Datasets:
tamarpeleg
/
EC_exercise

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC_number
stringclasses
260 values
Active_site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
Q6AXJ9
2.7.11.22
ACT_SITE 126; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MEKYEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPIIKKIALREIRMLKQLKHPNLVNLMEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDFGFARILTGPCDYYTDCVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAELLSGAPLWPGKSDVDQLYLIRKTLGELIPRHQQVFSTNQFFSGVCVPEPQEMEPLELKYPNLSYQALSLMKGCLRMDPAERLSCEQLLEQPYFDSLREESESVTRELDRKKRTRQPRKHLPPGYLPQLASSTVFPAVENRRNYNNLRKFNYHLPNI
102
A0A1D5Q074
3.1.1.4
ACT_SITE 83; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 128; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MARDFQQLPPLLSAGIMQLALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPLFFYWPYGCYCGPGGRGQPKDATDWCCQTHDCCYDHLKTHGCCIHTDHYRYSFSHGDIHCSDKGSWCEQQLCACDKEVAFCLKRNLDTYKKRLRFYWRPRCQGQTPGC
130
A0A2K2AAJ3
3.1.1.11
ACT_SITE 375; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASKLITLCTTSLLLLLLCSPSLANYSFSSIFNTPETICENTRFPHFCKSSLPHNKPGTIHDYAKISFQQSLSHAQRLPSTLYKSTILALEDCLFLAQENIDYLSYVMETLKSSADDALQGYQAEDLQTLLSATLTNQETCLDGLQYRSSSSSIKNALLVPISNGTMHYSVALALFTRGWAHSTMKGRYLTERKHVFSDLEDGASKGLPLMMSSKDKQIYDKVVVVDPYGSGKFRTITEAVAAAPNNTFASNGYYVIYVVAGVSNEYVSIPKSKKYLMMIGAGINQTVITGNRSVDDGWTTFNSATFAVLGQGFVAVNITFRNTAEAIKHQAVAVRSGADMSTFYKCSFEGYQDTLYTHSLRQFYRDCDIYGTIDYIFGNAAVVLQNCNIYSRLPLDNQFNTLTAQGRTDPNQNTGTSIQNCTIKAAKDLASSNSSTKTYLGRPWKEYSVTVIMQSFIDSVIDPAGWSAWSGEFALSTLYYAEFNNTGPGSNTTNRVQWPGYHVISGTEAANFTVSNFIAGGFWLPGTGVPYVGGLQ
125
B9RSX6
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MMARDGILIAISSLLVLAAVGVSNADGLSLRFYNTSCPDAELIVRNITRNRAQSDSALGAKLLRMHFHDCFVRGCDASILLDAVGIQSEKDTIPNQSLSGFDVIDEIKTQLEQVCPGVVSCADILALASRDAVSLSFQKPLWDVLTGRRDGTVSLASEVNGNIPSPFADFNTLMQQFSNKGLDVNDLVVLSGGHTIGVAHCATFTNRLYNFTGIGDMDPSLDKTYAELLKTKCPNPSNPATTVEMDPQSSLTFDKNYYDILLQNKGLFQSDAALLENTQSARIVRQLKTSNAFFAKFAISMKKMGAIEVLTGNAGQIRQNCRVVNP
14
A0A8I6A077
3.1.3.48
ACT_SITE 297; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 299; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"
MTPRKNFSGFLKTVCEDRRDLQSSHISVCKETAVLMEEEQDLPERPVKKAKMQEPGEQTLSQVNNPDTSDQKPETASLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFASSTNASLISTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDTENTALAATTYQTEKPGAMGPAPATQRLPSDSSTSPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
149
B7P242
2.5.1.18
ACT_SITE 17; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1"
MAAPTKVAVELFYDVISPYSWLAFEALHRYRTPWNLDLKLRPFFLGGVMKESNNRPPAMVPNKAAYMQADLRRSSKLFQVPIKVPDFFFEFITTKSTINAQRFLVALQLRQPQFLEEASRGFWKRFYQDNKDIAEEDSIAAVGQAIGMDAATLKETLGLMKDDSVKEGLKKNTSDAVDVYGAFGAPTIVAHVPGGKPEMFFGSDRFEQMACVLGKQWHGPVLPQGAKL
77
A0A2C9UH80
5.1.3.3
ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 325; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MGKFCLVFCISILVAFGEVINGYQEEEKIGVYELKQGDISLKLTNYGARIISLFLPDKNGKLDDVVLGYDSAQDYKNDTSYFGATVGRVANRIAGAQFTLNGTQYKLVPNEGKNMLHGGPKGFSKVVWKVKKYKPDSRSPHIIFIYHSLDGDQGFPGNLRVAVGYTLIGNKLSITMKAKAKNKATPVNLAQHAYWNLAGQNSGDILSQELQLFASHYTPVDNQLIPTGKIVSVKGTPYDFLKPYTIGSRIKQLANGYDINYAIDDSEKKKKTMMKKVAIVKDKKSGRAFELFSNQPGVQFYTSNSLTQKGKGGFVYKPHAALCLETQGFPDAVNHPNFPSQIVNPGESYNHYMLFKFSVY
