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I haven't done a Thankful Thursday post in a long time. But since we're at the mission headquarters for a few days with good internet access, I decided to play a little catch up. Because we DO have a lot to be thankful for...
I had a lovely, lovely time last Friday with a few of my girlfriends. We went to Tecumseh to a large fabric store and made a stop in the cheese store there too. I resisted the urge to buy fabric -- the sticker shock alone was enough to make me pause; when did fabric become so expensive?
Sunday evening found us attending an outreach picnic at a church in northern Indiana. Who doesn't love a good potluck picnic?
We're really liking the new (to us, at least) trend of hotels providing much cheaper long-term parking options. Mike found a hotel only a couple miles from the airport where we could park our car and take a shuttle over to the airport. Such convenience!
We're renting a car while we're here in Atlanta, and they gave us an upgrade at no extra cost. I wonder if the guy didn't feel a little bad after making us pay an extra $18/day on required insurance?
I'm really, REALLY thankful we were close to an Apple store yesterday when my Macbook Air decided to stop working. Because initially I was majorly panicked!
I hope to see you at the end of the summer. I am just not sure when jared has to be back...I keep asking him to look it up but sadly I am not high on his priority list!ha!
so excited to hear your fun...and looking so forward to hugging your neck on Saturday when we all get together. I'm babysitting my great niece and nephew tomorrow @ lunchtime and should be finished around 3pm...
I definitely want to try to get to Mike & Rita's while you guys will be there. Once I know the dates I shall MAKE A PLAN!


Maybe, but I think it was also probably more historically accurate because, let’s face it, what big time publisher (populated almost entirely by white people) at the time would be likely to even give the time of day to a group of black maids from Mississippi? Just my two cents.
VERY well said Brani
Brandi, sorry. 🙂
Hear, hear!! White ladies (including myself) have to stop wanting to tell stories with black people in them that are really only about *us*. See: The Blind Side, The Secret Life of Bees, Gone with the Wind. You know, black ladies have really great and interesting things to write and say about their own lives (Toni Morrison, Alice Walker, Audre Lorde, and more)–maybe it’s time we listened!
I haven’t seen the movie, but I loved the book. I am looking forward to the movie though! I just need some free time…
It’s also important to remember that the 60’s in Mississippi were definitely full of racism – blatant and hateful. Some of that is sure to come through this book – it has to if it wants to remain as authentic as possible.
I don’t say all of this to debunk your point – it is a valid one for sure. I just think The Help (the book anyway) won’t fall under this category. Just my 2 cents! 🙂
I think readat aren’t too clear in the movie…
There’s a big difference between portraying racist events and being racist in the portrayal of those events. The movie isn’t racist because the black maids were treated unfairly by their white employers; it’s racist because it diminishes the maids and exalts the “good” white characters.
Take Minny for example: in the book, she finds the strength to leave Leroy from within herself. Was it facilitated by finding her voice through the stories she told Skeeter? Yes, but the strength still came from within. In the movie, it took Celia’s fried chicken to give Minny the strength to leave Leroy. Her strength came from outside instead of from her.
This is a great analysis of the movie. I loved the book and love the movie, but for the story that’s at heart. Yes, it may not be perfect in the eyes of everyone, but if the experiences are true (and the book is much more detailed than the movie, of course) then I have to think


Chris Guerrieri's Education Matters: Yeah the name is the problem or just how out of touch is the school board?
Teachers are not against accountability or evaluations but is it too much to ask they have a tool that is fair, appropriate and administered by individuals that know what they are doing and are reasonable?
How about in addition to changing the name the board directs its admins to use it the way it was designed to be used?


Location: Victorian College of the Arts (VCA), Melbourne.
Date/Time: Sunday, 6th October, 2019.
What if FM Alexander himself had been able to seek help for his vocal problem with a Body Mapping teacher? In this workshop we’ll be using FM’s own words in Use of the Self to illustrate how to identify and address some of the mismapping he was experiencing. And by extension, many of the most common mismaps that interfere with giving direction and experiencing easier movement.


When you live in an area that is compact, the fact that you will not have much space for storage, and the more things fell apart, the less space you want. The good news is small living room furniture, like end tables and bedside lamps, which will have some closet space, often lying at the bottom. This can help to reduce the old art simply stacking the boxes in a corner and will release some much needed space. Mentally, partition rooms can work just as well as a physical partition. Elements such as curtains and monitors are available and can go a long way in separating space in a small area. If you are trying to create a separate sleeping, eating and areas in your studio or loft seating, the entertainment centers and bookshelves can work quite well.
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All patients twelve (12) years of age or older in the emergency department, inpatient setting, or psychiatric outpatient clinic who are being evaluated or treatedshall be screened for risk of suicide using a validated tool. When indicated based on the results of the screening, patients shall be assessed for level of risk and risk stratification. Patients shall be screened, assessed and cared for as outlined in this policy.


Relying on advanced hardening of flight deck doors, closed circuit television of the passenger cabin to monitor disruptions, and with the addition of air marshals and security- trained flight attendants to control unruly passengers, TSA is ready to begin trying to predict in advance passengers who need additional security examinations.
7. Criminal background investigations of aviation industry workers.
37. Fining passengers for screening violations.
44. Inspector general reports on security failures.


Claire Enders Admitted to the Freedom
Presenting Claire with her Freedom, the Master, Alderman Sir Paul Judge, congratulated the newest Freeman Entrepreneur, and looked forward to her active involvement with the Guild’s Outreach and Charitable works.


ore product styles: Vintage & Retro Fashiontatic Website Hosting Made Easy
n code within it. Sites which require few authors and contain seldom content changes are the best use cases for static website. Marketing websites or personal blogs are the most used static websites. They are economical, highly reliable websites with little to no manual intervention or administration as well as scalable to handle enterprise level web traffic.
The must haves of this process include:
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- Enter password. ( email and password is one time thing if surge has your email and password eventually you do only 4 steps other than these two)A Public Health Approach to Preventing Opioid Misuse: Targeting Pharmacists
Over 4 billion prescriptions are filled by American pharmacists every year.
Furthermore, pharmacists in Texas, the state with lower rates of opioid abuse and overdose, were more likely to discuss misuse with clients compared to pharmacists from Utah. Some of the reported barriers to screening included the pharmacists feeling awkward about asking patients about opioid misuse and not having access to screening tools. The researchers propose evaluating a screening and brief intervention protocol for pharmacists in order to prevent and reduce the burden of opioid misuse. </s> Infection Control
Free E - Certificate included I CPD Certified I Video training I Free COVID-19 Course included
- Demonstrate an in-depth understanding of how bacteria are transmitted
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- Understand the standard infection control procedures for cleaning & decontamination
In module one, the course instructor will guide us through the layout of the course and outline each module.
Module 7: Cleaning & Decontamination.
Esther asked:
Hi sorry me again I'm a slow learner I like to take my time so I'll understand what I'm doing so it might take me more than required time to finish.
Hello Esther, Thank you for your question. If you fail to complete the course within a year, you just need to inform us about that and we will happily extend your subscription and that's without any fees. </s> “Mad Men” returns April 5, 2015, for the final episodes of season seven. I’ve been trying to mentally prepare for the ending, but the idea of no more “Mad Men” makes my brain hurt.
But alas, my friends, nothing lasts forever, and we’ll always have The Pierre Hotel — at least on DVD, blu-ray, a streaming service, or in our hearts.
You’ll recall that’s where Don and some colleagues temporarily set up shop with their own ad agency after McCann Erickson bought the company.
The sideburns are scruffier, the fashion is more eye-popping, and the hair is shaggier (with the exception of the finally coiffed Don, of course).
[…] other day, I posted a few photos of the final episodes and the “Love Hangover” trailer, but below are a few more photos, mixed in with some from the previous season seven episodes. Lots […] </s> Reg for a year.
Gelison, whose name means ‘Pi


Worth Linen is Founder and CEO of WLA Inc., a Direct Marketing Consulting FirmMagazine Publishers, Catalogs and E-tailers, Consumer Financial Service Companies, and Venture Capital Firms. WLA also manages the direct mail fundraising program for The USO, generating over $60 million per year to help support the magnificent men and women of our military, our wounded warriors, and their families.
Other current and former clients of WLA include American Express, Bear Stearns, BMG Music, Bookspan, CyberDefender, GE Capital, General Atlantic, General Catalyst, Guthy-Renker, Harper Collins, Higgins Capital, New Vitality, Paramount Solar, US Naval Institute, Wit/Soundview, and many others.
Worth is an old hat in the Direct Marketing Industry, having started his career in the 1970s at Wunderman Worldwide, where he ran the gamut from Assistant AE to Vice Chairman. He won numerous awards: an Effie, a Lion D'Or, and 5 ECHOs, including the first Diamond Echo ever awarded.
In 1991, Worth left the agency world to become CEO of BMG Music Service. Under his leadership, BMG grew from a $250 million-per-year loser into a billion dollar company with 11 million members and the highest profits of any Bertelsmann division.
In 1997, Worth was recruited by GE Capital as Chairman of The Signature Group, an $800 million telemarketing company serving the Credit Card Industry. In two years, he improved Signature's market share by 20 points versus its chief competitor, Cendant, and ultimately sold Signature for $950 million, enabling its parent company, Montgomery Ward, to emerge from bankruptcy.
Worth has served two terms on the Data & Marketing Association's Board and Executive Committee, was co-chair of its online Privacy Committee, and served on its Internet Advisory Committee. He served as General Chair of the Caples Awards and Chairman of Direct Marketing Day in New York. He has also spoken frequently at DMA events and lectured at New York University's Direct Marketing program.
WLA has had three DMEF (now Marketing Edge) internships and is committed to the mission of helping attract new star-quality talent to the Direct Marketing Industry.


