the highest binding affinity for RAD51. Similar GST pull-down results were obtained using HeLa nuclear extracts as a source for RAD51 (Supplementary Fig. S1C). Given that the BRCA2 C-terminal region exclusively binds to assembled RAD51 oligomers, we reasoned that the BRC4 peptide is able to disrupt RAD51 multimers present in solution, which is in agreement with binding of the FHTA cluster to the RAD51 oligomerization motif (9, 10, 14). Most importantly, coimmunoprecipitation experiments in U2OS cells inducibly expressing GFP-tagged RAD51 demonstrated that BRC4wt, but not BRC4mut, is capable of interfering both with BRCA2 binding to RAD51 and RAD51 oligomerization (Fig. 1E; Supplementary Fig. S1D and S1E). Taken together, our results indicated that a short, synthetic BRC4-derived peptide is proficient in blocking BRCA2–RAD51 protein–protein interaction.
Detailed biochemical studies have demonstrated that the full-length BRC4 repeat covering both FHTA and LFDE tetrameric cluster motifs selectively interacts with RAD51 and inhibits RAD51–DNA complex formation (15, 41). To increase the likelihood of intracellular peptide uptake (42), we reduced the length of the native BRC4 peptide sequence from 35 to 16 amino acids, including only the first FHTA module, which was shown to mimic the RAD51 oligomerization motif (14). In line with our findings, a similar 17-mer N-terminal BRC4 peptide was reported to compete with full-length BRC4 for RAD51 binding, albeit with modest potency (15). We further corroborated the importance of the FHTA sequence by showing that BRC4 16-mer peptides harboring a mirrored ATHF sequence display greatly reduced RAD51 binding affinity.
Importantly, intracellular BRC4 peptide uptake in the low micromolar range was sufficient to impair BRCA2–RAD51 complex formation. A high uptake efficiency was likely achieved through a combination of the potent CPP R9 with the beneficial biochemical properties of the BRC4 peptide, including its positive net charge, hydrophobicity, and three-dimensional conformation (18). CPP internalization involves both endocytosis and direct translocation, whereby direct cell penetration is preferred because endocytosis can lead to the trapping of peptides in endosomes and their ultimate degradation (18). Multiple factors, including the CPP, cargo identity, concentration, cell type, and differentiation status, influence the balance between both uptake mechanisms (18). We primarily observed a diffuse fluorescent staining and only minor punctuate patterns, indicative of direct translocation as the preferred uptake mechanism. The substantial number of peptide molecules reaching the intracellular space might compensate for the short half-life. Even though only 5% of intact peptides are present 24 hours after transfection, the absolute peptide number per cell at this stage still adds up to 106 functional peptides. According to a recent proteomics study in the U2OS cell line, most proteins involved in DSB repair processes, including BRCA2, were shown to be of low to moderate abundance (102–104 copies/cell; ref. 43). On the basis of these numbers, we speculated that BRC4 peptides are present in high molar excess over their endogenous BRCA2 target protein even 24 hours after uptake.
RAD51 and its property to self-assemble are under dynamic control to enable faithful homology-directed DSB repair. Yu and colleagues proposed the presence of three RAD51 fractions in the cell: a mobile fraction of RAD51 monomers, an immobile oligomerized fraction, and an immobile BRCA2-bound fraction (44). Strikingly, they found the BRCA2-bound fraction to be selectively mobilized upon DNA damage and suggested a dual BRCA2 function of RAD51 sequestration and mobilization. Importantly, the other fractions did not change, suggesting that only the BRCA2-bound RAD51 fraction is involved in DNA repair. Notably, R9-BRC4wt did not affect viability under unstressed growth conditions of conventionally cultured cancer cell lines. Thus, we hypothesize that under normal, undamaged conditions, RAD51 is stably bound to BRCA2 and the peptide's affinity for RAD51 is not high enough to disassemble the protein complex. Accordingly, the BRC4 mimetic peptide is only able to disassemble mobilized BRCA2–RAD51 complexes. We speculate that upon mobilization and ultimate RAD51 loading onto ssDNA, the protein complex becomes increasingly unstable


Thread: Can CSS affect only a segment of a webpage?
Is there a way to have a style sheet take effect only over segment of a webpage...say, from the top of a webpage down to the middle of the webpage?...or, from the middle of a webpage down to the bottom?
I guess you could wrap (for example) the bottom half of the page in a DIV, and use local style declarations within the DIV tag...
You could also just put an inline STYLE sheet right in the middle of the page, and (I think) it would affect everything thereafter...
If you're targetting Netscape4, that browser allowed setting styles via javascript dot-syntax. You can declare separate styles any number of times on the page, but the statements must be declared at layout, and can't be modified thereafter. FYI...


some. She is a good mix of both me and her dad, shes still little so we shall see when she gets older.
My daughter looks JUST like her daddy, shes the female version of her daddy but she has my blue eyes :)
My son looks like the male version of me LOL.
this is me and her not too long ago, I think she has some favors of me and her Dad both :-)
on May. 4, 2012 at 2:22 PM
im in the middle u tell me? ? lol


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7. Rate of GST on Centralized Air Conditioning Systems. For (works contract) Rate of GST on Split Air Conditioning System fixed in room. And Rate of GST on movable Air conditioning System. Client Registered in Goa or Client registered outside Goa.
1. C OR B To B.
2. Suppl .
Flat 2 & 3, Mayfair Apartments, Luis Miranda Road, Margao Goa, 403601 and hold GSTIN 30AHDPG2197E1ZV is migrated tax payer w.e.f. 01/07/2017 and .
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There is a need for additional information to interpret the questions on which applicant has asked for advance ruling, hence it couldn't be confirmed whether all the questions in application from point a) to f) are within the purview advance ruling.
Authorized Representatives appeared for hearing on behalf of the applicant on 17/06/2020. They made their submissions on each point raised and as mentioned herein above under brief facts and are heard.
On this authority is of the view that, isought. Orstate Supply or Intra State Supply.
For classification of any supply as Interstate Supply or Intra e location of the supplier and place of supply. In the instant case, as said by the applicant,1 )(b) of the IGST Act since, .


Are you looking to find How To Stop My G?


WMAL : Where Washington Comes to Talk - Head of Social Security Says Program is 'Fraying'
Head of Social Security Says Program is 'Fraying'


Welcome to Yakama Power Yakama PowerYakama Power accounts to your username.


“Now, do you have any questions for me?” If hearing that line has struck fear in your heart, you have likely been at an interview where that tricky question was asked. T, but it is difficult to keep them in mind when you are on the spot. Read this list of top job interview questions to ask potential employers and commit them to memory. Then, when the time comes, you will impress hiring managers with your preparation.
This shows employers you are interested in succeeding and not just landing the job. When you know how to be a better employee by pursuing skills and experience that are relevant, you will be an asset to the team and employers know this.
How Did You Come to Work Here and Do You Like It?
Asking personal questions helps you develop a rapport with your interviewer while learning valuable information about the company at the same time. This can help you evaluate what the company’s strengths are with regard to its employee culture.
Do You Have a Written Policy for Promotions and Advancement?
Putting your ambitions out there in the beginning shows employers you are highly motivated for success and ready to know what it takes to make it in their company. Job interview questions like these can also help you determine whether the job has the potential for upward mobility.
What Can You Tell Me About the People I Will Be Working With?
By phrasing the question this way, you tell your employer you fully expect to be hired. Team players want to know about their team so they can better work together. You might also learn whether you’ll get along with the team and determine if it’s the right fit for you.
What Is Your (or the Company’s) Vision for the Future?
Depending on who is interviewing you, ask them directly or for the company’s general vision of where they plan to go, what goals they have and what growth they expect in the near and more distant future.
Tell Me About Your All-Time Best Employee and What You Liked About Them.
Again, you are showing your desire to succeed and be an asset to the company. Learning what your potential manager appreciates in an employee right away will help you perform to their standards when you do take the job.
What Do You Like Most and Least About Working Here?
This is another personal question that establishes a connection and helps you understand the working environment. This can lead to more questions, depending on how your interviewer answers, so be prepared to follow up with specifics.
What Can You Tell Me About the Person Who Did This Job Before Me?
Answers to tjob atmosphere. Did the previous employer quit or get fired? Pay close attention to the answer you receive because there are likely a lot of little clues included.
Show employers you are forward thinking and ready to get on board with their game plan. This allows your interviewer to probe your ambitions and goals a little further while showing your determination to stay and succeed. Knowing the right job interview questions to ask will do more than help you gather information; it shows employers more about you than they would get with their own questions and it helpsinterviewing you. Save these questions and create your own so you can be prepared on your next interview.


My body belongs to my husband. When we got married two became one. His body is for me, and my body is for him. If he doesn’t wish me to show off my body to other people I think that’s understandable.
Craig ended up running the newsletter for UMW by himself. I stayed home and slept off anxiety meds. I intended to go and do my job. Craig was going to be accompanying me to offer support. But my anxiety was so high that breathing was difficult. Craig told me to stay home. I feel so guilty that he did it himself.