211
G7I8E1
3.2.1.1
ACT_SITE 212; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 237; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MGNSTSVTTTKGQKPPETHTHNNEVSVINLSSHQGPDAVLRDGKEILFQAFNWESHKYDWWANLESKVPDIAKAGITSAWLPPPTHSFSPEGYTPQNLYSLNSKYGSEHQLKALLQKLKQQKVRAMADIVINHRVGTTQGHGGMYNRFDGIPLPWDERAVTSSTGGLGNRNTGAIFHGFPNIDHTQDFVRKDIIGWLQWLRHNVGFQDFRFDYAKGYSPKYVKEYIEGPKPMLSVGEYWDTCNYNGSTLDYNQDNHRQRIINWIDGTGQLSTAFDFTTKGILQEAVKREFWRLRDAQGKPPGVIGWWPSRSVTFVDNHDTGSTQAHWPFPSDHVMEGYAYILTHPGTPTIFYDHFYDWNNSFHEQIVKLIDTRKRQDIHSRSPIRILEAKHNVYSAIIGEKVCMKIGDGSWSPSGREWTLSTCGYNYAVWHK
157
Q2G2A3
1.8.1.4
ACT_SITE 446; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MVVGDFPIETDTIVIGAGPGGYVAAIRAAQLGQKVTIVEKGNLGGVCLNVGCIPSKALLHASHRFVEAQHSENLGVIAESVSLNFQKVQEFKSSVVNKLTGGVESLLKGNKVNIVKGEAYFVDNNSLRVMDEKSAQTYNFKNAIIATGSRPIEIPNFKFGKRVIDSTGALNLQEVPGKLVVVGGGYIGSELGTAFANFGSEVTILEGAKDILGGFEKQMTQPVKKGMKEKGVEIVTEAMAKSAEETDNGVKVTYEAKGEEKTIEADYVLVTVGRRPNTDELGLEELGVKFADRGLLEVDKQSRTSISNIYAIGDIVPGLPLAHKASYEAKVAAEAIDGQAAEVDYIGMPAVCFTEPELATVGYSEAQAKEEGLAIKASKFPYAANGRALSLDDTNGFVKLITLKEDDTLIGAQVVGTGASDIISELGLAIEAGMNAEDIALTIHAHPTLGEMTMEAAEKAIGYPIHTM
36
F6Y7X8
2.7.11.1
ACT_SITE 326; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 343; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MNYREQLMSRAVPGQFDDADSSDSGSMVSMETSKDAQAVSENSHQPLNEVDEEIQENDFEEYEDYDDDDDDWDWDDEVGKLTKGFSSSGGSNPQVNRQTNHLNSSKMSTPADKALRKFENKINLDKLNLADSVINKVTEKTRQKDADMYRVKDKADRATVEQVLDSRTRITLFKMLSRGIISQINGCISTGKEANVYHASTTDGENRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVQTWAEKEMRNLIRLNIAKIPCPEPIMLKHHVLVMSFIGKDDMPAPLLKNAQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYCNGDVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFLKHSVAVMTVRELFEFITDPSITKDNMDDYLLKAMEIAGQRTEEQRSNQDHVDEEVFKRAYIPRTLNEVKNYERDVDIMMKMKEEDMALNVQQDNILYQTVTGLKKDLSGVQKVPALLEKQSEQVDSDSENTSDSEEPDSEEHGDQPHPRTYPIDHEMDKKERKKIVKEAQREKRKNKIPKHVKKRKEKVAKMKKGR
99
Q9JJ78
2.7.12.2
ACT_SITE 166; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MEGINNFKTPNKSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKISLLCDDHYRTVYQKRLTDEAKILKNLNHPNIIGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADVFAFGLTLWEMMTLCIPHVNLPDDDVDEDATFDESDFDDEAYYAALGTRPSINMEELDDSYQKAIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKH
108
A0A8M1RSA0
2.3.2.26
ACT_SITE 1440; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MATGTTTTAREHLLVVRRRSPHMRYTLSPENLRSLSAQGGSGGGGSRGGAPEPMGLQRANSDTDLVTSDSRSSLTASTYQFTLGRGQNLVISWDIKEEVDATDWIGLYHIDETCPANVWDSKNRGVNGTQRGQIVWRLEPGPYFMEPETKICFKYYHGVSGALRATTPCITVKNPGVTVGAEGQVDGQSVTEHCRKLVSFTLSDIRAQGLKKGMFFNPDPYLKMSIQPGKRNGFPTFSHHGQERRTSIISNTTNPVWHGEKYTFVALMTDVLEIEVKDKFAKSRPIIKRFLGQLIIPVQRLLERHTAGDQHVSYTLCRRLPTEHVSGQLHFRVEITFNGHEDAMGSLLGASAMNGDPGSPSDDEDVLQPVSRMVRGPSPTGSEGSLHGDAFRPDECMMDPEEDRLLRDGAPDLAEGAPAHTHRQSSLNDYLDAIEAPKPPGDRPLGASSPKLRSSFPTDTRLNAMLHIDSDEDEEGHASRDTALTNGMPRPEGHASSERGKGEVHVKNRERLESEAASSATDTEATASVSSSGTTKSQNGGGAEGGQEGAAISGGLTQSISSFQQPALRIQDEEGAAPQASSRTEGSSEAPAVSEASASAIYTVNEVGGATATNQPERMNSSEMTNQEEEDEEIWQRRRSLQASGNESQAEAMELGNEVRRTADEAQAALITDGETGACAQVNGHQPMRSLPSVRHDISRYQRVDEPLPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTITNERTEEQAAEMPPDDLTTSDLLHHSIPEYRRDGVVGPASSRSRLTLLLQSPSAKFLTSPDFFTVLHSNPSAYRMFTSNTCLKHMISKVRRDAHHFERYQHNRDLVAFLNMFANKQLDLPRGWEMKHDHTGKPFFVDHNCRATTFIDPRLPLQSARPSSLLAHRQHLSRQRSHSAGEVGDDPRHAGPAVLPRPSNTFTANRNQCQDLVPVAYNEKIVAFLRQPNIFDILQERQPELIRNHSLREKVQFIRNEGASGLARLSSDADLVILLSLFEEEVMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSKLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDNDIEDMLDLTFTVNEEVFGQITERELKPGGANIPVSEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLGDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKMLTAVEETSTFGLE
65
Q552C1
2.7.11.1
ACT_SITE 1156; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTSVGTTLIVKPANNSGGSDGNIKNNNNNNNNNNNNNNNNNNSNSGNNSNNNSFIDDQVLHTGYLTKQGGRIQNWKIRWFVLKRGTLSYYLSPINWEYTKPRGVIYLTKKTELKEVDHRNRRHCFAVNPNYISENQSIIQQQQNQPILRSSSDSVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSKLYPNSTRIYLISAQTVFDKSKWIEMIKLAISSDNSQDSKLKRANHQLEKVKDLVFSNRKGSIPTFPSLLNRTIATESLNDLIKVHLSKKRFYFYHDNLTLPALSYIDSESPVNLQEIHHQHLILLQQQKEELNKKLKKIQQQNNIGGGGSGSNIANSANKINNKNNDKINGVGSGEDKNNNKGGGGDNNSQSSSSSVSPTTVSPSVSPLSSSPTKPPIILSKKPLPTPPRNISTSDNGSGTDSPFYNSAITRLPLISTSVGMVGPNGMVNITSMNTTTTTTTTTTTTAPTTTNTNTNIKPLPGIQQNKLQLIQNKDGGGGGGGVLKRTNPLLSTSAPSMAYNQLVANSGIIHKHQPKIVVFHLVRDSFQISNIGGCSFNFEILSPFDPNFTLNFIPSSGTIQKGDSLTVLVELMAYNHIETDIYSTLHIIGGMEFTLFCRIETDPYLPLFLKSCAGSVLPLEKQMKMESFMKKNPTMVKSIQELAHTLILDGRNIIPLHLSNNININNNNNNGGGGSGYNIGGGSNNSIGGSGSNNNSNVNISNGWNIENSNRRNSGGCLNLVGGSGGGGLINNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGSGLLSSSPLITISNQNTPTPQARVKLSKYILNFQRNQKKNSVGDVESVKIYQLLTDKFLISNSGSADASFQFHFPSRGKKNDLFSLSLVPTNGTVSKGEWFYIKSTLTVFVETEISEMIQLIINQREVHHILITVKCENIHPGNKEIDLEKEVVLHERLGTGATGDIYRGLISQDNLNRHISNQDSSGSNSSGSGSGHNWLIARNPSNDIINKDAIIGSGPQIIVAVKKLHPLADPSPEMIQDFYNEVRVLSMFNHPNVVKYVGGCTKIANWSIVMEYVPGGNLMDVLANPVLVIPYKLVLRMALDIAKGLHYLHSLGILHLDMKSPNLLVSSLSTSAKVNIKVADFNTCINRSRITAGFFNRHTGSGDNNKVEKDSKKGTTLWMAPEVIRGAMYSEKCDVYSFAIIMWEMVTRKLPYSHIAFNCEVEDQVLKGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSISKMIESNDITEQKAKASFKGLRRTQSNSTLNLLQVQNNNNNSNNNNNNNNNNNNNNSNSNLNNCNNSSPNLGTNSANNDSGVSVLQTCSDIGVGSTGTNSGTSGTNSGFDSPVIVTKDYHLISNLQKLDLHSNDGSDTNGSQIGFKSDINSKKSSLEVHSKHKSKRFSYDGGSSRASINTLNNDSNLPFKFSPPSTPQSSFLQLKKLDKELKSNLESNAGTKHSFIRYKPSFTNVTSAKSKLNLNNNNNN
99
Q7T0L5
1.8.1.9
ACT_SITE 477; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MRIASVVRKAGLLGGIHHDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPRGTKWGIGGTCVNVGCIPKKLMHQAALIGSTMKDAPHYGWGTPYEIQHDWGKMAGAVQNYVKSLNWGHRIQLQDKKVKYFNLKANFVDEHCIRGVTKAGKETLVTAQNIVIATGGRPKYPTHVPGALEYGITSDDLFWLKESPGKTLVVGASYVSLECAGFLTGIGLNTTAMVRSIPLRGFDQQMAYLVADYMESHGTKFLWKCTPSHVEKLKNGKLQVTWKNTQSGKEGVDIYDTVMWAVGRAAETQYLNLEKVGVKIKPETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLAIRLFSGSAELMDYDSVPTTVFTPLEYGCVGISEEEAKERYGDDNIEVFHAFYKPLEFTVAERDASQCYIKIICLRKHDQRILGLHLTGPNAGEVIQGFALGIKCGATYPQLMCTVGIHPTCAEEVTKLHITKRSGLDPTVTGC
37
Q8Y8G6
3.1.3.48
ACT_SITE 8; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 14; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 124; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"
MVKVVFVCLGNICRSPMAEGLFRKEVANAGLTDEIKIDSAATGTWNLGKPPHRGTQEVLKKHGVDYQAMRARKISDADFKEADFIIGMDQQNLADLNALNNNPDVIIRSLMSFVSGQEDKDIPDPYYTGDFDETERMVTEGVKALLAYITKK
149
Q8K3R3
3.1.4.11
