 Mary's Church Choir, with the Rev. Harrington Lees, vicar. 1920
- ReferenceGB 216 P/123/CW/834
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Feminist health advocates rally against Prop. 73
By Michelle Burton Brown
HEY ARNIE
While invited guests and the media awaited the arrival of Gov. Arnold Schwarzenegger inside the air-conditioned Sierra Nevada Brewing Co. two weeks ago, pro-choice advocates braved 97-degree temperatures outside the brewery to demonstrate their opposition to Proposition 73, if a female seeking an abortion is under 18 years of age. At the present time, 33 states have parental-involvement laws.
According to pro-choice advocates, the law targets teenagers who have compelling reasons for not involving their parents in their family planning and reproductive decisions. Under existing California law, teenagers have the right to family-planning related services such as those relating to birth control, abortion, prenatal care, childbirth, adowithout the consent of their parents.
Schwarzenegger has endorsed the idea of parental notification, but has not taken a position on the measure.
The Women’s Health Specialists (WHS) of Northern California advocates reproductive freedom and opposes any legislation that places rThe organization’s stance is that abortion is a medically safe and simple procedure and that it is unconstitutional to deny sexually active women access to preventative family planning procedures. Proposition 73 is on the Nov. 8 California special election ballot.
“Ca6,” Schnitger said. “It’s polling 50/50, too close to call and he’s.”
Proponents of the initiative say that they are not seeking a parental consent law, only a 48-hour waiting period to notify parents that their daughter is seeking an abortion. According to the Institute of Governmentaly, Proposition 73 would also require that physicians report abortions and that the State compile statistics. The mother of a teenager who received family planning services at the WHS, without her mother’s consent, was used to campaign for the law. The amendment was never implemented and was challenged in 1997. The state ated a minor’ “ion.”
Past attempts to place legislation similar to Proposition 73 on the ballot in California failed. However, according to the North Bay Progressive, the current initiative, financed in part Don Sebastiani, Sonoma winemaker and former assemblyman, and Tom Monaghan, the founder of Domino’s Pizza, obtained enough signatures to qualify it for the ballot.
Feminist health care providers argue that parental notification laws will result in delayed medical care for the most vulnerable teens, putting them at risk for health complications, premature parenting and possible physical abuse. Philips noted that Texas has one of the most recent laws, now 5 years old, and as of June 5 of this year, the law changed from notification to mandating consent.
“M’s ” Schnitger said. “ant.”
Schnitger views the initiative as a thinly veiled attempt to reverse the hard-won reproductive freedoms women have worked diligently to obtain and an erosion of rights granted under Roe v. Wade. She pointed to legislation in other states as an example of what could happen in California and across the nation.
“In .”
Sen. Tom Coburn, R-Okla., and Rep. Todd Akin, R-Miss., introduced legislation (S 1279, HR 3011) in both the Senate and House that would require mandatory parental consent for a teenager to obtain birth control. All clinics receiving federal funds would be required to notify parents of a minor’s request for contraception five days prior to dispensing it to her.
The legislation would affect reproductive health care services to about 5 million low-income
In Japan, Schnitger said, “w.”
While other countries look to the United States for medical models that respect the reproductive rights of women, pro-choice advocates fear that the hard-won freedoms obtained by women are in jeopardy.
“’s ”
She went on to say that the restriction is spearheaded by anti-choice groups because they want to make it difficult for women to get an abortion.
“Th”
“’s what sets us apart from other women’n’s”


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DEE-VEE-DEE REVIEW BY BILL SHUTE!
Lippy is a kind of blowhard with a twist of WC Fields to his delivery (voiced by Daws Butler). Animation reference websites (whose knowledge is more encyclopedic than mine) state that Butler based the voice on comedian Joe E. Brown and that the voice is pretty much the same of Peter Potamus (who ran at H-B from 1964-66, so Lippy was first----the Warner Archives put out Peter's collected works on DVD in 2016). He's very much a nice guy….lion…
Hardy is a worry-wart, who finds the worst interpretation of everything that happens, is paralyzed by fear, and never wants to try anything new or different. He's voiced by the great Mel Blanc (you'll also hear Blanc doing other minor characters in these shorts), who is perfect for the hemming and hawing and cynical mumbling the character does non-stop. The irony here is that hyenas are supposed to be laughing all the time—but this is an over-worrying, depressed hyena!
I've been watching these 52 shorts randomly, but to focus on the first three here, you can see the basic format. In the first one, they are adrift at sea and run into a pirate. In the second one, they are riding the rails on a train and get thrown off by the railroad security heavy (nowhere near as brutal, though, as Ernest Borgnine as Shack in the classic EMPEROR OF THE NORTH, this being a kid's cartoon) while dreaming of eating some watermelon (Lippy tells Hardy to be happy by thinking of something fun to eat, and mentions watermelon), which they do eventually get. In the third one, they are rambling around the countryside and encounter a mad scientist (the music at one points references the theme song of the Alfred Hitchcock TV show!
Cartoons, like comedy shorts, often provide me with the kind of absurdist "head cleaner" (to use the language of cassette or VHS tapes) I need during a long day or a stressful period. It's like pushing my own personal re-set button. Hanna-Barbera were at the height of their powers in the early 60's. Virtually every set of animal cartoon characters they created during this period is now considered a classic which has held up very well over the decades, and one certainly can't say that about later periods of H-B animation (though they always continued to have at least some worthwhile projects in any era). If you have a taste for this sort of thing, you should definitely score a copy of this fine 2-DVD set, with all 52 (!


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Man admits killing mother as part of an assisted suicide pact
Moore is scheduled to be sentenced Dec. 18.
Labels: Assisted Suicide; Conviction, homicide, manslaughter


