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10.15252/msb.20209833 | Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection | 2021 | Figure 1 | <p><strong>Figure 1. Interferons protect human intestinal organoids from HAstV1 infection.</strong></p><p><strong>A</strong>. Cryo-sections of human organoids were analyzed for the presence of enterocytes (E-cad), Goblet cells (Muc-2) and tight junctions (ZO-1) by indirect immunofluorescence. Nuclei are stained with DA... | https://api.sourcedata.io/file.php?figure_id=41858 | [
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10.15252/msb.20209833 | Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection | 2021 | Figure 3 | <p><strong>Figure 3. Single-cell profiling and multiplex <em>in situ</em> RNA hybridization of human ileum-derived organoids.</strong></p><p><strong>A</strong>. UMAP of scRNA-Seq data from human ileum-derived organoids (n=16,682 cells); dots corresponding to cells are colored by the cell type.</p><p><strong>B</strong>.... | https://api.sourcedata.io/file.php?figure_id=41862 | [
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10.15252/msb.20209833 | Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection | 2021 | Figure 5 | <p><strong>Figure 5. Multiplex <em>in situ</em> RNA FISH visualizes immune signature in HastV1-infected and bystander cells.</strong></p><p><strong>A.</strong> One image per condition was used to show the multiplex in situ RNA FISH. A representative region of the images was chosen and cropped in order to have a zoom-in... | https://api.sourcedata.io/file.php?figure_id=41866 | [
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10.15252/embj.2021109783 | Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II | 2022 | Figure 1 | <p><strong>Figure 1</strong></p><p>Eukaryotic Spt5N binds histones H3-H4 via an evolutionarily conserved motif. (<strong>A</strong>) Domain structure of Spt5 / NusG proteins. The enlarged inset shows a conserved region of Spt5N from <em>Saccharomyces cerevisiae</em> (S.c.), <em>Schizosaccharomyces pombe</em> (S.p.), <e... | https://api.sourcedata.io/file.php?figure_id=45929 | [
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10.15252/embj.2021109783 | Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II | 2022 | Figure 2 | <p><strong>Figure 2</strong></p><p>Mutation of the histone-binding motif of Spt5N is lethal, even in the presence of wild type Spt5. (<strong>A</strong>) Linearised versions of the indicated plasmids were transformed into <em>SPT5-9MYC</em> budding yeast cells and integrated at the <em>ura3</em> locus. For each transfo... | https://api.sourcedata.io/file.php?figure_id=45931 | [
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10.15252/embj.2021109783 | Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II | 2022 | Figure 3 | <p><strong>Figure 3</strong></p><p>The histone-binding activity of Spt5N is dispensable for progression of the Pol II elongation complex through transcription units. (<strong>A</strong>) Experimental procedure, based on the yeast strains YCE281, YCE350 and YCE356. (<strong>B</strong>) Immunoblot analysis at the indicat... | https://api.sourcedata.io/file.php?figure_id=45933 | [
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10.15252/embj.2021109783 | Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II | 2022 | Figure 4 | <sd-panel><p><strong>Figure 4</strong></p> <p>Spt5N histone binding activity preserves nucleosome integrity during transcription. (<strong>A</strong>) Samples from the experiment described in Figure 3A were also processed for MNase-Seq. For each of the three indicated strains, the histograms represent the normalized DN... | https://api.sourcedata.io/file.php?figure_id=45935 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 1 | <p>Figure 1: Endothelial Ang-2 upregulation correlates with WHO grading in human gliomas. ELISA displaying human Ang-2 (A) and Ang-1 (B) level in serum of healthy patients (Ang-2 n=4; Ang-1 n=21) or patients with low grade glioma (WHOII) (n=5), anaplastic astrocytoma (WHOIII) (n=7) or glioblastoma (WHOIV) (n=39) are sh... | https://api.sourcedata.io/file.php?figure_id=5251 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 2 | <p>Figure 2: Endothelial Ang-2 expression reduced