ACT_SITE 305; /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"; ACT_SITE 350; /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
MTSQIQDLLATDQDLLLMQEGTMMRKVRTKSWKKLRYFRLQNDGMTVWHGSQPESMPKPTFSISDVERIRKGQDSELLRYLVEEFPLEQGFTVVFHGRRPNLDLVANSVEEAQIWMRGLQLLVDLVASMDHQEQMDQMLNEWFQQADRNQDGRMSFREAQRLLLLMNVEMDEEYAFSLFQEADVTQSDDLGSEEFVQFYKALTKRTEIEEIFEDFSSDKQKLTLLEFVDFLRKEQKEKDHAPDLALELIDRYEPSENGRLLHVLSKDGFLKYLCSKDGNIFNSDCLPIYQDMTQPLSHYYINSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGHTLTSRILFKDVLATLAQYAFQSSDYPLILSLENHCTWEQQRTMAHHLTEILGEQLLRNTLEGLLVDSMPSPEQLRGKILVKGKKLRTIEVDKEEEEEEEEEELEKDEGPDLDPASPELDTQPQPETQGQAAGNKKERKKKVMKCPMSCLLICGHVMAQAPSSIPESILLSKQFLLLSSTTIMCPDLSALVVYLRTVPFCSFTHSKENYHIYDISSFSESKAKNLIKEAGNEFVQHNARQLCRVYPSGLRTDSSNFNPQEHWNVGCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNPERPISLYKAQILVVQVISGQQLPKVDKTKETTVVDPLVKVELYGVPEDTKEQETSHVENNGINPYWGETFYFRLQVPELAMLRFVVKDYSRKSRNNFIGQYTLPWTCMKQGYRHVSLLSRDGTSLNPASIFVYTCMQEDLDMDEP
153
A0A9J7L0A2
2.7.11.13
ACT_SITE 577; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50"
MVVFNGLIKVRVCEAQDLRPTDYATRHAVVRPASQVLDPYVKLNVDDTCFGQTTAKPKTLNPKWKEDFTTEVHNGHTVGVTVFHNTTIGPDDFVANCNVTFEELLQEQGGSADIWVDLEPAGKVHLIVELKGAACEPGKTTLAAAASASASASAVAEKVFRPGMGRHQRKNAMRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELVVTKCPGQKEPIQDEFLTSRFSINMPHRFSTHTYKRPTFCDHCGSLLYGLFKQGLQCEACKMNVHMRCQKNVAHNCGINPKEIALKLAELGLTGDKLTPRKKKGGSMAYHQGRPHQVNKARDLWKSLKQTVPASWVQDKKLKTSNTHDTAKKAELEGKGDNEKQDKRPHSAPRIDDKEKPCTDLNEKPQDVEENASSTSSNSTMTSPDLSGAPDIRHRRLKLDDFNFIKVLGKGSFGKVMLAELKESDDVYAIKVLKKDVIIQDDDVDCTMTEKRVLLLSRKHPFLTALHACFQTKDRLFLVMEYVNGGDLMFQIQRARKFDEPRSKFYSAEVILALMFLHEHGIIYRDLKLDNILLDADGHIKLADFGMCKEGILNGKLTTTFCGTPDYIAPEILQELEYGPSCDWWALGVLLYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVAILKAFMTKNPAKRLGCVAAQGGEAAIKQHVFFKDIDWEALLDRRVKPPFRPKIKTKKDANNFDQDFTREEPVLTPTDDAVVKAINQEEFKGFSFTGDDTEV
100
A0A8J0U0F8
2.3.2.26
ACT_SITE 758; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MSNQGSRRNGPVKLRLTVLCAKNLVKKDFFTFSLASTAGLPDSFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSITISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGSGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGASCGQTSDPRISERRVRSQRHRNYMSRTHLHTPPDLPEGYAFFSGAKIERRTFTTENHIFSERIHSPESKLEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLGNVNCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQQLKEQQPPQVVSLCQLPDEVECLTVPRYKRDLVHKLKSLRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHDMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGELIQHELKPSGKSIPVTEDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIICGLGKIDVSDWKSNTRLKHCTTDSNIVKWFWKAVESFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNNLPKAHTCFNRIDIPPYETYEKLYEKLLTAIEETCGFAVE
65
A0A804L6P1
3.1.1.11
ACT_SITE 165; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MPSNRVLRVATDGSGEFRTVQEAIDAVPLSNRVRTVIQVAPGLYREPVYVPKTKNFITLAASRPESTILSWDNTATRINHHQPSRVIGTGTFGCGSTIVEGEDFIAENITFENKAPQGSGQAVAVRVTADRCAFYNCRFLGWQDTLYLHHGKQYLRDCYIEGSVDFIFGNSTALLEHCHIHCKSQGFITAQSRKSSQDSTGYVFLRCIITGNGGTSYAYLGRPWGPFGRVVFAYTWMDACIKPVGWHNWDKSENERSACFYEYRCSGPGCCLTNRATWSRELVDEEAEQFISHLFVDPDPSWPWLAQKMAIRVPHSA
125
O64780
2.7.11.1