Special Issue of Filmicon: Strategies of the Documentary
The special issue of Filmicon “Strategies of the Documentary” seeks to address the diverse aesthetic, historical, medial, and theoretical connections between moving images and all possible aspects of the ‘documentary.’ In light of the many facets of this key term, the issue does not confine itself to practices or traditions of documentary cinema in Greece. It rather explores the multiple cinematic acts and modes of registering, representing, evidencing, authenticating, certifying, and instructing. It discusses the indexical nature of photography and the digital image, the factual as well as fictional functions of audio-visual recording, the archival status of documentary film in Greece, its ideologies, deceptions, and omissions, the filmic depiction of documentation processes, the documents presented on-screen or lost in the Mediterranean Sea. This thematic focus responds to three interrelated circumstances:
Please follow Filmicon’s guidelines for authors: http://filmiconjournal.com/journal/submissions#guidelines
Please email your article (attached as a word document) to all editors by the 20th October 2019:
ulrich.meurer@univie.ac.at
Associate Professor Maria Oikonomou (University of Vienna / Thessaloniki)
Ever since its emergence as part of the British cultural studies during the 1970s, television studies have charted a progressive yet certainly complicated course. From a neglected cousin, television studies have succeeded in becoming independent from film and media studies, to the point that they have now come to be considered an ‘established field’ with its own degrees and courses at different Anglophone universities. Furthermore, thanks to its disciplinary hybridity, the study of television in countries like the UK and the USA has attracted extensivethus resulting in an exponentially rich body of monographs and articles that read and decode – among other formats – the polysemy of television shows and series.
The academic study of Greek television, however, has a limited place in the national and international bibliography. Previous studies have adopted mainly autobiographic, historical and sociological approaches in an attempt to capture ‘the big picture’ of Greek television and chronicle the evolution of the medium, as well its impact on viewers across different time periods and cultural moments. It can be argued that with the exception of television critics and relatively recent academic interventions in collective volumes and articles, such as Kaklamanidou (2017), Vamvakas & Paschalidis (2018), and Aitaki (2015, 2017, 2018), the discussion around Greek fiction still remains in its infancy. This lack of systematic engagement with the area of television fiction, combined with the closure of the MEGA channel, signifies a need to discuss and reconsider Greek television’s traditionally ‘unserious’ cultural archive, especially within the context of commercially oriented television.
The scope of the special issue may include (but is not restricted to) the following themes revolving around Greek TV fiction:
Textual and contextual analysis of case studies
Representation of gender, sexuality, body image, ethnicity and/or disability
‘Identity politics’ and intersectionality
Production, reception and consumption
Book-to-TV adaptations
Television series and audiences
Television fiction and fandom
Television fiction in the Internet age
Programming strategies and reruns
The case of MEGA channel
Authors should submit a 300-word abstract for their papers including a title, aim and brief background, sources of data & method, and potential arguments/results if already known by 20 January 2019 and a short bio of maximum 100 words should be submitted via e-mail to greektvstudies@gmail.com. The editors will make a decision and will contact authors by 1 February 2019.
Any queries should be addressed to the editors of the special issue Georgia Aitaki and Spyridon Chairetis at: greektvstudies@gmail.com
Spy and ambivalences in Greek TV comedy texts produced in the 1990s and 2000ser’s level. He sjournals and blogs, includingFilmicon: Journal of Greek Film Studies, Social Anthropology, and Oxford Queer Studies Network.
LAST CALL FOR ARTICLES:
We still have space for 2-3 more articles for the upcoming issue of Filmicon: Journal of Greek Film Studies, scheduled to come out at the end of the year. The turnaround for the blind peer review process will be quick, so the deadline for submissions is also rather tight. We therefore mostly appeal to those of you who may have part-completed/completed work, or those who think they may be able to commit to a short deadline.
This is an open issue, so there is no restriction in terms of theme.  Submission guidelines can be found here.
Please contact Tonia Kazakopoulou (toniakazakopoulou@gmail.com) or Maria Chalkou (mchalkou@yahoo.co.uk) at filmiconjournal@gmail Please submit articles by email using filmiconjounal@gmail.com.
Call for expressions of interest in hosting/organising the 4th Contemporary Greek Film Cultures conference in 2020/21
The third Contemporary Greek Film Cultures international conference: Strategies of the Documentary, took place between 16-19 May 2018, hosted by Maria Oikonomou and Lilia Diamantopoulou at the University of Vienna. Many thanks to the organisers for a successful and truly inspiring event, which has helped expand our understanding of what Greek Film Cultures – plural – could mean. And our thanks to all the contributors for really thought-provoking papers.
Please write to: contemporarygreekfilm2013@gmail.comOctober 2018, using the subject line 'CGFC 2020'. Do not hesitate to contact us any time before that if you have further queries.
Following on the secondce in Belgrade in 2017, The Great War(s): Our Story aims to explore how the Great War and other conflicts in the region have been narrated through cinema. The. . [...]
BALKAN CINEMA ON THE CROSSROADS: FROM NITRATE TO DIGITAL (International Conference, Belgrade, 11-13 June, 2017) CALL FOR PAPERS
FILMICON’S SPECIAL ISSUE, CALL FOR ABSTRACTS: Old Games, New Rules: Rethinking Genre in Greek Cinema from the 1970s to the present (abstract submission deadline: 15th May 2016)
In this context elitism and commercial failure have been simplistically ascribed to the films and filmmakers of Greek Cinema of the 1970s and 1980s, while methodological approaches derived mainly from auteur theory and cultural criticism have been applied to their work. Thus, commercial successes such as Petrina hronia/ Stone Years (Pantelis Voulgaris, 1985), Loufa ke parallagi/ Loafing and Camouflage (Nikos Perakis, 1984) or Rembetico (Costas Ferris 1983) and their relationship to genre have been disregarded, while the generic features of Nikolaidis’s and Panayotopoulos’s films (just to mention two of the most significant filmmakers of New Greek Cinema), within particular local and international contexts, have attracted little attention.
Although in the 1990s and 2000s genre cinema gained growing importance as post-classical expression in both art and mainstream global cinema, and Greece saw a resurgence of commercial and art film, only a few studies have explored genre in contemporary Greek film production. The flourishing of popular comedies drawing on the conventions of Old Greek Cinema and/or Greek TV series, the emergence of melodramas with a camp or queer sensibility, of crime films with sociopolitical nuances and even hybrid horror films with figures such as the vampire and zombie are only a few aspects of this unexplored field. It goes without saying that the relation of the so called ‘Greek Weird Wave’ to genre is also in need of a meticulous research.
Contesting genres: hybridity, parody, transtextuality and other generic transformations.
Genre and the nation.
Representa.
Genre and the representation of the past: the heritage film, the nostalgia film, the historical film, the period film and the costume drama.
Genre and authorship: rethinking established auteurs of the New and contemporary Greek cinema under the genre category.
TV genres (TV series, commercials) and their impact on screen, especially in the 1990s and 2000s.
Genres and film reception. by 15th May 2016filmgenregron their proposals by the 12th of June.
The deadline for article submissions is the 30th of November 2016, while the special issue is expected to appear in October 2017. All submissions should be in the range of 5,000-8,000 words, written in English, and prepared for an anonymous peer review process. Please note that prospectivshould not currhe special issue Afroditi Nikolaidou, Anna Poupou and Maria Chalkou at: filmgenregr@gmail.com.
EARLY CINEMA IN THE BALKANS AND THE NEAR EAST: BEGINNINGS TO INTERWAR PERIOD (International Conference, Athens, 5-7 June, 2015) CALL FOR PAPERS
Special Issue on ‘Contemporary Greek Film Cultures’ (deadline: Friday 1st Nov. 2013)
Te committee (Mikela Fotiou, Tonia Kazakopoulou and Philip Phillis) greatly supports the Filmicon initiative and is delighted to collaborate with its Editors on a Special Issue dedicated to the study of Greek Cinema. So, the second issue of Filmicon will be a special volume stemming from the conference Contemporary Greek Film Cultures 2013 taking place in London on the 5th and 6th July.
Please do not hesitate to ask questions and contact us at: contemporarygreekfilm2013@gmail.com


TTerry r
Terry r's 4 posts
Terry r: If you use the Rowridge transmitter fit a group A type aerial for best gain over the frequencies in use. A good quality 18 element yagi should work ok unless you have any local obstructions in the signal path.
See Freeview reception - all about aerialbout aerial types...
Terry r: A Yagi is a "traditional" type tv aerial. It is named after Dr. Hidetsuga Yagi who invented it in 1926 with Shintaro Uda. According to Wikipedia Dr. Yagi was a professor at Tohoku Imperial University in Japan.
PP Shelley
I live in North Bristol BS37 6XA,I don't have an outdoor aerial as we have a sky dish but would like to have freeview in other rooms. Would an indoor aerial be any good?


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His concessions to get the job may cost vital U.S. defense spending.
They couched their demands in claims of high principle and fixing a “broken” House by returning to “regular order.” Some of what they sought could do some good, such as holding votes on all 12 spending bills for a change. Democrats and some Republicans prefer trillion-dollar omnibus bills that hide a thousand special-interest favors and earmarks. Holding votes onbalanced-budget resolution are symbolic but have no chance of becoming law.
But note that the rebel demands included gaining seats of power for themselves. They won two seats on the Rules Committee that sets the terms for floor debate and amendments. This could narrow Mr. McCarthy’s maon.
They also won a 2022. That includes defense spending, which would have to fall by $75 billion if the cuts are split with nondefense accounts.
Whatever happened to “regular order”? The holdouts have imposed their own budget policy here on the rest of the GOP House. The GOP’s defense hawks may be able to carve out more for the military than for social spending, but the pressure for defense cuts will be great.
That’s a terrible signal to send adversaries who are increasingly belligerent, as well as to defense contractors who need certainty about funding to make proper investments. The dovish House Republicans will find themselves allied with President Biden and the Democratic left, of all people. The Senate will have to save the day.
The biggest potential problem for Mr. McCarthy is his agreement to let any single Member of the majority party move to “vacate the chair” for what is essentially a no-confidence vote on his Speakership. The claim is that this is no big deal and was merely the status quo before Nancy Pelosi had Democrats vote to change the rule.
All of this—and other details that we’ll no doubt discover in the coming days—will complicate the ability of the GOP to govern. With a Democratic White House and Senate, the only leverage House Republicans have is the ability to deliver 218 votes. The gang of 20 this week has demonstrated that the tail of one House faction can wag the majority. Don’t be surprised if others do the same.
This week of House melodrama won’t matter in the long run if Republicans can unite and govern like a coherent majority. If they can’t, Mr. McCarthy may regret the high price he paid for the honor of being called Speaker. The country may regret it too.