pericyte coverage and increased macrophage infiltration in experimental glioblastoma. GL261 cells were intracerebrally transplanted in wild type or Ang-2 gain-of-function mice (Ang-2 DT). Brain tumor sections were stained with antibodies against CD31 and desmin (A), and... | https://api.sourcedata.io/file.php?figure_id=5252 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 3 | <p>Figure 3: Infiltrating leukocyte subsets in human glioma. Paraffin sections of healthy human brain (n=3), low grade glioma (n=12), anaplastic astrocytoma (n=7) and glioblastoma (n=9) were stained for IBA1 (macrophages/microglia), CD15 (granulocytes) and CD3 (T-cells) (A). Quantification of leukocyte subsets in human... | https://api.sourcedata.io/file.php?figure_id=5253 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 4 | <p>Figure 4: Dual anti-Ang-2 and anti-VEGF therapy acts synergistic on vascular normalization and macrophage infiltration in experimental GBM. Immunofluorescence staining of CD31 and desmin in GL261 glioblastoma after single and dual treatment with anti-Ang-2 (AMG386) and anti-VEGF (aflibercept) (A). Corresponding quan... | https://api.sourcedata.io/file.php?figure_id=5254 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 5 | <p>Figure 5: Anti-VEGF therapy led to decreased infiltration of CD68+ macrophages in human GBM. Anti-CD68 (A), anti-CSFR1 (B) and anti-CD206 (C) immunohistochemistry of patient samples derived from treatment-naive GBM (n=24), post-radiochemotherapy (S/RTx/CTx) (n=7) and post-radiochemotherapy + bevacizumab (S/RTx/CTx/B... | https://api.sourcedata.io/file.php?figure_id=5255 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 6 | <p>Figure 6: Bevacizumab therapy leads to reduced vessel density and increased Ang-2 expression. Immunohistochemistry stainings with antibodies directed against CD31 (A) and Ang-2 (B) in treatment-naive GBM, post-radiochemotherapy (S/RTx/CTx) and post-radiochemotherapy + bevacizumab (S/RTx/CTx/Bev) therapy are displaye... | https://api.sourcedata.io/file.php?figure_id=5256 | [
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30573670 | 10.15252/embj.201899466 | CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion | 2018 | Figure 3 | <sd-panel> <p><strong>Figure 3. Multiple PAM influence on binding to a target site</strong></p> <ol type="A"> <li> <p>DNA and crRNA sequence used for experiments of a single target and multiple PAMs. DNA sequence is shown for the single-target single-PAM construct and schematic representation is shown for multiple-PAM ... | https://api.sourcedata.io/file.php?figure_id=24324 | [
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30573670 | 10.15252/embj.201899466 | CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion | 2018 | Figure 4 | <sd-panel> <p><strong>Figure 4. Mechanism of lateral diffusion</strong></p> <ol type="A"> <li> <p>DNA sequences used in tandem target experiments. Complementary sequences to crRNA are marked in pink boxes and PAMs are marked in green boxes. Distances between the protospacers are indicated above the sequences. An illust... | https://api.sourcedata.io/file.php?figure_id=24325 | [
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10.1101/2020.03.24.005298 | A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis | 2020 | Fig. 6. | <sd-panel> <p>IEM detection of viral markers in MERS-CoV-infected cells.(A-G) Immunogold labeling of thawed cryo-sections of MERS-CoV-infected Huh7 cells (12 hpi) for the detection of the indicated viral proteins. (A-C) Structural proteins were detected on virions (black arrowheads) and, for the M and S proteins, also ... | https://api.sourcedata.io/file.php?figure_id=33434 | [
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30530633 | 10.15252/embr.201846221 | Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning | 2018 | Figure 2 | <sd-panel><p><strong>Figure 2</strong> - <strong>Small <sd-pretag id="sdPretag283779571sm" type="tissue" role="component">intestinal fetal</sd-pretag> organoids recapitulate suckling-to-weaning transition <em>in vitro</em></strong>.</p><p> <strong>A-G</strong> <sd-pretag id="sdPretag685066530sm" category="assay">Real... | https://api.sourcedata.io/file.php?figure_id=23969 | [
