FW: Could you provide an overview of the broad impact that digital disruption is having on businesses? Is it reshaping the way companies enter new markets, transform existing business products and introduce novel delivery models, for example?
Sherry: The industrial internet is expected to drive a $220bn market by 2020. The question for industrial companies is: how can we get some of that value? So dacross all their operations. It is changing ns. If we look at it more widely, digital transformation impacts productivity by enabling organisations to improve efficiency. When it comes to large organisations, even 1 percent of productivity gains can impact a company’s bottom line by millions. For instance, in the commercial aviation industry alone, a 1 percent saving in global aviation fuel usage could yield savings of about £23bn over 15 years.
Fellahi: The term digital disruptioninnovation that usually pits emerging companies against established giants. However, the current disruption macro-narrative understates how some established firms are successfully reinventing themselves. It is a myth that start-ups have a monopoly on innovation or the ability to disrupt. The key now is for companies to understand how to fight complacency, experiment productively and learn quickly.
Samani: The impact of digital disruption really cannot be overstated. It is completely reshaping the way all companies operate, from massively streamlining overarching business processes to everyday processes, such as instant messenger tools and cloud storage. I honestly do not think that I could have predicted the absolute wealth of change and opportunity that we are now seeing on a daily basis. We are now at the point where a six year old can run a YouTube channel and earn millions each year. This is having a revolutionary impact on the way companies are looking to make money.
FW: Could you point to any high-profile examples of digital transformation trends across the globe? In which industries and sectors is it particularly prevalent?
Kimner: There are emerging and prevalent trends today, such as the adoption of, which have not only profoundly changed our behaviour, but have changed the overall global dialogue. Social media has given a voice to many who otherwise would rarely have the opportunity to reach wide audiences. This can be both positive and negative, as filters are removed and it becomes morigital advertising is also going through a revolution and is fundamentally changing the landscape for what constitutes a viable business model. For example, advertisers today pay millions of dollars related to YouTube videos and other content channels. Healthcare is also seeing a revolution in applying artificial intelligence to diagnose health issues. Nearly every industry is likely to be impacted, including the insurance, banking, transportation, manufacturing and health sectors, among others. New digital technologies shape how products are designed, how consumer feedback is collected and evaluated, how payments and funds are transferred, and how and where people travel.
Samani: Every single industry is feeling the effects of digital transformation. While there are the obvious examples, such as Netflix, Amazon and Spotify, that are changing the way we live our lives, the reality is that all companies now operate on a digital level. The oil industry’s adoption of the ‘digital oilfield’ has already massively reduced operational costs and increased output, proving how vital technology is becoming to almost every process that underpins businesses today.
Trull: The biggest opportunities, from a business perspective, will be related to entering markets that have traditionally been avoided due to low margins, increasing speed to market through automation and gaining better insights into customers and their needs.
Samani: Digital transformation demands courage, and remarkable vision. I have heard senior executives talk about keeping things the same, and yet each of us can cite companies no longer in business that were market leaders only a few years ago. Some of the biggest brands today are less than 10 years old, and there is now a huge opportunity for organisations with the bravery and insight to tap into emerging trends to revolutionise their sector, changing the way we as a society operate on a daily basis, including how we order food and taxis, and consume media.
Kimner: The opportunities are only limited by how quickly companies can adapt and determine how to capture and exploit information and technology. For example, organisations are employing the use of real-time telemetric data to monitor a variety of events and behaviours, from manufacturing processes and system performance, to driving habits. Digital transformations are occurring in nearly every industry as organisations are figuring out ways to use sensors to collect and analyse information, leverage geospatial and other location information, and develop additional channels to connect and communicate with businesses and consumers alike. While these opportunities are numerous, they also bring risks and challenges.
FW: What are some of the practical strategies that companies can deploy to help manage the impact of digital disruption and the transformation this necessitates across their operations?
Samani: Companies need to realise that digital transformation is much less about the technology itself, but about the practical strategies that underpin its deployment. Managing a transformation process is reliant on having everyone in the company on board, and businesses therefore need to ensure they have an extremely effective communications system in place, making the benefits to each member of staff clear in order to drive employee motivation and ensure that improvement and innovation remain key priorities for all.
Kimner: One of the most practical strategies is simply being self-aware. Firms need to persistently look at the digital landscape to understand how it is changing and evaluate potential impacts. This may sound obvious, but many companies do not consistently incorporate the type of external or forward-looking analysis required to fully understand the impacts or opportunities in the digital economy. There are numerous information sources, including consulting companies, technology journals, analyst papers, tradeshows and conferences, and even news outlets that can help shed light on the evolving digital landscape. Sometimes, the challenge is to know how to filter out the signal from the noise in the chatter and determine what is science and what is science fiction.
Sherry: To manage the impact of digital disruption, businesses need to start from the top and ensure that their culture and organisational structures are aligned to the technological shift that digital transformation brings. This means transforming business culture at the same pace as driving technology change. Tostrengths and vulnerabilities lie and where they want to be in a few years’ time. This will help ensure their digital transformation strategy encompasses all aspects of their business and next step is to build partnerships and adopt technology solutions which will help them drive efficiency, productivity and business agility.
Trull: Focus is critical to digital transformation projects. Chief information officers (CIOs) need to relentlessly prioritise key projects and work with other executives to clearly communicate their vision and get others to buy into it. It is equally important to move quickly once the vision and digital strategies have been established. CIOs should ensure that they can achieve quick and meaningful wins to support investment from leadership. Early wins should be focused on customer-facing innovation. Infrastructure improvements are typically requiredthese projects should occur simultaneously to the customer or employee facing improvements. Finally, digital transformationmust build the technologies into a cohesive platform.
Kimner: It is incredibly important for executive management to lead the discussion and embrace strategies arounddo not have a deep understanding or competency in the technology sector. Not only do they need to continually survey the external landscape for opportunities around innovative technologies, but executive management must remain diligent in spotting how competitors and others are using technologies that could render their products or processes obsolete.
Sherry: Involvement of the C-suite is vital, because not only does it open up broader understandings of the company’s business needs and possibilities, it also helps drive growth and business profitability across all operations. Without the full support of the C-suite, digital transformation would not be successful as it requires a significant organisational and cultural shift which should be driven from the topand must be driven by business leaders. Rarely will a digital transformation initiative succeed without a C-level sponsor.
FW: What challenges typically arise when companies are rolling out a programme e? In your experience, how should they go about mitigating these challenges?
Trull: One of the biggest challenges is organisational resistance to change. This really cannot be underestimated. Well-established businesses have longstanding, entrenched processes and business models that have been built and supported by career employees. Disrupting those processes or business models can result in significant resistance from employees and line managers.C-level sponsorship and good project management. Communication is essential, especially related to the ‘why’ behind the transformation initiative. It is also important to quickly identify the employees who are going to be the biggest supporters of the initiative and work with them to amplify the benefits from the project.
Kimner: Often the biggest hurdle to rolling out any type of transformational programme, including adopting technology as part of a digital makeover, is overcoming inertia. Firms often become entrenched in how they do things. This organisational or structural rigidity spans everything from policies and processes to reporting lines, authority and decision making. Often, individuals within an organisation feel threatened when a transformation programme is undertaken. Sometimes this will manifest itself in counterproductive activities, a lack of support for progress or even sabotage of a programme. To mitigate any potentially negative behaviour, it is important for executive management to be unified in their support for and communication of the programme and the need to change.
FW: In your experience, how much of a shift in organisational culture does a digital transformation process generally require? To what extent does the success of the process depend on managing cultural issues?
Samani: If a company already has a clear organisational structure in place, managing a digital transformation project is much easier. In order to make the project successful, senior leadership must have the means to communicate a vision to employees, making the benefits of the project clear to all. Employee buy-in and contribution across all levels is absolutely vital to the success of a project, and underpinning this is communication.
Kimner: The impact of a transformation on culture really depends on the scope and scale of the programme. For example, a company that is adopting robotics in a manufacturing process will need to manage the cultural aspects of this transformation differently from a retailer who decides to move from a ‘brick-and-mortar’ presence to one that is exclusively online. However, while the nature and extent of changes are determined by the programme, all transformations generally impact culture in some way. And, cultural changes necessitate that executive leadership, management and supporting functions are all aligned on the changes and anticipate where cultural shifts may cause pushback or conflict.