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David Denby's "Jungle Fever" was written as a dispute to Chinua Achebe's argument against the significance of Heart of Darkness. Achebe argued that Heart of Darkness supports the dehumanization of Africans which has helped fuel the Western discrimination against Africans. Denby creates an argument of how has significant importance to literature. Denby argues his point through his journey in a college classroom. Denby observes a Literature Humanities class at Columbia College that is reading Heart of Darkness. The instructors name is Professor Shapiro. Denby allows the reader to listen into the classroom discussion. "Who comes from a savage race?" is how the discussion kicks off. A student answered this question, saying "We all come from Africa", that student was also Professor Shapiro used this type of rhetorical question, drawn from Heart of Darkness, as a way to challenge everything his students thought they knew about savagery, civilization, and constraints. This is exactly what Conrad was trying to do, challenge his readers and society. This is how Professor Shapiro takes his students on an adventure to find the significance of Heart of Darkness and find themselves. Denby argues how Heart of Darkness has made many contributions to literature. "Its perfectly true that Heart of Darkness contains a few...ambiguous remarks...but how do such remarks matter...what readers remember is the squalor of imperialism". He explains how the overall point of Conrad is not to express his opinions on race but on imperialism. Albeit Conrad seems to show the opinion of Africans at the time, that is not the point. The point is that imperialism is a "rapacious and pitiless folly"


After months of hype, it's finally time to play ball
FORT WORTH, Texas -- No matter how many swings Annika Sorenstam takes over the next two days, she is way under par in how she has handled the storm that has engulfed her since the Bank of America Colonial invited her in February to play.Annika Sorenstam drew quite a crowd for Wednesday's pro-am, which was cut short by rain. Will the wet weather dampen her chances Thursday? Stay tuned.
Sorenstam is the cover girl on the June issue of Golf Magazine. Lesley Stahl profiled her for "60 Minutes". She bantered with Jay Leno. She has endured endless press conferences, and answered the same questions over and over with grace and good humor. At 9:58 a.m. ET Thursday, the speculation will end.
"I can't prepare any more," she said Wednesday afternoon, after steady rain ended the pro-am as she and her partners stood on the 11th tee. Sorenstam, without putting out on every hole, was 1-over.." Sorenstam drew the only gallery of any size in the pro-am Wednesday. If the comments of the fans who followed her are any indication, Sorenstam has won the hearts of North Texas golf fans.
"Annika, we're pulling for you," one man said quietly to her at the sixth tee.
"Texas luuuvvs yew!" one man yelled as she walked the ninth fairway.
Sorenstam turned and smiled in response. She signed autographs, waved, posed for photos and provided the sort of warmth to her partners and the gallery that is the trademark of the LPGA Tour. When Bob Albers, one of her amateur partners, made a birdie putt at No. 5, Sorenstam said, "Nice putt!" and walked over to him to bump fists.
"She can handle the pressure," said Albers, 62, a 4-handicap from Portland, Ore., who has played in two other pro-ams with Sorenstam. "That's what makes her a great player."
She has also impressed the other players in the field. Although they have bristled at answering so many questions about her, and some of them have made it clear that they don't believe she belongs in the tournament, there is a genuine curiosity about how she will play.
"Her attitude is perfect," Rocco Mediate said. "She's handled everything, all the crap, as well as it could be handled. She was asked to play. She had the guts to say, 'O.K., I'll see what I can do.' Most people wouldn't do that. She's not the bad guy. There is no bad guy."
"I hope she plays as well as she can possibly play," Tom Lehman said. "I hope she plays the best golf of her life, and she can see where she stacks up."
As for the sentiment that she shouldn't be in the field, David Toms, a member of the PGA Tour Policy Board, said there are no plans to insert a "men-only" clause in the Tour by-laws. But he didn't rule it out, either.
"There is a lot of stuff going on here from a media standpoint, a security standpoint, a lot of things going on that we don't normally deal with," Toms said. "Would we, would our staff, would the players that play this Tour, that have dedicated all their time to this Tour, would they want to do that every week and haonths?"
In all likelihood, Toms said, the last three months are a one-time thing, which is just as well. Any attempt to pass such a rule would unleash a torrent of bad publicity for the Tour. "You had to make a rule like that 50 years ago," Mediate said. "If we do that now, we'd have a big problem."
The rain that has drenched the 7,080-yard, par-70 Colonial course is supposed to clear out Wednesday night. By Sorenstam's estimate, the rain added 300 yards to a course that's already several hundred yards longer than she plays on the LPGA Tour. "The only good news is that the greens are softer so I can fire more at the flag," Sorenstam said. "I'm going to hit a few longer clubs than I expected."
"The only bad thing is the weather," Mediate said. "The weather got her. It's so long we're hitting driver and three-wood on (the 246-yard, par-3) 4."
Sorenstam hit driver at the fourth, and, as on Tuesday, she failed to reach the green. However, she holed her 30-foot pitch for a birdie, her only one in 10 holes. She made bogey at No. 5, where she missed the fairway and the green, and made bogey again at No. 7, if you concede her the six-footer she picked up after one of her amateur partners holed his third shot for a birdie. "The course is wet and long," Lehman said. "Like Augusta, the softer greens make it possible for everybody to compete. Soft greens and a long course don't always favor the long hitter. At the end of the day, it may help her."
Though Colonial is said to drain well, there has been so much rain that lift, clean and place is a possibility. While that would help Sorenstam, it would help the 113 men in the field, too, which would send the cut score lower. That's the sort of analysis that will mercifully come to an end, as will the hype that has built up over the last three months.
"If she can go out and play well and have confidence," said Mark Steinberg, her agent, "make the cut, no cut, it's not relevant. ... Most of the Tour players are like us. They just wanted to see what she would do. She has been so respectful of the game, the event and them.This Week in Golf: Annika's Colonial keys
It's Annika vs. just about everyone at Colonial
Maisel: Welcome to the Annika Tour
2003 Bank of America Colonial
Price the forgotten man at Colonial
Colonial tee times


8.
Deputies getting $1.3 million in new radios
CONYERS - Rockdale County Sheriff’s deputies will soon be getting up-to-date radio equipment aspurchase of 338 new portable and dash-mounted radios for $1.3 million. The BOC heard the requisition request at its Feb. 5 work session and will vote on it at the Feb. 12 meeting.
The funding for the Motorola radios will come from the Sheriff’s Office’s capital requests portion of the 2019 budget, which also includes $178,835 for an upgrade in intercom and paging equipment in the 2007 section of the county jail.
A total of 231 portable radios for use by deputies and 107 dash-mounted radios for installation in patrol vehicles will be purchased for a total price of $1,309,864.80. The low bid on the radios came from Motorola Solutions and is a state contract price.
BOC Chair Oz Nesbitt Sr. said the new radios will be a big deal for the Sheriff’s Office.
“This will give them the equipment they need in terms of the communication devices out on the street,” he said. “The current units they are operating are out-of-date, and from a technology standpoint, this was needed as part of the upgrade for the entire department. This will really give them a big boost in the right direction and make sure they have coverage out there.”
Among other requisitions heard at the work session Tuesday was $348,984 for the purchase of 300 new computers for Rockdale County.
The purchase is part of Technology Services’ capital requests portion of the budget. The new Dell Optiplex 7760 All-In-One 27-inch computers are being purchased from Insight Public Sector in Tempe, Ariz., at a unit price of $1,163.28 and are being bought under a state contract price.
The BOC is also expected to approve this bid at the Feb. 12 meeting.
Insight noted in its project quote that the price was good only until Feb. 10, based on possible tariff increases that Dell anticipates. Dell is among several name brand computer companies that uses components made in China. If nnot successful, there could be a 10-25 percent increase in tariffs beginning in March, which may mean that companies pass production cost increases on to their customers.
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OLED display makers: OLED display makers can be a good investment opportunity - especially companies that have a focus on OLED displays - such as Samsung Display and LG display, BOE Display and more.
OLED equipment makers: There are several public equipment companies (for example Coherent and Applied Materials) that enjoyed the recent OLED capacity expansion as new OLED fabs require new equipment to produce OLED displays. These companies could be a good investment opportunity to investors who believes a new wave of OLED capacity expansion is near.
Read the full story Posted: Jan 16, 2020s. SDC was supposed to start the plan in 2019, but according to a report from China the Company is delaying its initial investment. Originally mass production was supposed to begin in Q1 2021, but this may happen later if the investment is delayed.
The first order is a follow-on order for $4.3 million in connection with the U.S. Army's - which is expected to result in more orders as this is a multi-year program. The second order if from a major defense contractor (eMagin did not detail further) - and worth $5.6 million.
eMagin says that these financial results present a significant improvement, r.
Read the full story | 1 comment | Posted: Nov 10, 2019
Photonics-based solutions provider Coherent reported its financial results for Q3 2019 - revenues of $335.5 million and a non-GAAP gross profit of $122 million.
Samsung reports stronger OLED sales in Q3 2019
S.
Universal Display reports excellent quarterly results and increases its guidance for 2019 again