ACT_SITE 625; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDFLFLLLERKNKHMGKKRVVLLWLSIFISFSSAEITEESPLSIGQTLSSSNGVYELGFFSFNNSQNQYVGISFKGIIPRVVVWVANREKPVTDSAANLVISSNGSLQLFNGKHGVVWSSGKALASNGSRVELLDSGNLVVIEKVSGRTLWESFEHLGDTLLPHSTIMYNVHTGEKRGLTSWKSYTDPSPGDFVVLITPQVPSQGFLMRGSTPYFRSGPWAKTKFTGLPQMDESYTSPFSLTQDVNGSGYYSYFDRDNKRSRIRLTPDGSMKALRYNGMDWDTTYEGPANSCDIYGVCGPFGFCVISVPPKCKCFKGFIPKSIEEWKTGNWTSGCVRRSELHCQGNSTGKDANVFHTVPNIKPPDFYEYADSVDAEECQQNCLNNCSCLAFAYIPGIGCLMWSKDLMDTVQFAAGGELLSIRLARSELDVNKRKKTIIAITVSLTLFVILGFTAFGFWRRRVEQNALISEDAWRNDLQTQDVPGLEYFEMNTIQTATNNFSLSNKLGHGGFGSVYKGKLQDGREIAVKRLSSSSEQGKQEFMNEIVLISKLQHRNLVRVLGCCVEGTEKLLIYEFMKNKSLDTFVFDSKKRLEIDWPKRFDIIQGIARGLLYLHRDSRLRIIHRDLKVSNILLDEKMNPKISDFGLARMFHGTEYQDKTRRVVGTLGYMSPEYAWAGVFSEKSDIYSFGVLLLEIISGEKISRFSYGEEGKTLLAYAWECWCGARGVNLLDQALGDSCHPYEVGRCVQIGLLCVQYQPADRPNTLELLSMLTTTSDLPLPKQPTFVVHTRDGKSPSNDSMITVNEMTESVIHGR
99
Q89AK1
1.2.1.12
ACT_SITE 150; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0A9B2"
MTIKIGINGFGRIGRVLFRLAQLRSNIEILAINDLINVQYIAYMLKYDSIHGNFNGKIVIKNETLFVNGKKIRITNEKDPKNLMWGDLNIDVVIESTGIFLTTEDSYKHIQAGAKKVIITSPPKDNTPMFVRGVNFNEYVGQKIVSNASCTTNCLAPLAKVINDEFEIVEGLMTTVHATTATQKTVDGVSYKDWRGGRSALQNIIPSTTGAARAVGKVLPELNGKLTGIAFRIPTANVSVVDLTVRNKKIATYEDICQIIKYASNHDMKEVIGYTEDHVVSSDFNGNTLTSIFDAKAGLSLNNNFIKLVSWYDNECGYSSKVLDLSEFISTFS
22
A0A1D6E0S8
2.7.11.1
ACT_SITE 652; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MPSRSPACRPRGRNRRSAADAVARPLALALILVSTLPRAAHSQDLALPPVQPRGVRRTMTCDNIPEPFGTRSRGASRLPGFEVTCGPNREAMLSIGGDAYMIDFVSVSGSYVVVFAEPITQVCYDGKGKPTPDTGTGAKSSEGTTTTFTWSLEGTPFTFSKSNKLVNFGCNRTLMANFFIVPGDSSPLYTSCTTTCNTLQISGSCLGEACCEAPMDQVNGAKAFSLSFERTTANGTGEEDGTCSAAFFLDKDETVFTFSGDEVRPLKTALLPPGERRMVLDWAIGSTSCEQTQSYTFEKLCKYGTCVDAPTGAGYLCKCPSGYDGNPYVSDGCQDINECRNYNSNNCTYQNLCNNTLGGYTCSCPENNIGDGYRTGTGCNTTLATPVSPSQQPQGINVCDHPEKNPCTYIKYCIDLEGVVSCACPEGMSGDGRKNGRGCCFSCQKHFPLDTVLGVSLVLMVTTTTAASCYCWAVKKRELGRKRAELFRKNGGLLLQQRFSTITSQGEDQYSSKIFSAEELKAATDNYSESRILGRGGQGTVYKGILPDQTVVAIKKSKVFDESQVEQFVNEIAILSQIDHPNVVKLLGCCLETQVPLLVYEFISNGTLFQHIHNRNATRPLTWEDCLRIAAETADALAYLHSASSIPIIHRDIKSSNILLDGNFVAKIADFGASRSVPFDQTHITTLIQGTIGYLDPEYFQSSQLTEKSDVYSFGVVLAELLTRQKPISAARPEDSCNLAMHLVVLFNKGRLLQEIEPHILAEAGEDQCYAVAELSVRCLNVKGEERPAMVVVASVLQELRRSFTIDQAVGIKDESIQENSEQEEKHLHESRSIPSLQSSEVSTQCSMEAKMSSFC
99
Q5KCS8
3.5.1.98
ACT_SITE 169; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MTLTDYPTFSSSPFFYDPRNPVLPEAEQGHIRAHSNPSVAYYHPKNVGNYHYGERHPMRPHRLELTNQLVLSYGLHEKMSYHAPRAATEEELLEFHEADYVDFLKRVTPKNAQALTKDWTKFNVGDDCPIFYDLFSFCKQYAGGSLAAARKLSSGSADIAINWSGGLHHAKKGEASGFCYINDIVLGILELLRYHPRVLYIDIDIHHGDGVQEAFYLSNRVLTVSFHKYAADFFPNTGNLSEIGSDLGKYFCLNVPLQDGIDDESYISLFKAVMEPTITIFKPSAIVLQCGADSLGCDRLGTFNLSIAAHGECVRFIKSFGLPLLALGGGGYRQSSVSRCWTYETGVLAGVQLSNELPQNNYYEFFAPDYKLHPPLTGKIQNLNTAKSLERIRISIREKLRYLGGAPSVQMQEIPPDLQGLLEEDEKSAAEKMDEKEEERREGKGKEIDWLDREVGGSGDGVGSGRYFGGARRRF
184
P57080
3.4.19.12