Sherry: Many companies, ws, looked at what the most disruptive Silicon Valley companies have done and have created process frameworks that encourage innovation and change. These frameworks allow organisations to build teams around problems quickly, at low cost. This allows parties to invest and scale very rapidly. Traditional hierarchies simply do not let you move that fast.
FW: In the Information Age, where data is often critical to business success, what role should the chief information officer (CIO) play in the digital transformation process?
Sherry: CIOs are increasingly looking to reinvent IT from being reactive to business needs to proactively creating solutions that drive better outcomes for the business. This means transforming the role of the IT function from being back office administrators to integrated team leaders. As t key driver for transformations, the CIO’s role ns. Today, CIOs are becoming key decision makers in the boardroom and they have a say on business initiatives that stretch well beyond technology, ranging from HR and organisational management through to product innovation and business culture. To be successful, CIOs need to partner with their chief operating officers (COOs) to be able to bring in an industrial company’s inherent domain expertise.
Samani: The role of the CIO will become less about the actual delivery of a certain project or technology, but rather to nurture innovation. Recent Gartner research found that 95 percent of CIOs expect their roles to significantly change as a result of digital transformation and it is likely that their role will become much more focused on employee development going forward, driving and rewarding creativity within teams and across the business as a whole.
Fellahi: We are in an era where people expect their fridge or car to do a lot more, and these digital experiences influence customer expectations. Increasingly, companies are exploring IoT applications, such as voice activation, and are testing and evaluating technologies to understand whether there is critical mass to justify going to market.
Samani: The IoT has been a massive driver of change in recent years; devices such as Alexa and Google Assistant have brought the store front into the home, giving customers and businesses a much closer relationship than ever before. Businesses now have access to a huge amount of customer data and they need to treat this incredibly sensitively, not only in the ways they use it but they must also ensure this data is kept secure as an absolute priority. This level of trust is changing the existing relationship we have with businesses; trust is now the cornerstone and businesses need to ensure they maintain this as much as possible.
Kimner: Many firms are only in the early phases of evaluating how to leverage the IoT for commercial or other purposes. In the consumer space, devices that link household appliances, heating or cooling, security and other basic functions, are areas of early exploration. Initial adoption has been focused on enhanced connectivity and linkage between devices to share information or perform simple tasks, such as ordering goods and services. Direct ordering of staple goods, for example, can change traditional shopping patterns. Early adopters are also seeing some level of added convenience in being able to control various household systems and monitor their homes while they are away.
Sherry: The IoT has had a significant impact on consumer businesses, creating opportunities for product innovation in a number of areas including wearables, smart home and fitness devices, smart metering and many others. However, the industrial internet has the potential to bring greater disruption than the consumer IoT by driving productivity and efficiency across industrial organisations. Conservative estimates suggest the industrial internet market is about £173bn globally, compared to the consumer internet, which is about £131bn. The industrial internet is already disrupting heavy industries and changing the way industrial organisations operate, driving a lot of innovationutilities, rail, power generation, oil & gas development, healthcare delivery and manufacturing. This is going to transform not only the way these industries operate but also their relationship with the customers.
Trull: We will seeto five years. Although new technology is often over-hyped in terms of its potential impact, I believe blockchain technologies will result in new business models and improvements to the way consumers shop, buy and transact business.d opportunities that were just science fiction only a few years ago. The digital revolution will likely permeate virtually every aspect of our economy, as well as our personal lives.
Fellahi: Companies should explore many different avenu business strategy. Trendbots and blockchain, must be explored. It takes work not to have any blind spots.
Deborah Sherry iDigital in Europe. Her mission is to deliver the next industrial revolution. Her division delivers edge to cloud-based solutions that connect industry, transforming industrial companies into digital industrial leaders by turning data to intelligence that drives step-change improvements in productivity. She can be contacted by email: deborah.sherry@ge.com.
Western Union Digital


Worted
They’re showing their appreciation for all the water they got this year!
So pretty! It is one of my favorites.
So do i Christina. This one is very delicate and smells luscious.
I was delighted that my GL had two orange blooms this year. I do like your white ones.e.


! FFlamingo is sure to be a favorite for your little man! Pair with a Tommy Tee to complete the fun and easy to wear outfit.
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CompTIA Network+ (N10-00 CompTIA Network+ (N10-00 Network+ Study Guide (N10-007exam objectives, The Official CompTIA Network.


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In this photo taken Aug. 17, 2013, a cyclist pauses along the St. Lawrence River across from Quebec City on an off-road trail in Levis. The trail offers a dedicated lane for walkers and two lanes for cyclists, and is part of th)


Professional barrel racer and Vitalize® Ambassador Emily Miller is taking one day and one rodeo at a time. The young athlete from Weatherford, Okla., closed out a phenomenal 2017 season just short of making her first NFR appearance, but also faced some hurdles with her two main horses. Pipewrench, her primary horse has been sidelined with severe bruising in his feet, and Jet is currently having embryos flushed for breeding purposes.
“I just take one day at a time. I try not to look at December,” Miller said. “I ask myself where am I going this week? Where am I going next week? How are my horses doing? There are a lot of things that could happen between March 1 and Sept. 30.  I want to focus on setting realistic close-term goals, and those include entering smart and going to rodeos that the horse that is working the best at the time will do really well at.”
Miller’s primary focus has always been on her horses’ health, and that is one reason she is a Vitalize ambassador. Vitalize is a line of equine supplements produced by BioZyme® Inc., that contain Amaferm®.  Amaferm is a natural prebiotic that supports the horse’s entire digestive system. Designed to eat small amounts of forage throughout the day, horses today are often fed large amounts of grain once or twice a day. This undermines the horse’s digestion and can ultimately lead to digestive imbalance and performance issues.
Miller has been using the Vitalize® Equine High Performance Pellets and Vitalize® Equine Recovery Paste for nearly a year and notices a difference in her horses’ health and performance, especially when traveling.
“I never had ulcer trouble until I hit the road hard and traveling takes a toll on them. I’ve found if I keep them on a steady diet and the more preventative maintenance I can do, it just helps them in the long-run. Both the Vitalize High Performance Pellets and the Recovery Paste, have helped keep my horses more level so they aren’t struggling when we are gone for a long time,” Miller said.
With her two main horses in recovery mode, Miller has been competing this year on her youngest horse, Foxy. Foxy is a 6-year-old Palomino. And she is Pipewrench’s little sister. She has already won three pro rodeos for Miller this year, all in 14 seconds and under arenas.
Miller said Pipewrench is on the mend, and she will bring him back as soon as he is ready. He has run one pro rodeo for her this year but says both horse and rider need to refocus mentally as a team. She knows that once her horses’ feet and mental focus are in check, she will keep their gut in check with Vitalize.
“Our horses were made to be intensive grazers yet we feed them twice a day. I’ve always been a big believer in prebiotics and maintaining that healthy gut, especially traveling,” Miller said. “Do the best by your horses, focus on short term goals and the outcome will be better.”
Posted in Featured, News, Performance
Healthy Horses Housed OutsideVitalize Ambassador Helps Others While Working Hard