 returns to his beloved #99 MotoGP Repsol Honda bike. Without a doubt, Lorenzo was happy when interviewed in the press conference as the time away from the track is the longest in his 17 year career. The injury list in 2018 and 2019 has been substantial and his recovery a very important timeline to adhere to. It has become known that Lorenzo had doubts about his life and career. Recovering from a back injury in particular a fractured vertebrae is incredibly difficult. JL99: “I think this is the right time to come back because you can lose a lot of speed and a lot of pace if you stay so much time out of the competition.” We totally agree with his comments because the more time you spend on the bike, training and in the zone mentally, the stronger you are in comparison to others. JL99: “ve.” If you isolate and analyse Lorenzo, you will find out how strong he is considering his injury usually takes three months to recover completely. It is a brave and bold move to return and get back on a bike that goes very fast and at a circuit that is quite demanding. The goal is to get back to a strong performing standard. No miracles are expected this weekend with a win or podium finish. Lorenzo has to stay on board, bag the mileage and be looking at the long game which is also the season of 2020 where he has a job to do, that being a World Championship.
 A fast lap equals momentum, rhythm and consistency straight from the first corner.
 With that being said, KTM offered Johann Zarco’s job to the Jackass as a result of what transpired in Austria. Thankfully for Ducati and Miller fans, he resigned with Pramac Ducati for another year and with a factory bike in 2020 which is a game changer. Miller is grateful to have reached the agreement because the relationship has been comfortable from the start. It is the complete opposite to KTM who are in turmoil and trying to decide who takes Johann Zarco’s ride after the French rider decided to break his contract and mutually end a two year factory contract. He has not enjoyed himself for months so he would rather not race which is quite sad to hear. Right now, Zarco is feeling out for a MotoGP test ride though his 2020 outlook is very dark.
l! MO88: “Silverstone is always a very interesting Grand Prix, mainly because of the weather. We always have quite low temperatures and tricky conditions. After the great weekend we had in Austria, I’m looking forward to continue the good work with all the team, be closer to the top 10 and continue the hard work. Now we are very motivated and in a very good shape to continue on this line. The track itself is very challenging, it’s very long, there are many fast corners, but also hard braking points, so it’s a mix of everything that a circuit can offer. It will be interesting to ride a MotoGP bike there.” Media has been told to avoid asking questions of the Portuguese rider because he wants to focus on his job at hand which is fair.
Mentally and physically, if you are feeling good, at this level, you can click straight back in to a momentum of greatness. No doubt, pushing the limit at Silverstone is a challenge because if you make a major mistake it can end in injury and also disaster for a World Championship. Marc Marquez is relying on luck in a way because at this circuit you have good and back luck. MM93: “It is a circuit I like, one of our weak points on this track was the bumps but looks like they have resurfaced in a good way.” He liked the look of it from his bicycle when undertaking the sighting laps. MM93: “Stay focused and try to fight on Sunday for the best position” is the Marquez mentality and a battle is bound to take place with those chomping at his feet including Andrea Dovizioso, Alex Rins, Miller, Fabio Quartararo, Valentino Rossi and Danilo Petrucci to name a few. The reduction of the bumps will be key for the grip levels plus happiness of the riders.
Unfortunately, Joan Mir will miss the race as he is still recovering from a serious injury which has sidelined him due to the severity of impact. He has been told to keep undertaking his rehabilitation and come back when he is able to push hard. The accident that took place will have shaken Mir’s confidence and mentality so when he does return, getting back on the horse will be vital to his success for the remainder of 2019. It is only now that Mir can begin training and aim to enjoy the test at Misano where it is anticipated he will be 100%. Teammate Alex Rins is aiming to improve and reset after a disastrous few races. Rins: “I’m heading to Silverstone with a lot of motivation, I will aim to give my maximum there because it’s a track that I really enjoy and my current feeling with the bike is positive. It will take some time to check the new surface, and of course the weather can have an impact on the race weekend, but I think I can secure a good result either way. I’d like to send my best wishes to Joan as he is still recovering from his injury.” A similar state of mind is felt by DesmoDovi who is on cloud nine. Winning in Austria allowed the old Dovi to appear and smile. Riding the red beast at Silverstone is fun and really nice so we look forward to seeing him in action. AD04: “ sky-high. O” He may smile at the press conference event with Marquez, however, the battle is far from over between these two superstar motorcycle riders and heroes to the fans of the sport.


Congratulations to past pupil Stephen Gill who was runner-up for the 2021 Waterford Institute of Technology (WIT) BSc (Hons) Land Management (Agriculture) Award, sponsored by Allied Irish Banks plc (AIB), at the virtual Waterford IT Department of Science Industry Awards recently.
Currently in the final year of his Land Management programme at WIT, Stephen was among the highest-graded students for his research which focused on the components of yield in winter rye and winter wheat crops. Further details can be found in this article from the Offaly Independent. The WHS community is so pleased for you Stephen – well done!


Some of the best EDM I have ever heard!These guys should definitely be in top 10!
Vangelis should be number one!He won an Academy Award for "Chariots of Fire" also he did the Music for "Blade Runner" Also his song went to number one!
Vangelis, he's my man!His concerts are awesome backed by full orchestra and singers, He's the best composer ever!
There is no greater composer than Vangelis his concerts are out of this world he is backed up by singers and a full orchestra!
One of the true pioneers and major influences of this genre. # 90?
Number #16, you havin' a laugh!. This pioneer of Electronic music has in his lifetime broken 4 world records for concert attendances, puts on the worlds best laser light shows found anywhere on the planet, and at the grand old age of 63 can wipe the floor with any of these so called artists above. Who hasn't heard of the multi million selling albums which started it all in the late 70's Oxygene and Equinoxe, both superb albums. Others to listen to are the excellent Magnetic Fields, Rendez-vous, and if you have the box set as I have then the very rare Houston concert from 86 is a must. Jarre should be number 1...
LMFAO should be in the top ten at least!I can't believe their not even on the first page!
They revolutionised music in EDM, the buzz of daft punk's discovery had cooled and these three music magicians revitalised the industry. Should be top 10 at least!
I caught some sort of documentary last night about (SHM) and they were being filmed in different parts of the globe. Every event was jam/packed!
197 BEST ELECTRONIC BAND EVER!


The construction of the church began in 1296 and completed in 1436. The Gothic architecture of the monument is absolutely amazing and it is fairly on the list of the UNESCO World Heritage Site.
The stunning dome was inspired by the Roman architecture and has remarkable cultural details from the Medieval Ages and the Renaissance. The beautiful church dominates Florence landscape in all its glory and is the most famous landmark in the city…
This fantastic architectural achievement is enough reason to pay a visit in Italy. Besides the cathedral, there are interiors with beautiful paintings from famous Italian artists and some wonderful feature frescoes, that you must see at least once in you life.
The best part is that you can visit this very attraction whenever you want, since it is open to view anytime and of course if you see the city of Florence, you won’t need an excuse to visit such a majestic and picturesque city.
Also it is pretty easy and simple to find the monument, since it is posited in the center of Florence and you can reach it on foot, while walking to the streets and exploring the wonderful town.


Given by An, 2008
Lew Grade, Baron Grade (1906-1998), Theatrical agent, television executive and film producer. Sitter in 6 portraits.


NEWARK, N.J. (AP) — The New Jersey Devils will be without leading goal-scorer Jack Hughes for the rest of the season due to a left knee injury.
The Devils made the announcement about the No. 1 overall pick in the 2019 NHL draft in between the first and second periods of Tuesday night's game against the New York Rangers.
Hughes was hurt Sunday in the second period when he was checked along the boards in his own zone by Islanders forward Oliver Wahlstrom. A medical evaluation showed Hughes has a low-grade left MCL sprain.
The team said he is out for the season and will begin rehabilitation and conditioning immediately.
The Devils are out of playoff contention.
Hughes was having his best season with 26 goals and 30 assists for 56 points in 49 games — including 15 goals and 15 assists since Feb. 1. He had 11 goals and 21 assists in the pandemic-shortened season in 2021.
Coach Lindy Ruff said Hughes took incredible steps this season.
“So proud of the effort he put in this summer to get the work done and improve his shot and improve his strength on one on one play,” Ruff said. "Worked extremely hard at faceoffs and worked on improving that part of his game. He’s a kid who just wants to keep getting better, and he has the puck an incredible amount in the game.”
Ruff said Hughes' absence — along with a seemingly serious lower leg injury that forward Jimmy Vesey suffered on Tuesday — is going to create chances for other to step up.
Vesey was hurt in the third period after attempting to check Rangers defenseman Braden Schneider behind the New York goal line. The hit was glancing at best and it seemed Vesey's left leg gave out. He had to be assisted off the ice and did not return.
Ruff said Vesey will have an MRI on Wednesday.
Hughes brothers have arrived and they're eyeing a long stay
Jack and Quinn Hughes have come a long way from playing mini-sticks together in their basement.
Next generation of players headline 11th annual NHLPA Rookie Showcase
The 11th annual NHLPA Rookie Showcase brought together 27 of the top NHL rookies and prospects for an eventful weekend of firsts.
Taking neither his captaincy nor health for granted, Nico Hischier is raring to go for a fresh season with the New Jersey Devils.