Tribune Co. Sets Newspaper Spinoff For August 4 July 15, 2014 2:35 pm / 0 Comments / Economy, National News
newspaper industry Tribune Co Tribune Publishing Company
New York (AFP) — U.S. media conglomerate Tribune Co. on Tuesday approved the spinoff of its newspaper division — including the big Los Angeles Times and Chicago Tribune dailies — for August 4.
The new unit called Tribune Publishing Company will be publicly traded under the symbol TPUB, under a plan approved by the board of directors.
The parent firm, to be renamed Tribune Media Company and which is focusing on broadcasting through its WGN cable channel and local stations, will own 1.5 percent of the publishing unit after the spinoff. The media arm also includes digital assets such as the websites Cars.com and Careerbuilder.com.
The company became privately held after it emerged from bankruptcy in 2012. The reorganization $13 billion in debt.
In addition to the Chicago and Los Angeles dailies, the newspaper division includes The Baltimore Sun; the Sun Sentinel in Fort Lauderdale, Florida; the Orlando Sentinel; the Hartford Courant in Connecticut; The Morning Call in Allentown, Pennsylvania; and Daily Press in Hampton Roads, Virginia.
Tribune Co. discussed the possibility of selling its newspaper operations in a single transaction, but few buyers appeared to be interested in more than a single newspaper.
Some reports said media tycoon Rupert Murdoch, who controls News Corp. and its big dailies along with the media group 21st Century Fox, may be interested in the Los Angeles Times or the entire division.
Last July, Tribune Co. said it would spin off its newspaper division in a separate company “to maximize shareholder value.”
AFP Photo / David Mcnew


s unsafe, threatening. Dressing nicely but appropriately helps other women trust you as a friend.
This is what happens when we don’t use discretion. Once your words are out of the bag, they can end up anywhere.
When you are socializing with people from the department, play out beforehand what you will disclose and not disclose. You don’t ever have to be rude unless someone gets out of line. Smile. But be careful about passing along information that could jeopardize the well being of your husband. Better yet, stay clear of controversial work topics and share about the other aspects of your lives.
About that time she met a woman who was also a deputy wife. Cyndi was a little older, and her husband had been with the county for several years. She took a liking to Renee, and they soon found they had much in common. Soon this friendship blossomed into a mentoring relationship. Cyndi called Renee from time to time and asked her how she was faring. She’d answer questions and listened to Renee’s concerns. She gently guided Renee to keep on investing in her marriage and children and offered understanding and helpful ideas. Unlike the lonely deployment experience, she felt supported and strong.
In recent years I have been able to pay it forward. I am now a mentor to several ladies and feel honored that younger women want to meet with me. I love listening and sharing wisdom and asking questions to get them to really think about the deep stuff.
Second, the Third Strand meets needs that we can’t And then he became a highway patrolman, and that made things even more difficult. In my lonely nights alone while Chief was working, the Third Strand was with me. In the times I feared my husband wouldn’t come home, the Third Strand comforted me with His promises (Psalm 91). In my clumsy miscommunication, the Third Strand gave me clarity of mind and new perspectives that would help me articulate my feelings and thoughts. In my fatigue of the days, months and years of constant battling for our marriage, the Third Strand gave me strength. And in my inadequacies, He somehow made up the difference. It’s kind of a mystery, but one I rely on to sustain me through the difficult days.
Over the years I have worked with, served, taught, mentored, spoke to, and counseled hundreds of women of all backgrounds. I’ve learned through trial and error how to be a friend and observed those that do friendship well. I’ve come up with some general rules of engagement that will help you pick some good friends and be a good friend in return.
! Bu I ! But I like to be listened to, so I have had to teach myself to shut my mouth and listen to others.


Bradley Kuhn of the Software Freedom Conservancy (SFC) first heard the term 'sustainability' being applied to free and open-source software (FOSS) four or five years ago in the wake of Heartbleed. He wondered what the term meant in that context, so he looked into it some. He .... 'd... 'the largest independent open-source company'. 'Aso...e.....


Jo and Georgia were key players within their respective England Basketball age group teams this summer at the European Championships. Georgia Gayle featured for England U18 in Romania, whilst Jo Lowry earned her first cap with the U16s in Estonia. Seven weeks of tough training and preparation tournaments around europe preceded the European Championships during July and August, which saw both girls working extremely hard but thoroughly enjoying the experience.
England U16 won the silver medal after losing to Germany in a closely contested final, with both teams remaining unbeaten and dominant throughout the previous 10 days of the tournament. England have now earned promotion into the top European Division at this age grouplack of funding in the sport. Jo was a regular starter for England and for her own Junior Hatters team last season, she demonstrated good offensive control at point and great defensive capabilities.


Retaining old customers and acquiring new ones have always been focus points for retailers. New technologies, new product choices and fierce competition in the retail space – all these add to the complexity in deciphering consumer behavior. In such a scenario, how do retailers find answers to the what, why, when and how about their customers?
The correct analysis of this information can help in channelizing business and marketing decisions, so shouldn't managing customer data should be top priority for a retailer?Why is customer data management an outsourced activity when it brings much more value to retailers if performed in-house?
Outsourcing customer data management- what are the risks involved?
Customer data management is routinely seen as a non-core function by retailers. More often than not, retailers take the decision to outsource this crucial business process on various grounds – either the organization lacks the technical expertise in data design and programming, or it wants to focus more on key functional areas. While retailers are knowledgeable about their overall businessa lot of technological understanding of the nitty-gritties of a technical process. Outsourcing data management is thus seen as a viable trade-off. But is it really?
What retailers could do if they performed the activity in-house?
Such is possible only through in-house data management and processing of customer analytics. We live in an age where each customer counts and so we need to know everything about her before we try to design a campaign/ promotional offer – when does she visit the store, what kind of items does she buy, what brands does she prefer and what price is she willing to pay?This information can be analyzed only from data that has been collected from multiple touch-points, and has been analyzed with a specific agenda in mind. Insights on targeting customers and pushing the right buttons can only come from dashboards and analytical solutions that can be constantly tweaked and customized according to a retailer's specific requirements. Can an outsourced vendor really do this?
Does your retail analytics solution provide you with near real-time, actionable insights from customer analytic!


Now discontinued only £69.00 on remaining stock at any TESCO ! My local Tesco had just sold their last one this afternoon but the assistant said this is national deal so def worth checking your local Tesco. Also if you want the 8g version it is still £119.00
except only one person seems to have been able to purchase one....
On display in Wisbech at £69 and available.


In the article based on modern studies of biography development by Western European and American scholars are demonstrated the changes in the approaches to writing biographies during the 1980-2016. Considering the processes of transformation of these studies in the context of changes in the intellectual climate of the Western European and American academic environment, the author demonstrates the ways in which the biography occupied an important place among academic studies. Also the article focuses on the connection between the “biographical turn” and the crisis of the historical narrative, caused by the proliferation of the postmodern narrative theory of historical discourse.
The need for the rethinking of approaches to the studies of individuals lives, especially prominent political and public figures, was due to the poor awareness of professional historians about their private life and the lack of clear tools for its study. In this regard, the rethinking of the theoretical foundations of biographical works is actualized and the search for new forms of writing biographies has become more active. This study demonstrates examples of new tools used by modern researchers in an attempt to move away from writing biographies in accordance ofreasons for such changes. One of the most important changes in this context was the application of new literary techniques in writing biographies, as well as the use of interviews and methods of oral history for their creation.
1. HAMILTON, N. (2017) Biography as corrective. The biographical turn. Lives in history [Online] – Available from: https://read.amazon.com/?asin=B01M68GKFY (Accessed: September 30, 2017).
2. HAMILTON, N. (2009) Biography: A Brief 3. MILLER, J. (2014) A historical appreciation of the biographical turn. a press, p. 19-47.
4. LEE, H. (2009)5. HOWES, C. (2017) What are we turning from. Research and ideology in biography and life writing. The biographical turn. Lives in history.6. DE HAAN, B. (2017) Personalized history: on biofiction, sourse criticism and the critical value of biography7. KLEIN, C. (2017) Biography as a concept of thought: On the premises of biographical research and narrative. The biographical turn. Lives in history.8. ROLLYSON, C. (2017) Liberationfromlowdarkspace. Biographybesideandbeyondtheacademy(Accessed: September 30, 2017).
9. WHITE, H. (1978) Introduction: tropology, discourse, and the modes of human consciousness. Tropics of discourse.Essays in cultural criticism. Baltimore and London: The Johns Hopkins university press, p. 1-27.
10. WHITE, H. (2002). Metaistoriya. Istorcheskoje voobrazheniye v Evrope ХІХ veka. Ekaterinburg: Izdatel’stvoUral’skogo universiteta.
11. SCHIFF,S. (2012) Theduallivesofthebiographer. The New York Times, 26 November, 2012. [Online] – Available from: https://opinionator.blogs.nytimes.com/2012/11/24/the-dual-lives-of-thebiographer/ (Accessed: September 30, 2017).