ZAMBOANGA CITY – Marines raided a suspected Abu Sayyaf hideout on Thursday and captured 3 people and three speedboats in a daring operation near the Sabah border.
The capture of the trio coincided with the arrest late Thursday afternoon of an Abu Sayyaf militant – Bads Adjam alias Abu Jihad – in Santa Maria village in Zamboanga City.


Sometimes you may want to generate forests or create spheres automatically, as doing it by hand may be too tedious. WorldEdit has a number of tools that allow you to do just that. These commands don’t need a region; they use the block that you are standing in.
As most commands in WorldEdit, these commands all accept patterns as arguments.
These commands actually use your “placement position”, which defaults to your current location. You can use the //toggleplace command to instead use your first selection point (the one selected via wand left-click, or //pos1).
Cylinders¶
//cyl <pattern> <radius> [height]
//hcyl <pattern> <radius> [height]
For better control over the edges of the shape, you can use decimal numbers for the radius.
For elliptical cylinders, you can instead specify two radii: one for the east-west axis, one for the north-south axis.
//cyl <pattern> <radiusEW>,<radiusNS> [height]
//hcyl <pattern> <radiusEW>,<radiusNS> [height]
Example: Creating cylinders and circles
Creating a filled glass cylinder of radius 5 and height 10:
Creating an elliptical hollow cylinder out of stone with radii of 5.5 and 15 and height of 1:
//hcyl stone 5.5,15 1
//sphere [-r] <pattern> <radius>
//hsphere [-r] <pattern> <radius>
Both hollow and filled spheres can be created. By default, the center of the sphere will be the block above the one that you are standing on. If you provide the -r (raised) option, the sphere will be raised by its radius so that its bottom is at your feet instead.
Like cylinders, you can create ellipsoids by specifying multiple radii (which can again be decimals). The order of the radii is north-south axis, up-down axis, and then east-west axis.
//sphere [-r] <pattern> <radius>,<radius>,<radius>
//hsphere [-r] <pattern> <radius>,<radius>,<radius>
//pyramid <pattern> <size>
//hpyramid <pattern> <size>
This command creates a pyramid out of the given pattern with the specified height. That is, if you specify a height of say, 5, there will be 5 layers, each one block shorter than the last (in each direction, from bottom to top). The side-length of the lowest layer will be twice the height.
Forests¶
Forests can be generated with this command. The size parameter indicates the width and height of the square area to generate the forests in. The density can vary between 0 and 100, and numbers like 0.1 will work. Note that the default density (of 5) is already rather dense. The size is the apothem (radius) of a cuboid, centered on your placement position.
This command operates the same as the forest generator in region operations except this one takes a size from your placement position, instead of using your selection.
Depending on the platform used, WorldEdit may not be able to //undo the generation of these trees.
Pumpkin patches¶
WorldEdit can generate some pumpkin patches. The size parameter is the width and height of the square area to generate the patches within, radiating out from your feet. The density of the patches is currently not adjustable.
Generating Arbitrary Shapes¶
//generate <pattern> <expression>
Aliases: //g, //gen
Generates any shape that can be described with a mathematical formula:
This uses the expression parser.
-r - Use raw coordinates, with one block equaling one unit
-c - Shift the origin to the center of your selection, with one block equaling one unit
-o - Shift the origin to your placement position (your position or pos1, with /togglepos), with one block equaling one unit
Without any of these flags, coordinates will be normalized to -1..1 (from selection min/max points, meaning the entire selection is 2x2x2 units), note that each axis may be a different number of blocks per unit depending on your selection skewness.
-h - Generate a hollow shape. Blocks will only be set if they neighbour any blocks that are not part of the shape.
Since the expression parser only takes numbers as variables, type/data variables and query functions only work with blocks that have legacy type/data values. If you need to use it with newer blocks (> MC 1.13), use a placeholder and //replace that placeholder after generating your shape. The <pattern> arg of the command is not restricted, only the expression.
The expression should return true (> 0) for blocks that are part of the shape and false (<= 0) for blocks not part of the shape. The expression is tested for each block in your selection.
Example: Generating various shapes
Torus of major radius 0.75 and minor radius 0.25:
Gnarled hollow tree:
//g -h oak_log (0.5+sin(atan2(x,z)*8)*0.2)*(sqrt(x*x+z*z)/0.5)^(-2)-1.2 < y
Rainbow Torus:
//g white_wool data=(32+15/2/pi*atan2(x,y))%16; (0.75-sqrt(x^2+y^2))^2+z^2 < 0.25^2
Rainbow Egg:
//g white_wool data=(32+y*16+1)%16; y^2/9+x^2/6*(1/(1-0.4*y))+z^2/6*(1/(1-0.4*y))<0.08
//g red_wool (z/2)^2+x^2+(5*y/4-sqrt(abs(x)))^2<0.6
Radial cosine wave:
Circular hyperboloid:
Want more cool shapes? Try out a program like MathMod which comes with tons of shapes and helps you make more. Note that WorldEdit uses isometric (x,y,z) formulas, not parametric (u,v,t). Also, you may have to scale your x, y, and z variable depending on your selection size and the domain of the function.
Generating Biome Shapes¶
Just like the generate command, you can use an expression to set a biome in a particular shape. This uses the same syntax as above, but takes a biome id instead of a pattern.
As of Minecraft 1.15, biomes are stored in 3 dimensions. Since 1.16, WorldEdit uses the full 3D biomes, but there are some new limitations from Mojang. See Setting Biomes for more details.


GLOWCAT H-P111 Gun Black Dolphin Fish Natural Pearl Cage Essential Oil Diffuser Beads Cage Aromatherapy Locket Necklace UnFade
Fish Expandable Wire Cuff Bracelet Bangle Tassel Charm Natural Pearl Cage Perfume Stainless Steel Dolphin Locket Bangle KB163


Eating here felt like being transported back to Italy- this is how a true Italian restaurant should be, taste and feel like. The menu is small as the restaurant concentrates on pasta as well as a variety of starters but everything is cooked with fresh produce of the highest quality and the prices are low for what they offer.


Unfortunately, the Army doesn't use LatLong for navigation, although I am familiar with the system. But, using it for navigation, especially land navigation, is not something I have done. Oh well, I will keep looking.
So, what have others used to teach cadets? Particularly, ground team land navigation?
Does CAP have a source for UTM maps?
How do ground teams communicate with air crews?
Via radio. (and sometimes hand signals and panels).
Do air crews use UTM?
CAP doesn't source maps, that's on the individual. To that end, the USGS has all their maps free online and you can either print them or order them. As to the communications issue, aircrews use lat/long (and shouldn't) so knowledge of both systems are key, but that burden is unfairly put on the ground team. To that end, there is an app called "Coordinate Converter" that will make that easier for you.
Can someone explain what is standard operating procedure for air crew/ground team coordination?
Please do, and feel free to use my name to move things forward.
up a Gazeteer at Staples for their mapping.
An issue which still regularly cause issues on CAP missions.
The term never comes up in SARExs, only in philosophical discussions.
As a person that uses both UTM and Lat/Long on a regular basiso Geographic Coordinate System is perfect. CAP has a tendency to use Lat/Long for the simplicity that aviation uses Lat/Long. That is, the FAA prints the sectionals using Lat/Long and not UTM. The USGS prints maps using UTM with a general Lat/Long superimposed on. For common day-to-day use maps, Lat/Long is what is used. Therefore, it is more accessible to us. While UTM provides a 10 m x 10 m (in practical sense for printed maps, but in theory 1 m x 1 m when using tools), it is not very accessible to members. Yes, now we have smartphones, but we know how smartphones perform when we are in a critical phase of an operation. Unfortunately, carrying around a whole set of USGS maps is not practical, and you cannot always count on phone internet access. While UTM is great for ground teams, it is not practical for aircrews. Likewise, while UTM, or even Lat/Long, is not always practical for ground teams, the Lat/Long is typically easier to get from either a smartphone or a DeLorme map. However, if mission base knows how to use UTM and is willing to work with two geographic coordinate systems (UTM vs Lat/Long), then by all means use UTM. But I would not expect an aircrew to know how to use UTM, nor would I ever expect them to make the conversion between UTM and Lat/Long. That conversion would be a better task for the ground team. Thus, if you are going to convert anyway, might as well use the Lat/Long. Also, for the work we do Lat/Long gives a decent location for the accuracy we are working in. That is, it does not matter whether we are 1 m off, or even 10 meters off, our location will be found easily.
I know how to do lat/long, but I'm rusty as all get out. Its a skill every GTL should have, at the very least.


Dear reader, our final newsletter in 2012 focusses on UNFCCC COP18 in Doha. Although participation in Doha was much lower than usual at COPs, the gender related activities were manyfold and got lots of attenes. It was great to work with you.
WEDO: The Doha Gaps: Seeking Miracles, Solidarity and Good Old Fashioned Hope to Fill Them GGCA: Gender in Doha 2012Heinrich Boell Foundation: The "Doha Climate Gateway": will the camel go through the eye of the needle?