The primary responsibility of a Doroub travel agent is to make the process of travel planning easier for our clients and ensure they experience the best trip possible. Travel agents work directly with the public and converse with clients to determine the best possible travel destinations, transportation arrangements, and accommodations for the client's needs. We may make suggestions to the client based on our experience, or offer complete travel packages from various resorts or cruise lines. We are often restricted to a budget, and must be highly organized to offer their clients travel arrangements that suit both their financial limitations and leisure or business travel expectations.
Doroub travel work with computers or call airlines, cruise lines, resorts, and rental companies to secure travel arrangements for customers. We research information on our client's travel plans and relay important information including weather conditions, travel advisories and required documents for their destination. Safety is also a factor in international travel, so we keep abreast of the latest news, ensuring that each planned destination is safe for our customers.
Doroub travel work year-round, but are especially busy during peak vacation times in the summer and during holidays. During those times, we are busy on the telephone planning trips and making last-minute itinerary changes for current customers. They also sell vacation packages from cruise lines, resorts and other destinations. During the off season, Doroub travel are busy researching destinations and learning about the latest offerings of prime travel resorts and locations. We will also uncover new destinations and find the best trips for a travel purpose, whether it be business-related or for personal leisure.
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ery. Mark iHowever, here there was no exception about sexual misconduct compared to Matthew.
ὁ δὲ Ἰησοῦς εἶπεν αὐτοῖς Πρὸς τὴν .
This response of Jesus about divorce can also be found in Matthew, chapter 19:8. Jesus responded to the Pharisees (ὁ δὲ Ἰησοῦς εἶπεν α, (Πρὸς τὴν σκληροκαρδίαν ὑμῶν). Moses wrote this ordinance or commandment for them (ἔγραψεν ὑμῖν τὴν ἐντολὴν ταύτηin Matthew, there was one exception for divorce, the sexual misconduct of the wife. Here in Mark, there is no exception, no divorce.


low calorie indian vegetables. low calorie subzi collection. The chief and foremost use of veggies is always creating a new subzi. We have researched and created new low calorie recipes that are suitable to be consumed on a weight loss diet. While making these healthy subzis, in this section we have avoided the use of the following ingredients.
• High carb veggies like potatoes, sweet potatoes, yam and purple yam.
• Excessive amounts of oil / ghee.
• Given up on fresh cream completely.
Instead we have focused on….
• Using a variety of greens.
• Using a different combination of masalas and spices in each recipe.
• Using a non-stick pan to limit the use of fat.
These delicious fibre rich low calorie dry subzis recipes will never make you miss those fat laden subzis that gain weight. Gavarfali ki Sukhi Subzi is a lip-smacking dry subzi that you can enjoy with steaming hot phulkas of your choice. Cluster beans are really rich in fibre and this recipe gives only 52 calories per serving and it's a great source of Folic Acid and Calcium. If you're fond of brinjals then you must definitely try this Ringna Vatana recipe and I'm sure you won't regret trying it. Apart from being rich in fibre it is also a great source of protein. Who does not love bhindi's? You will surely start loving this green vegetable if you try our low calorie recipe for Bhindi Masala. Being prepared with zero oil it is low in fat and gives only 83 calories per serving.
Try this unique combination of dals and broccoli with this Spicy Broccoli Subzi recipe perked up with cumin seeds. Broccoli is an amazing low calorie vegetable with lots of health benefits. Another innovative recipe we have is for Bharwa Lauki, a flavourful recipe in which lauki is stuffed with low-calorie paneer which makes it more nutritious and rich in calcium and protein. This creamy Dahi Chane ki Subzi is sure to be loved by people of all generations. The pulses along with curds make it healthier and increase the protein and calcium content of it.
Here's a great way to enjoy a Rajasthani delicacy that is simply sumptuous and low in calories. Choose young and tender bhindis for this recipe that will cook quickly. Above all, the rich and fascinating aroma is so tempting that you won't feel that you're eating low calorie food.
combines beautifully with phulkas fresh off the tava! The benefits of fibre-rich cluster beans are enhanced by the introduction of flavour-imparting garlic, which also.


Purchase/receive your copy of the 2017 IFT Salary Survey
2013 IFT Salary Survey:


I'll bet silk stockings weren't rationed for Betty Grable, one of the most popular pinups in World War II. That would have been bad for morale!
This next story also comes as a sidebar to the report in the Richmond paper that tells of the return of the men of the 898th Engineers. To understand it, you have to take your mind back to a time when a woman didn't leave the house unless she was wearing a nice dress or a skirt with a matching jacket, and stockings on her legs. In World War II, material of all kinds was rationed so the government could use the mills to make all those millions and millions of G.I. uniforms. Women's skirts went up to the knee in order to save precious fabric--much to the delight of those same G.I.s. Unfortunately; silk was also rationed (parachutes you know) and women found even the newly invented nylon stockings almost impossible to find. Add that to the fact that on Ascension Island, the planes flying through were coming to and from the China-Burma-India theater--where silk was still available--and you have the following report.
The Reflector
"898th Silks Now Adorn Fine Area of U.S. Longitude"
"WACS and civilian girls working on the base [the Richmond Army Air Base] can stop hiding their wealth [ed note: meaning their gams!] now those silk stockings which the men of the 898th Engineers could buy at the PX on Ascension are disposed of. Twenty-day furloughs after their arrival at RAAB [Richmond Army Air Base] took care of those.
(RC notes: Hope those guys used an abundance of that leftover soap before they started trying to hand out the silk stockings.)


After failing to complete the 7 Day Roguelike challenge I was left with some working code for a simple pixel art game that had the basics that might help new game developers.
* source code for this post is available on Github
7DRL Game
To start you will need to download LibGDX setup application and generate a new project, there is information on getting setup on the LibGDX website. I will be using Eclipse Luna as my editor.
Here is my project setup, to keep this less complicated I am only launching this application on the desktop, I used a random name generator which came up with EvoScape.
Once you have created and imported your project into Eclipse (Gradle Porject) or your preferred editor run the application as a Java App, you should see this:
If you have worked with LibGDX previously I am sure you have seen this screen many times! There are only three files changed / created for this first part of the tutorial:
Add these two lines to the launcher so the game height and width are set:
Apart from the standard Texture and Spritebatch variables that LibGDX add as default these class variables are defined:
OrthographicCamera camera; Control control; // Display Size private int displayW; private int displayH; // Temp x and y co-ords int x, y; // For Movement int direction_x, direction_y; int speed = 3;
// CAMERA displayW = Gdx.graphics.getWidth(); displayH = Gdx.graphics.getHeight(); // For 800x600 we will get 266*200 int h = (int) (displayH/Math.floor(displayH/160)); int w = (int) (displayW/(displayH/ (displayH/Math.floor(displayH/160)))); camera = new OrthographicCamera(w,h); camera.zoom = .4f; // Used to capture Keyboard Input control = new Control(displayW, displayH, camera); Gdx.input.setInputProcessor(control);
Gdx.graphics is used to get the width and height of the screen, we have set the screen size to 800 by 600 but we can allow the user to resize the screen or go full screen, these values can later be updated when the screen size changes.
public class Control extends InputAdapter implements InputProcessor {
switch (keycode) { case Keys.DOWN: down = false; break; case Keys.UP: up = false; break; ....
WASD and the arrow keys set the up,down,left, right values to true on press and false on release, these boolean values can be used to determine if movement should occur. Backspace is used to toggle debug, this will be useful for displaying collision hit-boxes and displaying debug info later on and esc key is set to exit the application. The other functions already added will be explained in another post.
Looking back to the gameclass.java file and the render funciton:
// GAME LOGIC // Reset the direction values direction_x=0; direction_y=0; if(control.down) direction_y = -1 ; if(control.up) direction_y = 1 ; if(control.left) direction_x = -1; if(control.right) direction_x = 1; camera.position.x += direction_x * speed; camera.position.y += direction_y * speed; camera.update(); // GAME DRAW batch.setProjectionMatrix(camera.combined); bbIn part two we will look at creating a small island, using a simple chunk system.