Related | How to Use Multiple Google Profiles Simultaneously in Chrome
Fix Issues With Sync in Chrome
1. Resume Sync
If Chrome shows Paused text on your profile icon, it means that the sync has been suspended due to some reason. To very first fix would be to try resuming it, as follows:
Step 1: Tap on your profile icon, you will see Sync is off with a button to Turn on sync. Tap it and log in with your Google account and password if asked to log in and enable synchronization.
Step 2: Once you are logged in, a Turn on sync prompt will appear. Tap on Yes, I’m in to turn on sync.
2. Keep Sync on When You Quit or Restart Chrome
A lot of Chrome users face the issue wherein sync automatically gets turned off every time they close Chrome. If you are facing any such issue, then follow the below steps to change the cookies settings and rectify the same.
Step 3: Now click on Cookies and other site data.
3. Clear Cache and Cookies
Step 2: On the Clear browsing data page, select Advanced and check all the options including, etc.
Google account keeps the Chrome sync active across all devices. It uses cookies for the same. To fix the Chrome sync pause problem, allow cookies for the Google account page, as shown below.
Step 3: Under settings head over to Privacy and security settings.
Step 5: Now, head over to Customised behaviors and then Sites that can always use cookies. Tap on add to add a specific website.
Always allowing cookies for the Google account page will fix the sync paused problem.
These were some common ways you can fix the Google Chrome sync paused problem. If the sync gets turned off every time you close Chrome, change cookies settings. Clearing cache and cookies may also help in fixing the issue..


Motorhome Poland Campervan is available for hire in Warsaw Poland.
In general, people tend to visit in the summer months, from May to October. A large land area, it contends with a colderone from the west. Due to this, weather is difficult to predict, and unlike Spain or elsewhere, it isn’t possible to say with certainty if winter will see a blanket of snow over the country to paralyse traffic, or if the summer will be sunny and warm. On average, spring and autumn are good times to go; the crowds of the hottest summer months have either faded or not yet started, and it is pleasant and generally warm.
The major cities, such as capital Warsaw, are vibrant and modern with a youthful, well-educated population. Those who live here work hard and play hard, with a lively nightlife and clubs that party until dawn. Cafes are popular too, and the cuisine is great – eating out is definitely recommended! But despite the quick pace of life, the old parts of the cities, in some cases reconstructed after World War II destruction, are still charming places to visit, and flower-sellers come to the marketplaces in the mornings, as they have done for hundreds of years.
If you are travelling by motorhome,Poland’s many charms. From the big cities to the rural countryside, where scenes long since gone in other parts of the world are still to be found – such as horses pulling carts along the quiet roads. Unspoilt and lovely, rural Poland is stepping into another world.
In summer, the beaches are well-known and Poles and foreign holiday-makers alike flock to the Baltic coast, near Gdansk, for instance. Poland is, perhaps surprisingly, other watersports. The beaches are clean and unspoilt, miles of golden sand stretching along the shallow coastline of the warm sea.


Origin of Pagan Idolatry, G. S. Faber.
37:1 Primitive Culture, Edward B. Tylor.
41:1 Herr Schiefner calls attention to the similarity between this name and the Sanscrit "bhâme," which he says is found in the Vedas, meaning the sun, and also an epithet for fire.
45:1 Primitive Culture, Edward B. Tylor.
47:1 The Origin of Pagan Idolatry, G. S. Faber.
48:1 Primitive Culture, Edward B. Tylor. </s> The president of the Sag Harbor Board of Education on crafting this year’s budget, why he wouldn’t cut programs and making priorities
How long has the budget process taken for the 2009-2010 budget?
We get updates, every once in a while, every month or two. The Budget Advisory Committee sees a lot more of the data in the beginning, although we do see it at the committee level. I’m on the Long Range Planning Committee, so I see that part of that in great depth. Of course we can see any part we want, but there is so much to see. But January is when we really start looking at the budget.
Well I think the budget has been more guided by the superintendent this year. I think he’s brought some new ideas and some thoughts that we may not have had before. He has certainly come up with some ways for us to save some money. He is very traveled in his experience with education in the sense that he has seen many things.
The [budget] process has also changed, and it is hard for me to say what happened before my time on the board, but in my three years it has gone from being delivered to us with very little information, to being delivered to us with a lot of information and explanation.
Â What are some of the items you feel are necessary in this year’s budget?
By cutting back on that, you have these situations where there may be $1 million worth of parking repairs. That may not be done next year, but certainly over the next five to ten years they will have to be done. It will just be intolerable and impossible to drive a car into them. So if you take care of the facility better, maybe we won’t have these lump sum commitments that are going to be required of us.
If we had to make cuts from this year’s budget – where do you see those things coming from?
I don’t see a lot of cuts this year. Even if we go to austerity, we are only talking a couple hundred thousand dollars. I don’t know the answer – that would be a discussion to have in public with the other six board members and the superintendent. Would you not do the middle school girl’s soccer team? Would you cut some of the clubs? I think we would probably look at a cross section of things. I think we wouldn’t try to cut the program If you said we were only going to have three classes in each grade level – then you need to have that discussion with the community. It needs to be a general discussion over time.
If we were in a depression there is no doubt in my mind that I would do whatever it takes to get school taxes down. But I don’t see that happening.
I believe that school boards and school meetings are the beginning level of democratic government. Number one, you are not paid so lobbying doesn’t work. In addition, if someone doesn’t like the way I do something, or any of the board members, your term is at most three years.
[The school board] teaches us about democracy at a local level, where one to ten votes can make the difference in a budget passing.
Â </s> Remarkable Role Model
featured during the most recent football season on cans and bottles
of Diet Dr Pepper.
honoring both student commitment and athleticism. Antron’s account
To read more about this impressive young man, turn to page 2 of the current issue of Spirit magazine HERE. </s> SAINT LEO, Fla. - The Saint Leo men’s golf team (313-310-299—922) concluded action at the Argonauts Invitational in 14th-place on Tuesday, carding a three-round best +11-over 299 during the final stage of the Invite


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In the end, looking over the whole series and my time spent with it, I glad I read it.  at the start. I feel the first half of the series was much, much stronger than the second half. 7. Bokeem Woodbine’s star […]
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Eager to flee after Jenn appropriates his life savings and drags his name through the mud, X. Accepts a well paid but precarious position for the enormously rich family of an old college friend in the “abracadabrapolis” of Dubai. His job is to sign off on transactions for the Batros Family Funds. But with the […]
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The NFL continued to prosper this season as a business entity. Regular season games averaged 17.6 million television viewers per broadcast; that was the second most in NFL history to the 17.9 million viewers per game in the 2010 season, according to the league. An NFL game was the most watched show on TV during […]
“Y’know like that last just goes into a warehouse somewhere,” Carlin laughs. “I mean, bless them, but I pictured my dad’s stuff just going into an archive and not being seen by anyone.” She adds that George Carlin’s archives are a different […]
Only a handful of times. Something I noticed right off the bat is the quality and durability of them. $500 is a bit steep but if price isn an issue, you will be very pleased. I remember when I was in college, education was about learning from my professors. Learning to express myself, reason and […]
Get, says Roger Barker at London Also passing closer together because they following the same defined routes[…]
The reason? The event was a salute to composer Michael Giacchino with aspecial emphasis on his work on 8. Another cosmic moment photography started on the sequel on Thursday. That day, by email, Lindelof answered a question I had asked him about the pressure and possibilities of this next voyage. Results 49 patients (mean age […]
The highly viscous PMMA cement, activated by radiofrequency, was then inserted into the prepared fracture zoneue scale before the intervention, on the second day, and 6, 12 and 18 months after the intervention. The results were tested for significance by means of paired Wilcoxon rank sum tests […]


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I do have a couple of favorite yoga exercises that I do every day. Stretching my hip flexers out helps a lot when I work for London escorts. It is one of those simple t putting on a yoga outfit. You can actually do it while you sit on the floor watching TV and it makes you feel good. tried it as well, and they say it has helped them to trim their waist line.
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Jealousy is a funny thing according to Harlow Escorts
Personally, I get jealous very easily, and sometimes I find it difficult to cope when my husband is away from home. Not only do I miss him a lot, but I also find myself wondering what he is up to. Is he just doing his job, or is he seeing somebody else. In reality, I know that he is not seeing anybody else. First of all he doesn’t have the time and I know that he thinks the world of me and his little family.
Not ont of confidence in your own relationship and that you are comfortable in your own skin. Harlow escorts are lucky to be able to find the right companions.
I did not meet my husband until later in life, and I feel very protective of him, this is probably one of the reasons I get about jealous and worried when he is away from home.
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For so many years it haunted. And in the end, all it took was a decision. One decision.
When an old friend reappears in her life, Hollywood screenwriter Lilith is forced to confront childhood demons that threaten to destroy the world she has created to keep herself – and others – safe.
When I Close My Eyes starts out as a bit of a slow burn but it heats up significantly in the final third and I couldn't read it fast enough. It's beautifully written with some chapters being incredibly poetic in their length and carefully chosen wording.
It took me a little while to get into the book as Lilith is the type of person who keeps everyone at arms length so she is very difficult to get to know. Once I got to know her, I really felt for her as she is haunted by her past and even her name. Sensitively touching on the subjects of OCD and sleepwalking, I began to empathise with Lilith and even started to understand a little more about this debilitating condition.
While I was reading I kept wondering where the story was going to go but I could never have imagined the twists and turns it would take. Jemma Wayne certainly has a few surprises in store for her readers in this hugely entertaining novel.
When I Close My Eyes is a beautifully written contemporary novel; it's sensitive, lyrical and surprising. An absolute delight to read.