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30530633 | 10.15252/embr.201846221 | Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning | 2018 | Figure 3 | <sd-panel><p><strong>Figure 3</strong> - <strong>Fetal organoids resemble adult organoids after one month in culture</strong>.</p><p> <strong>A-G</strong> Relative expression detected by <sd-pretag id="sdPretag1421187240sm" category="assay">Real</sd-pretag>-<sd-pretag id="sdPretag897429407sm" category="assay">time qP... | https://api.sourcedata.io/file.php?figure_id=23971 | [
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30530633 | 10.15252/embr.201846221 | Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning | 2018 | Figure 4 | <sd-panel><p><strong>Figure 4</strong> - <strong>Dexamethasone accelerates maturation of fetal organoids.</strong></p><p> <strong>A, B, E, F</strong> Maturation is accelerated in <sd-pretag id="sdPretag749573958sm" type="molecule" role="component">dexamethasone</sd-pretag> treated fetal organoids ( ) compared to contr... | https://api.sourcedata.io/file.php?figure_id=23973 | [
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30530633 | 10.15252/embr.201846221 | Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning | 2018 | Figure 5 | <sd-panel><p><strong>Figure 5</strong> - <strong><sd-pretag id="sdPretag1949810976sm" type="cell" role="component">Spheroids</sd-pretag> and <sd-pretag id="sdPretag779744354sm" type="tissue" role="component">organoids</sd-pretag> show the same protein expression pattern, independently of culture stage/passage.</stron... | https://api.sourcedata.io/file.php?figure_id=23975 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 1 | <sd-panel> <p><strong>Figure 1. Subcellular localization of CA7 and CA2 in fibroblasts.</strong></p> <p>(A) NIH3T3 fibroblasts co-expressing DsRed-CA7 and EGFP-CA2 (<em>n</em> = 4 independent replicates).</p> <p>(B-E) Co-localization of EGFP and the two CA isoforms with filamentous actin studied in fibroblasts expressi... | https://api.sourcedata.io/file.php?figure_id=39022 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 2 | <sd-panel> <p><strong>Figure 2. CA7 binds to filamentous actin and increases actin bundling.</strong></p> <p>(A) Actin co-sedimentation assay shows that CA7 binds to F-actin. The binding is enhanced at more acidic pH (6.5 vs. 7.4) <em>n</em> = 3 independent replicates at each actin concentration, two-way ANOVA, P < ... | https://api.sourcedata.io/file.php?figure_id=39024 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 3 | <sd-panel> <p><strong>Figure 3. CA7 overexpressing NIH3T3 are resistant to latrunculin B treatment.</strong></p> <p>(A,B) NIH3T3 cells transfected with DsRed (A) or DsRed-CA7 (B) were incubated in growth medium with 5 µM Latrunculin B for 0, 2, 5, 10, or 30 minutes, or in an equal amount of DMSO for 60 minutes. Analyse... | https://api.sourcedata.io/file.php?figure_id=39026 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 5 | <sd-panel> <p><strong>Figure 5. Subcellular localization of the chimeric CA7 constructs in fibroblasts.</strong></p> <p>(A-C) NIH3T3 fibroblasts expressing EGFP-CA7-mutant1 (A), EGFP-CA7-mutant2 (B), and EGFP-CA7-mutant3 (C). F-actin is visualized with Phalloidin-594. In the right-most panel of (A-C) are the normalized... | https://api.sourcedata.io/file.php?figure_id=39030 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 6 | <sd-panel> <p><strong>Figure 6. Localization of the overexpressed CA2 and CA7 in neurons.</strong></p> <p>(A) Isoform-specific subcellular localization shown in cultured hippocampal neurons (DIV14) co-expressing DsRed-CA7 (<em>left</em>) and EGFP-CA2 (<em>middle</em>).</p> <p>(B,C) Representative confocal images of pre... | https://api.sourcedata.io/file.php?figure_id=39032 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 7 | <sd-panel> <p><strong>Figure 7. Layer 2/3 cortical pyramidal neurons in CA7 KO mice have high dendritic spine density and smaller spines but mEPSC frequency and amplitude are not affected</strong></p> <p>(A) Comparison of mEPSCs in cortical layer 2/3 pyramidal neurons from P30 - P40 WT and CA7 KO mice. Sample traces of... | https://api.sourcedata.io/file.php?figure_id=39033 | [