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electric GT category  For now, there’s no introduction date for a new race series featuring the new category just yet, although we do get some technical details.
According to the FIA, cost control and cutting-edge technology are the primary focal points with the new class, which is open to specialists in electric vehicle construction. Additionally, manufacturers that are already committed to GT3 racing can also participate and will be able to utilise 1,490 to 1,530 kg, with a maximum power output reaching 430 kW (585 PS or 577 hp). The association notes that setting a weight threshold beyond that of to keep costs down.
Aside from battery layouts, teams will have the freedom to choose their own powertrain setups, be it two or four electric motors, with two or four-wheel drive allowed. Race cars under this category are expected to have a zero to 100 km/h time of 2.4 seconds and hit a top speed of 300 km/h.
,” said Jean Todt, president of the FIA.
,” said Leena Gade, president of the FIA GT Commission.
Source: Read Full Article </s> A Guide to Graphic Design Trends for 2020
With the year 2019 being on its verge, it’s time to welcome 2020 with open arms.
The future cannot be predicted but trends can! We have no idea about what heights the graphic design industry will achieve in 2020 or how the industry will work in that year, but we certainly know the trends that will play a major role in scripting the future of the graphic design world. The industry has always been an ideal place for people with deep admiration, a creative mindset, and a huge inspiration. Therefore, for all those creative buds cum graphic designers here is a list of top 5 trends that will define the future of the graphic design industry in 2020.
- Shiny Metals
Using metallic materials in graphic design has turned out to be a trendy way of branding and product design which is expected to be one of the important trends of the year 2020. Though it requires minimalist overall design, yet the focus remains on the metallic design itself. Gold is the most commonly used colour for this metallic design as it looks luxurious. The effect can also be achieved using a matte surface of any colour.
- Muted Colour Palettes
The last few years of the graphic design industry have seen a rise of bold colours in designs because of the brand. That time was the colours of electric yellow, bright blue, and toxic greens. But in the year 2020, you can expect to see a change in taste from those vivid colours to muted colour palettes. Now, you must be wondering what sort of colours muted colour palettes basically are? Well, they are slightly desaturated with contemporary, white or black colours. In short, muted colours are opposite of vivid colours.
- Image Text and Masking
Undoubtedly, colour gradients are reckoned amongst the important trends of graphic design. And for the third in a row, it would be a major trend. Earlier, they were just used as a striking background. It is expected that brands will replace flat colours to make one brand distinct from another. Not just this, it is also expected that with the advent of muted colour palettes in the graphic design world, gradients will also become less vivid and bright.
- Collages and Drawing Photos
Doodling has become one of the major trends in the space of graphic design. make drawings in our notebook. It started as a fun trend but now has become a big hit. As a result of that, we can see those doodles on designs. It gives a design a more informal, handcrafted and personalized touch to make a design look appealing. Designers often prefer to use a similar trend which includes to make then interactive. It is a unique trend that you are going to see in the year 2020.
The world of graphic design is super diverse and impressive and the year 2020, will definitely be the year of graphic design seeing its alluring trends. To know more about these trends in detail, connect with Auxesis Infotech as theyevelopment and have years of experience serving the industry. </s> A website is judged by the design it keeps
When you move your eyes around a website, your attention remains constant only because you realize that the colors, fonts, and layouts must be appealing to your eyes. So, it is the content along with the designs that keep your website going and that is the truth! Web designs are essential to keep the website pluck the attention of the audience and make them stay on your website. If your designs fail to get appreciated, then it’s natural that even Google will not be able to help you climb the stairs of success despite being rich in content. This is because designs speak a lot about the quality of work being performed in the business! Take a look at the content to acknowledge the importance of web designs in your online presence.
Web designs must be focused on creating User Experience. The designs crafted by designers complement the content present on the website which must be attractive and at the same time act as the best resource. The designs or visualsugh videos, images, and others allow them to relate to the business emotionally or aesthetically. Unless the visuals tap the senses, they will not work in the correct format in bringing conversions alive through the website.
When you are running an online business and representing all your products and services online and not through any physical store for instance, then what else will be essential like the content and the designs speaking your heart out to the audience? Conversions would happen only when the impressions convert into engagements from traffic to deals! Small children can relate to a product that is more color


Ok. Here is the scenario.
I need a script that has a form ("form.html"). On this form it has inputs that have names of "name" "id" "date" "article". They type in those fields and press submit. The info in turn goes to articles.php3. How can I get just the articles to be on ??
So if you have any ideas how to do this, let me know. Oh, and one more thing. Do you have to put a VARCHAR limit on a field in a MySQL database? Because sometimes articles can be lengthy. Anways, thank you. Any help is deeply appreciated.


Increasingly, financial institutions are seeking to get crypto into the  — and which, as of December, contained about $11 trillion in assets. Last year, the plan provider ForUsAll. Earlier this year, Fidelity Investments, among the country’s largest 401(k) providers, said it would soon let participants invest as much as 20% in Bitcoin, if employers choose the option.Bitcoin advocate, immediately said he’d be in.
Advocates offer various justifications for this misguided idea. They say Americans deserve more choice, citing surveys showing that millennials in particular tend to see crypto as a desirable investment. They say digital assets can diversify a given portfolio because their price fluctuations aren’t synced with other markets. Proper financial education, they insist, can help people understand the risks.
Please, no. People have a hard enough time navigating the US retirement savings system — and merely saving enough for old age — without to grasp. The diversification argument is specious at best: Crypto has a limited track record, and Bitcoin has lately plunged even more than other markets, down more than 50% from its November 2021 peak. Not to mention and ensuring safe custody in a largely unregulated realm.
To their credit, regulators aren’t buying the idea. The Labor Department, which oversees 401(k) plans, issued guidance emphatically reminding employers of their fiduciary duty to participants People should be free to squander their money, but not in their 401(k)s. and warning that including crypto among investment options will invite investigation. For the most part, companies seem perfectly willing to comply: In one recent poll, less than 2% of 401(k) plan sponsors said they were considering adding cryptocurrency as an investment option.
Yet the industry and its supporters keep trying. Congressional RepublicansLabor Department from restricting 401(k) investment options, opening the way for crypto and much more. If lawmakers have a modicum of responsibility, they’ll let such initiatives die quietly. If not, one must hope employers will hold the line.
Of course, people should be free to invest their money as they please — outside their tax-advantaged retirement accounts. Someday, crypto may prove to be something more than a purely speculative instrument. It’s nowhere near that now.


A spirit that holds the form of a beautiful maiden engulfed in flames. They appear in locations where fire magic is abundant, which led many to assume they were spirits of those who died from fires. Research has now proven that they are a type of spirit, but they have yet to uncover the mysteries behind them. There are a number of spirits shaped like maidens all around the world, and they are all known for growing more powerful either naturally, or by absorbing the energy of other living beings.


s mistrust of GM crops. It is as though contact with ‘manipulated’ fruit and veg has affected their own genetic makeup.
A bizarre group of distorted teddies are more specifically concerned with Genetic Modification. Even their dull metallic sheen has something of the lab about it, being as recognisable as ‘Theo’s teddies are very cute indeed. The trouble is, they are also very weird. Surely, no child could empathise with a teddy that had eight octopus legs or griffin’so fisherman’s to indicate just how enormous he wanted these grapes to be, before adding,
The funny thing was, he was smiling as he said it.
Theoland, solo show, 2001, Ha Gamle Prestgard, Norway, </s> The Insider - Babies in Cabo
In this 37th episode, we discuss Criss Angel's proposal in Cabo, our latest playing card release of The Aristocrats, the latest and greatest new releases on The Wire, and of course your lovely, yet slightly-going-down-hill comments!
To watch tonight's episode, click on that pretty little face to your left. For all past and previous episodes, check out The Insider Vault. </s>
Washington House votes for powdered alcohol prohibition - Goskagit
BONNEY LAKE, Wash. (AP) —  at least one person, fire officials said.
2015-04-13T13:08:57Z
House Democrats release transportation revenue plan - Goskagit
2015-04-13T12:18:50Z
OLYMPIA, Wash. (AP) — House Democrats on Monday released their take on a transportation revenue package, a version that looks similar to the Senate's $15 billion 16-year plannearly 12-cents a gallon.
Washington state man flees after N. Idaho rollover crash - Goskagit
2015-04-13T17:19:29Z
Teacher goes from spectator to Masters champion caddie - Goskagit
Volunteers needed for Earth Day and at other nonprofits - Goskagit
2015-04-12T16:59:12Z
2015-04-13T00:15:51Z
All-day kindergarten, smaller classes challenge for schools - Goskagit
DES MOINES, Wash. (AP) — When the Highline School District decided to give its kindergarten students a full day of learning — a few years ahead of a state requirement — they had to get creative to find places for the 5-year-olds to learn their ABCs.
Nelson Cruz homers in 10th, lifts Mariners over Athletics - Goskagit
2015-04-12T16:37:43Z
2015-04-12T15:54:46Z
Juniper Trail reroute offers new and improved viewpoints - Goskagit
2015-04-12T13:45:55Z
Fed review of Canada lynx to take longer than expected - Goskagit
2015-04-11T06:30:27Z


He snorted. Like some Elmer Fudd farmer was gonna make him toe the line?
While sharing the video on her Instagram handles, she was seen quoting, “My house I am a princess of my husband heart and my house (sic).”
Once this colorful rock gets mined,/ it seems time to head to the stars./ Is the mankind really that blind?/ Somebody make end to this farce!
Social media makes it so we are plugged into the world. But what happens when the people you want to bug block you?
I, myself, just don’t see the fun in blocking old friends and boyfriends. Unfortunately, they do not agree with me. I have been trying to reach out to certain people for years. And maybe I did wrong them but I certainly can’t fix the problem if you have me blocked!
I cannot validate your feelings if you don’t tell me what they are. I cannot make amends, if you do not let me speak to you. No one can block me in this place, for I own the domain. And that does give me some comfort. But not as much as it would if I could just actually speak to you in person. Does your hate really run that deeply?


 newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing HT, the book goes on to cover retinal and anterior segment imaging and imag...
...
, an area that has seen considerable advances over the past several years respective chapters, , focus on...
This open volume provides readers with an open access protocol collection and wide-ranging recommendations for preclinical renal MRI used in translational research. The chapters in this book are interdisciplinary in nature and bridge the gaps between physics, physiology, and medicine. They are designed to enhance training in renal MRI sciences and  '...
Cardiovascular biome...