A Football Fans Fantasy! GE television overpowers interference and distance!
Postscript . By the end of the year on December 23, 1951 Du Mont televised the first ever live coast to coast professional football game the NFL Championship game between the LA Rams and Cleveland Browns thanks to the transcontinental cable lines that had been set up earlier that fall.
Along the lines of America's utter obsession and fanaticism for the 3 major sports, especially football, now that there are 800+ viewing channels, WiFi streaming just about anywhere on the planet, and of course the electrical power or battery power to watch and listen to the U.S.'s greatest game, if you can't be at the stadium… WHAT are Americans actually watching or listening to on their TVs or devices?
I chose not to watch it. A sixty minute game shouldn't last over three hours! I have better things to do with my time.
I admittedly have never watched a football game on television let alone the SuperBowl except occasionally he half time extravaganza, but haven't done that in years. It holds zero interest.


A new strand of MDMA which is shaped like a LEGO block contains triple the common dose, according to medical experts.
Warnings have been issued ahead of New Year's Eve by NSW Health after the seizure of the party drug in the state's far north.
NSW was rocked this year when MDMA was involved in the death of six people at music festivals.
The NSW Poisons Information Centre's Professor Andrew Dawson said the new strand was extremely highly-dosed.
"While one MDMA tablet/capsule alone can cause life-threatening toxicity, the risk is greatly increased if high doses or multiple MDMA tablets or capsules are consumed over a short period, or if MDMA is consumed in combination with alcohol or other stimulants," Prof Dawson said on Saturday.


Can brown bears be found in North America?
What are the bears that live in the North American brown bear?
What is the biggest brown bear in North America ... The bears roam both inside and outside the park, and their range has been expanding as their numbers have grown.23 . 2017 .
Is Brown bear A grizzly?16 . 2021 .
The interior grizzly and the coastal brown bear (including Kodiak brown bears) are both scientifically named "Ursus arctos". The main difference in the two is related to geographical range. The Kodiak brown bear is classified as "Ursus arctos middendorffi" and is considered a distinct subspecies. ...18 . 2016 .
What is a North American brown bear called?
Two subspecies of brown bear are native to North America: the grizzly bear ( U. a. horribilis) and the Kodiak bear ( U. a. middendorffi ). Grizzlies were once widespread throughout North America, inhabiting the Great Plains region with north/south ranges from Alaska to Mexico, and west/east ranges from California to Ohio .
Polar Bear.s.


More than ten students from courses that finished earlier this year or late last year are now averaging over £1000 per week from Portrait Photography. These past students had no previous experience in photography. It is amazing how quickly it is possible to reach this target and more. Especially when some ‘established’ photographers cannot achieve this.
But it is necessary to have everything right. The marketing, the systems and much, much more. Not just take great pictures. Buying evermore gear and software will not help.
Recently, on a photography forum an established photographer complained about the number of ‘no shows’ he is getting. One of the ways to address this problem is to call the customer a few days before the booking. He was doing this but in such a way that he was putting the customer off!
There is so much knowledge required to be a financially successful portrait photographer. It is only too easy to lose a lot of money in a short space of time without the right guidance. Having found the right support make sure to follow the advice.
This depth of knowledge cannot be gained in one, two or four day courses. There is simply too much to assimilate. Intermittent days of tuition over a four to six month period are necessary.


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995| 2021-01-01 08:00:00| 3| 53.166926049881624| 2021-01-01 09:00:00| 3| 10.009505806123897| 2021-01-01 10:00:00| 3| 58.067700285561585| 2021-01-01 11:00:00| 3| 81.58883725078034| 2021-01-01 00:00:00| 4| 78.1768041898232| 2021-01-01 01:00:00| 4| 84.51505102850199| 2021-01-01 02:00:00| 4| 24.029611792753514| 2021-01-01 03:00:00| 4| 17.08996115345549| 2021-01-01 04:00:00| 4| 29.642690955760997| 2021-01-01 05:00:00| 4| 90.83844806413275| 2021-01-01 06:00:00| 4| 6.5019080489854275| 2021-01-01 07:00:00| 4| 32.336484070672| 2021-01-01 08:00:00| 4| 55.595524107963| 2021-01-01 09:00:00| 4| 97.5442141375293| 2021-01-01 10:00:00| 4| 37.0741925805568| 2021-01-01 11:00:00| 4| 19.093927249791776|
Now it's time to put all of the features and concepts together. We've seen how to use
o create date ranges that are more dynamic using date math. Once again, PostgreSQL makes this straightforward because date math is handled automatically.
Instead, it's often easier to use
Create 6 months of data with one-hour intervals, ending now()21-08-01 00:00:00' - INTERVAL '6 months', '2021-08-01 00:;
This example is the same as the first, but here we specify the timestamp that we want to end on. PostgreSQL can still do the date math for us (subtracting 6 months in this example), but we get control over the exact ending timestamp to use. This is particularly useful when you want the actual time portion of the timestamp to begin and end on even, rounded hours, minutes, or seconds. When we use
For this last example, we're going to specify the start timestamp instead. This can be useful when you need to test a specific fiscal period or maybe some logic that deals with the turning of each year. In this case, maybe you just need a month of data but it needs to cross over from one year to the next. In that case, trying to figure out the math of how far back to start and how far to go forward might be more complicated than you want to worry about.
Speaking of calculating how many rows you want to generate… 😉
Calculating total rows
Using this formula, we can quickly determine how many rows will be created by changing any combination of the total range (start/end timestamps), how many readings per hour for each item, or the total number of items. Let's look at a couple of examples to get an idea of how quickly you could create many rows of time-series data for your testing scenario.
As you can see, the numbers start to add up very quickly.
generate_series() function. We also learned that when you select multiple sets (using
Part 2: GeL
Learn how to use custom user-defined functions to create more realistic-looking data to use for testing, including generated text, numbers constrained by a range, and even


As a fifth generation Northern Californian, David Stonesifer has always been attuned to the beauty of his native landscape.  He has lived in Los Gatos for over 30 years.  David is known as an astute colorist of Plein Air paintings, primarily Oil on Canvas.  He also paints bold still life compositions.
Copyright © 2013 David Stonesifer. All rights reserved worldwide.  Images may not be used or reproduced without permission of the artist.


