follow-up call, the same customer service and the same buying experience as if you had bought a $50,000 motor car. The same goes for the treatment in our service department – regardless as to what car you book in for a service you get the same level of treatment, follow-up and overall attention. Where do you see opportunities for a dealer like yourself to excel given that you are away from the major metropolitan centers?"I don't see any real difference between any dealer – be they in the city or out in the country – the same principles should apply, just service your own PMA to the absolute best of your ability. "Treat your customers well, promote your dealership, get good people on board and keep them. These are all the keys to running a good business regardless of where you are. Do you believe there are differences between a major metro dealer and a smaller dealer?"It's all scale and relevance. Let me ask you if you believe there's a difference between having $1,000 in the bank when you were young and that's all you had. Then you had $10,000. Did you treat it any different?What about when you got to $100,000 in the bank3 In-Depth with Benchmarker How important is it to engage key members of the team in your VISION for excellence?How would you feel if you were up in the back of the plane in economy and the captain was up there washing dishes with the flight stewards and wasn't communicating with the co-pilot?Sure, the co-pilot MAY have some experience, and may be able to do everything the captain can do but you expect the full attention and service of the entire flight crew. It's exactly the same at the dealership. Time and again you can witness dealerships that 'glide along' on their own flight path, going where the breeze takes them because there is no-one firmly at the controls having shared a flight plan, and a backup plan for the flight plan and a firm course of action that ensures that the dealership is going to land exactly as planned at the end of the month." How does the pooling of concepts and best practice strategies in your business development group gatherings help you?"I find the BDG meeting concept (similar to performance groups facilitated by Sewells Group worldwide) invaluable. Comparative data, six-month trends, networking, benchmarking, industry data…these are all provided. Paddy O'Brien's input with the Sewells Group MRA Performance Model formula (Mix, Retained, Activity) have been great for our dealership as this was a new concept to us. Of all the things that I can't or won't make time for, the BDG meetings have become paramount for me and are viewed as 'must attend' meetings of the greatest importance."Mike McCready joined the motorcycle business straight out of school, working in parts and then sales there for four years. He then worked at Car Auction House for two years before joining Robertson Holden as a new car salesman in 1997. He moved from there to the position of used vehicle manager and then general sales manager from 1999 before becoming dealer principal in 2005. Robertson Holden has three outlets employing 49 people and selling around 700 cars and 100 trucks a year Edition: September 2014 | sewellsgroup.com 24 INTERVIEW In Tough Times, Don't Kill the Team!When times get tough, don't kill the team, says Mike McCready of Robertson Holden in Palmerston North, New Zealand. "When market conditions tighten, we focus on our proven procedures to ensure our people are carrying out their job functions correctly – and doing so with a smile. Also, we re-evaluate non-essential expenses and focus on those which generate enquiries or add significantly to our customer experience. "Firmly, though, we say don't kill the team: if the effort is going in, we back them and support them all the way." Retaining and motivating key staff members is high on Mike's priority list: "Simply put, our belief is: Communicate!Communicate!Communicate!
"Paddy O'Brien (global chairman of Sewells Group) tells me we are humble about our achievements; but I don't feel what we do is exceptional. We try to get the little things right and maybe in doing this the perceived 'Big Things' don't feel so enormous to us. I expect we have one of the strongest returns in NZ but our group has some very good operators with some being stronger in certain areas. We try to learn to learn from their experiences both good and bad."
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agency noted that Greenland's summer melt now lasts 70 days longer than it did several decades ago, paving the way for the possibility of more burns.


ith an all-of-the-above strategy."
While briefing reporters today, President Obama said thprice of gas, yet the president failed to offer any new solutions to increase American energy supplies and help make prices more affordable. Again stating there is "no silver bullet" to reduce prices, the president continues to blame soaring prices on speculators and called for more clean energy projects and increased taxes. These are the same tired talking points from his 2008 presidential campaign except with a new twist -the president has finally acknowledged that any meaningful energy policy starts with an "all-of-the-above" strategy. But while the president may say he is for "all-of the-above" his actions say "nothing-from-below."
rise almost $2.00 per gallon. This is unacceptable and that is why thhearing on gas prices tomorrow. "President Obama continues to say that he supports an "˜all-of-the-above' national energy strategy. Unfortunately,not followed in line with this statement."
The House has passed multiple bills to increase domestic energy production, secure access to North American energy supplies, and help provide relief at the pump. If the president is serious about embracing "all-of-the-above" he should support these bills and urge his Democratic colleagues in the Senate to pass them as soon as possible. Has the president really had a change of heart?Or is this just more of the same empty rhetoric?