By: abrukhome In: health 1 month ago
Majority of the people believe the penis is a bone or a muscle but it’s actually not. The penis is composed of 3 sponge-like layers, so whenever a man feels aroused, it gradually fills with blood. The accumulated blood results in increased pressure which prevent the blood from flowing out and the result leads to erection.
Sometimes sexual impotence or erectile dysfunction is an indication of a bigger issue. Some of the causes of erectile dysfunction include:
Unhealthy decisions such as eating an unbalanced diet, drug abuse, smoking, and many more can actually play a big role in increasing the risk of erectile dysfunction. Introducing foods rich in flavonoids increase the rate at which men exercise, it also makes men lessen smoking and drinking thereby reducing the risk of having erectile dysfunction
That’s why it is always safer and betteror better still if after taking a prescribed drug, you notice any decrease in the strength of frequency of your erection, you should consult a doctor immediately.
Causes, Stages and Diagnosis of Breast Cancer in Unmarried and Married women
By: abrukhome 1 week ago
Cheating Goes Beyond Sex
Reason Why Some Successful Marriage End in Divorce


f Agatha Christie’s darkest tales, the Evansville Civic Theatre production’s growing sense of dread will keep you guessing to the very end.


The control of directivity represents a new stake in the reproduction of the sound sources by electroacoustics devices. Nowadays, thanks to signal processing, current loudspeakers can respect quite well spectral and temporal properties of the signal. The remaining step is to account for spatial information – radiation – of the real sound source they intend to reproduce. In a larger frame, this research direction fits in the field of studies devoted to the spatialization domain, from a technological and perceptive point a view. The introduction, sums up a previous work that proposed a general method for reproducing the acoustical field radiated by a source, using a multichannel device controlled by digital signal processing. The general principle is to approximate a given directivity pattern by linear combination of the fields radiated by a set of loudspeakers laid out on the faces of a polyhedron. The introduction reminds mainly the following points : the experimental measurements, the theoretical hypotheses of the method and the optimization procedure that leads to the design of digital filters. This work, undertaken in parallel using simulations and prototype developments, showed the scientific and perceptive interest of the process with two main conclusions : first, thets, and secondly, encouraging performances of radiation reproduction for several basic directivity patterns, although being limited to a restricted frequency range. The second part presents ongoing developments, putting the emphasis on signal processing issues. Studies are devoted, on the one hand, to the general improvement of the system (particularly, its bandwidth) and, on the other hand, to the optimization of the directivity control. This one can be measured in terms of perceptive relevance and real time processing that are significant characteristics when considering the integration of the method in a musical context. A new prototype has been designed, with six independent loudspeakers mounted on a cubic frame. The directivity control rests on the preliminary constitution of a set of basic directivities – namely the first spherical harmonics – with which it is possible to tune the cardioïcity and the three-dimensional orientation of the directivity pattern. Actually, this original approach, derived from the initial method mentioned in the introduction, raises new issues as regards to the digital signal processing. First of all, given the equally importance of phase and magnitude properties in the design of the directivity filters, different modeling approachreproduction error is discussed. In other respects, the combination of the basic directivities is an efficient method to realize a continuous variation of the radiation pattern, for it avoids usual interpolation and commutation problems with filters. However, it leads to a new level of constraints, because it requires a design coherence – especially for the phase – of the whole set of filters related to each elementary directivity. Finally, together with usual computer cost optimization, foreseen applications during music performances impose real time processing constraints and the lowest latency. The third part is dedicated to the simulation of musical instruments. For this application, it appears significant to tune independently the spatial and spectral characteristics. In particular, listening in a room tends to average the spectral contributions radiated by the instrument in the different directions. Then, it seems crucial to develop an accurate method for analyzing and synthesizing the power spectrum. A practical procedure, based on room acoustics diffuse field theory, allows the automatic design of a correction filter to be applied on near field recording of the instrument in order to create a signal carrying the power spectrum information. Choosing this signal as an input for the multi-loudspeakers device allows to maintain a faithful power spectrum reproduction, while offering control on the directivity pattern. The results will be discussed by considering reproduction examples of several instruments (harpsichord, flute, human voice,…). The last part, reviews musical experience already acquired through the collaboration with a composer. The musical application is driven by software written in Max/MSP and includes several specific tools such as graphical interfaces or MIDI controllers that will be briefly described. Various esquisses consider different ways of playing with directivity : spatial counterpoint, chimerical instruments, duo between a real instrument and its realistic or distorted image, reverberation enhancement, real-time control by an instrument player, … The short term of this cooperation takes shape by involving this new sound diffusion system in a music performance programmed for summer 2001.


SAN FRANCISCO (CBS.MW) -- California regulators voted Thursday to force the state's cash-strapped utilities to rescind past employee layoffs that adversely affect customer service.
The order also prevents Southern California Edison EIX, -0.37% and Pacific Gas & Electric PCG, -0.08% from implementing any other worker layoffs if they slow down or affect the quality of customer service.
Shares of PG&E shed 18 cents to close at $12.92 Thursday as shares of Edison fell 37 cents to $13.59.