Actor:Brett Marx, David Pollock


dished out seven assists and had 30 penalty minutes in 17 games during the 2007 Calder Cup Playoffs, helping the Bears to their second straight Finals appearance. The 6-3, 205-pound Sloan joined the Bears for two playoff games, recording one assist, as Hershey won the Calder Cup in 2006.
Sloan shows 30 points (7-23-30) and 313 penalty minutes in 252 career regular-season AHL games for Syracuse, Manitoba, and Hershey. </s> The Alternative
Beautiful Chaos Wheat Bags
"I’ve always been a creative, hands-on person. In my professional life, I work in mental health. More recently, I’ve had some severe health concerns of my own. My wheatbags represent a culmination of my personal health journeycontribute to both peoples’ mental and physical well-being. We are living in a time when compassion and wellness are key. I hope to contribute to both in some small way through my role in what I like to call “Beautiful Chaos.”" - Tenille
Use: Heat in a microwave for 1-2 minutes or freeze in the freezer. Use as needed.
Colour: Please put in the notes of your order what colourbased on what's available. </s> In July, 2017, the Digital Library of Georgia (DLG) announced its new Georgia Historic Newspapers (GHN) website. I wrote about it at New Website Devoted to Georgia Historic Newspapers Available.
- Houston Home Journal (Perry), 1990-1993
5 college level student newspapers will be added.
- Red and Black Archive
Great news from Georgia!. To read the complete announcement article from DLG, click on Forthcoming Newspapers. </s> DOC Operation Midnight Tango download – theaquariumwiki.co.uk
A Valentines Wish oRefore he takes Emily hostage and tries to takeut the bad guys escape and save not nly his life but also Emily s It was a uick read probably cause it was filled with so much suspense and continuous action you don t want to put it down If you like the Intrigue genre you ll like "this book I really enjoyed this book A perfect book for reading while sitting n the beach Das Buch "eigentlich ganz gut geschrieben Nur war es leide. Peration Midnight series began in with Operation Midnight Tango and concluded in with Operation Midnight CowboyBelow is a lsit
Linda Castillo ↠ 7 Summary.
Zack Devlin an undercover CIA agent takes corrections fficer Emily Monroe as his hostage to escape with his life and hers The evidence stacks up to someone The Other Islam on the insidef the facility experimenting Last Man Standing on the inmates with an experimental drug called RZ 902 Manyf the inmates have disappeared and died for no known reason Light, Gesture, and Color or cause Zack goes undercover as an in mate and a leakn thutside soon leads himn the experimental list The. Operation Tango de l'infiltration en coopration pour Operation Tango est "un nouveau jeu d’infiltration uniuement jouable deux en coopration Reprenant en uelue "le principe de Hacktag l’un des joueurs se dplace en vue FPS l’intrieur de diffrentes pices et doit viter de se faire reprer par les ennemis patrouillant la zone Operation Tango Official Reveal Trailer YouTube Midnight's Edge Recommended for you Gridiron Champions Kickstarter Trailer Duration DLloydTV Recommended for you Deathstroke Knights Dragons The Movie Operation Midnight Tango ISBN Operation Midnight Tango By Linda Castillo Fiction Romance General Mills Boon Intrigue Publication date July ISBN Digital Book format ePub Adobe DRM Buy ePub Our price HOSTAGE TO LOVE Taking gorgeous corrections fficer Emily Monroe as his hostage But when he helped Himself To Operation Midnight to Operation Midnight Harleuin Intrigue Operation Midnight Tango Harleuin Intrigue by Castillo Linda COVID Update September Biblio is pen and shipping rders Read here Skipcontent Toggle book search form Select type f book search you would like to make Enter terms  Search Advanced OPERATION MIDNIGHT RENDEZVOUS by Linda Operation Midnight Tango September Paperback Operation Midnight Rendezvous Linda Castillo Harleuin Intrigue September Featuring Mike Madrid; Jessica Atwood pages ISBN EAN Paperback Add to Wish List Romance Suspense | Romance Series Deep cover  but DogFace one look at her revealed her Operation Midnight Tango book by Linda Castillo Buy a cheap copyf Operation Midnight Tango book by Linda Castillo HOSTAGE TO LOVETaking gorgeous corrections What You Owe Me oFree shippingver Order Buffalo


Pre-order the long-awaited autobiography from x.
Now a grandparent, looking back on his remarkable life, he traces his steps back to being a three-year-old tearing around 1950s London on his tricycle, to boarding school where he had an appendix removed simply to get out of football, to Bedales, where he met Camilla, Duchess of Cornwall (and became intimate with a matron), to balancing his growing love of theatre with his love for educating, the 'woolly jumper years', the stint as an MP, the years of close friendship with the Queen, to becoming a septuagenarian Twitter star and stalwart fixture in British entertainment.


- Grommets, Buttons or Zippers?We offer Samhis available fastening options (even though we don't sell buttons or zippers). The point-of-resolution hyperlink pointing to this page might say "when you need to fasten material together your choices are grommets, buttons or zippers."
- Common Uses of Grommets. We explain how various industries make use of grommets. The point-of-resolution hyperlink might say "You might be surprised by all the industries that have discovered ways to use grommets."
- Grommet Technology. We examine the differences between okay grommets and stellarGrommets have improved greatly due to new grommet technology."


1. Describe the very different ways that John and Vertue respond to Wisdom's teaching of pantheism. What would be different if all were One?
2. How does the Man help John? Do you believe Christ can influence and aid a person prior to his/her acknowledgement of him as Savior?
3. How does John's pantheism segue into theism as he prays while inching precariously along the edge?
4. The Man reappears in response to John's prayers. What is meant when the Man tells John he cannot have it both ways?
5. What do the Rule and pictures represent? How do the shepherds and the Rules fit together with the pagans and the pictures?
2. The characters John has met on his pilgrimage appear as wraiths on the bank of the pool and attempt to dissuade John from diving in. Which of these arguments against salvation have you heard in today's world?
4. What is next for the two pilgrims?


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Reinforced door opens from the left or right with top and bottom safety bars for added protection.
Strong, quick-snap locking system with screws and thicker plastic at assembly points for security.
Heavy-duty plastic is thicker than other brands and tapered for a stronger kennel.


R… H. Jackson Brown Jr One thing that I find to be ever present is the smile that my grandsons always put in my mind and on my face...
Do you expose all your trade secrets to your competitors?
Do you leave all your listing materials with a prospective Seller? What makes you special? How often do you see a pile of prelisting packets or CMAs laying on the counter of a Seller and wonder what happens to all these when the would be client chooses one of the brokers? I have been offered th...
Hip,hip, hooray. Finally, we get to publish more photos in our MLS!
Hip,hip, hooray. Finally we get more photos in our MLS! Dateline June 17, 2013. As previously announced, NWMLS is working with CoreLogic to increase the number of photos that can be uploaded to listings. On Wednesday, June 26th, Matrix will allow up to 25 listing photos to be uploaded to each lis...
Warning! Not all University Place homes for sale are incorporated into the University Place School District. My listing is! Come home to a well maintained spacious rambler in Woodlake Estates! The house sits on a shy 1/4 acre lot, just a short walk to the Chambers Bay Golf Course (Home of the 201...
Your listing is over priced; what do you do when the market catches up?
My Clients had fallen in love with a house about 6 months ago bput the sellers had priced it about $10,000 to high and wouldn't budge off their asking price. Well guess what? The market caught up with the Sellers price point and my Buyers were really excited. The house has been on the market for...
Be grateful for the home you have, knowing at this moment, all you have is all you need... Sarah Ban Breathnach...
Home for sale in University Place WA!
Remember why you took this journey to begin with… Charles Kuralt Sometimes we seem to get lost with our priorities. It doesn't matter how rich and famous you become, if you sell your soul to get there. Every night, I clear my head and meditate t...


Happenings December 3, 2012 O Canada!
And speaking of shopping, we can't help but want to sing "O Canada," due to the incredible business meetings we have had andtop department stores and retailers. While our trip might have been short, we are still buzzing on our caffeine splurges at Tim Horton's. Until we meet again Canada, with love, Alex and Ani!


Converting SWF to MP3 format.