"Richard just told me to let him get up on his feet and see what happens," said Gomez. "He didn't want me to take too much away from him so I didn't, and he traveled beautifully…
"…He can get lazy when he makes the lead, so I have to keep him focused…Today, when he saw the cameras as we crossed the finish he shied away from them a bit. He's a young horse, and he's only getting better. He has a bright future."
"The horse is a good horse," said Hughes. "I think we're going to try the Met Mile (at Belmont Park, on May 27)."
"I had an easy lead but he didn't run his best race for some reason," said Maldonado. "It was a slow pace and the winner had a great trip."


According to findings from the CSO.
One in five households say they experienced 'great difficulty' making ends meet.
The study finds the median household disposable income in 2021 was 46,471, compared with 43,915 in 2020.
One in four single parent households were in arrears on utility bills last year.
The at risk poverty rate fell from 13.2 per cent in 2020 fell to 11.6 per cent last year.


Vn the hopes of scoring the coveted full-size candy bar. Be prepared with the goods and perhaps this year’s trendiest Halloween décor item: the candy chute!
For trick-or-treaters: many communities ask that you
Beggar's Night (learn the history of this Greater Des Moines-specific ritual here) Friday, October 30, from 6-8 p.m.
*Get the most milage out of your costume in Clive, where kids get an extra hour to collect treats from 5:30-8:30 p.m.
Bucking the customary Greater Des Moines Beggar’s night holiday, the city of Grimes hosts Trick-or-Treaters on the traditional Halloween night, Saturday, October 31st from 6 – 8 p.m.


Asparagus is the edible shoot or spear of the plant “Asparagus officinalis”. It is a member of the Lily family. Asparagus is very hardy. It comes in White, Green, and Purple varieties. t has been consumed for over 2000 years. It was originally valued for medicinal purposes. Today there are over 300 varieties, only which 20 of those are edible.
Asparagus is usually available from February to June. It is harvested at 6 to 8 inches. Look for spears that are firm and whose blossoms are tight. Store wrapped in a wet paper towel or trim a little off the end and then store in a glass with a little water in the bottom. After harvesting, the woody end needs to be snapped off at its natural bending point. The stalks can also be peeled to remove some of their fibers. Store the stalks in water or wet towels. To cook, plunge in boiling, salted water, and then shock in ice water to stop the cooking if not going to be eaten immediately. They can also be sautéed, roasted or grilled successfully. Small spears can be cooked as is. If the spear is thicker- it usually requires to be blanched first. Asparagus is sold as three different sizes: pencil, standard, and jumbo. The pencil thin variety usually does not need to be peeled. It is very tender and is sometimes suitable to be eaten raw. Jumbo asparagus should be peeled and is very fibrous.
5 pounds pencil thin asparagus 1 tbsp salt 2 tbsp unsalted butter, plus extra for greasing 1/2 cup freshly grated Parmigianino Reggiano Trim the tough lower portion of the asparagus with a vegetable peeler. Cut the bottom 2 inches off of the asparagus, making all the asparagus the same length. Bring a pot of water to a boil, add the salt, and drop in the asparagus; if you can, keep them standing upright. Cover; cook or tongs; cool. Butter a 9” round baking dish. Arrange the asparagus in the dish with the tips facing the center. Sprinkle with the Parmigianino; top with the butter. Bake for 25 minutes or until slightly browned, using a fork to turn every 5 minutes to prevent sticking. Serve hot. Serves 4.


I cannot overemphasize how crucial it is to have a legal advocate – not just someone with a law degree -- on your side when you or your child is facing criminal charges. You need a lawyer who is committed to your future beyond the outcome of your case, one who has insight into how criminal proceedings can affect family and employment, citizenship and other collateral concerns.
I am that lawyer. Motivated by a passion for protecting citizens' constitutional rights, I have focused my legal practice on representing the criminally accused in San Mateo County, California, for the past six years. I sympathize with the families involved in criminal proceedings and work hard to serve the best interests of everyone involved.
Keeping Families Together And Avoiding Jail Time
I intervene to protect my clients throughout the criminal justice process, from pre-arrest representation, to post-arrest and post-conviction matters. I handle criminal cases with sensitivity toward family dynamics and advocate for alternative solutions that target underlying causes instead of punishing individuals.
I am one of few criminal defense attorneys in the area who handles all of the following:
Unlike other firms that approach criminal defense with a minimize-the-damage mindset, I approach every case with investigative integrity. I never begin by negotiating a plea bargain because I believe that the government should always be held to the highest level of proof before the gavel hits the sound block.
Contact A Criminal Defense Lawyer In Redwood City
If you suspect that you are under criminal investigation, or if your son or daughter has been arrested, don't wait to contact a lawyer. A proactive defense is the best defense, and I offer all my clients free initial case evaluations. To get in touch with me, email or call 650-288-6855.
Red Wood City, CA 94063
The Law Offices of Emily K. Andrews is located in Redwood City, California, and serves San Carlos, Atherton, and other cities in and near San Mateo County.