Introduction: for some fashion bloggers or fashionistas, hats are the best piece with concave shape. Peopl e also choose hats to decorate when they don't want to wash their hair and are in a hurry to go out. In 1936, the hat master set up a hat making workshop in Paris. And when designing hats, we will make all kinds of exquisite hat decorationsWhat brand is the baseball cap with the word "m"


time with only a paper round after school to fuel the sugar rush, the QL was waaay out of my league financially and besides, I was still Commodore through and through.
I did, however get my first QL about 4 years ago which was kindly given to me by a now retired IT collegue of mine who had brought it from new back in ’84. It was boxed and had been kept in beautiful condition complete with prestine manuals, software and and various brochures. Certainly one of the nicest looking examples of an old computer I have ever seen.
I gleefully took it and played around with it for a bit but in all honesty it sat in it’s box….unused and unloved again. Shame on you StiGGy! That’s no way for a computer to be kept and so after a quick chat, I decided that it would be better if I donated to the Retro Computer Museum where it could be used again and accessible to all.
Over the years, I’ve kinda grown fond of the QL and although mock it we do at RCM (because it really does make a nice door wedge, hammer and/or cricket bat) it does grows on you bit by bit the more you see it. The hunt for another one was on and so to eBay I went.
Flippin eck! it looks like these are becoming quite the collectable these days judging by my search results. Maybe it’s the underdog/cool factor similar to the Nintendo Virtual Boy, Sega Nomad or even MB Vectrex which has increased the price?
Well, whatdoyouknow…fate I guess but just the other day I got chatting with two colleges at work who both have old and untested QL’s sat in their lofts and said that I could have them….’as you’re into all that old computer junk’ Woot woot!
I took my small LCD TV to work with me so that we could test them and also to let my co-workers check out the new cardboard prototype pinball machine i was putting together’ (see previous blog post – )
The first QL, given to me by Luke our IT Helpdesk chap, simply refused to display a picture on screen. The power LED was lit but that’s about it. There’s no ‘start-up’ whir from the Microdrive unit and likewise no motor noise when inserting a Micro cassette.
That one requires a little more attention so we placed it to one side and moved onto the other.
The next one is from Ian, one of our software developers and it sprang into life immediately with the familiar red boot screen in glorious shaky RF on my TV (must get/make myself an RGB to Scart cable).
Luke’s QL came with a whole bucket full of Micro cassettes so we set about loading up exciting arcade titles such as…erm…’Abacus’..well, it might be an arcade hit?
Sadly not, but that’s o.k we’ve got plenty of other exciting titles to try such as ‘Gas Bills’, ‘Math’, ‘Addresses’ and ‘Letters’ – Hmm, it appears that the original owner of this particular QL actually was using it for serious things after all :)
Hunting through the many cassettes I finally found one labelled Games Collection and was rather excited to see after a short whirl of the Microdrive the following games menu displayed on screen.
Starting from the top we loaded each in turn. All but one failed after about a minute with ‘load error at line 130′ or ‘line 250′. It did make us smile after waiting a good five minutes only to recieve ‘loading error at line 3′. Only line 3 after five minutes!
The game that did work was called Zfred and appears to be a clone of QBert. The keyboard controls are just terrible and so is the game but heh, I’m happy to see at least something work.
We tried a few more Micro cassettes but again, most failed to load. I suppose after all these years of non use we were lucky to get something to load especially as the Microdrive system wasn’t exactly renown for it’s reliable.
Going back to the games collection cassette, I tried it again and again but each time it failed. However, it seemed to fail at different lines of the game code and so with a determined fierce stare…a bit of swearing, and a ‘gentle’ tap on the QL case we ‘willed’ the cassette to load….and it flippin well did. I don’t think i’ve ever been so excited about a game of Breakout :-)
Let the competition begin. Left/Right cursor to move, CTRL to launch the ball and Up cursor to make your bat move quicker. It’s a flipping hard game too…very hard…in fact, our top score between myself, Neil and Rob was…erm hmm…20 points!
It didn’t matter though, it was working and a fun QL lunchtime was had by all.
So, going forward what next?
Well, the faulty QL actually came with a floppy drive expansion board and if it works then this provides a few more options to play with.
Interestingly, Dr Phu demonstrated how to connect a standard PC floppy drive to work with the QL and read software directly fro 3.5″ 720k disks. It’s an interesting idea and one I’m keen to try if the interface does indeed work. I’ll be take it down to the Retro Computer Museum to further testing.
Here’s RCM’s setup and floppy drive we had during last months gaming event.
Which, as always prompted a bit of a mini competition with some of the other RCM staff members.
Mike showing is keyboard skills with the gawd awful but strangly addictive QL port of Scramble called – Death Strike.
Death Strike is one of a handful of games belonging to a game pack that was released only a few years ago – Don’t you just love the retro gaming scene that keeps the classics computers alive.
Oh and final thing I want to mention about the QL….it doesn’t need RetroBriting!
I’ve bought many Spectrum games and applications lately. Also have a machine, but no datassette or disk drive yet… Looking forward to test out some of the stuff for this platform. :D
You can load .wav files of Spectrum games played back by any source that has a phono output. E.g a mobile phone, mp3 player or your PC sound card connected to a Spectrums tape input. Best of all you can play them at high speed to load games in a few seconds. I used to do this on Spectrum’s with my iPhone before I had a DivIDE device.
Yeah, I looked at this thing in many a magazine when I was younger. Clive might not have made machines with tip top build quality, but he could certainly put a poster together – £399 at launch and then down to a still eye watering £199 when Clive came to his senses!
Incidentally, I have noticed all retro related prices on eBay going up recently – hunting for a replacement c128 earlier, jaw dropped and that was just at the £60+ shipping charges!
Yep, it seems retro is big business these days with all those dusty comps lurking in the loft now labelled as ‘rare’ and listed at a premium price on eBay.
Try the various retro forums, kit usually is traded at lower priced because it’s one fan to another.
I’ve got a broken key on my c128 but I don’t think I’m ready to pay upwards of £60 just yet :) </s> Section Navigation,
Vol. 4, Issue 173, p. ra31
Kwang-Hyun Park1*,
Jung Min Lim2,
Jong Kwan Park3,
Soo-Wan Chae4,5, and
Uh-Hyun Kim1,5
23 .


We will be making a day trip for 2 dives to our favorite iron ore pits! Call us for cost and details.


Thesaurus by lindah CC 3.0 http://www.flickr.com/photos/lindah/303793178/
My Roget’s Thesaurus is pretty beat up. It’s a paperback with creased binding. The cover is missing the top corner. Half an inch of paper has peeled away from the bottom of the spine. It looks well used if not well-loved.
Until I pulled it out last week, I don’t think I’d used it in years. Certainly not enough to warrant its bedraggled condition.
In high school, however, I used it all the time…to the point of detriment for my writing. I was trying to find better, more sophisticated ways of saying things. Instead, phrases came out over wrought and pretentious. Maybe the saying shouldn’t be “write what you know,” but rather, “write words you know.” Simplicity is always clearer and more powerful.
The reason I brought it out recently was to find another way to say “shard.” I’d used it a few times on one page and when I read the passage out loud, all I could hear was “shard, shard, shard.”. Even after editing, it was in there too often. I felt bad dragging the old book out, like I shouldn’t be resorting to such a shady tactic, but it worked. I found the word I was looking for: fragment. Duh, I should have been able to come up with that myself.
No matter how bad I feel using a thesaurus, I can’t even contemplate tossing it. Part of that is because it’s a book and you just don’t throw a book away, and part of it is because of the shard situation. One day, in the very distant future, I may need it again.
Where do you stand (if at all) on thesauruses? Thesauri?
Tags Editing, references, resources, thesaurus, words, Writing
5 thoughts on “Thesaurus”
By the time I had to do a lot of writing for school, Word had its own built-in thesaurus (shift+F7, I even memorized the shortcut) so I didn’t really bother with flipping through a hard copy very often. And even now I’m more likely to search online if I need more options. I don’t think using a thesaurus is bad — it’s quite useful for helping you remember words you know but can’t recall off the top of your head. It’s only detrimental if you choose a word when you don’t know its exact meaning or connotations.
Ah, so young…ha, I didn’t realize that I was showing my age.
You’re right, thesauruses aren’t bad in and of themselves. I guess, I’m just gun shy since I abused them so egregiously in the past. Thanks for the permission…I need to remember to give it to myself every once in a while.
I think a thesaurus is a wonderful thing for three reasons,
1) You can learn new and funny words.
2) You can use it exactly like you just did and thus not overuse a certain word.
3) It sounds like a kind of dinosaur to me (possibly because it’s “dinosaurus” in my native language).
Seriously, though, I’m with you on not overusing the thesaurus. 🙂
Number 3 is the best reason of all to like the thesaurus! 🙂
Pingback: I Suck at Scrabble Or Why I Love My Dictionary « The Empty Pen