Understand the role of metabolism and metabolic individuality in the development and treatment of diseases using systems metabolomics.
Using metabolomic data, the main objective of our research is to identify metabolic mechanisms that translate genetic risk factors and their interplay with lifestyle and environmental factors into the development and progression of complex diseases, including Alzheimer's disease and chronic kidney disease. Thereby, we have a major focus on investigating how a person's individual metabolic make-up, its changes over time, and its link to genetic variation affect health and disease. We use metabolomics and other omics data from large epidemiological cohorts in combination with advanced computational approaches as tools to access and understand relevant metabolic individuality and its determinants in healthy populations. This forms the basis for elucidating the role of metabolic disruption in age-related diseases, their co-occurrence (multi-morbidity), and heterogeneity in a systems medicine context. Our ultimate goal is to translate our results into applied precision medicine by shifting metabolomics from a valuable research tool to a practical clinical instrument for monitoring metabolic health.
Unravel the determinants of metabolic individuality in data from large cohorts by mapping out significant associations of metabolites with intrinsic (e.g., age) and extrinsic (e.g., life style) factors.
We aim to understand the different factors influencing a person’s individual metabolome. These factors include intrinsic, non-modifiable features such as age, sex, and genetic variation as well as potentially modifiable features such as disease, medication, physical activity and nutrition. We utilize metabolomics and other omics data from big epidemiological cohorts to perform large-scale genome-wide and metabolome-wide association studies (GWAS/MWAS). Here, the metabolome can serve as an intermediate readout, connecting the genetic disposition of individuals with various diseases and risk phenotypes.
Investigate metabolic disruptions in neurodegenerative diseases.
Our computational neurobiology team is studying failures in multi-omics regulatory networks in neurological, neurodegenerative, and mental disorders. The focal omics level in our analyses is the metabolome that we use as intermediate readout for disease risk, state, stage in progression, and resilience. Using advanced computational approaches, we use this readout and interface it with genomic, transcriptomic, and proteomic markers to build multi-level frameworks that can be interrogated to identify functional hypotheses across all available molecular and regulatory layers.
Our work is embedded in several international collaborations and consortium efforts funded by the National Institutes of Health. Our current research focus is on Alzheimer’s Disease (AD), where we are partners in the Alzheimer’s Disease Metabolomics Consortium (ADMC), the Accelerating Medicines Partnership – Alzheimer’s Disease (AMP-AD) and Molecular Mechanisms of the Vascular Etiology of Alzheimer’s Disease (M2OVE-AD) consortia, and Major Depressive Disorder (MDD) within the Mood Disorders Precision Medicine consortium (MDPMC).
Provide decision support for nephrologists to personalize treatment of chronic kidney disease based on metabolic networks.
Our CKDNapp team is part of the BMBF-funded e:Med junior consortium "CKDNapp - Chronic Kidney Disease Nephrologist's App" (www.ckdn.app). The consortium is developing a clinical decision support software (CDSS) to assist the practicing nephrologist in personalized treatment of chronic kidney disease patients. Our CKDNapp will predict adverse medical events and disease progression, refine diagnosis of CKD staging, return transparent reasoning for all predictions and recommendations, offer in silicio modification of patient parameters by the physican, and will deliver comprehensive literature support. It will be made available as an easy-to-use software for smartphones, tablets and desktop computers.
CKD atlas: In addition to CKDNapp, we are looking to integrate multi-omics data to build a resource that can help biologically justify the results provided by CKDNapp. Indeed, CKDNapp uses machine learning methods to computationally model the complex CKD system and these models do not provide biological justification for the decisions they make. Further to the biological justification, CKD atlas will offer researchers the opportunity to gain new insights into metabolic profiling and pathophysiological mechanisms related to chronic kidney disease.
Explore dynamic changes of the human metabolome in response to metabolic challenges such as diet and exercise.
The human body must continually adapt and dynamically respond to physiological challenges, such as food intake, exercise or stress. Metabolite profiles taken at multiple time points during or immediately after a specific challenge allows to monitor this systemic metabolic adaptation in a time-resolved manner, i.e., metabolomics enables us to watch metabolism ‘at work’.
On the one hand, we use challenge studies and time series metabolomics data to untangle the complexity of metabolic responses and their individuality as observed in healthy populations. A better understanding of these processes will help in optimizing and personalizing non-pharmacological disease treatments or prevention through diet and exercise.
On the other hand, we are interested in detecting features of impaired responses that could serve as early signs of a disease (i.e., analogous to oral glucose tolerance tests that allow to diagnose diabetes earlier compared to checking fasting glucose only).
In addition to time series data collected over a short period of time following a specific trigger/challenge, we use longitudinal metabolomics data with repeated measurement over several years for long-term health monitoring in large cohort studies and for following metabolic trajectories of disease.
Elucidating the complex molecular underpinnings of health and disease through integrative multi-omics networks.
Advances in high-throughput technologies have led to the generation of vast amounts of data profiling different biological layers, including DNA sequencing data (genomics), RNA expression levels (transcriptomics) and metabolite levels (metabolomics). Analysis of these single-omics have provided us with valuable insights, but fail to take the complex interplay between these layers into account. Using networks as a flexible and mathematically well-defined framework, we are working on ways to integrate, visualize and analyze heterogeneous, multi-omics datasets.
For complex diseases, which have been linked to perturbations across molecular layers (e.g., transcriptional changes, altered abundances of proteins and metabolites), this integrative analysis has the potential to guide the identification and prioritization of novel therapeutic targets and drug repositioning candidates, as well as provide further insights into the underpinnings of these heterogeneous diseases (e.g., Alzheimer’s disease and chronic kidney disease). Furthermore, we provide easy access to these integrative resources through freely accessible web services, such as the AD Atlas.
Provide easy access to metabolomics results and analysis for the wider scientific community.
With our web-services we enable the exploration and interactive visualisation of metabolomics results in our studies. Data sets with huge numbers of metabolite associations or time courses, that would be otherwise hidden in supplemental tables of publications, become thus easily available in online repositories as source and inspiration for further investigations.
Our AD Atlas and the SNiPA web-tools go one step further with the integration and annotation of knowledge from public available resources across multi-omics layers. They provide intuitive methods for data queries and show results in the context of previous findings to explore and understand underlying (patho)mechanisms.
How does age-related metabolic decline affect brain health?
CKDNapp - a versatile and free toolkit for physicians treating patients with chronic kidney disease
Inna - stock.adobe.com
Can metabolite profiles serve as intermediate readouts for the effects of genetic variation and life style on health and disease?
How does diet and exercise affect our metabolism and how can we use them to optimize and personalize disease prevention?
Have you ever struggled with extracting published results from supplements? We make the full wealth of omics results from our large-scale association studies available to easy-to-use web-based tools.
everythingpossible - stock.adobe.com
Scientists at our Lab
Head of Team CompNeuro
Head of Team CKDNapp
Sai Krishna Bharadwaj Marella
Lina-Liv Willruth
Helmholtz Munich | Maria Wörheide
The AD Atlas is a network-based data integration resource for investigating Alzheimer's Disease, its biomarkers, and associated endophenotypes in a multi-omics context.
Metabolomics & Exercise
Profiling the metabolic response to acute and long-term exercise.
dTosh - stock.adobe.com
Helmholtz Munich | Gabi Kastenmüller
Online Association Databases
With omicscience.org we provide easy access to the results of several metabolome-wide association studies which otherwise would be hidden in the publication supplements.
Metabolomics & Nutrition
How does our food shape the composition of our metabolome?
The HuMet-Repository
Visualize and explore the time-resolved responses of the human metabolism to various challenges.
HuMet-Repository
Genomic Annotation Resource
SNIPA Webservice
A continuously updated interactive, genetic variant-centered annotation browser.
Memed ÖZASLAN - stock.adobe.com
Understand the role of metabolic individuality in health and disease using systems metabolomics.
2022 Nature Communications DOI: 10.1038/s41467-022-30875-7
Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Anh Nguyen, Michelle Cinel, Alex Smith, Gavriel Olshansky, Tingting Wang, Marta Brozynska, Mike Inouye, Nina S. McCarthy, Amir Ariff, Joseph Hung, Jennie Hui, John Beilby, Marie-Pierre Dubé, Gerald F. Watts, Sonia Shah, Naomi R. Wray, Wei Ling Florence Lim, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Tenielle Porter, Michael Vacher, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J. Saykin, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, John Blangero, Peter J. Meikle, and Eric K. Moses
We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for... View full abstract
We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, involving 667 genomic regions (479 previously unreported), with validation in two independent cohorts. A meta-analysis revealed an additional 70 independent genomic regions associated with lipid species. We identified 134 lipid endophenotypes for CAD associated with 186 genomic loci. Associations between independent lipid-loci with coronary atherosclerosis were assessed in ∼456,000 individuals from the UK Biobank. Of the 53 lipid-loci that showed evidence of association (P < 1 × 10-3), 43 loci were associated with at least one lipid endophenotype. These findings illustrate the value of integrative biology to investigate the aetiology of atherosclerosis and CAD, with implications for other complex diseases.
2022 Metabolites DOI: 10.3390/metabo<DIGITS>
Sebastian Gehlert, Patrick Weinisch, Werner Römisch-Margl, Richard T. Jaspers, Anna Artati, Jerzy Adamski, Kenneth A. Dyar, Thorben Aussieker, Daniel Jacko, Wilhelm Bloch, Henning Wackerhage, and Gabi Kastenmüller
Effects of Acute and Chronic Resistance Exercise on the Skeletal Muscle Metabolome.
Resistance training promotes metabolic health and stimulates muscle hypertrophy, but the precise routes by which resistance exercise (RE) conveys these health benefits are largely unknown. Aim: To... View full abstract
2022 Alzheimer’s & Dementia DOI: 10.1002/alz.12714
Richa Batra, Matthias Arnold, Maria A. Wörheide, Mariet Allen, Xue Wang, Colette Blach, Allan I. Levey, Nicholas T. Seyfried, Nilüfer Ertekin-Taner, David A. Bennett, Gabi Kastenmüller, Rima F. Kaddurah-Daouk, Jan Krumsiek, and Alzheimer’s Disease Metabolomics Consortium
The Landscape of Metabolic Brain Alterations in Alzheimer’s Disease.
Introduction Alzheimer's disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global view of AD-associated metabolic changes... View full abstract
Introduction Alzheimer's disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global view of AD-associated metabolic changes in the brain has been missing. Methods We metabolically profiled 500 samples from the dorsolateral prefrontal cortex. Metabolite levels were correlated with eight clinical parameters, covering both late-life cognitive performance and AD neuropathology measures. Results We observed widespread metabolic dysregulation associated with AD, spanning 298 metabolites from various AD-relevant pathways. These included alterations to bioenergetics, cholesterol metabolism, neuroinflammation, and metabolic consequences of neurotransmitter ratio imbalances. Our findings further suggest impaired osmoregulation as a potential pathomechanism in AD. Finally, inspecting the interplay of proteinopathies provided evidence that metabolic associations were largely driven by tau pathology rather than amyloid beta pathology. Discussion This work provides a comprehensive reference map of metabolic brain changes in AD that lays the foundation for future mechanistic follow-up studies.
2022 Frontiers in Nutrition DOI: 10.3389/fnut.<PHONE>
Patrick Weinisch, Jarlei Fiamoncini, Daniela Schranner, Johannes Raffler, Thomas Skurk, Manuela J. Rist, Werner Römisch-Margl, Cornelia Prehn, Jerzy Adamski, Hans Hauner, Hannelore Daniel, Karsten Suhre, and Gabi Kastenmüller
Dynamic Patterns of Postprandial Metabolic Responses to Three Dietary Challenges.
Food intake triggers extensive changes in the blood metabolome. The kinetics of these changes depend on meal composition and on intrinsic, health-related characteristics of each individual, making the... View full abstract
Food intake triggers extensive changes in the blood metabolome. The kinetics of these changes depend on meal composition and on intrinsic, health-related characteristics of each individual, making the assessment of changes in the postprandial metabolome an opportunity to assess someone's metabolic status. To enable the usage of dietary challenges as diagnostic tools, profound knowledge about changes that occur in the postprandial period in healthy individuals is needed. In this study, we characterize the time-resolved changes in plasma levels of 634 metabolites in response to an oral glucose tolerance test (OGTT), an oral lipid tolerance test (OLTT), and a mixed meal (SLD) in healthy young males (n = 15). Metabolite levels for samples taken at different time points (20 per individual) during the challenges were available from targeted (132 metabolites) and non-targeted (502 metabolites) metabolomics. Almost half of the profiled metabolites (n = 308) showed a significant change in at least one challenge, thereof 111 metabolites responded exclusively to one particular challenge. Examples include azelate, which is linked to ω-oxidation and increased only in OLTT, and a fibrinogen cleavage peptide that has been linked to a higher risk of cardiovascular events in diabetes patients and increased only in OGTT, making its postprandial dynamics a potential target for risk management. A pool of 89 metabolites changed their plasma levels during all three challenges and represents the core postprandial response to food intake regardless of macronutrient composition. We used fuzzy c-means clustering to group these metabolites into eight clusters based on commonalities of their dynamic response patterns, with each cluster following one of four primary response patterns: (i) “decrease-increase” (valley-like) with fatty acids and acylcarnitines indicating the suppression of lipolysis, (ii) “increase-decrease” (mountain-like) including a cluster of conjugated bile acids and the glucose/insulin cluster, (iii) “steady decrease” with metabolites reflecting a carryover from meals prior to the study, and (iv) “mixed” decreasing after the glucose challenge and increasing otherwise. Despite the small number of subjects, the diversity of the challenges and the wealth of metabolomic data make this study an important step toward the characterization of postprandial responses and the identification of markers of metabolic processes regulated by food intake.
2021 medrxiv DOI: 10.1101/2021.09.14.<DIGITS>
Maria A. Wörheide, Jan Krumsiek, Serge Nataf, Kwangsik Nho, Anna K. Greenwood, Tong Wu, Kevin Huynh, Patrick Weinisch, Werner Römisch-Margl, Nick Lehner, The AMP-AD Consortium, The Alzheimer’s Disease Neuroimaging Initiative, The Alzheimer’s Disease Metabolomics Consortium, Jan Baumbach, Peter J. Meikle, Andrew J. Saykin, P. Murali Doraiswamy, Cornelia van Duijn, Karsten Suhre, Rima Kaddurah-Daouk, Gabi Kastenmüller, and Matthias Arnold
An Integrated Molecular Atlas of Alzheimer’s Disease.
INTRODUCTION Embedding single-omics disease associations into the wider context of multi-level molecular changes in Alzheimer’s disease (AD) remains one central challenge in AD research. METHODS... View full abstract
INTRODUCTION Embedding single-omics disease associations into the wider context of multi-level molecular changes in Alzheimer’s disease (AD) remains one central challenge in AD research. METHODS Results from numerous AD-specific omics studies from AMP-AD, NIAGADS, and other initiatives were integrated into a comprehensive network resource and complemented with molecular associations from large-scale population-based studies to provide a global view on AD. RESULTS We present the AD Atlas, an online resource (www.adatlas.org) integrating over 20 large studies providing disease-relevant information on 20,353 protein-coding genes, 8,615 proteins, 997 metabolites and 31 AD-related phenotypes. Multiple showcases demonstrate the utility of this resource for contextualization of AD research results and subsequent downstream analyses, such as drug repositioning approaches. DISCUSSION By providing a global view on multi-omics results through a user-friendly interface, the AD Atlas enables the formulation of molecular hypotheses and retrieval of clinically relevant insights that can be validated in follow-up analyses or experiments.