Sometimes I think, we think, God can only be found in places and spaces that have been deemed His. Like a confession booth or a church or your grandma’s house. And on occasion, perhaps, He will stop by other places to scorn someone or to point a finger, shaking it with wild frenzy at an adult child who continues to be so very naughty. Or maybe, we think, He stops by during that cup of coffee and what seemed like a coincidence might have been the Almighty moving His Divine chess pieces. But mostly, God is in the clouds, the rainbow after the storm, in children’s giggles and in buildings, especially the ones with stained glass and choirs. Or so we think.
But what if God is everywhere? What if we can find Him in the honey bucket as much as the pew? What if He were to peek behind our cubicle like He did behind a burning bush for Moses? What if God does not limit Himself to that which we deem His? What if it is true that He deems us as His and there we find Him?
My family and I just packed enough clothes to have to do without underwear for only a few days of a very long road trip. We logged over 3000 miles in our car. We played the alphabet game. We sped through rain storms and got sunburns crossing state lines. We saw the redwoods and more palm trees than we thought imaginable. We ate churros, bahn mi sandwiches and iced coffee in more places than we care to admit. We visited old friends and made strangers new ones. We counted down miles to the next stop. We heard “Are we there yet?” a hundred times. We taught our kids Def Leppard songs which might be the very reason we are truly hoping we can find God in a confession booth.
On this trip I heard God speak through Russell Wilson. I met God in a lighthouse. I understood the Lord’s heart on top of a tour bus in the heart of the city. I got some Truth when we were Shangheid in San Francisco. I remembered His Divinity when He said “It is indeed a small world” in the middle of Disneyland. I heard God question our happiness waiting in the longest lines for the shortest rides in what we deem the happiest place on earth. I asked God in the bathroom stall of a Chinese restaurant, “Can You use a fortune cookie?” …He might have answered. In the middle of the Redwoods, He told me what we should be looking for. God didn’t wait for me to come back and say hi next Sunday morning. I found God on vacation.
Contrary to what we often believe, God is not on vacation, unless you are…. and then He is. He is not away, busy at work, He is at our work. He is not in Heaven only, but also on Earth. God is not only in Church, but outside of Church. I did not go on vacation from God, nor did He go on vacation from me. We traveled together.
This makes sense that God would be our travel companion. When you look at Jesus who was Immanuel, God with us, He traveled with men and women “on the way”. Jesus showed up and taught in a boat to a hillside of listeners. He sat and fished with men trying to, I am sure, catch the biggest fish. He journeyed toward weary travelers and collided with desperation at a well. Jesus saw Zach in a tree and said “Let’s have lunch” and called travelers to follow Him along the road. He did not just teach in synagogues. He did not just sit in the temple. He did not just speak in certain places at certain times. No, not Jesus, and even still, He travels with people and invites us to travel with Him.
Over the next few weeks, as you summer, I will share the very simple ways I found a profound God in simple ways on vacation. (So come back and visit or subscribe to the blog and follow along with me.) I am hoping that as I share my search for Him in my travels, you will begin looking for Him in yours.
previous.


E-learning has become a mainstay in the educational milieu.The exponential growth of information has made it imperative for learning to happen quickly.
This book taps on the networked technologies and wireless devices to transform education through quality.
Online instructors and providers who continually seekwith technology at the forefront, will find this book as a useful companion.
One of this book's objectives is to establish a long lasting mark on quality for e-learning because the perceived lack of quality is recognised by many as an inhibiting factor for the expansion of e-learning.
The existence of a reference textbook on quality for e-learning might, it is strongly believed, contribute to strengthening cross-country confidence in the quality of e-learning, and serve as a reference worldwide.The future of all institutions engaged in online learning, e-learning and web based learning lies on the quality of programmes and courses that they are offering.
Chrispen Chiome, author Revisiting quality in ODL, lecturer Educational Leadership PhD candidate Zimbabwe Open University.
Member Southern African Society for Educators (SASE)& Education Association of Southern Africa (EASA) Contributor.


The Cincinnati Bengals are an NFL Football team, who play at Paul Brown Stadium, located in Cincinnati, OH. Paul Brown Stadium currently seats about 6553incinnati Bengal.


minute for example:
  ScriptApp.newTrigger('updateCharts').timeBased().everyMinutes(1).create();
  let               let charts = slide.getSheetsCharts();
                 charts.forEach(chart=> chart.refresh());
Workaround with Documents
File > Publish on the Web > c
 </s> Q: template specialization based on const-qualified instantiation Suppose I have a templated class:
        A(T& val) : m_val{val} {}
        T& val() { return m_val; }
        const T& val() const { return m_val; }
    T& m_val;
Can I have template specialization which is different for lines (1) and (2):
    A<int> x {a}; //(1)
    const A<int> y {a}; //(2)
    const A<int> z {b}; //Is it possible to avoid this inner const-qualifier?
 </s> Q: How can I find source code folder within docker container when debugging in VScode I have a containerized C++ application, I've build the image and also able to run the model executable file inside the container in windows prompt
docker diff container_name
This doesn't look like a source code folder at all, what have I done wrong, I don't understand.
If I check the running container docker ps
CONTAINER ID    IMAGE    COMMAND     CREATED        STATUS       PORTS      NAMES
xxx             xxx    "/bin/bash" 21 minutes ago Up 13 minutes             xxx
I noticed '/bin/bash' looks strange to me, the folder I attached only contain some bash cache etc instead of the really source code, where did they go??? I'm so confused. I've been stuck with this for a whole afternoon. Can someone help me, thanks.
A: Provided the container is still running and has not been terminated or has not correctly been set up (or else docker ps might not list it), as a diagnostic tool, you can use the exec command, available from Docker 1.3 that allows to run a command to an existing running instance of a container. So you can open a shell, ssh, or just ls and explore its file system to understand what that running container instance is about.
While not a complete solution, I hope this helps.
 </s> Q:
How can CORS be disabled in google chrome in mobile device or android studio emulator?
 </s> Q: How to display only image from HTML Hello,
       "content": "<div> some content </div>"
So I'm using react-html-parser package to convert it to JSX.
let imageTagStr = content.match(/<img\s+[^>]*src="([^"]*)"[^>]*>/i);
A: You can do this by firstly editing the string to isolate the  tag:
const firstSplit = content.split('<img')[1].split('/>')[0].concat('/>');
const finalsplit = '<img'.concat(firstSplit);
*Split the string where the <img tag starts and grab the second part of that split
*Split it again where it ends and grab the first part of that string
Using regex and .match you can do something like this:
A: This is not a React problem.
let doc = new DOMParser().parseFromString(YOUR_STRING, "text/xml");
And then parse it using just javascript.
 </s> Q: Loop through a string array in laravel I'm trying to loop through a a string and get array of records where the service status is equals to complete or cancelled. I'm having an issue of get all the records instead it response with the last record from the list.
        $history = bookings::select('*')->whereIn('service_status', ['complete', 'cancelled'])->where(['specialist_id'=>$id])->orderBy('time', 'DESC')->get();
        if($history->isempty()){'Empty Record', 'data' =>[]]);
            for($i = 0; $i < count($history); $i++){
                $b_id = $history[$i]->id;
                $service = $history[$i]->service;
                $time = $history[$i]->time;
                $date = $history[$i]->date;
                $location = $history[$i]->location;
                $payment = $history[$i]->payment_type;
                $price = $history[$i]->amount;
                $special


Police in a remote Aboriginal community have been branded “draconian” and “overzealous” by its chief executive after 19 people were charged with alcohol- related offences in the past month.
Bidyadanga chief executive Peter Yip said the community, which has been designated dry by by-laws for eight years, is not afflicted with the issues which have plagued others in the Kimberley.
Last week, 19 of the 33 people appearing in the Bidyadanga Magistrate’s Court appeared on charges stemming from possessing or consuming alcohol on community land.
The maximum fine for breaking the by-law is $5000.
“We’ve been trying to work with the community but we’ve been forced to start taking out warrants on houses where we know a lot of alcohol is consumed,” he said.
Parts of the community, including teachers’ and nurses’ houses and the Catholic Mission, are exempt from the by-laws.
Sen. Sgt Clark said it was very hard to police the bylaws when half of the community was dry and the other half was not.
“Most community people will just drink their alcohol quietly at home, but unless people are causing trouble they shouldn’t be hassled,” he said.
Mr Yip said the council was looking at reviewing the by-laws, and considering a section 175 blanket ban, which has been implemented in other communities.