Spinal cord injuries are some of the most terrifying injuries that can occur. While there are an array of drugs doctors give their patients for pain and other issues, those medications can pose serious side effects harmful to the user. So, what else is out there? CBD. Although CBD isn’t a “cure-all,” there is research that indicates it could help with various issues that coincide with spinal cord injuries.
The spinal cord is probably the most important part of the body after the brain and the heart. It’s in charge of sending information to your brain through the central nervous system. It controls everything from movement to sensory information. So, when it’s injured it can only cause problems throughout the rest of the body. There are two different spinal cord injuries that occur, incomplete spinal cord injuries, and complete spinal cord injuries. Incomplete spinal cord injuries occur when only part of the spinal cord has been severed, causing partial loss of functionality. Complete spinal cord injuries occur when the spinal cord has been entirely cut off from the central nervous system, taking away complete functionality. When the spinal cord has been injured, whether it’s an incomplete or complete injury, there are many symptoms and problems that can occur throughout the whole body. Typical problems that occur are pain, muscle spasms, loss of bowel control, and sleeplessness. However dreadful these may be CBD can give us some insight and possibly some relief for these issues.
Pain is the most common reason for CBD use. Many people with fibromyalgia, arthritis, and chronic pain due to injury use CBD to help relieve their soreness. The most common types of pain that comes with spinal cord injuries are nociceptive and neuropathic pain. Nociceptive pain occurs when the nociceptive nerve fibers activate due to inflammation, chemicals, or physical damage. Neuropathic pain, or nerve pain, occurs when the nervous system is damaged, diseased, or injured. A review from studies taken from research between the 1980’s-2007 concluded that CBD is effective for overall pain management. This includes both nociceptive and neuropathic pain. In addition to this they concluded that CBD had no adverse side effects, unlike pharmaceuticals, and could also potentially help with insomnia due to chronic pain.
Muscle spasms, or spasticity, can also occur after a spinal cord injury. Spasticity occurs when motor neurons in the brain produce lesions causing involuntary movement. This can make everyday tasks such as, tying shoes, or brushing your teeth incredibly difficult. Spasticity is also seen in diseases such as, cerebral palsy and multiple sclerosis. It’s also a common occurrence after a stroke. In most cases of spasticity the blood brain barrier (BBB) becomes pervious to T-cells from the immune system and allows them to enter the brain. Since this is foreign land for the T-cells it kills the neurons resulting in lesions to that area of the brain. Research suggests that CBD has strong anti-inflammatory properties, so it can potentially reduce the effect on T-cells in the brain.
Although there isn’t much research on loss of bowel control, or neurogenic bowel dysfunction, that occurs in spinal injuries, there is research that suggests that it can help in cases of crohn’s disease and colitis. With crohn’s disease and colitis, the digestive tract or the intestine become inflammed causing abdominal pain, diarrhea, and a multitude of other possible issues. Referring back to my last paragraph, research suggests that CBD has strong anti-inflammatory properties, which could assist in relief of these diseases. So, could CBD possibly help with neurogenic bowel dysfunction? Maybe, unfortunately there’s no way of knowing at this particular time, but with CBD potentially helping with crohn’s and colitis, the future seems bright.
There may not be any concrete evidence at the moment, but new positive data about CBD is coming out everyday. Researchers are continually working on finding facts to help further the use of CBD and other cannabis properties in a positive and healthy way.
Do you have questions about our products or CBD in general? We’d be happy to help assist you anyway that we can. Please feel free to reach us at 719-358-7553 or e-mail us at info@discovercbd.com.
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. - AdÏmis¶siÏbleÏness, n. Ð AdÏmis¶siÏbly, adv.
AdÏmis¶sion (?), n. [L. admissio: cf. F. admission. See Admit.] 1. The act or practice of admitting.
2.3. The granting of an argument or position not fully proved; the act of acknowledging something ?serted; acknowledgment; concession.
4. (Law) A
6. (Eng. Eccl. Law) Declaration of the bishop that he approves of the presentee as a fit person to serve the cure of the church to which he is presented.
Syn. - Admittance; concession; acknowledgment; concurrence; allowance. See Admittance.
AdÏmis¶sive (?), a.Implying an admission; tending to admit. [R.]
AdÏmis¶soÏry (?), a. Pertaining to admission.
AdÏmit¶ (?), v. t. [imp. & p. p. Admitted; p. pr. & vb. n. Admitting.] [OE. amitten, L. admittere, admissum; ad + mittere to send: cf. F. admettre, OF. admettre, OF. ametre. See Missile.] 1.
2. To give a right of entrance; as, a ticket  one into a playhouse.
AdÏmit¶taÏble (?), a. Admissible.
AdÏmit¶tance (?), n. 1. The act of admitting.
2.
3[Obs.]
4. Admissibility. [Obs. & R.]
S ½No admittance.¸ Its secondary or moral sense, as ½admittance   to the church,¸other larger localities, etc., where admittance could not be used. So, when we speak of admission to a concert or other public assembly, the meaning is not perhaps exactly that of admittance, viz., access within the walls of the building, but rather a reception into the audience, or access to the performances. But the lines of distinction on this subject are one definitely drawn.
Ø Ad·mitÏta¶tur (?), n. [L., let him be admitted.] The certificate of admission given in some American colleges.
AdÏmit¶ted (?), a. Received as true or valid; acknowledged. - AdÏmit¶tedÏly, adv.  Confessedly.
AdÏmit¶ter (?), n. One who admits.
AdÏmix¶ (?), v. t. [Pref. adÏ + mix: cf. L. admixtus, p. p. of admiscere. See Mix.] To mingle with something else; to mix. [R.]
AdÏmix¶tion (?; 106), n. [L. admixtio.] A mingling of different things; admixture.
AdÏmix¶ture (?; 135), n. [L. admiscere, admixtum, to admix; ad + miscere to mix. See Mix.]
AdÏmon¶ish (?), v. t. [imp. & p. p. Admonished (?); p. pr. & vb. n. Admonishing.]] 1.½Admonish him as a brother.¸
2 Thess. iii. 15.
2.
Admonishing one another in psalms and hymns.
AdÏmon¶ishÏer (?), n. One who admonishes.
AdÏmon¶ishÏment (?), n. [Cf. OF. amonestement, admonestement.] Admonition. [R.]
Ad·moÏni¶tion (?), n. [OE. amonicioun, OF. amonition, F. admonition, fr. L. admonitio, fr. admonere. See Admonish.]Syn. - Admonition, Reprehension, Reproof. Admonition is prospective, and relates to moral delinquencies; its object is to prevent further transgressio A person of any age or station may be liable to reprehension in case of wrong conduct; but reproof is the act of a superior. It is authoritative fault-finding or censure addressed to children or to inferiors.
Ad·moÏni¶tionÏer (?), n. Admonisher. [Obs.]
AdÏmon¶iÏtive (?), a. Admonitory. [R.] Barrow. Ð AdÏmon¶iÏtiveÏly, adv.
AdÏmon¶iÏtor (?), n. [L.] Admonisher; monitor.
Conscience is at most times a very faithful and prudent admonitor.
AdÏmon·iÏto¶riÏal (?), a. Admonitory. [R.] ½


Ockwell, (20) unknown, (21) Sylvia Summers, (22) Charles Heritage.
Following the sudden ded, in view of the economic climate, to delay the Coronation of Queen Elizabeth II until June 1953. In Wickhamford, Mrs J. Mason planted a commemorative tree at the corner of Manor Close, according to the Evesham Journal. After a fancy dress procession, there were sports in Mrs K. Daffurn’s meadow. At tea the children were given souvenir mugs and barley-sugar sticks, later having ice-cream. Adults also had tea, and dancing in the Memorial Hall continues till midnight. A box of food was sent to every person in the village unable to attend the festivities.
3. Frances Bell; 4. Donna Cole;
6. Elizabeth Poulter;
10. unknown;
13. Stephen Roberts; 14. Mark Carter or Richard Poulter;
A check through the Evesham Journals to look for references to events in Wickhamfor (1887 and 1897), and the Coronations of Edward VII and George V (1902 and 1911) has found nothing being reported. Similarly there were no mentions of village events to celebrate VE Day or VJ Day in 1945, although at least the former would have taken place. Any additional material to enhance this article would be welcomed.
Tom Locke – June 2012 </s> To gain access to the BAFE® Registered Company Portal please enter your email address, your registration code received via email and choose a password. Please note the required email address is the primary contact for your registered scheme
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Le Diner en Blanc is an event which is 27 years old and was founded by Francois Pasquier in Paris. The concept of this unique event is about thousands of people dressed in elegant white clothes with fine wine and food will set up their tables and chairs on a public place and have dinner together.
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Website: </s> How to Escape the Rat Race Living in Thailand
Everyone dreams of escaping the rat race, however, many expats leave their country of origin to create a new life in Thailand only to end up in the same situation: living to work instead of working to live. Here are a few tips to escape the rat trap so as to have more time to explore Thailand and also have more freedom in your life.
How Stuff Ends Up Owning You
The rat trap of life, which ends up with you working the maximum amount of hours you can without having a breakdown, then desperately rushing around paying bills and doing chores in the little free time you have left is depressing. A big step in cutting down this crazy never ending stressful spiral is to simply not hoard so much stuff. We are persuaded to buy things we don’t really need all the time by advertisements and hype. By selling off your unneeded possessions through websites that specialise in trading in your local area or via ebay etc, you can get rid of useless items that need constant upgrading, repairs, or need to be cleaned or generally looked after. Therefore, you spend less money and also make a profit by getting rid of non-essential household items. Initially when you buy something you assume that you are the owner of it, but think again; let’s take a pool table for example . . . if you bought a pool table you would then have to clean it every week and if you don’t play on it often you will feel bad because it was expensive, so it is now controlling you by taking up your time with having to play on it regularly to avoid guilt and to clean it. A good practise to develop a minimalist mindset is to get rid of one piece of clutter or sell off one unneeded item per day. That will be 365 unneeded items per year eliminated from your life! Giving you more space, enabling you to live in smaller, cheaper accommodation requiring less housework, plus freeing up some valuable time.
The BS of Keeping Up with the Joneses
’t! what people think. After all, you will end up with the greatest symbol of real wealth when you end up working part time and waving them off to their full time jobs.d