ACT_SITE 178; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 608; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDAQILQQALKDSNGNLELAVAFLTAKNAKTPPQEETGYYQTALPGNDRYISVGSQADANVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPIEVWRDSRNPYDRKRQEKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAMGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSDNSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSSASGPLPSQSLPSTTEQQGPCASDLPGSSSPASGAALPLRSVIHKPFTQSRIPPDLPMHPAPRHITEEELCVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYIDDKAQFLIQEEFNKETGQALVGMETLPPDLRDFVEEDNQRFEKELEEWDTQLAQRSLQEKLLAAPKLREAEASATTAQAGGADYLEQPSRSDLSKHWKEETLRVIAKASHDLEDKGPETVLQSAIKLEYSRLVKLAQEDTPPETDYRLHHVLVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHADYKKFRETTMYLITGLENFQRESYIDSLLFLLCAYQNNKELLSKGPYRGHDGELISHYRRECLLKLNEQAAELFESGEDGDVNNGLIIMNEFIVPFLPLLLVDDMEEKDILAVEDMRNRWCSYLGQEMEANLQEKLTDFLPKLLDCSTEIKGFHEPPKLPSYSAHELCERFARIMLSLSRTPADGR
175
A9WHG7
3.5.1.88
ACT_SITE 153; /evidence="ECO:0000255|HAMAP-Rule:MF_00163"
MAIRRILRIDDAEDRKILKMQCRPVKLPDRNLKQLVADMFETMRAAHGVGLAAPQIGIPIQLCIIEIPAEYEERADGSVVEVAPAEPYVLINPRIVKMSGEEVMRDEGCLSLPGWYGMVPRQTWVTVEFQDLNGKHHRLRRAGDLLGWAIQHEVDHLNGILFTERIRDLSTLRDITKERDAQPVDQAP
183
A0A1S3XRC2
3.1.1.11
ACT_SITE 254; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASAALILSLLIAVQLPYLRSLSLQSSSYSPLENQEKDNIGQLEEWISLNVKHYNRKRAASLKWMQESVRNRKQQVPSSSSLDPRLRNAELNKILISVNQEGIGNFKTIKEALASIPVYNKRRVILDIKPGVYREKINIPRSLPFVTFRGDSSDPPRITGNDTAAAAGTDGRPLKTFQSATVSVDADYFVAINVIFENTAAHVVGSVGEQAVALRISGNKAAFYDCSFYGSQDTLYDHKGLHYFNNCFVQGSVDFIFGYGRSLYEVSSSFLNSHILLPHRTSSTY
125
Q89UP6
3.2.1.21
ACT_SITE 203; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 392; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"
MSADFSRRHFAKLAGLAALGAATGVGAAESETPASAGRGAPFPKDFLWGTATSSYQIEGAVNEDGRGKSIWDVFSHTPGKIEDGSTGDRANEHYHRYREDVALIKALGVRAYRFSIAWPRVFPDGTGQPNPKGLDFYNRLVDELLASGIEPYATLYHWDLPQALQDRVGGWQSSDTSKAFADYAAYVAARLTDRVKNVFTVNEVGRFVNFGYGWGIDAPGLKLPAVQLNQARHHVALAHGLAVQAIRASGRAGTRVGAAENIAACVPAIATAENIRAAEIATRELNAGFLGVVLEGRYTDGFLAYAGADAPKFTAEELKIIGAPTDFVGLNIYAPQFYVTASDRAPGFHVLPFPTSFPHMNSEWLRVGPEVIYWAPRLAAKIWNIETIYISENGTSSEDRIAADGQVYDLDRIMFLRNYLTQMQRAVAEGVPIRGYFLWSLMDNFEWIFGYGKRFGLYRVDFETQARVAKLSAAFYRDVVARNAIGV
161
T1ESZ0
2.1.1.37
ACT_SITE 486; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MFTFAGCVIDIIEEIQSSLLGLRKVSINVQKSDQCHKDNLEKNFQSPEKKKFKSSQLAKKSLKKFKCTLKSSLLLCDQESSYDKIFEIGQIVWARLYFCSFWPAVIIDGAMCGQKQASHDNYWVFWFGDHKVSEVTLNNVVDFRTTFDQNYNNKNFKKNYEKGVSEACKLYYSRIGKNADSDKIALNWISLYDTNDEHADNMLKETDLSIPDWIIKILDEYSKQNERIRIANDSDEEDDDVNSNHSNHDCRVKLNKDIDSNTANQETWFNWKSEKGACLSCRANIGAYNHPFLLGKLCITCKNRLIDNIFVFDTDGFNMFCVICGQAGEVFLCDKLGCNKVFCCRCMTDILGKSQVHAIKSGEMWTCFICDPTSHHLIGCNGVVENWKEELNYMFQPNPSILPRTRRRMKVLSLFDGISTGKVVLDQLDVDLEIYYASEIDEDSLLVSKGRHGGGVVHWLGDVTNINSEMLEKIHPIDLLIGGSPCNEFSVANPGRKGLSEDGTGVLFFEFYRILKELQALMTPDRPLFWLFENVSSMQKHCKATMTRFFMCHPATLDAKYFSAQNRSRLFWGNIPNMYCPPQYNKNLAPDLLNESLFPGRRSQVVKLRTVTTKQNSLLQGCRNEMPVSMLDNNEESLLWIPELERVFGFPDHYTDIGDLPRTRRQKLIGQAWSVHKLELVVNLIYIRFCLIQLNKKSECLRKDNHQKQFRMFKKSKNLGEKRKA
47
Q92QM8
2.7.7.7
ACT_SITE 143; /evidence="ECO:0000250"
MIDSAAPPSGFCRDCLKEQAAHSRRCLACGSPRLLRHSELYRLTLAHIDCDAFYASVEKRDNPELADKPVIIGGGKRGVVSTACYIARIHGVRSAMPMFKALEACPQAVVIKPDMEKYVRVGREVRAMMQELTPLVQPLSIDEAFLDLSGTERLHHDPPARTLARFAKRVEQEIGITVSVGLSYCKFLAKVASDLQKPRGFSVIGQAEAADFLKAKPVTLIWGVGKAFAATLERDGIRAIGQLQTMEEADLMRRYGTMGRRLYRLSRGLDERSVEIDGEAKSVSSETTFNDDLARQEDLVAHLRGLSEQVAFRLRKSALAGQTVVLKLKTADFKTRTRNRRLESPTRLADRIFRTGLQLLEKEVDGTKYRLIGIGVSDLVDPDLADPPDLVDPQASRRAAAEDAINRLRDKFGKTSVETGYTFGKGRRGQ
121
O35955
3.4.25.1
ACT_SITE 40; /note="Nucleophile"