That is the effect of this week. One preempts local government from imposing public health crisis-related restrictions such as curfews and mask mandates for more than a week, and the other loosens existing preemption law to give local governments the power to limit smoking in public beaches and parks.
But when it comes to protecting public health in the face of a public health emergency, or in the aftermath of a hurricane, legislators don’t want local government to have the same reach.
“We have seen not only throughout the countryfreedom, rights, etc. when dealing with the pandemic,” said Sen. Manny Diaz Jr., R-Hialeah, sponsor of Senate Bill 1924.
Senate Bill 1924, whichTuesday, an emergency order issued by a mayor could be extended if it has the support of local governing bodies. Rommel’s bill, which passed the Pandemics & Public Emergencies Committee on March 10, would allow the extensions to go a maximum of 42 days, approved in seven-day extensions.
Current law allows city and  for seven days and extend it indefinitely in seven-day increments as needed.
Under questioning from Sen. Tina Polsky, a Boca Raton Democrat, Diaz conceded that while the bill attempts to limit the ability of mayors to issue executive orders, the governor has the same executive authority to indefinitely extend his emergency rules.
“We elect local government to support our local needs, and they should have the freedom to rule as they need and not be dictated to by a timeline that may not work,” Polsky said.
The bills are just some of a lengthy list of preemption bills advancing through the Legislature. On Tuesday, the Senate Community Affairs Committee also passed Senate Bill 284, ific building design elements, such as color, type or style of exterior, style or material of roof structures or porches and exterior ornamentation, in single and two-family dwellings. The bill exempts communities that have homeowners associations or gated communities.
Sen. Travis Hutson, a St. Augustine Republican, argued that the bills will allow local governments to advance clean energy options without prohibiting energy sources already in place. Hutson said cities in California have started to ban gas stations.


• It plays fast. – You click on a song and it virtually starts instantly. There is no annoying buffering
Whether it is the iPod, iTunes or the iPhone, consumers incorrectly assume Apple was first, ignoring the ground-breaking work from the Rio player, LiquidAudio and Palm. I personally wish that history will ultimately kinder to these digital pioneers.
I signed up for a Premium Account (the free version is not available in The Netherlands) I use Spotify a lot and even my teenage son who listened at YouTube mainly, is now addicted to Spotify. I guess that proves the great potential of the service.
But strange things are happening. Spotify has stopped selling premium accounts in The Netherlands and probably more European countries. Crazy!


Would YOU want to camp in the centre of New York?Luxury....
'From all the cities we've visited we like Buenos Aires the most. It has a great, unique vibe!'
The pair couldn't pick a favourite destination but said: 'Galapagos (Ecuador) is like a paradise. In Bolivia, Salar De Uyuni is amazing. !


Settlement of allegations that Respondent failed to follow its own policy or otherwise exercise adequate controls around a $250 million buy-back of Respondent’s stock during a pause in discussions with a potential acquireruy-back, at an average price of $97/share, the acquisition was announced at $150/share.