Methods: The expression of Rac3 in lung adenocarcinoma specimens and paired noncancerous no Lesilence Rac3 A p38 MAPK inhibitor (LY2228820) was employed to inhibit activity of p38 MAPK pathway. Cell invasion and migration in vitro were examined by invasion and migration assays, respectively. PathScan® intracellular signaling array kit and western blot were employed in mechanism investigation.
Results: Rac3 expression was frequently higher in lung adenocarcinoma than paired noncancerous normal tissues. Rac3onode metastasis, and was associated with worse survival outcome. Silencing of Rac3 inhibited cell invasion and cell migration in lung adenocarcinoma cell lines. Knockdown of Rac3 decreased activity of p38 MAPK pathway. LY2228820, which was an important p38 MAPK inhibitor, inhibited Rac3-induced. E-cadherin expression was increased and vimentin expression was decreased after silencing of Rac3 or following the treatment of LY2228820.
Keywords: Rac3, lung adenocarcinoma, invasion, migration, p38, EMT.
Lung. The major histological subtype of NSCLC is lung adenocarcinoma which has poor 5-year survival rate because of tumor invasion and metastasis. There are many personalized treatments that have been developed for lung adenocarcinoma, such as gefitinib, erlotinib, crizotinib and ceritinib, but less than 15% of patients with lung adenocarcinoma are ideal candidates for these targeted therapies in the world [2]. Thereforf invasion and migration of lung adenocarcinoma and find a novel therapy target.
The small G protein Rac3 (ras-related C3 botulinum toxin substrate 3) belongs to Rho subfamily of Ras proteins [3]. Rac3 proteins cycle between an active state bound to GTP and an inactive state bound to GDP. Rho and Rac-GTPases are known to be involved in human carcinogenesis, cancer cell proliferation, migration and aggression [4 -10]. Rac3 is highly expressed in a wide range of tissues [3], and [11]. Rac3 gene has been mapped to chromosome 17q23-25, a region that is frequently deleted in breast and ovarian carcinomas [3,12]. Current studies indicate that Rac3 promotes cell proliferation and cell aggressiveness in breast cancer [9,10], and is also involved in esophagus and ovarian cancer development [13,14].
In our previous studies, we proved that Rac3lung adenocarcinoma cell lines [15,16]. However, the role of Rac3 in lung adenocarcinoma cells invasion and migration is not clear. In this study, we analyzed clinical lung adenocarcinoma samples and determined the relationship between Rac3 expression and lymphonode metastasis. Furthermore, we investigated the role and mechanism.
Eighty lung cancerobtained from patients pathologically diagnosed as lung adenocarcinoma.ns at the Department of Thoracic Su0. None of patients received routine chemotherapy after surgery. All patients had completed survival follow-up data. Thto the day of death.
Eighty surgically excised4μm paraffin-embedded sections were prepared. The sections were firstly deparaffinized in xylene, and then dehydrated by graded alcohol. After retrieval using sodium citrate buffer (pH 6.0),human Rac3 monoclonal primary antibody (Abcam, USA, 1:100 dilution) overnight at 4℃. Biotinylated anti-rabbit secondary antibody was used at 37℃ for 20min. Steptavidin peroxidase was conjugated at room temperature for 20min. The sections were visualized using 3, 3'-diaminobenzidine (DAB) solution, couterstained with hematoxylin, and dehydrated in ethanol in the end. Two independent pathologists examined the immune-stained slides randomly. Cytoplasmic or nuclear immunostainingf Rac3 staining was graded as follows: 0 for no staining, 1 for light brown color, 2 for medium brown color, and 3 for brown color. The percentage scores of positive cells were as follows: 0 (≤5%), 1 (>5%-25%), 3 (>50%).The final scores of each sample were multiplied to give a score ranging from 0 to 9. Rac3 expression levels were defined as follows: - (score 0), + (score 1-2), ++ (score 3-5), +++ (score 6-9). The Rac3 expression levels were categorized into negative expression (-) and positive expression (+~+++).
The human lung adenocarcinoma cell lines, A549 and H1299, were obtained fromroutinely maintained in Dulvecco's modified Eagle's medium (DMEM Hycld 100O2.
LY2228820 were purchased from selleck company (Shanghai, China). The medium was supplemented with 5 μM LY2228820 for inhibition of p38 MAPK pathway, with DMSO as a control.
The complementary DNA (cDNA) sequence of Rac3 was designed from the full-length Rac3 After testing knockdown efficiencies, us-based vector PscioR (Addgene, Boston, MA, USA). A nontargeting scrambled RNA PscioR vector was generated as a negative control. Lentivirus particles were prepared as described previously [17]. Lung adenocarcinoma cells were infected with the Rac3 siRNA-lentivirus or negativeat Day 7 and examined at Day 10. Cells were incubated in serum-free DMEM at 37oC for 4 h, then 10% DMEM was added and incubated for the following experiments.
Transwell invasion assay was performed using 24-well invasion chambers (Corning, BioCoat, USA) with an 8 micron pore size PET membrane that has been treated with Matriel Matrx. Cells were trypsinized and resuspended, then inoculated into the upper Matrgel chamber in 500μl of5 cells/well, and incubated for 24 hours in A549 cells or 36 hours in H1299 cells. DMEM medium containing 30% fetal bovine serum in the lower chamber served as the chemoattractant. At the end of incubation, the noninvading cells on the upper membrane surface were erased with cotton swabsGiemsa for 5 min. Nine visual fields of each chamber were randomly chosen under a X71 invading cells was counted. The invasion activity was quantified by cell counter.
Transwell migration assay was performed according the protocol of cell invasion assay, except that the 24-well chambers (Corning, BioCoat, USA) were not treated with Matriel Matrx. After 72h transfection, A549 cells were incubated for an additional 24 hours for migration, the H1299 cells were cultured for 16 hours for migration. Nine random fields of vision for each chamber were migration activity was quantified by cell counter.
Cells migration was determined by wound-healing assa3×104 cells/well and incubated overnight. The center of cell monolayers was scraped with scratch instruments to create a scratch of constant width when the cultured cells reached a density of >90%. Then cellular debris was washed twice with serum-free DMEM medium, and DMEM medium with 0.5%FBS was added. Cell2. Wound area was observed and photographed at 0h, 8h and 24h with X71 microscope (Olympus, Tokyo, Japan).gap length from five random fields of vision and the percentage of change in the wound% change = (average gap length at time 0h) - (average gap length at time 8h/24h) / average gap length at time 0h ×100%.
Cells were trypsinized and resuspended. antibody array kit (Cell Signaling Technology, CST) according to the manufacture's procedure.
Western blot analyses were performed 4 days after lentivirus infection. Cells were harvested and lysed in 2×Lysis Buffer (100mM Tris-HCl, 2% mercaptoethanol, 20% glycerol, 4% SDS). Proteins were quantified using a BCA Protein Assay Kit (HyClone-Pierce, Cat no.). Equal amount of proteins (2080 V for 150 min.. Secondary antibodies were then incubated with membranes for 2LUS/Kit (Amersham). GAPDH was served as a loading control. The Primary antibodies used were as follows: Rac3 (Rabbit, Abcam, 1:500 dilution), E-cadherin (Mouse, CST, 1:500 dilution), vimentin (Rabbit, CST, 1:500 dilution), GAPDH (Mouse, Santa Cruz, 1:2000 dilution). The secondary antibodies were anti-mouse IgG (Santa Cruz, 1:5000 dilution) and anti-rabbit IgG (Santa Cruz, 1:5000 dilution).
Simon automated western blot was performed by using the SimonTM machine (ProteinSimple, San Jose, CA, www.proteinsimple.com/simon.html) according the manufacture's procedure. Briefly, Samples were diluted to final concentration to 1-3μg/μl with sample buffer and master mix (containing fluorescent standards and DTT) and then heated at 95℃ for 5me were loaded into proper wells in microplates according the manufacturer's instructions. The procedures of plate loading, the separation and immunodetection were fully automated. The Primary antibodies used were as follows: p38 (Mouse, Abcam, 1:50 dilution), p-p38 (Rabbit, CST, 1:50 dilution), β-actin (Mouse, Santa Cruz, 1:2ProteinSimple) and anti-rabbit IgG (ProteinSimple). Data analysis was performed by the Compass Software (ProteinSmiple)The immunohistochemistry results and univariate analysis of lymphonode metastasis were performed by Chi-square test. Multivariate analysis of lymphonode metastasis was performed by was analyzed by log-rank test. Other data were expressed as the mean±S.D. byLac3 was positively expressed mainly in the cytoplasm, and significantly expressed in lung adenocarcinoma tissues (Fig. 1A). Rac3 expression was significantly higher expressed in lung adenocarcinoma specimens compared with paired noncancerous normal tissues (P<0.0001, Table 1). Rac3 expression in different tissues was shown in Fig.1 and Table 1. The relationships between lymphonode metastasis and clinical pathological features including Rac3 expression were investigated, we found that lymphonode metastasis was significantly associated with Rac3 expression, gender, TNM stage, differentiation and smoking history (P<0.05, Table 2) in univariate analysis. Furthermore, Rac3 expression and TNM stage are independent risk factors for lymphonode metastasis in multivariate analysis (P<0.05, Table 3). Rac3 positive expression group in lung adenocarcinoma patients had lower overall survival than Rac3 negative expression group (P<0.05, Fig.2).
Rac3 expression in different tissues (n=80).
Lentivirus-mediated RNAi technology was employed for Rac3 knock-down. High infection efficiency was confirmed by GFP fluorescence 3 days after lentivirus infection (Fig. 3A). The effect of lentivirus-mediated RNAi on the expression of Rac3 was examined by qRT-PCR and Western blot analysis in A549 and H1299 cell lines. Compared with control group, the mRNA level of Rac3 in Rac3-siRNA groups was greatly decreased (P<0.001 Fig. 3B Rac3-siRNA groups (Fig. 3C).Rac3 via lentivirus-mediated RNAi was specific and efficient.
We performed transwell migration assay and wound-healing assay for cell migration assays in vitro. Compared with control group, the number of migratory cells were significantly decreased after 16 or 24 hours incubation in transwell migration assay (P<0.01 Fig. 4A-B). In wound-healing assay, cells migrated into the wound area more slowly, and the migration rate was significantly decreased than those in control group at 24h (P<0.01 Fig. 4C-D). These results indicated that Rac3 silencing inhibited the migratory abilities of lung adenocarcinoma cells in vitro.
To investigate the effect of Rac3 silencing on the invasion of lung adenocarcinoma cells in vitro, we performed invasion assay using 24-well invasion chambers. The number of invadingafter 24 or 36 hours incubation (P<0.01 Fig 4E-F), which indicated that Rac3 silencing inhibited the invasiveOverall survival curve according to Rac3 expression in 80 lung adenocarcinoma patients. Kaplan-Meier method estimated overall survival. P value was obtained by log-rank test.
ToRac3 affects lung adenocarcinoma cells invasion and migration,was used to detect the changes of signaling molecules in A549 cells before and after Rac3 knockdown. The data indicated that the phosphorylation of p38(Thr180/Thr182) was down-regulated in Rac3-RNAi group (P<0.05 Fig. 5A- knock down of Rac3 significantly down-regulated p-p38 expression (Fig. 5C). By contrast, no Rac3 silencing-induced changes were observed in p38 expression (Fig. 5C). The results indicated that Rac3 knock down could significantly inhibit possibly via p38 MAPK pathway.
was used to inhibit activity of p38 MAPK pathway test cell migration and invasion activities by the treatment with LY2228820, with DMSO as a control. Ourand invasion cells were markedly decreased after 18 or 20 hours incubation following the treatment of LY2228820 at 5μM in A549 cells (P<0.01 Fig. 6A-B).
Western blotof Rac3, EMT and p38 MAPK pathway. Our results showed that E-cadherin expression was markedlyin A549 cells (Fig.7A). Following the treatment of LY2228820 at 5μM for 24h, the expressions of E-cadherin and vimentin were similar to Rac3 knockdown (Fig.7B). These data strongly suggested that Rac3 regulated EMT through p38 MAPK pathway.
The rapid progression, recurrence and metastasis of lung adenocarcinoma which is the main subtype of lung cancer are the main reasons for poor prognosis and treatment rate. Therefore, it is of great important to find the precise molecular mechanism involved in lung adenocarcinoma invasion and metastasis. Rac3 waain, breast and prostate tumors, which played an important role in cancer development [9-11,18,19]. Accumulating evidence has suggested that Rac3 might act as an oncogene in various human malignant tumors. Most studies were mainly focused on the role of Rac3 in cell proliferation, except for the report that Rac3 promoting cell aggressiveness in breast cancer cells through Rac3/ERK-2/NF-κB signaling pathway [9]. The roles of Rac3 in tumor invasion and migration were seldom investigated, especially in lung cancer. To the best of our knowledge, our study reported for the first time that silencing of Rac3 inhibitedWe examined Rac3 expression in lung adenocarcinoma patients, and found that Rac3issues[16]. Moreover, we identified that of lung adenocarcinoma. These data suggested that Rac3 could be a potential biomarker of lung adenocarcinoma for metastasis. The number of patient specimens was small and there were no data on recurrence and distant metastasis of lung adenocarcinoma, which brought limitations to this study. More patient specimens and clinical data on metastasis of lung adenocarcinoma should be involved in the future.
In this study, we detected modifications of some signaling molecules in cancer cell growth, invasion and migration by Intracellular signaling array kit. Selected signaling molecules were further detected by simon western blot analysis. We found that knock down of Rac3 inhibited activity of p38 MAPK pathway. In terms of the clinical importance of our findings, we found that a selective p38 MAPK inhibitor, LY2228820, reduced the Rac3-induced cell LY2228820 demonstrated antitumor activity of various cancers in vitro and vivo, including NSCLC[20], aLY2228820 were acceptable for patients with advanced cancer in phase I study[21]. LY2228820 enhanced the efficacy of standard chemotherapeutic agents used in clinical treatment of ovarian cancer, and wain phase II study [22].
P38 MAPKs play important roles in tumor cells invasion and metastasis [23]. Numerous studies have suggested that P38 MAPK sig[24-27], which[28-30]. Evidence in literatures implicates that p38 regulates EMT protein marker E-cadherin and vimentin expression [31,32]. So we further detected E-cadherin and vimentin expression, and found that vimentin expression was decreased and E-cadherin expression was increased by silencing of Rac3 or the treatment of LY2228820. Previous studies have proven that p38 downregulates E-cadherin induced promotion of EMT in head and neck squamous cell cancer [31], and plays an important role in downregulation E-cadherin during gastrulation [33]. Evidence in the literatures indicates that E-cadherin acts as a suppressor of invasion and metastasis in various cancers, including lung cancer [34-37]. Silencing the expression of P38 and JNK inhibited TGFβ1-mediated EMT of A549 cells, accompanied by the down-regulation of vimentin [32]. Recent studies have demonstrated that vimentin expression was closely related with invasion and metastasis of gallbladder carcinoma [38], prostate carcinoma [39], breast cancer [40-42], cervical carcinoma [43] and NSCLC [44]. Dauphin M et al. [45] reported that vimentin expression was correlated with the distant metastasis of NSCLC after surgery the lymphonode status in NSCLC. We speculated that Rac3 was not only associated with lymphonode metastasis, but also the distant metastasis of lung adenocarcinoma since Rac3 regulated vimentin expression in lung adenocarcinoma cells. to confirm the role of Rac3 on in the future. The Walker MP et al. [46] found that Rac3, as an estrogen receptor (ER)α co-activator, promoted cell migration of ERα positive breast cancer. Recent research showed that estrogen promoted lung adenocarcinoma cell metastasis through ER-EMT signaling pathway and reduced intercellular adhesion force by PI3K/AKT signaling pathway [47]. Therefore, it is worthy for us to explore the relationships of Rac3, ER, ER-EMT and PI3K/AKT signaling pathways in future studies.
Rac3 regulates EMT through p38 MAPK pathway. A: Western blot analysis was employed to detecte after sliencing of Rac3 in A549 cells. Bf in A549 cells. GAPDH was used as internal control for western blot analysis.
In summary, we explore the role of Rac3  Our results suggest that Rac3 was overexpressed in lung adenocarcinoma tissue, and was closely associated with the lymphonode metastasis and worse overall survival rate. Furthermore, we demonstrate that Rac3 promotes cells invasion, migration and EMT of lung adenocarcinoma through p38 MAPK pathway. Our results indicate the crucial, and Rac3 i00821Liaoning Bai Qian Wan Talents Program (Grant No. |||PHONE_NUMBER||| ), the Liaoning Province Science and Technology (S&T) Project (Grant No. |||PHONE_NUMBER||| ) and Project for Construction of Major Discipline Platform in Universities of Liaoning province (Grant No. 2016009)IRB Approval No. AF-SOP-07-1.0-01). All samples were obtained from the BioBankhad been previously collected according to official.