kankles). They came, saw, conquered. My child entered this world with her momma having peace that she was bringing her into an organized beautiful home. No longer drowning. It’s not just what they did, but the system they put in place that is still going a year later. Thank you, thank you, thank you!
She looked to us to do what we do best.
We come into all situations respectful of where the client is and simultaneously encourage them where to go.
... creativity abounds and thinking outside the box is where we like to hang out.
There's nothing wrong with a room that multi-tasks.
A room like this needs to be organized. In addition, our client needs to realize that, on top of everything else she does, she must continue to be organized.
We wanted her to “shop” her closet. What an innovative approach to a closet!
Half of organization is learning to let go and the other half is learning to identify and manage what is really important.
We love watching the faces of our clients when they see there is more space in a closet than they ever thought!
A job that looks daunting can be done in a short amount of time with focus and cooperation. </s> Ravnica Tournament Pack at StarCityGames.com!
Ravnica: City of Guilds features the return of gold cards, Birds of Paradise, Dark Confidant and more! Order from StarCityGames.com and save! </s> ADMMI Engineering had been instrumental in handling major turnkey projects in Oil & gas, Water and waste water industry. Aided by our expertise in this region for the last three decades, we design, construct, install and commission the complete plants for On Site Electrolytic Chlorination (OSEC) systems and various other equipments for treatment plants. Few of the major installations we had undertaken in the last few years includes Shweihat S1 pumping station, Zadco Umm Al Dalk sea water electro chlorination, Saadiyat and Reem islands, Mafraq and Jebel Ali sewage treatment plants and Umm Al Nar utilities for the Arabian Power Company. </s> Frank Warren (@postsecret) is founder of PostSecret, an art project inviting strangers to anonymously mail in their secrets on homemade postcards. What started as a passion project quickly became a worldwide phenomenon. PostSecret.com has become the largest ad-free blog in the world with over 800,000,000 visitors and has evolved into six New York Times bestsellers, a viral TED Talk, a MOMA and Smithsonian exhibit, and hundreds of PostSecret Live events. Frank has received over 1,000,000 postcards mailed to him from around the world?  Aown lives from these three life-changing books?r, Spotify, Youtube or Google Play.
What was the first book to give voice to "the people" versus the power?
What are 2-3 specific suggestions Frank shares to help us build trust with new people?
How do we learn to become better storytellers? </s> . </s> Installing cameras in your apartment could be as to install. This  amazing cameras on the market. Depending on your needs you could consider installing Xiaomi smart home or Xiaomi Xiaofang IP camera.
Xiaomi Dafang smart home camera and Xiaomi Xiaofang IP camera are good cameras but there are small differences between them. The Xiaomi Dafang smart home camera captures up to 9m while Xiaofang IP camera captures up to 5m. You could choose the one that covers a wide distance if you need a wide view of your home.
To escape the extra cost of buying an external storage card you have to buy Xiaomi Dafang smart home camera. It has local storage that can support SD card up to 32G while Xiaofang IP only supports a micro SD card. This means if you need to store a lot of information Dafang home camera would be your choice.
Both of these Xiaomi smart home cameras allow you to use a phone or tablet when you want to know the situation wherever you are. The only difference is that the former one sends you an alarm when it is triggered or when it senses smoke, motion, CO sensors and intelligent detection. Installing it in your home could save you from unsuspected fire breakouts. The latter one has limited detection features because it does not have intelligent detection.
When it comes to night vision detection, the former is the best. With its improved infrared LEDs, Xiaomi Dafang camera gives you a clear ultra vision at night. This gives you a clear image of the situation you are monitoring.
Looking at the angle view of the Xiaomi Dafang camera and Xiaomi Xiaofang IP camera the latter gives you a wide view of the situation. With its improved panoramic view, Xiaomi Xiaofang IP camera allows you to track what you are monitoring while changing its angular position. It has a wide angle view of 360 degrees while Xiaomi Dafang camera has a limited view of 120 degrees. This is usually the best when you want to keep in check what is happening in your house while you are at work.
How to Maintain Purple Pampas Grass? </s> a further separation system, which systems are used in series to separate the stream. The method has particular application in the separation of a sour (i.e. sulphur containing)


Let me see if I understand correctly: Because the protesters did not address a marginally related question that no one asked them, they are hypocrites. Not quite standard logic, but I can take that as his position.
DC voting representation is manifestly unconstitutional without it being a state. And it being a state would defeat the entire constitutional purpose of a separate federal district for national governance. Nonetheless, there's two obvious solutions Tea Party goers would certainly support.
Or you could beat the "taxation without representation" problem by making the District a tax-free zone. But good luck getting congress to do that.
DC residents have not gotten the vote because a) they are more black than the rest of the country b) they are more DemocratIC than the rest of the country and c) there has not been a DemocratIC president and a DemocratIC House and a DemocratIC Senate for long enough to even get halfway though fixing up the total mess that the Republican morons typically leave behind to get on with issues such as advancing democracy in our own land.
According to Matthew Yglesias, all that would be required for statehood is a majority vote in both houses, and some fancy footwork on federal buildings. I have no idea if that's correct but just imagine the reaction if we tried! My guess is the teabaggers would need mass CPR.
DC residents are not people of the African deserts, nor of the Argentinian pampas, nor of the Artic tundra, nor of the Asian steppes. They are "of" the several states. They have an inalienable (innate, inherent, intrinsic) right, as full members belonging to this nation, to participate in the making of the laws under which we all must live.
Who else wants to channel Beavis and Butthead...hehhehehhhuhhhh ehhe hhhhheh, "He said 'Teabaggers'" hehhe hheh heehh hehhh
?


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Eric has presented his research on Central Texas negro league history and other topics to groups ranging from the SABR 44 National Conference, elementary schools, Nerd Nite, and on Central Texas NPR. He is co-chairman of SABR's Asian Baseball Committee.
This blog is set to document the unique and forgotten stories and characters behind baseball's history with a special emphasis on Texas baseball history. And when it comes to stories of these men and events I believe that Buck O'Neil's quote on Satchel Paige best sums up my approach: "Of course the stories about Satchel (Paige) are legendary and some of them are even true."