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27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf1 | <p>(<b>a</b>) Knockdown of <named-entity id="named-entity-253">RARα</named-entity> in NIH3T3 mouse fibroblasts was conducted using two different shRNAs, sh1 and sh2, compared to control (Ctr). Left, representative immunoblot. Actin is shown as loading control and full-length blots are shown in <sir rid="S1" refobjid="n... | https://api.sourcedata.io/file.php?figure_id=3208 | [
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27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf2 | <p>(<b>a</b>) Immunoblot for <named-entity id="named-entity-259">LC3-II</named-entity> in control mouse fibroblasts (Ctr) or those knocked down for <named-entity id="named-entity-260">RARα</named-entity> (<named-entity id="named-entity-261">RARα</named-entity>(−)) maintained in the presence or absence of serum for the ... | https://api.sourcedata.io/file.php?figure_id=3209 | [
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"mapping_status": "mapped",
"ncbi_gene_id": "19401",
"original_type": "gene",
"role": "intervention",
"text": "RARα",
"type": "geneprod",
... | |
27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf3 | <p>(<b>a</b>) Rates of degradation of long-lived proteins in mouse fibroblasts untreated (None) or treated with 40 μM <named-entity id="named-entity-268">ATRA</named-entity> and maintained in the presence or absence of serum. Values are expressed as a percentage of proteolysis; <i>n</i> = 3. (<b>b</b>) Percentage of ly... | https://api.sourcedata.io/file.php?figure_id=3210 | [
{
"ext_dbs": "Uniprot///Uniprot",
"ext_ids": "Q91VR7///Q9CQV6",
"ext_tax_ids": "10090///10090",
"ext_tax_names": "Mus musculus///Mus musculus",
"mapping_source": "unknown",
"mapping_status": "unmapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"tex... | |
27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf5 | <p>(<b>a</b>) Mouse fibroblasts expressing the KFERQ-mCherry1 photoactivatable reporter without (None) or with 20 μM of the indicated compounds imaged 16 h after photoactivation. Insets show higher-magnification images. Nuclei are labeled with <named-entity id="named-entity-284">DAPI</named-entity>. Scale bars, 10 μm. ... | https://api.sourcedata.io/file.php?figure_id=3212 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P10276",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "RARα",
"type": "geneprod",
"unipr... | |
27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf6 | <p>(<b>a</b>) Rates of degradation of long-lived proteins in control mouse fibroblasts or <named-entity id="named-entity-299">RARα</named-entity>(−) or <named-entity id="named-entity-300">LAMP-2A</named-entity>(−) (<named-entity id="named-entity-301">L-2A</named-entity>(−)) cells left untreated (None) or treated with 2... | https://api.sourcedata.io/file.php?figure_id=3213 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "16784",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "16784",
"original_type": "gene",
"role": "intervention",
"text": "LAMP-2A",
"type": "geneprod... | |
27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf7 | <p>(<b>a</b>) Immunoblot for the indicated proteins in homogenates (Hom) and lysosomes (Lys) isolated from cells untreated (None) or treated for 12 h with 20 μM of the indicated compounds. (<b>b</b>) mRNA levels of <named-entity id="named-entity-311">LAMP-2A</named-entity> in control mouse fibroblasts (left) or <named-... | https://api.sourcedata.io/file.php?figure_id=3214 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "16784",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "16784",
"original_type": "gene",
"role": "assayed",
"text": "LAMP-2A",
"type": "geneprod",
... | |
10.15252/embj.2019101996 | The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin | 2019 | Figure 1 | <sd-panel> <p><strong>Figure 1. The N-end rule pathway controls LT-induced NLRP1B inflammasome activation.</strong></p> <p>A, B Effects of basic and bulky hydrophobic amino acids on LT-induced pyroptosis and caspase-1 activation in RAW<sup>RA</sup> cells. Cells were pre-treated with 10 mM indicated amino acids prior to... | https://api.sourcedata.io/file.php?figure_id=30609 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P15917",
"ext_tax_ids": "1392",