man Truck Series as a relative unknown. Since that time, he has worked very hard to master his role as the play-by-play announcer for SPEED. Allen has kept things in perspective and shares the same gift with Voda. They let others shine.
This season, Waltrip has improved tremendously and that might be to the credit of Steve Byrnes. On Monday nights, Byrnes hosts This Week in NASCAR where Waltrip is a regular panelist. As opposed to the mild-mannered Allen, Byrnes is not afraid to step right in and stop Waltrip in his tracks when he is off on a tangent. The result has been that Waltrip has learned to listen.
As a group, the SPEED team has shown time-and-time again that less is often more on TV. Without the flashy graphics or the fancy features, SPEED has let the racing on all kinds of tracks lead the way. My belief is that is why the series has experienced a resurgence this season. Fans get the race and not the hype.
This Friday, the Trucks get the big Texas Motor Speedway to themselves in primetime under the lights. Voda hosts the pre-race at 8:30PM and the race kicks-off shortly after 9PM. Adding some spice to the Texas mix will be the fact that sports car ace Max Papis, Red Bull's chosen son Scott Speed and the one and only Kyle Busch will all be racing along with the series regulars.
The Daly Planet will be live during and after the race for your comments. As the season comes toward the end, perhaps you can use this post to offer your views on the coverage of the Craftsman Trucks Series this season on SPEED and suggest any changes you might like for next year.
Appreciate your kind words JD. Three to go!
Anon 9:23PM,
As I said to you in an earlier post, the Atlanta TV trucks were not ready for Thursday TV in TX.
SPEED owns the series TV rights and always tries to get as much of it on TV as possible because it is the only NASCAR series they carry.
Any TV network wants to sell more ads and carry more content of something they have already paid for. Your argument makes no sense.
As you may have noticed, SPEED is also covering Nationwide Series practice and qualifying this weekend.
I look forward to the trucks the most.
Good no nonsense commentators, well except for Mikey, hard racing, and the races are not to long.
Rick and Phil work real well together no matter who the 3rd member is.
I watch practice when they show it.
I watch most every qualifying show.
I even watched most every minute of rain delay coverage. (I know I need a life)
Really enjoy the trucks!!!
I just wish someone would run a live leaderboard. I'm not coordinated enough to watch a ticker and the race. Also, it's to easy to miss something looking at a ticker.
I love the TRUCK races!!
and if that is really the real 'rick allen'...please tell your music producers to TURN DOWN the loud screechy guitar music when you boys are talking before the race.
That is my MAIN gripe, if only gripe, with the Truck broadcast. ;)
I would rather hear the dulcet tones of your voice and the other boys rather than that NONSENSICAL loud music that covers up most of what y'all are saying.
Just so you know...she is always like that. We switched her to decaf earlier this season.
John you talk about how Krista's and Rick's style are similar, couldn't be that Midwestern up bringing could it? Krista from Iowa and Rick from Nebraska. My experience with most folks out of the heartland is that they are friendly, respectful and have a good sense of humor. I think people tend to gravitate to good people like that. Oh, good upbringing doesn't hurt either.
That certainly is an interesting concept. Must be something in the water.
I hope it goes well in the future but manufacturer parcipitation may determine whether it stays viable or not. When you're trying to market a product that has fallen out of favor in the eyes of the general public, it's hard to convince the bean counters to spend money. When they introduce the TOT in a couple of years, the differences will disappear but it will be "safer". When the power grab gets started in Cup, it never stops as it trickles down.
Truck racing is the best of the three series these days, at least on TV. (Actually, it's the bst in real life, too.)
Thanks, Rick, for helping to make it that way!
I always enjoy the truck races - they're the only racing that keeps me excited about watching! SPEED does it right in all categories - now if we could just get the cable companies to carry the SPEED channel without charging extra, life would indeed be good. And need I mention, the ratings would be higher also.
Count me as one of those that absolutely love the Truck Series as well. I love the racing, love its seperate identity from the Cup Series, love the on-air crew, and love the race fan friendly approach of the production truck.
Just to throw out a thought, I think it would be great if the powers that be at Fox/Speed would reward these Truck Series guys and gals for their great work by letting them handle the Cup All-Star Race broadcast on Speed next year. Rick, Phil, Adam, Ray, Krista, and the entire production truck / behind-the-scenes crew. In my mind they are certainly deserving.
I'll be out there tomorrow for practice and qualifying, I'll see if I can hack the the track's wireless and stream with a webcam :)
Looking forward to the race Friday night. They always put on a great show here.
I love the truck series, Rick, and Phil, Mikey not so much. I think the broadcast is better with just the two of you. If you need a third person, maybe try someone else in 2009. In time I think Doug would have been good, but he is a crew chief now. It was good to see Camping World come on board, because things did not look good for the series to continue.
Thanks again Rick, and Phil for a great job.
Sorry Krista, I did not mention you. I have enjoyed you, and your work since the Totally Nascar days.
I'd hate to see you leave the truck series, but you would be a great fit in a lot of other roles if you wanted them.
I love the Truck series.
I think one reason the TV numbers are up is because NASCAR hasn't tainted the series with a bunch of BS changes. The trucks are pretty much the same as when they started years ago. It's what Cup racing used to be like in the 90s. I hope they continue to drive under the radar so the Emperor doesn't fix something else that isn't broken.
Nice to see a celebrity (Rick Allen) write in. That's so cool. JD, you've hit the big time. First John Kerner and now Rick.
Isn't it the height of irony that the very drivers and types of drivers that bring SPEED such success in this series are THE VERY ONES and