Staff Editorial: Grinnell’s financial aid policies must reflect values
November 16, 2012	The Committee on Admissions and Financial Aid presented three options for changes to the College’s admissions and financial aid policies this week. The policies are meant to address what is projected to be an unsustainable financial path for the College. See the front-page article for more details. We appreciate the administration’s transparency during the financial planning process, especially visits by Vice President for Enrollment Joe Bagnoli to Joint Board and a town hall meeting Thursday.
A few of the changes are relatively painless, such as ending the indexing of merit aid, or even good ideas, such as notifying the most academically qualified students of their admission earlier to entice them to come. However, most of the options presented lower the academic excellence of the student body, negatively affect higher-need students, or compromise diversity and the percentage of first-generation students.
One of the aspects of Grinnell we value the most is that there is not an overwhelming concentration of students from wealthy families. Socioeconomic diversity is one of the main characteristics that sets Grinnell apart from other top small liberal arts colleges and is one of the main reasons many of us came here. We must maintain this diversity. Furthermore, steps meant to attract more wealthy students, even if they allow the College to technically remain need-blind, are penalizing students who happen to come from less wealthy backgrounds, which is fundamentally contrary to Grinnell’s core value of social justice.
Therefore, we urge the administration, Board of Trustees and everyone involved in the decision to make as few of these changes as possible. It is far better to make too few changes and need to change more later than to make unnecessary and unjust changes out of an abundance of caution about the College’s financial future. It is best to allow time for alumni giving to increase, the standing of the College to improve in the minds of the top prospective students or the endowment to end up performing better than projected. For example, encouraging alumni to donate to a fund specifically supporting financial aid could increase giving.
However, some changes do seem to be necessary now. Much of options A and B is acceptable. The main exception is using merit aid to increase the yield on wealthier students. Using merit aid techniques such as earlier notification of awards is a good strategy to increase the yield on students who actually have the most academic merit. But merit aid should be used on students with the most merit, not students in the middle of the spectrum who are also wealthy. Essentially paying people to come to Grinnell because they are wealthy, despite the fact that the policy would lead to a drop in academic quality, is blatantly unjust. While the admissions office can adopt this policy without board approval, we urge them not to.
In addition, we oppose more rigorous enforcement of financial aid deadlines and policies. It is unjust to prevent higher-need students, often in the most difficult family situations, from being able to come to Grinnell because of how their parents fill out forms. It is also unclear how this policy would be implemented, raising the possibility that third and fourth-years could have to drop out if they did not meet the new financial aid application requirements.
We would accept options A and B besides the merit aid for wealthier students and stricter financial aid policies, but, again, still urge as few of them as possible to be adopted.
Option C is absolutely unacceptable. Eliminating need-blind admissions, even in only a small stage of the admissions process, is taking the importance of wealth in admissions to an extreme and likewise takes injustice to an extreme.
We urge students to make their voices heard in the process by attending the town halls in the next few weeks and by speaking to SGA and the administration. The attendance at the first town hall Thursday night was way too low. Only two students not on the staff of the S&B or in SGA Cabinet were there. SGA needs to do a much better job publicizing these town halls. A Facebook event created the night before and an all-campus email sent five hours before are not enough notification. We hope SGA will intensely publicize the next town halls. The town halls at the beginning of the semester had too much presentation and not enough student response. This round of events is a good opportunity to increase student participation at the events. We encourage all students to attend in order to educate themselves and participate in this important conversation about balancing our finances and our principles.


Ranbir Kapoor and Alia Bhatt had gotten married in April after nearly five years of being together. Their intimate wedding celebrations took place at their Bandra residence. More recently, Alia Bhatt had by….. coming soon".
Alia had also added a picture to the post featuring two lions and their little cub. Commenting on the same post, filmmaker Karan Johar said, "Heart is bursting”.
Speaking about his life after marriage, Ranbir shared at an event, "I used to say in films that 'shaadi is like dal chaawal till you die and life mein thoda tangdi kebab, hakka noodles hona chahiye (referring to his famous dialouge in Yeh Jawaani Hai Deewani )... but boss, zindagi ke tajurbe ke baad I would say dal chaawal he best hai . Alia mere dal chaawal mein tadka hai, achaar hai, pyaaz hai, sab kuch hai. I couldn't have asked for a better partner."
Apart from the Aditya Chopra-produced Shamshera, soon he will also be seen sharing screen space with his wife Alia Bhatt in 'Brahmastra - Part One: Shiva''. The movie will also star Amitabh Bachchan , Mouni Roy, and Nagarjuna Akkineni and is slated to be released on 9th September.


Ththe Lagos State Governorevencommendationyesterday, following an interview grantChannels Television, where he enumerated the many physical projects the administration is currently undertaking. Mr. Sanwo-Olu said, amongst other things, that the Lagos Rail Project would cost over N100 billion, a project that is a first by any sub-national government in Africa.
Mrs. Abisoye said that the courage shown by the Lagos State Government iof the unmatched fearlessness with which my Principal, Governor Babajide Sanwo-Olu, is leading the way. He and the State Executive Council have chosen to implement massive physical projects that will surely pay dividends in the near future by creating f transportation and logistics, which will in turn create jobs for the teeming population”.
“As an agency, we believe we have come a long way in the last five years and our resolve, to reduce unemployment and give opportunities to all willing Lagosians, remains strong. This year, we are on track to touch the lives of at least a million Lagosians with our various voucher programmes, loans, training and so on.
The post LSETF Boss lauds Lagos Gov on infrastructural development, economy appeared first on Vanguard News.


On the latest episode of Agent Success Secrets, I had the pleasure of speaking to Greenville, South Carolina Realtor Haro Setian. Haro came to Keller Williams in 2009, when the market was, of course, not in the best state. Despite entering the industry at a difficult time, Haro has absolutely thrived since then. Now, he’s going to explain how he did it.


Biometrics' precision load cells provide a complete, Designed for both static and dynamic applications including the fields of medicine, industrial ergonomics and sports science. The load cells are focused to the needs of the researcher, with high precision and ease of use in mind.
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One of the most dangerous occupation in the world is a taxi triver! Here we offer out of the box smart card solution suitable to serve as a portable payment system. For example taxi cab. As a payment terminal an Windows tablet with NFC reader could be used.
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This system has to be integrated with Cloud server so records could be reviewed by authorized persons at any timeDual Interface) smart cards.
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Yikes! 97 Percent of Your Employees May Not be Able to Identify a Phishing Email (INFOGRAPHIC)
Posted By Shubhomita Bose On August 18, 2017 @ 7:30 am In Technology Trends | No Comments
When you think of cyber attacks [1], you may imagine complex campaigns against major corporations and governments. The reality, however, is far more common and serious – especially for small businesses [2].
Hackers often trick well-meaning employees into giving access to their business systems by getting them to unwittingly click on a link in an email. This method of cyber attack is known as phishing — and it’s on the rise.
But what’s perhaps even more worrying is that most employees may not even be able to identify phishing. That’s according to data [3] published by Texas-based eLearning company, Inspired eLearning.
Statistics reveal 97 percent of people cannot identify a sophisticated phishing email — putting confidential business data at risk.
Consequently, businesses end up losing a lot of money. The study suggests phishing scams cost businesses about $500 million a year. For a small business, the impact is understandably much bigger.
Protect Your Business Against Phishing
The Anti-Phishing Working Group (APWG) found phishing attacks have been dramatically rising since 2004 with a 65 percent increase from 2015 to 2016.
The ever-increasing threat of phishing scamvisit their security features.
Train Employees to Identify a Phishing Attack
But the most crucial aspect to be considered is employee education, as 91 percent of hacking attacks start with phishing emails. It pays for businesses to train employees to identify a phishing attack that arrives via email. Emails asking for sensitive data such as passwords and personal information are most likely phishing emails that employees must recognize.
s: Inspiredelearning8/identify-a-phishing-attack.html
[1] cyber [2] especially for sma[3] data: https://inspiredelearning.com/blog/phishing-statistics-facts/