SProject No. IAA400400806) and by the Czech Science Foundation (Grant No. GAČR 13-04580S).
intraperitoneal injection) and chronic (via drinking water and/or diet) cadmium intoxication was investigated in the model study. The rat strains Long Evans (LE), Spontaneously hypertensive rat (SHR), and Brown Norway (BN) were tested and compared, and total Cd levelsin the liver of experimental animals. The liver MT concentrations were determined by using adsorptive chro-nopotentiometry and modified Brdička reaction and were significantly correlated (r = 0.965) with the total liver Cd content. Moreover, the Cd application resulted in increasing zinc liver contents confirming intensive MT synthesis in the rat liver. In the blood plasma, specificwas determined suggesting increasing activity of GR with the amount of applied Cd for all three strains, whereas ambiguous results have been found for the activity of GST. Therefore, MT concentrations seemed to be more sensitive indicators of the Cd intoxication compared to the assessment of the specific enzymatic activity.
Keywords: metal intoxication; liver; blood plasma; detoxification; Rattus norvegicus L.
1999, Vasak 2005). MT plays important roles in Cd retention in tissues and dramatically decreases biliary excretion of Cd. Cd-bound to MT is respon-sible for Cd accumulation in tissues and the long biological half-life of Cd in the body. Induction of MT protects against acute Cd-induced lethal-ity, as well as acute toxicity to the liver and lung (Klaassen et al. 2009).
A common model used in toxicology to estimate the potential hazard of contaminants for human health is rat, where after exposition to Cd, induc-tion of MT in several tissues, especially in liver, has been well documented (Chan et al. 1992a, Szakova et al. 2009). Comparing to liver, Cd induces MT to a lesser extent in the testes indicating the higher susceptibility of testis to Cd toxicity. Moreover, the significant reduction of daily sperm produc-tion in intraperitoneally treated rats exposed to high Cd dose was accompanied by the decrease of MT level (Xu et al. 2005). Different response of Sprague-Dawley rats on Cd and Hg intraperitoneal exposition was observed by Chan et al. (1992a). The presence of Hg induced the synthesis of MT only in kidney but not in liver, whereas Cd injections induced MT synthesis in both liver and kidney. Even exogenously administered MT to rats showed protective effect against potential liver damage (Kara et al. 2005). The induction of MT could be affected by co-exposure to more elements. Wang et al. (2009) exposed the Sprague-Dawley rats to Cd and Pb in drinking water for 8 weeks to investigate the possible combined effect of these metals on the expression of MT in kidney. They found significant increase of the MT expression during the combined exposition to the elements indicating their possible interaction in the rat or-ganism. In the opposite, zinc can protect against acute CdMT nephrotoxicity of mice (Tang et al. 1998) and testes damage in Wistar rats (Amara et al. 2008). Selenium application can increase the protective effect of Zn against the Cd toxici-ty. Jihen et al. (2009) documented that Se or Zn administration during exposure to Cd has only partial corrective effects on Cd-induced oxidative stress in liver while Se and Zn together assured a more efficient protection of the organ against the observed oxidative stress in male Wistar rats.
lately. Among them, differential pulse voltammetry (DPV), chronopotentiometric stripping analysis (CPSA), and high-performance liquid chromato- characterized by the lowest limits of detection (Dabrio et al. 2002; Adam et al. 2010). Among the electrochemical techniques, the application of constant current chronopotentiometry gives better separation of signals than voltammetry (Sestakova and Navratil 2005; Serrano et al. 2006). For separation of the individual MT isomers, CE belongs to the most preferred techniques (Beattie 1998). However,MT in tissues and body fluids has been developed and verified with an acceptable limit of detection (Chan et al. 1992b).
as MT synthesis and the activity of detoxification enzymes in the rat organism are strongly affected by the individual rat straiindividual rat models on the interpretation of the results of various indicators characterizing response of the rat organism exposed to Cd.
cooling, the digest was quantitatively transferred into a 20-ml glass tube and filled up to the volume by deionized water. A certified reference material MB 12-02-01 Bovine liver (Analytika Ltd.) was applied for the quality assurance of analytical data. In this material the content of 0.48 ± 0.03 mg/kg Cd, 0.325 ± 0.014 mg/kg Se, and 162 ± 6 mg/kg Zn is certified. In our experiment, 0.54 mg/kg Cd, 0.290 mg/kg Se, and 163 mg/kg Zn was determined. Total contents of Cd and Zn in the digest) with axial plasma configuration (VistaPro; Varian Australia Pty Ltd., Mulgrave, Australia), equipped with au-tosampler SPS-5. Measurement conditions for all lines were: power 1.2 kW, plasma flow 15.0 l/min, auxillary flow 0.75 l/min, nebulizer flow 0.9 l/min. For determination of low concentrations of Cd in the digests,the instrument Varian AA280Z (Varian Australia Pty Ltd.) equipped with a GTA120 graphite tube atomizer was applied. The total seleniumthe instrument Varian AA280Z equipped with a continuous hy-dride generator VGA-77.
deter-mination, rabbit MT (Cd-Zn-MT, lot 052K7012; Sigma-Aldrich Corp., St. Louis, USA) was used. All chemicals were of analytical purity grade, deion-ized water (0.054 µS) (Milli-Q-Gradient; Millipore, Billerica, USA) was used.
Determination ofwas performed by using the following procedure: oxidized glutathione (GSSG) was reduced by glutathione reductase and NADPH to reduce glutathione (GSH). GSH than spontane-ously reacted with 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) forming 5-thio(2-nitrobenzoic acid) (TNB) where the TNB concentration was measured at λ = 412 nm. Reaction mixture was prepared by mixing 50 μl of reaction buffer (100 mmol/l phos-phate buffer (pH 7.5), 1 mmol/l EDTA, 250 μl of 2 mmol/l GSSG dissolved in the reaction buffer, 125 μl 3 mmol/l DTNB (all Sigma-Aldrich Corp.) dissolved in the reaction buffer, and 50 μl of the plasma sample. The reaction started after addi-tion of 25 μl of 2 mmol/l NADPH. The reacaddi-tion was performed in 1 cm quartz cuvette at 25°C and absorbance was measured continuously for 4 min (Glatzle et al. 1974).
at λ = 340 nm. The reaction mixture was prepared by mixing 210 μl of reaction buffer (100 mmol/l phosphate buffer (pH 6.5), 0.1% v/v Triton X-100; Sigma-Aldrich Corp.), 250 μl of 2 mmol/l GSH (Sigma-Aldrich Corp.) dissolved in reaction buffer, and 25 μl of plasma sample. The reaction started with pipetting 15 μl of 33.3 mmol/l CDNB (Fluka Chemie GmbH, Buchs, Switzerland) dissolved in ethanol into reaction mixture. The reacHabig et al. 1974).
Statistical methods. The data obtained for Cd concentrations in liver were subjected to Dixon’s test for identification of outliers (significance level α = 0.05) using MS Excel 2007. Subsequent-ly, one-way analysis of variance was used at the significance level α = 0.05 (STATISTICA software package, Version 9.1, 2011). Correlation analysis was used for assessment of the relationships among the variables where Pearson’s correlation coeffi-cients were applied for the data characterized by the normal data distribution and non-parametric Spearman’s correlation was used in the remaining cases (Meloun and Militky 2004).
results summarized by Swiergosz-Kowalewska (2001).
Figure 1 summarizes the MT concentrations in the liver extracts where no significant differences occurred between LE and BN strains whereas higher MT concentrations were determined in SHR strain. For all the strains, the MT values correlated with the liver Cd content where the equation y = 0.194x + 2.86 has the correlation coefficient r = 0.97 which confirms linearity (P < 0.05). This is in agreement with data from literature (Hogstrad and Haux 1992; Dallinger et al. 1999), where for dependence of MT content on Cd concentration correlation coefficients 0.96 or 0.86 were reported. A similar range of MT concentrations, when calculated for 1 g of liver (51–569µM), was reported for example in the liver and kidney of fish samples (Krizkova et al. 2010) suggesting the similar rate of the MT synthesis regardless of the animal species.
S-transferase activity (GST) showed in the case of LE strain no difference between control group and group with Cd in water. Increase of the specific activity was found in group with intraperitoneal injection of 0.6 mg per 100 g of body weight. At laboratory rat strains SHR and BN, similar relations could be observed. There was again no difference in glutathione S-transferase activityWe could see a significant (P < 0.05) increase of the GST activity in groups with intraperitoneal injection of Cd in the amount of 1.25 mg per 100 g of body weight in both these strains, but there was insignificant increase of glutathione S-transferase activity at groups with intraperitoneal injection containing 0.6 mg Cd per 100 g body weight.
the diet where lower bioavailability was observed for the Cd application in the diet, as expectable. However, the results suggested the potential effect of individual rat strains where the SHR rats showed higher ability to Cd accumulation especially in the case of high intraperitoneal acute intoxication with 0.6 mg Cd per 100 g of body weight (Table 1).
important determinants of Cd-induced hepatotoxic-ity in rats (Yamano et al. 1998). The inter-element interactions related to the Cd-MT induction are af-fected by individual elements as documented by Saito (2011) where the response of rats to silver injection was investigated and the silver concentrations in the MT fractions of silver-injected rats were higher than those of the control rats although they did not increase in response to injection of silver. Moreover, their results indicated that Zn contents in kidney and Zn concentrations in MT did not increase in response to silver injection. Therefore, the response of MT synthesis to risk elements intoxication of rats is evidently element-specific.
All three strains of laboratory rats used in this study reacted on the injection of Cd, but not on the exposition to Cd in water. Ognjanovic et al. (2003) observed increased activity of antioxidant defense enzymes: copper zinc contain-thione reductase, and glutagluta-thione S-transferase as a response of male Wistar rats to acute exposure to Cd (0.4 mg Cd/kg of body mass). For glutathione reductase activity, the increase has been observed with the increase of applied Cd concentration for all three strains, in agreement with the literature (Ognjanovic et al. 2003; Flora et al. 2008). In the case of GST activity, a more complex dependence was observed. This could be explained by differ-ent function of these enzymes. In GST measure-ment, strain LE appeared as the most sensitive to Cd exposition – the increase of GST activity was significant already after the intraperitoneal ap-plication of 0.6 mg per 100 g body weight.
The increase of the GR and GST activity in blood plasma after Cd injection confirmed that Cd causes induction of oxidative stress and acts toxically on the organisms, which is in agreement with other reports (Neal et al. 1997). The GR activity increased after intraperitoneal application of a small amount of Cd, whereas for GST activity, a higher amount of applied Cd was needed for significant increase in strains SHR and BN. This could be interpreted by a different function of both types of enzymes. GR acts mostly as an antioxidant defense enzyme (Flora et al. 2008). GST acts in detoxification of the organism and so its antioxidative function could be only secondary (Casalino et al. 2006).
5% is absorbed through this pathway (Jarup et al., 1998). Another reason is a long time of Cd applica-tion. In our assay, Cd was applied in a small amount for 60 days. It has been shown that the activity of GR rises up after 30 days of peroral application and after 60 and/or 90 days the activity slightly lowers. That may be connected with other probably non-enzymatic antioxidative mechanisms (Jadhav et al. 2007). Domanska et al. (1999) observed changes in glutathione S-transferase activity produced by repeated exposure of male Wistar rats to Cd in the response to each subsequent exposure. It may be sug-gested that the response of glutathione S-transferase depends on the duration of the exposure to Cd, as well. Localization of enzymes may play an important role, too. The in vitro experiments showed increased mitochondrial catalase and glutathione reductase (GR) activities more than the cytoplasmic enzymes (Latinwo et al. 2006). Cd is bound to erythrocytes or albumin during blood transport and subsequently is deposited into different tissues. It is possible that the antioxidative mechanisms in blood plasma are not needed after a long-time exposition to a small amount of Cd, blood plasma natural activity may be sufficient for its detoxification.
According to Hispard et al. (2008b), MTS are the most sensitive biomarkers since they are induced in the kidney of rats even at low Cd concentration (2.5 mg Cd/kg) whereas the enzymatic biomark-ers are not relevant at such concentration, at least after 4 weeks of exposure. It is in accordance with our results where the MT concentrations reflected significantly the Cd accumulation rate in the liver. Moreover, the results demonstrated differences among the individual rat strains where especially the SHR strain differed from the others showing higher Cd accumulation and subsequently the MT synthesis ability in the liver according to the experimental animals. Thus, the applied experimental rat model canults concerning the assessment and prediction of the risk element behaviour in the animal organism.
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1.. Calhoun uses a cane at times to get around but is aggressively rehabbing from his injury. Ollie said Calhoun keeps his distance when Ollie is going over team issues so as not to distract the players -- but added that it's good to have Calhoun involved and for the players to see him still actively contributing. UConn officials confirmed Calhoun's statement last week that he plans on making the trip to Germany for the Huskies' opener against Michigan State at Ramstein Air Base on Nov. 9.
2. The freaky, scary injury to Wisconsin forward Mike Bruesewitz rocked the Badgers on Tuesday, according to a UW official. The Badgers were understandably anxious when they saw the gory cut on Bruesewitz's right leg after he sliced it on the back of a basket standard while chasing an loose ball. Wisconsin coach Bo Ryan was there to comfort Bruesewitz and the training staff was apparently quick to treat him before he was taken away by ambulance. Bruesewitz has become the leader of this squad and is easily one of the most well-liked Badgers in the past three years. He will have to take his time returning from this injury. He was apparently fortunate that the prognosis is for him to be out only four to six weeks. The Badgers have two big-time games in their first five that will be much harder if Bruesewitz isn't available -- a Nov. 14 visit to Florida and a Nov. 23 meeting with Creighton in Las Vegas.
3. Texas Southern was banned from the 2013 postseason due to rules violations. TSU hired Mike Davis to shepherd the program through the season before it knew of the penalties. If Davis wants the job long-term, the Southwestern Athletic Conference school should sign him to a lengthy contract to get the program right. Texas Southern isn't going to get a coach with Davis' experience. The school has him now -- it should do everything in its power to keep him.