"ext_tax_names": "Bacillus anthracis",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
"text": "LT",
"type": "geneprod",
... | ||
10.15252/embj.2019101996 | The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin | 2019 | Figure 2 | <sd-panel> <p><strong>Figure 2. The ubiquitin ligase UBR2 is required for LT-induced NLRP1B activation.</strong></p> <p>A RFP-ASC specks formation assay of the effect of <em>Ubr2</em> knockdown on LT-induced inflammasome activation. RAW<sup>RA</sup> cells were transfected with a control siRNA or <em>Ubr2</em>-targeting... | https://api.sourcedata.io/file.php?figure_id=30610 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "224826",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "224826",
"original_type": "gene",
"role": "intervention",
"text": "Ubr2",
"type": "geneprod"... | ||
10.15252/embj.2019101996 | The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin | 2019 | Figure 3 | <sd-panel> <p><strong>Figure 3. UBE2O functions together with UBR2 to mediate NLRP1B inflammasome activation.</strong></p> <p>A Immunoblotting of caspase-1 activation in Ubrs-knockdown BMDMs derived from the 129/Sv mice. Cells were transfected with the indicated siRNA for 60 h, and then treated with WT LT (+) or its E6... | https://api.sourcedata.io/file.php?figure_id=30611 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P29452",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "caspase-1",
"type": "geneprod",
... | ||
10.15252/embj.2019101996 | The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin | 2019 | Figure 4 | <sd-panel> <p><strong>Figure 4. LT cleavage of NLRP1B triggers N-end rule-mediated degradation of NLRP1B for inflammasome activation.</strong></p> <p>A Domain structure of NLRP1B. The LT cleavage site and the FIIND auto-cleavage site are marked.</p> <p>B Effect of LT treatment on NLRP1B protein level. 293T cells were t... | https://api.sourcedata.io/file.php?figure_id=30612 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P15917",
"ext_tax_ids": "1392",
"ext_tax_names": "Bacillus anthracis",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
"text": "LT",
"type": "geneprod",
... | ||
27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 1 | <p><strong>Fig</strong><strong>ure</strong><strong> 1. Therapeutic administration of IFN</strong><strong>α and IFNλ</strong><strong> differentially influences the outcome of IAV induced disease. </strong></p>
<p><strong>A</strong>. Relative antiviral activity of IFNα (circles) or IFNλ (triangles). AEC cultures were sti... | https://api.sourcedata.io/file.php?figure_id=9576 | [
{
"ext_dbs": "Uniprot///Uniprot",
"ext_ids": "Q8CGK6///Q4VK74",
"ext_tax_ids": "10090///10090",
"ext_tax_names": "Mus musculus///Mus musculus",
"mapping_source": "unknown",
"mapping_status": "unmapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
... | |
27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 2 | <p><strong>Fig</strong><strong>ure</strong><strong> 2. IFNα treatment correlates with increased inflammation during IAV infection. </strong></p>
<p><strong>A, B</strong><strong>.</strong> Mice were infected with PR8 and treated with IFNα (circles, 1.45μg/50μl), IFNλ (triangles, 2.6μg/50μl) or Veh Ctrl (squares) as prev... | https://api.sourcedata.io/file.php?figure_id=9577 | [
{
"ext_dbs": "Uniprot///Uniprot",
"ext_ids": "Q8CGK6///Q4VK74",
"ext_tax_ids": "10090///10090",
"ext_tax_names": "Mus musculus///Mus musculus",
"mapping_source": "unknown",
"mapping_status": "unmapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
... | |
27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 3 | <p><strong>Fig</strong><strong>ure</strong><strong> 3. IFNα, but not IFNλ treatment induces </strong><strong>pulmonary </strong><strong>cytokine secretion through activation of immune cells. </strong></p>
<p><strong>A, B</strong><strong>.</strong> IL-6, IP-10 and MCP-1 concentrations were measured by multiplex cytokine... | https://api.sourcedata.io/file.php?figure_id=9578 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P10148",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "MCP-1",
"type": "geneprod",
"uni... | |
27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 4 | <p><strong>Fig</strong><strong>ure</strong><strong> 4. Pathogenicity-related gene clusters are specifically induced by IFNα, not by IFNλ treatment. </strong></p>