1:1 CBD-THC Ratio - February 2023
Written by Fay Smith Updated on 1 February 2023 | 6 minutes read
The 1:1 CBD–THC ratio means a medical cannabis product contains an equal: THC ratios are available in flower extracts, edibles, topicals, tinctures, and capsules. Most dispensaries offer 1:1 products.
Nabiximols is an oromucosal spray of a whole cannabis plant extract with a 1:1 ratio of THC to cannabidiol(1). This spray , and Canada for treat entourage effect may occur when individuals consume a cannabis-based product with THC and CBD cannabinoid compounds(2). The “entourage effect” refers to the suggested contribution of terpenes to cannabinoid activity(3)
Terpenes are natural oils that give cannabis its aroma, color, and flavor.
Common adverse effects of Sativex (1:1 ratio) include dizziness and tiredness(4). However, symptoms such as anxiety, mood swings, and paranoid thoughts have rarely been described(5).
1:1 Ratio Overview
Approximately 100 cannabinoids have been identified from the cannabis plant(6). The main psychoactive component is (-)-trans-Δ9-tetrahydrocannabinol (THC), primarily synthesized in the plant’s flowers and leaves.
Cannabidiol (CBD), the nonpsychoactive counterpart of THC, is another significant cannabinoid in cannabis(7). It is believed to have poteCBD and THC’s actions are entirely different(8).
The variances in THC and CBD concentrations in the cannabis plant represent the differences in effects across cannabis strains(9).
CBD, the second most prevalent phytocannabinoid, contributes up to 40% of the plant’s extract(10). although it may counteract THC‘s action.
However, the CB1 receptor bindsdelta-9-tetrahydrocannabinol (delta-9–THC). CB1 mediates most of delta-9–THC‘s central nervous system effects(11)2When individuals take cannabis-based products with THC and CBD, the body experiences the “entourage effect”(13).
The “entourage effect” is the proposed favorable contribution of terpenes to cannabinoid action(14). The effect indicates that the real impact is higher than the sum of its components.
What Is a CBD:THC Ratio?
A CBD: THC ratio indicates the equal amounts of CBD and THC present in a medical cannabis product. CBD:THC ratios are possible in all cannabis formpsules.
Products with 1:1 CBD:THC ratio can be found at most dispensaries. Consumers usually rely on individual tolerance to CBD and their desired experience when finding the optimal ratio.
Different Health Benefits of a 1:1 Ratio
The 1:1 ratio may be beneficial for pain relief, particularly neuropathic (nerve) pain(15). However, beyond the trials done on Sativex for multiple sclerosis, there is no solid clinical evidence of distinct health advantages.
Meanwhile, the cannabis-extract oromucosal spray, nabiximols, made with 1:1 THC:CBD was demonstrated to cure chemotherapy-related nausea and vomiting in a smallh in Spain(16).
In addition, most of this study focused on the effects of Sativex, a 1:1 THC/CBD cannabis-based medicinal extract, on sleep in patients with chronic pain(17).
Clinical studies revealed that Sativex-treated individuals with chronic pain reported improved sleep quality(18).
However, some research indicates that 1:1 THC/CBD formulations do not enhance sleep duration while subjectively enhancing sleep quality(19).
Uses of 1:1 Ratio
Most clinical investigations on managing intractable chronic pain with CBD generally used a 1:1 CBD to THC ratio. This ratio was often administered in the form of the well tolerated oromucosal spray Sativex (Nabiximols in the United States)(20).
Combining the two often enhances the harmful and euphoric effects of THC dosing alone. CBD:THC formulations may reduce mean pain scores in chronic patients with multiple sclerosis(21).
The ratio also improved neurophysical measurements in response to noxious stimuli. The CBD:THC ratio may also reduce intractable chronic pain in advanced cancer patients and enhance refractory or neuropathic pain after failed spinal cord surgery(22).
How to Read Ratios and Doses
The first number will indicate the CBD content whenever consumers see a product with a ratio. The second number indicates the THC content of the same substance.
For instance, a 10:1 ratio tincture has ten times as much CBD as THC. Understanding that CBD comes first is essential since consumers may encounter ratios with more THC than CBD.
Each ratio has its spectrum of effects. Therefore, for consumers’ wellness, they need to checkratio or amount of CBD and THC best meets the consumer’s requirements.
How Does 1:1 THC:CBD Ratio Work?
The 1:1 ratio of THC to CBD seems to allow for higher doses of THC without increasing the risk of adverse side effects(23).
CBD counteracts some of THC’s psychoactive and sedative effects without affecting THC’s supposed results, including relaxing muscles and reducing spasticity(24).
THC, CBD, and other cannabinoid compounds are now being studied alone and in combination for therapeutic effects(25).
Other Common THC:CBD Ratios
Here are some other common THC:CBD ratios:
A 0:1 ratio indicates that the product contains no CBD in the THC mixture.
THC has been shown in clinical investigations to disrupt rapid eye movement (REM) sleep and shorten sleep latency(26). Sleep latency is the period between turning off the lights and the first cycle of any stage of sleep(27).
Individuals sensitive to THC may suffer its adverse effects, such as mood changes, hallucinations, and impaired memory(28).
Meanwhile, spectra are THC and CBD products with a 1:0 ratio of CBD to THC. The ratio indicates that the product is THC-free and should not induce psychoactive effects.
High-THC ratios are ones like 1:9 or 1 to any number higher than 9. Even though these products do not have as much THC as concentrates, they still have many of the same high-THC attributes.
Different Strains of 1:1 THC:CBD Ratio
The strains listed below are examples of commonly bred cannabis with balanced 1:1 or THC:CBD ratios.
Argyle’s genetics are mostly Cannabis indica. The Argyle variety is recognized for its woody and peppery overtones. The buds should be coated with amber trichomes and have a dark green hue.
The indica sativa ratio of Pennywise is 70/30. It initially bloomed with the assistance of TGA Subcool Seeds. The THC level of this strain ranges from 8 to 15%, while the CBD content is 12%.
TGA Seeds was founded in 2001 by a small group of devoted medicinal growers who had become weary of the prevalent misleading claims and fabricated marketing in the seed industry.
Cannatonic is a balanced hybrid cannabis strain with low THC and high CBD levels. Its THC level is relatively low, ranging between 3% and 6% on average. Despite its low THC level, this strain is crucial for individuals seeking CBD-rich strains, with an average CBD concentration of 6% to 17%.
Royal Highness’ chunky, lime-green flowers are mostly sativa (60% sativa, 40% indica). Royal Highness smells like spicy skunk out of the bottle. When burnt, these taste like charred wood combined with pungent cheese.
The ratio-infused edibles include both THC and CBD. The simplest method to determine if an edible is ratio-infused or not is to read the product’s label.
The packaging will indicate the THC and CBD concentrations of the substance. A 1:1 ratio of infused edibles will include equal levels of CBD and THC (in milligrams).
The mixture of edibles like gummies has the same amount of CBD and THC. Depending on the dose, THC may make individuals feel high, mainly if they have never used cannabis. If consumers use this ratio, it is best to start with low doses and slowly increase them based on how well they work.
Also, CBD gummies are simple to administer since each gummy has a fixed dose of CBD. Most CBD gummies on the market contain between 10mg and 25mg of CBD.
CBD edibles have an onset time between 30 and 90 minutes and a duration of between 6 and 8 hours(29).
There are no clinical studies on the 1:1 CBD-THC ratio. However, users may note that edibles with a 1:1 CBD-THC ratio may have the same benefits as other cannabis-based products(30).
What Is a 1:1 Tincture?
Cannabis is mixed with an alcohol- or glycerin-based concentrate to produce true tinctures. Tinctures may be administered sublingually for absorption via the thin membranes beneath the tongue. Tinctures may also be added to a variety of beverages or foods.
Users may note that CBD and THC levels are equal in the composition of tinctures. Depending on the amount, individuals may experience psychoactive effects, particularly first-time cannabis users. If consumers utilize a 1:1 ratio, they should begin with modest dosages and gradually raise them depending on their efficacy.
Different Side Effects and Risks of 1:1 Ratio
Whenever individuals consume THC, they run the chance of experiencing psychoactive effects.
This risk may be avoided by cautious dosing, selecting high-quality products, and developing an individualized medical marijuana treatment plan.
Individuals may also try a product with a higher CBD concentration or a 1:1 product with a lower THC concentration.
Although consumers take all measures, they may still encounter the following adverse effects after taking cannabis, including a 1:1 THC:CBD ratio of Sativex.
Common adverse effects of Sativex include dizziness and tiredness31). At typical dosages, Sativex does not impair driving ability or have substantial adverse effects on cognition and mood, even in the elderly.
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Successfully run by an Owner/operator since 1999, the business is well established and profitable.
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Average FME $285,000 over the past 3 years.


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Shocking news in a year of Drake holding the top spot for 15 consecutive weeks: the synthetic, indie Closer, lovechild of Halsey and the Chainsmokers, has fallen to number two after a measly four weeks. Four!


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I think we're not as bad off as the states. We didn't do quantitative easing for one thing.
I wonder where Shane is today? I'm curious as to what he thinksbe so "flexible" with the money supply. As far as I can tell, all this flexibility has earned us is the right to sit on a time bomb.
Banks consider more than just the "velocity of money" when deciding whether to hike rates. They know that unemployment is high, the economic recovery is still fragile, and that people simply could not afford significant rate hikes. People who might otherwise buy a house will opt to keep renting. Those thinking of opening a business will sit tight and wait. They'd be pricing themselves out of reach, and as their willingness to extend toxic debt and mortgages demonstrate, banks are acutely sensitive to a drop in the number of customers.
In fact, upon second reading, it becomes clear that this article is a thought exercise. Even if its observations and conclusions are accurate, it does provide two potential solutions and casts about for others. It is intended to stimulate discussion, not serve as a grim and dire warning. It also makes no recommendation concerning the gold standard or other "Austrian" practices.
By the way. If you "Austrian" types truly believed in what you were saying, you'd refuse all the benefits of the "inflationary" model of managing an economy. That means you don't use any portion of public resources, utilities, or infrastructure paid for with "inflation-generated" money, insist on paying full price for your own health care, and live more or less off the grid.
Shane could you please expand on the last paragraph of your post. I'm not sure I understand the hypocrite claim.
1. Publius & Co. maintain that it is counterproductive, destructive, and morally and ethically wrong to use inflation as a means of managing the economy, arguing that it inevitably leads to massive economic ruin. Which, if it gets totally out of hand, it can; but we're a ways away from there still.
2. If the government increases the money supply too far out of sync with the amount of available goods and services that back the value of its currency, that currency becomes devalued, and its real purchasing power declines. More currency and bonds are therefore issued to compensate for the inevitable rise in prices (inflation).
3. Some of that borrowed money is spent on infrastructure that everyone, including self-styled "Austrians," uses. Whether the government manages its economy well or not in a given year, the people do derive measurable benefits from much of that spending.
So my point is that if they want to be up-front about their beliefs, they should not use those services, as they then become participants in the economic ruin they preach is inevitable. It's not a direct link, but it is food for thought--society and economics have become far more complex and interdependent (and globalized) than they were at the time the traits of Austrian economics were established.
So Shane is saying that Publius and Co. should not use stuff they are force and will be forced to pay for?   And when Publius is a feudal lord and you one of his serfs because he bought up gold and stuff and you didn't, that will be karma.