Set during an idyllic ‘80s Italian summer, the heartrending coming-of-age film Call Me By Your Name has left millions overwhelmed. Based on the novel by André Aciman, directed by Luca Guadagnino and written by James Ivory, it has received awards for Best Adapted Screenplay from the Academy, BAFTA, Writers Guild, and Critics’ Choice.
The story centers around two young men falling in love but explores so much more. It is a story about first love, lust, innocence, and loss. The film stars Timothée Chalamet as Elio, a precocious 17-year-old whose world is forever changed when he meets a slightly older doctoral student, Oliver (played by Armie Hammer). Twenty-two-year-old Chalamet received rave reviews and industry accolades for his outstanding performance, winning the Independent Spirit Award for Best Male Lead and the Gotham Independent Film Award for Breakthrough Actor.
This critically acclaimed film had an all-too-brief, limited commercial run in the Philippines. That is why CC:Concepts is excited to offer an opportunity for audiences to enjoy this cinematic masterpiece by presenting the world premiere of Call Me By Your Name In Concert with The Manila Symphony Orchestra.
Film concerts feature full-length movies with their soundtracks performed live by a full-piece orchestra. There have been similar screenings of Gladiator at The Colosseum in Rome, Star Wars: A New Hope at The Royal Albert Hall in London, and The Godfather at the Tilles Center for the Performing Arts in New York, to name a few. Call Me By Your Name In Concert will be the film’s world premiere in this format. Filipinos will have the chance to experience the movie for the first time, with the soundtrack performed live by The Manila Symphony Orchestra.
Call Me By Your Name: Original Motion Picture Soundtrack features the compositions of Ryuichi Sakamoto, John Adams, Erik Satie, Johann Sebastian Bach and Maurice Ravel. It also includes songs by The Psychedelic Furs, Franco Battiato, Giorgio Moroder, Loredana Bertè, Bandolero, Joe Esposito, F.R. David, and Sufjan Stevens whose original song “Mystery Love” was nominated for the Academy Award for Best Original Song.
Ryuichi Sakamoto, John Adams, Erik Satie, Johann Sebastian Bach and Maurice Ravel
The Psychedelic Furs, Franco Battiato, Giorgio Moroder, Loredana Bertè, Bandolero, Joe Esposito, F.R. David, and Sufjan Stevens


are also paid travel expenses of up to £10 per day and midday meal expenses up to a maximum of £1.50 per day. The trial period allows you to decide if you like the job and also allows the employer to decide whether you are suitable. The employer promises to interview you for the job at the end of the trial.
Access to Work is an. Financial assistance is available for a wide variety of support to help you undertake regular employment, e.g. special aids and equipment, adaptations to employer premises, additional travel expenses, personal readers and support workers.
Some employers involved in the Employment option can benefit from the "Upfront Skills Shortage Subsidy". Where an employer offers a job lasting at least a year and good quality training that improves a person’s employability, the firm can receive three-quarters of the training and job subsidy payments at the start of a job. This comes to £1,730 for full-time 18-24 year olds and £1,460 for full-time employees aged 25+ (ND USSS, paras 1-7).
Despite the name of the subsidy, to qualify for the subsidy the employers do not have to show that the job is in a skills shortage occupation or prove they face upfront training costs. They must offer "significantly" more training than that required under normal circumstances and what they offer must be clearly set out in the Individual Training Plan.
The idea is to encourage employers to commit themselves to a significant amount of training towards the beginning of the Employment option placement. They must provide at least 15 days in the first 8 weeks of employment and a minimum of 26 days (or equivalent hours) during the first 26 weeks. The remainder of the subsidy and training payments is payable after 26 weeks, on achievement of the agreed training objectives.
Employers in the above list who apply for the Upfront Skills Shortage Subsidy will be visited by the ES (NDPG (18-24), ND USSS, paras 27-28).
For details of all these,.
be in employment expected to last at least 5 weeks.
If the job ends before 5 weeks you may not be able claim benefit for the first two weeks after finishing work.
If you claim the Lone Parent’s Benefit Run-On you will automatically continue to be paid HB and CTB for the 2 week run-on period. You will not have to fill out a separate form.
If you have been declaring part-time earnings while claiming JSA or Income Support then you may have built up a Back to Work Bonus which you will receive on moving into work. You can receive your Back to Work Bonus if you take a place on the New Deal Employment option.
The New Deal has been enhanced to include the Jobseeker’s Grant, which is meant to help meet certain costs associated with starting a new job. Award of the Jobseeker’s Grant is discretionary and can be used to encourage young people to apply for jobs and help them overcome barriers to interviews and employment (NDPG (18-24), C8, paras 286-287).
mandatory registration with professional bodies.
Employees can take out unemployment protection insurance to provide some income if they become unemployed. If you have such a policy, insurance payments will be suspended while you are on the subsidised job option, at the insurer’s discretion. The claim for unemployment insurance will be closed if during, or at the end of, the option you take up permanent unsubsidised employment. But if you return to JSA either during or after completing the option, the insurer will decide if the insurance payments should be reinstated. If you leave the option voluntarily or through misconduct, the insurer may not meet the claim (NDPG (18-24), Ch 5, paras 118-119).
What happens on the option?
When you take up a place on the Employment option you sign off JSA and become an employee. This means that issues such as health and safety and terms and conditions will all be handled by the employer "in accordance with [their] established procedures for all employees" (NDPG (18-24), Ch 5, para 5). You will be covered by relevant employment law.
The ES is required to monitor your option placement. You should continue to have contact with your ES personal adviser who should assess your progress and ensure that the commitments contained in the Employer Agreement and your Individual Training Plan are being fulfilled (NDPG (18-24), Ch 5, paras 264-266). The ES should indicate to you and the employer what the frequency and content of monitoring visits is likely to be. Monitoring visits are meant to ensure general compliance and identify any problems.
If you have problems at work or if you feel that the employer is not fulfilling the obligations set out in the Employer Agreement then you should contact your ES personal adviser or phone the confidential "hotline" number: 0800 163 339 or textline number: 0113 285 8654.
If you, ES monitoring staff or the employer identify a problem, then ES staff should try to resolve it through discussion with the employer. If you want to leave the placement or if the employer is dissatisfied with your performance, ES officials are instructed to "discuss the issues with the employer/employee with a view to resolving them" (NDPG (18-24), Ch 5, para 269).
If the ES identifies non-compliance by the employer and cannot resolve the problem, then the ES can "terminate the Employer Agreement and stop payments of both the subsidy and training money". However, ES staff are told that this "should only be done as a last resort, and [you] should be told/consulted about any possible implications before the Agreement is terminated" (NDPG (18-24), Ch 5, para 270).
During your first 6 months in the job, you are entitled to at least one day of training for each week (no matter how few hours you work in total). The training must be off-the-job and must lead towards an "approved qualification" (NDPG (18-24), Ch 5, Appen 1, para 1) This training may be delivered by the employer or by an outside organisation. In either case, whoever provides the training can claim up to £750.
The guidance says that "off the job training is defined as training towards a qualification … which would normally take place away from an employee’s usual paid duties". However, "on the job training in support of an NVQ is also acceptable". The document offers this clarification: "off the job training may include work to support NVQ assessment, job shadowing or familiarisation, computer-based training, supervised open learning, training in a company training centre or modules delivered by an education and training provider". In addition, "some jobs already contain a significant training element and this can be defined as the [off the] job element if it leads to an 2).
You must be given at least 26 days training over the 6 months of the subsidy. A day consists of at least 6 hours training for those on day release (NDPG (18-24), Ch 5, Appen 5, para 6).