Eight species of sea turtle remain today and five of them love to hang around the Sri Lanka coastline and nest. So don't be surprised if one pops up next to you while you're playing in the huge Indian Ocean waves. I most certainly was!
I knew that they were residents here and had been reading about them before the trip. Did I mention my mild obsession for non-humans?
This little cutie was only born the night before but he couldn't half swim!
If they are left to hatch on the beach they will likely end up as bird food or dug up and taken by poachers along with their Mother if she is there and sold as food or used to make ornaments. So say no to tortoiseshell people!
2 thoughts on "Sea Turtle sanctuary, Hikkaduwa"
Lovely pictures!Those turtles are so adorable!I didnt know there were turtles in Hikkaduwa!I actually planned a trip to Sri Lanka last year but had to cancel it due to some urgent issues and guess what one of stops I picked was Hikkaduwa only. Now after watching your pics, I gotta plan a trip again!😀 ..thanks for sharing!


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received a fund of Rs 250 crore from the Centre, but unless a plan is ready we can’t utilise it,” said Chandramauli Shukla, the chief executive officer of theject in Bhopal on January 28, hadd three cities – Bhopal, Indore and Jabalpur – from Madhya Pradesh.
Denying the rumors that Bhopal would be out of the list of the first 20 smart cities, Shukla said Bhopal would remain in the list as it was one of the most preferred location for development.
“Smart city project is an opportunity for a city to grow and develop. It is sad to know that people think only an area would be developed and the rest of the city would remain the same,” Shukla told HT.
The displacement of residents was one of the major reasons because of which the proposed location of the smart city project was changed. The residents of Tulsi Nagar and Shivaji Nagar took to streets and withdrew their protest only after cshifting of the smart city project to North TT Nagar last Month.
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investments and research funding to bring it off the drawing table. The company website suggests several potential markets for their future product. Their stand-alone system could provide clean energy and water for developing communities, home fuel production for hydrogen cars, back-up power for hospitals, businesses, or cell towers, and of course support for manufacturers or the larger energy grid.
Of course this is no utopian vision of clean energy for all. The solar system requires square footage to generate enough energy to produce the hydrogen. The company claims a “r 4.” That’s not a terribly small amount of space if you live in say, and apartment building or a small home. There is also the issue of cost, which the company does not seem ready to approach yet. The environmentalist in me would also want to know about the production process and weigh the benefits.
This is still a step in the right direction. Who knows? A few decades from now we could all enjoy clean hydrogen cars or power our air conditioners and appliances with hydrogen. We could generate our own drinking water or even recycle our gray water back into the system. Image a day when releasing water vapor via car emissions starts to effect the environment? Well, maybe not. But this technology certainly opens some important doors towards a much-anticipated green technology.
(for more info visit CNet news and Nanoptek.com)
(image courtesy of Nanoptek.com)
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So do you distinguish…?
So in terms of setting out to write a book, you don't distinguish between those genres?
It might do that. In the stories it's beyond metaphor. If someone were to ask me how I expected it to work in the everyday world I'd probably say that I did think it would give…
Very early on in The Lion in the Meadow the editor said to me "do you think that the mother saw the lion?
Yes, there are, and if you look in Italian fairytales, the Italo Calvino book, he mentions that there was a storyteller who was a female storyteller and she chose stories that featured women. But then there's also the thing that the heroines are named, and so they're much more characters than the…
You don't necessarily consciously write from the standpoint of certain political whatever, but you're working perhaps within those frames of reference you've read in your own reading or you're interested in in your own life. Is that just organic, does it all come together in it's own way?
Yes, that's right. And that represents, I suppose, the hope of a lot of communities, that some sort of goodness and kindness will triumph, even when it simultaneously …
There's also a bit of a tendency when people talk about realism, when you read a book where very hard events have occurred, the fairly happy middle class family of the stories of the 1940s and 50s, there are people nowadays who would say "oh, it's not very realistic, they're too nice a family", because our reality has shifted a bit, our literary reality, and has come to encompass the damaged or the fractured family. And of course, most families are damaged or fractured to some degree. They vary a great deal in how destructive they are with their products. Some stagger on and some keep going fairly nicely and others of course fall to pieces. But I think that to speak as if one is more realistic than another…
I think that when I was a child from about 10 onwards and I suppose still to the present day, though less than I did in the past I enjoyed reading ghost stories, they give you a very mysterious feeling about the world. I've never believed in them except as ways in which the mysteriousness was acknowledged. I do think that there's all sorts of odd things about time, not just time as a scientific idea, but as the way in which you…
At one stage someone says to her, I think it's Oliver, that she has locked them too, her storytelling and imagination has locked them into a sort of mode, where the ghost has separated out into three phases as it were and in the end becomes united again. The death of the child, of the young person, because their lives…
The image or motif of space, often a physical space, the underrunners, and the space in Dangerous Spaces and Harry's got her attic, her physical space and is looking for her place in the family, it seems to recur with you. Is it just the nature of adolescence that you're looking for your own place?
I think that's a theme that comes a bit in Underrunners, it's certainly comes in quite strongly in Dangerous Spaces, I think that that's true. I think that quite a lot of adolescents become rather fascinated suddenly with their own mortality, and they are fascinated by it without quite believing in it, which is probably one of the reasons we get quite a lot of teenage suicides. They test themselves against this ultimate reality. I don't really want to encourage anyone to do that, but it is part of our imaginative apprehension of the world. There's a story, I haven't written this book yet, and may never write it, but it certainly plays quite an important part, because at the end of the story which I envisage writing one day, the hero is a young man who is very much in love with a beautiful girl, and she tells him towards the end that she works in a funeral parlour, and that during the day she's been laying out somebody that he knows. We all have this very peculiar attitude to…this actually causes him to slip back in every sense of the word. It's a bit of a test that she's put him through, so that when he says, "it doesn't matter", she says "too late!


dstudents since 1916. The school creates St George Girls High School offers a broad curriculum and a range of extra and co-curricular opportunitiesthat allow, leadership and community domains. Ththe students to effectively allow them to engage inaThe school has ahighly effective individual support and wellbeing frameworkSt George Girls High Ssafeguards positive emotions across theschool community. Highly experienced teachers are partners in learning with their students and the teachers are committed to continual professional learningand reflective practice astheythemselves and theirstudents Studmore thanquality educational outcomes and a variety of post-school desitinations, theys