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We have to admit, stainless steel appliances add a sleek modern touch to any kitchen. Whether it’s a fridge, dishwasher or the humble toaster, stainless steel not only makes the kitchen look modern and stylish but it also comes with additional cleaning considerations.
The problem is, how do we make sure we clean theses sparkly appliances without causing long-term damage?  Which one is best to use? most people have is, they buy a brand spanking new stainless steel fridge for their home but find it difficult to clean it back to its original shine. Not all stainless steel cleaners are created equal and some will not work nearly as well as others on the appliance.
What makes stainless steel ‘stainless’?metal underneath.
If it’s called ‘stainless steel’ then why is my fridge so dirty?
Just because you have stainless steel doesn’t mean stuff can’t stick to it! Fingerprints, grime, and everything else can still stick to your appliances but the good news is that your appliance can be cleaned and returned to its former glory! This is the advantage of stainless steel. With the right tools and method, your stainless steel appliances can be buffed up and look as good as new.
Ok, first let’s look at what we DON’T want to do.
Don’t use anything rough that might scratch the surface.
This means we want to avoid any abrasive sponges, steel wool or brushes. These can scratch the surface. Once your stainless steel is scratched it is pretty difficult to repair –at. Also, make sure you check any cloths for any stuck food debris. You might think your cloth is stainless-steel-friendly but if you start buffing and find a stray scrap scratches up your steel you will wish you checked twice!
Don’t use chlorine bleach to clean stainless steel appliances.
Chlorine bleach can damage the surface because the steel reacts with the ions in the bleach solution. Stick with dishwashing soap and a cloth to clean your stainless steel appliances.
Don’t clean in circles or against the grain of the steel.
Clean against the grain or in circles. Doing so will take much longer to clean – as it will be harder to get into the grain of the surface. It also has the potential to damage the finish of your steel.
Here’s what you will need to clean up your stainless steel appliance.
Any soft cloth will do but a microfiber cloth goes the extra mile to ensure scratches are minimalised and the job is done right the first time! Make sure you keep 2 of these handy. One will be used to scrub with soap and water and the other will be used to buff the surface and bring out the shine.
Dishwashing soap is an appliance friendly cleaner you can use to make sure you get all that gunk off your appliance. While there are several, we prefer to stick with the tried and true soap method.
Good old water – straight from the tap.
Now Let’s Clean!
Your cloth doesn’t need to be soaked but it needs to be damp. Wet the cloth and squeeze out excess water so it’s not dripping.
Add some soap to the cloth.
Make sure you clean along the grain. This will be either horizontal or vertical. Scum and grime can get caught in the little grooves of the grain so make sure you clean along the grain to catch these. This also gives your appliance that extra shine as you snap up those little bits that are often missed. Don’t be afraid to go back over any surfaces to get rid of any left-over gunk. Make sure you clean the surface quickly. Any soap that lingers on the surface may dry out and leave marks and streaks.
This is very important and it helps bring out the shine in the surface. Remember to go along the grain, make sure you clear up any left-over soap or water.
We get it. We love our Stainless steel appliances too. It would kill us for something bad to happen to them. Just use water and dishwashing soap and you will ensure that your well-loved appliance gets the TLC it needs. A quick buff of your appliance afterwards with a dry cloth can bring that much needed life to your kitchen and make it feel as good as new.
Here at Mop Lovers we love to help out with some great cleaning tips to make your life easier.


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New York bans fracking. NSW should ban it too.New York Governor Mario Cuomo for banning fracking in the state of New York over health concerns and called on the NSW Government to follow New York’s lead.
“This was not a knee jerk announcement. Governor Mario Cuomo has been considering the issue of fracking for years. His Republic opponent recently lost an election after promising to allow fracking in New York.
“NSW would be wise to heed the information coming out of the US where the unconventional gas industry is far more mature. The US experience shows that this industry is a threat to health, the environment, and the climate,” he said.
In August 2014 the Courts order 243 reports where fracking or drilling for unconventional gas had contaminated underground water sources across 22 counties in that state.
January 1, 2015	8:31 pm
The 2014 film ‘Energized’ documents in a matter of fact way the effects of fracking in one area of Canada, including large tracts of waste land and ground water saturated with flammable gas. Vast areas of Queensland and NSW are covered by coal licences and applications. Locals in the NSW Southern Highlands are resisting coal seam gas exploration, in an area not far from Sydney’s water catchment areas.


If you are buying a property in Spain and are using the full services of a lawyer, then you will not need this service, many clients decide to not use Spanish lawyers as the Notary will check everything is perfect with the property, the Notary check that the property is free of debts and charges, that it is registered in the Spanish land registry and also for council taxes.
If you decide not to use a lawyer, the Notary will deal with the legal side of the title deeds, but then you will have to pay the taxes, and register the property yourself in the land registry and local council tax offices. If you are here for a long period of time after the completion in the Notary, and you speak fluent Spanish, you can do the work yourself, but if not then we can offer this service for 235 euros.
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Firstly we lost the young poult, that had had its leg caught in the incubator tray. To be entirely honest I am not sure that was all that was wrong with it; it was unsteady on its feet and although we had seen it eat and drink, I am not sure it was getting enough, and was weak.
On the piggy front, Friday we travelled back to the free range piggery to purchase a young gilt, in the hope of breeding pure Berkshires. So we made the 250km (approx 156 miles) round trip to see Christina at Berkshire Gold and picked out our girl- Sage.
B it does mean that they are not as used to human contact as our guys... So this is something I will be working on!
Introducing a new member to our herd was bound to cause excitement and probably a bit of tension. So there was one thing that required our attention first.


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Friday, February 12, 11, 1954, Abilene, Texas SLIGHTLY COOLERImporter''iBttVitó MVOL. LXXIII, No. 240 Auociated Pre»$ ÍAP) ABILENE, TEXAS, THURSDAY MORNING, FEBRUARY 11,2 Hamlin Children Die As Farm House Burns GONE, GONE!!!—Jack Eppler, owner of Sunbeam Supermarket, 1672 Pine St., looks at the cash register emptied of $500-$l,000 by two armed robbers Wednesday night. (Staff Photo by David Barros) Witness Says He Issued Fake Vouchers for Parr SAN DIEGO. Feb. 10 A state witness testified today he had issued school fund vouchers to fictitious persons at the express order of George Parr. He said he either gave the vouchers to Parr or cashed them and gave the money to Parr, Parr—cenUfr of the state’s attack on Duval County — stoofi in' the sun and grinned about it all. He said it was like a hockey game — with Atty. Gen. Ben Shep-perd and Gov. Shivers “passing the buck back and forth.” j “Fir.st,” he said, “there’s a blast from Shivers, then there’s a blast! from Shepperd. Now it’s Shivers’ time again.” i^arr is the political boss of Duval County in South Texas, has been for years. ‘Boss Rule’ Attacked Shepperd flew here thi* week personally to lead an attack on what he said was “boss rule” In the county. The use of funds of the Benavides Independent School District in the county is under investigation.lictitious persons at the express order of. Parr laughed at that. He said all that already has been published in newspapers. The political boss, a red-faced millionaire at 52, stood outside the door to his San Diego office and talked to a reporter. Some Turn on Parr Some of his former friends were reported to have turned again.st Parr. J. L. .MacDonald, a Benavides oilman and rancher, a bitter foe of Parr, said a group of long-time Parr supporters are revolting against I’arr. MacDonald said he talked last night with three representatives of prominent Duval County families who formerly backed Parr. He said the three told him they had given Parr an ultimatum to clean up the Benavides school district “or we’ll do it without your help.” MacDonald described the three as “good respected people—they’re disgusted with the school district and tired of living in fear,” Records Ordered In At the courthouse Judge Arthur Klein ordered Texas Rangers to round up all records of Duval County and the Benavides and San Diego school districts of the county. State Auditor C. H, Cavness and seven assi.stants stood by in San Diego, ready to start checking. ! The testimony and roundup of WINDS REACH 57-MPH Dust Blows Awoy; Cooler Air Due Abilene area residents. who breathed dust-filled air Wednesday, likely will have more pure and cooler air to inhale Thursday, according to the U. S. Weather Bureau at Municipal Airport. A heat wave which began Monday with a 73-degree maximum temperature likely will taper off Thursday and Friday with maximums of 60-6.') both day.s, the weatherman said. On Tuesday the mercury touched 81. It hit 77 Wednesday, despite fast-blowing winds. The dust, which blew in from the Big Spring area and .New Mexico, was settling after dark. Wednesday, the weatherman said. The duster lost its strength after dropoing visibility here to a mile shorfly after noon Wednesday and keeping it that low for four hours, he said. By 10 p.m., visibility had Increased to