a 60-inch rectangular bamboo top, with wire management cutouts at the corners, and a programmable memory handset—doesn’t look too office-like for your home or too quirky for an office, and is provides enough color and customization options to suit most people. Fully has sold the Jarvis for three years as of this writing, and is on its 18th iteration of small changes. Several Wirecutter writers and editors have been using versions of the Jarvis for years, and all of them find their desks in good working order and easy to recommend.
The frame (the motor and lifting legs) used by the Jarvis was customized for Fully by Jiecang, a major supplier of standing desk frames. The Jarvis’ steel feet are heavier than other desks’, about 6 pounds (2.8 kilograms) to most other standing desks’ 3 pounds (1.5 kg). Nearly every other Jiecang-made desk frame we tested telescopes downward, with the biggest piece attached to the desktop, while the Jarvis frame telescopes upward, putting more weight toward the bottom. Fully claims this lowers the center of gravity and reduces the sensation of wobble and tipping; another desk maker that uses Jiecang lifts in the other orientation dismissed the idea. Regardless, the Jarvis is one of the most solid and stable desks we’ve ever tested. Specifically, it is more stable front-to-back than our other pick, the Uplift desk, but slightly more wobbly in side-to-side movements. In both cases, these differences only showed up when shoving or shaking those two desks. Other desks we tested moved noticeably when simply leaning in to reach for coffee, and the Autonomous desk we tested couldn’t even hold its own against aggressive typing.
The Jarvis arrives in two boxes, one with the desktop and one with the frame components. Of the four desks we assembled in 2016, the Jarvis provided the best experience. When a Wirecutter staffer purchased a Jarvis Bamboo (with their personal email and payment), theytwo days later. The email noted the carrier, the time frame for delivery, the shipping origin, and had instructions for assembling the Jarvis attached. Most standing desk makers took 3-5 days to ship, with less notice and information provided, and one, Autonomous, left a staffer waiting for months.
In addition to bamboo tops, the Jarvis is also available with laminate or powdercoated MDF or hardwood tops, and even a few weirder options, but we think the bamboo top is the best-looking and the best value. It’s also available in a narrow “Junior” version, with an L-shaped frame, or as a treadmill desk.
Most of the issues you might encounter with the Jarvis, or any standing desk, come from human error. Having built more than a dozen standing desks between writers and editors, we know that, as with all assemble-it-yourself furniture, early errors like loose or too-tight screws or misaligned bolts can compound as you move on. But there are a few other quirks that down a button for a few seconds).
We recommend a particular Jarvis setup (bamboo, rectangular 60-inch desktop, memory-enabled console), because we think it’s the best value in the Jarvis line. The laminate tops,.
The Uplift Standing Desk at working height, with a one-inch-thick bamboo top, memory console, and white legs.
If you ordered the Uplift Standing Desk with the same configuration as our recommended Jarvis desk, it would cost just a few dollars less. Both firms offer Jiecang frames with near-identical configuration options, are headed by executives experienced in ergonomic design, and offer a seven-year warranty on their desks. What’s the difference? Well, the lifts are oriented in the opposite direction, the feet are aluminum instead of steel, and the bamboo desktop on the Uplift is one inch thick, a quarter-inch thicker than the Jarvis’s top. This allows for longer screws attaching the desktop to the frame, which Uplifts says makes their desks more stable than the Jarvis. Uplift offers two free grommet holes, a center grommet option not available for the Jarvis, and some desktops, frame, and accessory options that Jarvis lacks. The Uplift we tested had a better shipping, setup, assembly, and use experience than any model we tested besides the Jarvis, and it’s a good desk―especially if you want to venture outside bamboo and try other desktop options, like reclaimed teak. We haven’t tested Uplift for as long as we’ve tested Jarvis desks—this is partly self-fulfilling, because several Wirecutter staffers bought Jarvises since we started recommending them, so we have a wider pool of experience—but we like what we’ve seen so far.
The Uplift’s bamboo top is a quarter-inch thicker than the Jar


"L&F is one of only two companies that has been granted a 3M patent license to bring their product into the U.S., which speaks volumes about their battery cathode NMC technology," said Pradip Sheth, Director of the Battery Division at Targray. "They've also sold over 20,000 metric tons in the past five years and have been consistently rated number one by some of the top cell makers in the world. We're very excited to bring these quality materials to the European and North American markets."


W
Feb 15, 2018, 5:35 PM ET
WATCH Timeline of the Parkland, Florida, schoolid in their classrooms on Wednesday as a former student fired shots through the glass windows.
Another potentially life-saving measure came in the form of the classroom doors that locked, which teachers secured on Wednesday and kept the shooter out, and the school regularly held lockdown drills.
Sen. Bill Nelson, D-Fla., said today that the suspect, Nikolas Cruz, pulled the fire alarm and waited for students to come into the hallway.
'Exponential' increase in school shooting drills since Sandy Hook, Feb. 14, 2018, in Parkland, Florida.
Both teachers and students at the Florida school had been trained in different types of scenarios. A fire drill had been conducted at the school on Wednesday, hours before the shooting, and some students reported hearing a plan for a "code red" situation, which is used to refer to school shootings.
Chipman said that such examples of training help show "how can you take a horrible situation and have it not be absolutely catastrophic, which is hard to say."
"To me, I think the fact that only 17 people were killed in a school of 3,000 shows that there was a lot of bravery that day. Police responded quickly [and] teachers did everything they knew how to do," he said.
Effective law enforcement moves
Trump, who is not related to the president, pointed to the quick identification of the shooter as one key move.8, in Parkland, Fla.
Gomez called that an example of "really good, fast police work."
The frequent public status updates provided by multiple branches of law enforcement were cited by Trump as being helpful in the emergency situation.
"They're doing an excellent job in their crisis communications," he said, adding that the news conferences and Twitter updates "at least helps manage the parental and community anxiety. It's the lthat creates increased anxiety."
One issue that could be a double-edged sword was the suspect's expulsion from the school.
"We can't say that the best we can do is teachers that act as heroes and then have politicians pay for funerals," he added.


This one is a prequel that shows the origins of THE KING’S MEN before they became a bit corrupt and needed to be sorted out.
I will It looked like they were trying to beat a dead horse with this series and felt like they might have been going in the wrong direction to prolong it. I have to eat my words because the film ended up being exciting and surprising in how enjoyable it is.
Nice to see dramatic actor Ralph Fiennes in a more action-oriented role, but lets him also act. Though he also has a role in the latest James Bond films also. Here he is center stage.