& Results, 2017
November
Someysosomal-storage-disorders-pipeline-analysislysosomal-storage-disorders-pipeline-analysis
Some of the otherlysosome storage disorder include GlaxoSmithKline plc, Sanofi Genzyme, Amicus Therapeutics, Inc. and others.Pipelines


- Professional sized oval nylon bristle general brush
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The original “Booty,” off J. Lo’xx’s “Ms. New Booty” and commenting on Lopez’s butt-related skills: “The way she twerk it, not fair.”“They beggin’ me to drop down but right now Iggy on top.” Can’d’s Hot 100.


October 12, 2021 November 10, 2021 shaunstacy78@gmailcom Uncategorized
New Scream trailer hints at an OG character's death
T, and David Arquette's… Continue reading complex history of Marvel and DC's queer characters
It's Pride Month, so let's take a bit of a deep dive into the complicated history of queer comic book characters and the "Big Two" publishers, Marvel Comics and DC Comics. I started reading comic books in the early 90s, with my very first comic book purchase being Avengers #345 (Part 5 of "Operation: Galactic … Continue reading How Cruella nails the villain origin story
First of all, if you haven't seen Cruella yet, stop reading and go watch it. The aesthetic alone is worth it. Furthermore, I believe it to be one of the best movies of 2021. Yes, it's THAT good. The two leading Emma's, Stone and Thompson, delivery Oscar-worthy performances from beginning to end. The writing is … Continue reading How Cruella nails the villain origin story


And in typical me fashion, I ask ‘why’? Why lighthouses? According to some, it is merely a structure and usually similar in design and aesthetic.
Perhaps it is where this monolithic (in my mind) structure stands – precariously it seems on the edge of a cliff, tall and proud. I have an affinity with the ocean – the hypnotic sound of the waves, soothing no matter its volume or rhythm. An island girl at heart :-).
Perhaps it is the romantic stories I weave in my mind about its existence, a beacon to ships out in the dark, guiding; providing a sense of security that there is land even if treacherous. Its light a warning, to protect; not an invitation to draw near. Solitary.
The vision of self-contained strength even when alone and separate has been my companion for many years. No wonder the lighthouse analogy resonates! So now I know. Interesting how long it has taken me to make this connection.
As I write this post, the song ‘I am a rock’ pop into my head. This song, which first introduced me to Simon & Garfunkel, seems apt. Listening to it again, it occurs to me that the song does not compliment but rather, provides a good contrast to what I was talking about. The rock metaphor in the song is merely a defensive mechanism to protect self. It is a belief derived from fear…fear of pain and sorrow.
I realise this no longer hold true for me. For I am older now and a little wiser. My vision of strength has so radically evolved. A defensive measure like that can only shrink my world, reduce me to merely existing and feeds the fear within.
For those interested, this is ‘I am a Rock’ by Simon & Garfunkel.
Wishing you true strength,
Tagged Choices, enough, fear, Life, lighthouse, Love, Pain, resilience, Simon & Garfunkel, solitary, solitude, Strength, Vulnerability
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The European new car market increased 73% compared with May 2020.
JATO Dynamics measured data from 26 European markets and found sales totalling 1,073,987 units, taking the year-to-date total to 5,150,831. Despite this increase, volume was 25% lower than May 2019.
Total sales were boosted by increasing consumer demand for EVs and SUVs – with Volkswagen Group now leading in Europe across both segments. EVs took 16% of all registrations while SUVs made up almost 45% of the total volume.
Retotalled 171,415 units, up by 279% compared with May 2020, while BEV volume totalled 83,700, 261% increase, and PHEVs were up 299% to 87,700 units.