<p>Mice were treated with IFNα (1.45μg/50μl), IFNλ (2.6μg/50μl) or Veh Ctrl (50μl PBS), and whole lungs were taken at 18hrs post treatment for global analysis... | https://api.sourcedata.io/file.php?figure_id=9579 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P07351",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
"text": "IFNα4",
"type": "geneprod",
... | |
27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 5 | <p><strong>Fig</strong><strong>ure</strong><strong> 5. IFNα, but not IFNλ treatment induces cytokine secretion from human immune cells. </strong></p>
<p><strong>A</strong>. Human AEC cultures were stimulated for 4hrs with IFNα (circles) or IFNλ (triangles) at specified concentrations then assessed for stated ISG induct... | https://api.sourcedata.io/file.php?figure_id=9580 | [
{
"ext_dbs": "Uniprot///Uniprot///Uniprot///Uniprot",
"ext_ids": "Q8IZI9///K9M1U5///Q8IZJ0///Q8IU54",
"ext_tax_ids": "9606///9606///9606///9606",
"ext_tax_names": "Homo sapiens///Homo sapiens///Homo sapiens///Homo sapiens",
"mapping_source": "unknown",
"mapping_status": "unmapped",
"ncbi... | |
27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 1 | <p><strong>Figure 1</strong><strong>.</strong> <strong>High </strong><strong>levels of </strong><strong>ZEB1 expression </strong><strong>are </strong><strong>correlate</strong><strong>d</strong><strong> with low </strong><strong>MITF</strong><strong> level</strong><strong>s</strong><strong> and</strong> <strong>are</st... | https://api.sourcedata.io/file.php?figure_id=9817 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "4286",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "4286",
"original_type": "gene",
"role": "assayed",
"text": "MITF",
"type": "geneprod",
"uni... | |
27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 2 | <p><strong>Figure </strong><strong>2</strong><strong>.</strong> <strong>High ZEB1 </strong><strong>and </strong><strong>low </strong><strong>MITF</strong><strong> level</strong><strong>s</strong> <strong>are</strong><strong> associated with inherent resistance to </strong><strong>MAPKi</strong><strong> in </strong><str... | https://api.sourcedata.io/file.php?figure_id=9818 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "4286",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "4286",
"original_type": "gene",
"role": "assayed",
"text": "MITF",
"type": "geneprod",
"uni... | |
27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 3 | <p><strong>Figure </strong><strong>3</strong><strong>.</strong> <strong>ZEB1 expression is activated in </strong><strong><em>BRAF</em></strong><strong><em><sup>V600</sup></em></strong><strong>-</strong><strong>mutated </strong><strong>melanoma cell lines with acquired resistance to </strong><strong>BRAFi</strong><stron... | https://api.sourcedata.io/file.php?figure_id=9819 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P15407",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "FRA1",
"type": "geneprod",
"unipr... |
YAML Metadata Warning:The task_categories "named-entity-recognition" is not in the official list: text-classification, token-classification, table-question-answering, question-answering, zero-shot-classification, translation, summarization, feature-extraction, text-generation, fill-mask, sentence-similarity, text-to-speech, text-to-audio, automatic-speech-recognition, audio-to-audio, audio-classification, audio-text-to-text, voice-activity-detection, depth-estimation, image-classification, object-detection, image-segmentation, text-to-image, image-to-text, image-to-image, image-to-video, unconditional-image-generation, video-classification, reinforcement-learning, robotics, tabular-classification, tabular-regression, tabular-to-text, table-to-text, multiple-choice, text-ranking, text-retrieval, time-series-forecasting, text-to-video, image-text-to-text, image-text-to-image, image-text-to-video, visual-question-answering, document-question-answering, zero-shot-image-classification, graph-ml, mask-generation, zero-shot-object-detection, text-to-3d, image-to-3d, image-feature-extraction, video-text-to-text, keypoint-detection, visual-document-retrieval, any-to-any, video-to-video, other