The chemokine CXCL12 regulates multiple cell functions through its receptor, CXCR4. However, recent studies have shown that CXCL12 also binds a second receptor, CXCR7, to potentiate signal transduction and cell activity. In contrast to CXCL12/CXCR4, few studies have focused on the role of CXCR7 in vascular biology and its roleremains unclear. In this report, we used complementary methods, including immunocytofluorescence, Western blot, and flow cytometry analyses, to demonstrate that CXCR7 was expressed on HBMECs. We then employed short hairpin RNA (shRNA) technology to knockdown CXCR7 in HBMECs. Knockdown of CXCR7 in HBMECs resulted in significantly reduced HBMEC proliferation, tube formation, and migration, as well as adhesion to matrigel and tumor cells. Blocking CXCR7 with a specific antibody or small molecule antagonist similarly disrupted HBMEC binding to matrigel or tumor cells. We found that tumor necrosis factor (TNF)-?


THE COURT: "Will you indicate that by signing the jury waiver, please?"
DEFENDANT: "I'll do that."


really want; but ive run into a couple of problems when trying to mock out some implementations here for testing (feel free to tell me im doing it wrong etc.)
but I think it might be a good idea to express certain components as interfaces, rather than concrete types, eg.
Session, Receiver and Sender for example, ive got a fork of roughly what im proposing here https://github.com/lakahq/amqp
This'll allow us to create mocks from our applications/programs/clients etc.
type mockAmqpSession struct {}
func (m *mockAmqpSession) NewSender() (amqp.Sender, error) {
  return &mockSender{}, nil
Appreciate that its normal practice to have these interfaces in the calling library, however i dont think its possible to create the deep mocking structure required in this case. eg
type AMQPMockSession interface {
  // amqp.Session will not satisfy this signature
  NewSender() (AMQPMockSender, error)
type AMQPMockSender interface {
  // More Stuff
type MyCoolTopicGrabber struct {
    Session AMQPMockSession
func NewCoolTopicGrabber(sess AMQPMockSession) {
return &MyCoolTopicGrabber {
  Session: sess
        // YouGetNothingGoodDaySir.jpg
        NewCoolTopicGrabber(session)
If this is something you'd consider - I could commit to some time to adding this.
The approach I take and recommend to others is to create an abstraction around a library that fits with the consuming application. That way you can mock your abstraction or swap out the implementation if it becomes necessary. It also tends to reduce tight coupling of code.
As an example, some of the applications I work on use a PostgreSQL database. Instead of having anything depend on `database/sql` directly I'll create an abstraction package that contains all the SQL specific logic and exposes things like `db.AddEvent(...)` or `db.RemoveEvent(...)`.
I'm unlikely to switch to returning interfaces for a few reasons:
* It more or less prevents exposing fields on the returned struct. This isn't strictly true of course, but needing to type assert back to a concrete type makes for less than stellar usability and would be a non-starter for your use case.
* It turns API additions into breaking changes. If you were to create a mock for an interface declared in this library and I added a new method to the interface it would cause your code to fail to compile until you added the method to your mock. This doesn't happen with concrete types (technically there are some ways a method addition can cause problems when embedding is involved, but they're much less likely to occur).
* A bit subjective, but I think the documentation generated by godoc is worse for interfaces. With an interface the index would show only `type Sender` instead of `type Sender` followed by all the exported methods and their signatures.
I hope this helps illuminate some of the trade-offs and provides a potential work around for you. This isn't a "hard no," so if there's something I'm missresponse, everything you've said makes total sense to me, and the reasons you've listed i think are totally justified; ive had some fresh perspective so pretty sure this is no longer required (at least for our use case) so im going to close this?
username_0: I was investigating various Forth implementations and noticed that [`<` is implemented]barebones/barebones.f#L212) as
: < - 0< ;
While I couldn't get this Forth to run in an emulator, as far as I can see this implementation does not fare well with overflow. Consider `-128 1 <` (or whatever your cell size is) - this will evaluate as false, even though both numbers are in range of the cell and the former is clearly smaller than the latter of an "mod 2^n computation system", one with two's complement, I suppose.
Cell size is 16:
-128 1 < . -1 ok
-1 1 < . -1 ok
-32768 1 < . 0 ok
: < - 0< ; reDef < ok
The wrap-around can be avoided by using 32bit arithmetics. Implementing floored (clipping) arithmetics would also be possible, but that's quite costly on an 8bit µC without an instruction setwhile, and this should work for all numbers while still being quite efficient. Using this in my Forth does not exhibit any problems and passes the ANS test suite:
: < $8000 + >r $8000 + r> u< ;
<issue_comment>username_1: Very nice, this sure doesn't look obvious :-)
Changing the default behavior of signed number operators is a breaking change, though. I see 3 options: community vote, build option or a library function such as as `S<`.
<issue_comment>username_2: I never knew there was an issue with "<" and I've used it a lot. Better
minds than mine have clearly looked closely at this but I'm struggling to
see how CPW at the heart of < generates incorrect results.
So, at the risk of again looking like someone who hasn't grasped the
blinding obvious, are we fixing something that isn't actually broken?
<https://github.com/username_1/stm8ef/issues/254#issuecomment-47081960xpqbY5oUYlpjvQCvG8lI
61OuJwOks5vUgErgaJpZM4bh40VxBlY8eQh8zsibxspyB26hO1reNgks5
vUgErgaJpZM4bh40V.gif>
<issue_comment>username_0: Right now, `<` uses a subtraction, which behaves incorrectly on underflow. For example, `-32768 32767 <`, or even `-30000 3000 <`. These should clearly return true (cf. the [ANS Forth](http://forth-standard.org/standard/core/less) specification for this word, especially the test suite), but with the current implementation, false will be returned.
I believe that no programmer would intentionally rely on this inaccuracy, but this change, should it happen, should still definitely be mentioned in the changelog.
As to my proposed implementation, I see two ways to explain it.
Imagine a ring (*not* the abstract algebra one) of numbers from 0 to 65535 (-1). Because of the modulo wrapping, there's not really an entirely natural way of defining an ordering. However, we can put a separator between 0 and 65535, and unroll the ring into a truncated number line. This is what U< does. Notice how adding a constant to both parts of the comparison moves this separator around (or, the ring rotates and separator


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Home » Windows » Educational & Science Software » Science Software » RCCalc
Version: 1.0Platforms: WindowsCategories: Educational & Science SoftwareUpload Date: 30 Oct 14Developer: RelectNet Distribution Type: SharewarePrice: 1.99 $Downloads: 6
Currently 3.00/512345 Rating: 3.0/5 (Total votes: 1) This Calculator can calculate resistance and capacitance of resistors and capacitors connected in parallel or series connection. It is simple and easy to use. R&C Calculator requires no installation. Like it? Share with your friends!
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People are now wondering if the development of partition walls will pose any problems in the future. Is investing a good idea? Currently, stud walls are a clever answer to those issues.
A stud wall is a dividing wall that divides a room into two rooms inside of a house. Want to known the Cost of Stud Wall and how it differs from a typical wall lets examine it.
The below reasons say how stud walls are different from normal walls in terms of cost, time taken, etc.
The amount of time needed to construct a stud wall vs a typical wall varies. The stud wall will be completed in less time than a typical wall. The duration of the stud wall depends on the length and design you choose to build. Even more, dust can be avoided while constructing this stud wall.
Consider that you have leased space and wish to utilize it for business purposes. Alternatively, you may wish to temporarily use your own home for business purposes.
You may believe that building a standard wall will cause a lot of problems because offices need a lot of dividing walls and small spaces. The entire property could be damaged by removing the walls after use. The logical choice for this situation is a stud wallentire house.
if you want a partition wall but are concerned that the weight of the wall will strain the structure and possibly lead to cracks shortly. You can use this stud wall instead of stopping dividing your home It is made of plaster of Paris and comes in a variety of options, including iron and wood, so you can customize it to your preferences. Stop stressing or compromising on the interior design if a partition wall is involved because we can easily choose this stud wall which less in weight.
Since this stud wall is just 400–500 mm thick in general, you can save space by using it instead of building thicker walls between rooms. With the aid of this stud wall, you may joyfully save space if you need a divider in a tiny space. Choosing a stud wall is a smart move rather than wasting space and regretting the building of a regular wall.
In the end, stud walls are only used in the interior of the house since it is not appropriate to use them on the outside of the building, even if cost of stud wall less than standard walls and have numerous advantages over them.