Am I thinking too much?Should I wait until I have more credibility with the boss and try to change his policy?
@Pierre - How does that matter?If the company doesn't make any money, it's ok for them to steal?
If this company finds it this easy to compromise ethical principles so blatantly when it comes to software, how can you trust them to do the right thing under any circumstances?What is going to happen when you are in a situation where you require honesty from them, or the capacity to follow ethical principles of any kind in their dealings with you?
@Jon: What's that got to do with anything?
So it's a software company that believes people don't need to pay for software?I wonder how they sell anything...
If you're located someplace where this practice is normal, you'd have to change countries rather than jobs. Though there may be employers that do pay for software, they could be few and far between. Obviously if you're in the United States, blatant piracy would be a huge red flag (basing this on my own work experience here and other people's comments). In countries where MS Windows costs 10 times as much -- calculating the price in beers at a local pub, or whatever fixed unit you want (haircuts!bread!
Why not go for free software, if you can't pay for it?
How would you feel about using your product by another company without paying you?
23Use of pirated/cracked software for development5Ethics, Clients, and legal repercussions12How to deal with non-licensed software731Is it ethical to teach teens about software viruses?4W9Setting up an Ethical Guidance Committee for the protection of developers?39Should I include a selfdestruct-method to my applications?9Turning in code you developed in your company as homework assignments3Is it a good idea to collect anonymous usage statistics in a free program?


Ahoy, Mates! Don't missnce. Performances will be this weekend: October 28th and 29th at 6:30 p.m. Buy your tickets now at the Campus Store for 150 pesos. Come and support Faith Academy's up-and-coming talent. Arg!


- ISCO's first priority was achieved when, at the end of 2007, ISCO was recognised by IMO as a NGO with Consultative Status.
- Similar application will be made to other relevent international organisations
- Work will be completed on the ISCO web site, making it a user-friendly source of information and assistance to members
- Work will be progressed on the creation of the ISCO member database which will provide information on member capabilities to IMO, ITOPF and other organisations
- Useful downloadable material will be collated for inclusion in the web site members' area – useful forms, templates, protocols, safety procedures, and reference data for use in spill control operations.
- Other ideas suggested by members with the objective of ensuring that ISCO is the best source of practical help to its members.


?internal branches and the transmembrane internal helices comparable firm to those of the mammalian ZD6474 biological activity as the central cytoplasmic domains move from it, and in addition from the 4-fold axis. Along the ion pathway, SHGC-10760 exact relocation of the internal helices and internal branches results within an approximately 4 ? diameter boost of the ion gate. Whereas the ZD6474 biological activity internal helices of the K+ stations and of the RyR1 channel cross-correlate greatest with their corresponding open up/closed says, the cytoplasmic internal branches, that are not seen in the K+ stations, appear to possess at least as essential a job as the internalternal helices, the internal branches, and the h1 densities collectively create a competent novel gating system for channel starting by comforts. Author Overview Maintaining an accurate intracellular calcium focus is crucial for cellular survival. In skeletal muscle tissue, ryanodine receptor type 1 (RyR1) can be an intracellular calcium-launch channel that’s crucial for contraction. Right here, we utilized single-channel ways to demonstrate the current presence of functionally homogenous populations of RyR1 in either the shut or open condition ZD6474 biological activity and applied cryo-electron microscopy and picture processing to look for the 3D framework of every state. The 3D structures display that RyR1s ion pathway is shaped by two models of bundles, each that contains four rods along a common axis. One set (internal helices) stretches from the lumen to the ion gate, whereas the next (internal branches) stretches from the ion gate to the peripheral cytoplasmic domains. The construction of both bundles is actually different in both physiological says, allowing a 4 ? upsurge in size of the ion gate upon starting. ZD6474 biological activity This diameter boost is sufficient to make sure movement of calcium ions. Upon gating, the cytoplasmic domains go through a conformational modification that converges on the internal branches, revealing a long-range allosteric system that straight connects effectors functioning on the cytoplasmic moiety with the ion gate. Intro Maintaining an accurate intracellular Ca2+ focus that’s 10,000-fold less than the encompassing environment of the cellular, and the capability to dramatically boost intracellular calcium to result in downstream occasions in response to particular stimulus are fundamental for cellular survival [1]. Ryanodine receptors (RyRs) are high-conductance intracellular Ca2+ stations regulated by both exogenous and intracellular mediators, which launch Ca2+ kept in the endoplasmic reticulum. RyRs will be the largest ion stations known, with the average molecular pounds of 2.26 MDa, with most of its mass (4/5) forming the cytoplasmic domain. The skeletal muscle isoform, RyR1, has a bidirectional interaction with the slow voltage-gated calcium channel in the cell membrane, or dihydropyridine receptor (DHPR), which acts as.