YAML Metadata Warning:The task_categories "named-entity-linking" is not in the official list: text-classification, token-classification, table-question-answering, question-answering, zero-shot-classification, translation, summarization, feature-extraction, text-generation, fill-mask, sentence-similarity, text-to-speech, text-to-audio, automatic-speech-recognition, audio-to-audio, audio-classification, audio-text-to-text, voice-activity-detection, depth-estimation, image-classification, object-detection, image-segmentation, text-to-image, image-to-text, image-to-image, image-to-video, unconditional-image-generation, video-classification, reinforcement-learning, robotics, tabular-classification, tabular-regression, tabular-to-text, table-to-text, multiple-choice, text-ranking, text-retrieval, time-series-forecasting, text-to-video, image-text-to-text, image-text-to-image, image-text-to-video, visual-question-answering, document-question-answering, zero-shot-image-classification, graph-ml, mask-generation, zero-shot-object-detection, text-to-3d, image-to-3d, image-feature-extraction, video-text-to-text, keypoint-detection, visual-document-retrieval, any-to-any, video-to-video, other
SODA-SPROUT: Role-Filtered Named Entity Linking Dataset
Dataset Description
This dataset is an improved version of the SODA-SPROUT NEL dataset, specifically filtered to include only the most relevant biological entities for Named Entity Linking tasks. The dataset focuses on proteins and genes with roles of 'assayed' and 'intervention', which represent the core biological entities that are actually measured or manipulated in scientific experiments.
Key Improvements
- Role Filtering: Only includes entities with roles 'assayed' (104,286 entities) and 'intervention' (80,127 entities)
- Higher Quality: Removes less relevant entities like 'reporter', 'component', 'normalizing', and 'experiment' roles
- Better NEL Performance: Focuses on the most important biological entities for linking tasks
- Reduced Noise: 16,532 figure-level records (vs. 21,000+ in unfiltered version)
Dataset Structure
Statistics
- Total Records: 16,532 figure-level records
- Training Set: 14,880 records (90%)
- Validation Set: 825 records (5%)
- Test Set: 827 records (5%)
- Total Entities: 184,413 (104,286 assayed + 80,127 intervention)
- Unique Papers: 3,101 papers
Data Format
Each record contains:
- Paper Context: PMID, DOI, title, abstract, year
- Figure Context: Figure label, caption, figure URL
- Entities: List of gene/protein entities with:
text: Entity mention texttype: "geneprod" (for NER compatibility)original_type: "gene" or "protein" (from SourceData)role: "assayed" or "intervention"ext_tax_names: Organism taxonomy nameuniprot_ids: Ground truth UniProt accessionsmapping_status: "mapped" or "unmapped"
Usage
from datasets import load_dataset
# Load the dataset
dataset = load_dataset("EMBO/soda-nel")
# Access splits
train_data = dataset["train"]
val_data = dataset["validation"]
test_data = dataset["test"]
# Example record
record = train_data[0]
print(f"Paper: {record['title']}")
print(f"Figure: {record['fig_label']}")
print(f"Caption: {record['caption']}")
print(f"Entities: {len(record['entities'])}")
Role Definitions
- Assayed: Proteins/genes that were actually measured, quantified, or tested in the experiment
- Intervention: Proteins/genes that were manipulated, targeted, or used as experimental interventions
Data Sources
- Source Dataset: EMBO/SourceData
- Original Paper: SourceData: A platform for the large-scale curation of unstructured data from the scientific literature
- UniProt Mapping: NCBI Gene IDs mapped to UniProt accessions via UniProt REST API
Citation
If you use this dataset, please cite both the original SourceData paper and this improved version:
@article{source_data_2023,
title={SourceData: A platform for the large-scale curation of unstructured data from the scientific literature},
author={...},
journal={...},
year={2023},
url={https://arxiv.org/abs/2310.20440}
}
License
This dataset is released under the MIT License. The underlying SourceData is available under its original license.
Updates
- v1.1.0: Added role filtering for 'assayed' and 'intervention' entities only
- v1.0.0: Initial release with all entity roles
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