MLKQAVEPTGGFSFENCQRNASLEHVLPGLRVPHARKTGTTIAGLVFRDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADTEMTTRMAASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLVVGGVDLNGPQLYEVHPHGSYSRLPFTALGSGQGAAVALLEDRFQPNMTLEAAQELLVEAITAGILSDLGSGGNVDACVITAGGAKLQRALSTPTEPVQRAGRYRFAPGTTPVLTREVRPLTLELLEETVQAMEVE
180
Q9P376
3.1.3.16
ACT_SITE 170; /evidence="ECO:0000269|PubMed:11934898"; ACT_SITE 172; /evidence="ECO:0000269|PubMed:11934898"
MSKRLTPIHLPNSLNYPIEIASCLVPQGSYVKKGTPLLLYRFFTKVKEDQEDGSEVYVDREFVEQFECPVEGELVEWAVKKEESIENFSKIVAKLHEPCTHEVNYGGLCAICGKNITSQDYMGYSDMARANISMTHNTGDLTVSLEEASRLESENVKRLRQEKRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVLRDVRSFNLQEGPSGYTSCYYIKFRPGLAQFLQKISELYELHIYTMGTKAYAKEVAKIIDPTGKLFQDRVLSRDDSGSLAQKSLRRLFPCDTSMVVVIDDRGDVWDWNPNLIKVVPYEFFVGIGDINSNFLAKSTPLPEQEQLIPLEIPKDEPDSVDEINEENEETPEYDSSNSSYAQDSSTIPEKTLLKDTFLQNREALEEQNKERVTALELQKSERPLAKQQNALLEDEGKPTPSHTLLHNRDHELERLEKVLKDIHAVYYEEENDISSRSGNHKHANVGLIIPKMKQKVLKGCRLLFSGVIPLGVDVLSSDIAKWAMSFGAEVVLDFSVPPTHLIAAKIRTEKVKKAVSMGNIKVVKLNWLTESLSQWKRLPESDYLLYPSYDLPDRNLSEHSYSSSSDDEQRISELNDRELDEIDWQAADQDVENALKDLSDDNDFDTGSISASQSQPEALEVNTPIKRKADLIQPSYNYDGEKRRKENDNHEGYDLLPNSSTKGEESAENENELDDLADIMEAELSKDTA
144
O34431
7.2.2.10
ACT_SITE 326; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000305|PubMed:12161109"
MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGKKTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAEQSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEIEESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMGKIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVSLAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQNKMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIEKRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQDRKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYRPIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETAKAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQENGHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGRNIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGMDQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQTIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPIFHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK
258
A0A9J7LIX1
3.4.19.12
ACT_SITE 84; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 261; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"
MAEANSKPGESLDKALPSGVEYDEAIMAQQDRIQQEIAETSQLIGDHEDLLLLSKEYSEEDNVYQGKIKDLRSKYKCFRRTRGDGNCFYRAFGFSYLERLLDDRKDLERFKEVAAKSKDMLVSLGFPAFTVEDFHDTFMEVVEKVEQQIPVEDLLATFRDQGLSDYLVVYLRLLTSGYLQQNEDFFVNFIESYASVKEFCGHEVEPMARESDHIHIIALTSSLDVGVRVEYMDRAGSEEVNHHDFPEGTEPKVFLLYRPGHYDILYK
175
A0A8M3BDV7
2.7.10.1
ACT_SITE 791; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MASDPGLLPLLVWTISMQVLGSRGTSNNEVNLLDTTKISGDWGWLTYPSHGWDAINEMDEYFSPIHTYQVCNVMSPSQNNWLRTNWIQRDGARRIYIEMKFTLRDCNSMPGVLGTCKETFNLYYYETDRDVGTSIWESQFSKIDTIAADESFTNVDLGVRRLKLNTEIRGVGPLGKRGFYLAFQDIGACIAIVSVRVYYKRCTGMARNLAIFTDVVTGADSSSLVEVRGQCVDHAEERDTPKMYCSAEGEWLVPIGRCVCSAGFEEHRDNCIACEVGFYKPVAGDQQCGKCPLHSHSETRAALSCPCDANFYRSSTDPPSSPCTRPPSAPVNIISSVNGTSVSLEWVSPLDTGGRSDVIYDVLCQKCDKDGLQCEDCRVGVGGGNGVVNSNVNGASGDTSGAAGGTVGALNGLVVARSGAALVRFIPQRTGLTEPWVTVLNLAAHANYTFRIMALNGVTHLSNEQPQSVMVNITTNQAAPSEVMAVRQENASQNSVTLFWHEPAQPNGVILEYDIKYYEKDNEQQSYATLKSKNTSAKVSGLKPGTSYIFQIRARTSAGCGRFSQSVEIQTGKAPPLRNTNVTIIWICMASVTGLVTFLAVVICRKRQEERCGYSKAFQDSDEEKMHYQNGHVSFPEARFYIDPHTYEDPCQAVHEFAREIEASRIKIEKIIGSGEFGEVCYGRMKLPGKRDVPVALKTLKAGYTEKQRRDFLAEASIMAQFDHPNVIHLEGVVTRSKPVMIITEYMENGSLDSFLRRHDGQFTIIQLVGILRGIAAGMTYLADLGYVHRDLAARNVLVNSNLVCKISDFGLSRVLEDDPDAAYTTSGGKIPIRWTAPEAIAYRKFSSSSDVWSYGVVMWEVMSYGEQPYWNLTNRDVIKSVEEGYRLPAPMGCPGALHTLMLDCWQKDRNERPKFCQIVTVLDKLIRTPETLKSVETLCRLNSPLMNRSIPDFTSCRSVDEWLDTIKMGRYKDHFAAGGYRTLGHVMSMKQHDIQRLGVTLMGHQKKIMTSVQVMRAQVLNQSVPSVHI
97
Q9KPM0
2.4.2.1
ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01627"
MATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY
75
Q6FN26
5.1.3.15
ACT_SITE 158; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 263; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
MSIEETDSQVVITHPSNSNTSVTILKYGATVTSWKLNGEEQLWLSTAAKLDGSKPVRGGIPLVFPVFGKNQSDELLSKLPQHGFARNSTWEFLGQVKSNPPTVQFGLNPKIANQELVKLWPLDFNLILTIELGEDFLKTAIEVENASEENMKFNWLFHTYLHIEDIEDTMVSNLVGMKVYDQLLKESFIDKHPVVTFHQETDSIYQNVDSDRLIQVVGKGKPLHTVKRENLPDAVVWNPWVDKSAGMGDFEPKDGFKNMVCVEPGHVSDFVVLPPGQKWSAAQILSKQELNYQAIEP
210
O84469
5.4.99.12
ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
MTKKIVLQIAYQGTSYSGWQYQPNALSIQEVLETILKKIAGFRISVISSGRTDAGVHAQGQIAHFHCPDHPHFTDPRQIQKMLNALLPHDIVIRDAVMTDEDFHSRFSAIAKEYRYTLSLLPKPLPHHRLFCFSPRYKLNIARMQEAAQYLVGTHDFASFANLGREYSSTIRTLYTLDLSEQEHLVTVICRGNGFLYKMVRNIVGALLDIGKGKYPPEHLLDMLATKDRRKGPPSAPPYGLSLHHVCYPPPYQWFCKHEHNNSSEGK
217
Q6SW46
2.7.11.1
ACT_SITE 456; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10028"
MSSALRSRARSASLGTTTQGWDPPPLRRPSRARRRQWMREAAQAAAQAAVQAAQAAAAQVAQAHVDEDEVVDLMTDEAGGGVTTLTTLSSVSTTTVLGHATFSACVRSDVMRDGEKEDAASDKENQRRPVVPSTSSRGSAASGDGYHGLRCRETSAMWSFEYDRDGDVTSVRRALFTGGSDPSDSVSGVRGGRKRPLRPPLVSLARTPLCRRRVGGVDAVLEENDVELRAESQDSAVASGPGRVPQPLSGSSGEESATAVEADSTSHDDVHCTCSNDQIITTSIRGLTCDPRMFLRLTHPELCELSISYLLVYVPKEDDFCHKICYAVDMSDESYRLGQGSFGEVWPLDRYRVVKVARKHSETVLTVWMSGLIRTRAAGEQQQPPSLVGTGVHRGLLTATGCCLLHNVTVHRRFHTDMFHHDQWKLACIDSYRRAFCTLADAIKFLNHQCRVCHFDITPMNVLIDVNPHNPSEIVRAALCDYSLSEPYPDYNERCVAVFQETGTARRIPNCSHRLRECYHPAFRPMPLQKLLICDPHARFPVAGLRRYCMSELSALGNVLGFCLMRLLDRRGLDEVRMGTEALLFKHAGAACRALENGKLTHCSDACLLILAAQMSYGACLLGEHGAALVSHTLRFVEAKMSSCRVRAFRRFYHECSQTMLHEYVRKNVERLLATSDGLYLYNAFRRTTSIICEEDLDGDCRQLFPE
99
A0A078JQ24
3.1.1.11
ACT_SITE 193; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MPRPNHHHRRKPSHSKKKISICDDFPKNLPPPDTDTTSYLCVDKNGCCNFTTVQSAVDAVGNFSQRRNVIWINSGMYYEKVVIPKTKPNITLQRQGFETTAIAWNDTAYSANGTFYRASVQVFGSQFLAKNISFMNVAPIPKPGDVGAQAVAIRIPGDEAAFVGCGFFGAQDTLHDDRGRHYFKDCYIQGSIDFIFGNAKSLYQDCQIISMANQVSAGSKSINGAVTAKGRNSKDENSGFSFVNCSIGGTGWNNFNDPSRDATIFYGEYNCSGPGANISKRAQYVQKLNETQVAQFINMTFIDGDQWLQYFDI
125
A0A6I8PCM0
2.7.10.1
ACT_SITE 865; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000631-1"
MSVRGSALGFLLLWEAALGLYFPRDTYSEKLYVDQPAGTPLLYVQALRDSQQEVPRFQLGQHLYGSYRSQLHENLWFQIHEDTGLLYLNRSLGWKDLKSLSALNGGYPLLNIHLHVFLSPKPFWENECLWPSCAKVSLSIINTTAPTCSSLKAREFCFLDTGLSFRIKENKPPGTFHQFRLLPVQQLCPNISISYQLIADAGVPFRCDKESMEVSTRRPLDREQREKYELMAKCTVRMEAREVDVVVPFPVTVYDEDDTAPYLPRGINTADAVVEYKRKEGTILAKLTVQDADVTPSSGELIRKYTNTIVTSDPWVSESFRVDHMPNETTVNSNGSLVRATQHEYRLVLNRSFPITESRSVQVDVLVNDTDFQGPEGSLLLHFNVTILPVSIRFQNSSYSFSVNRNAHQYAQIGKICIENCKEFYGVNIVYRLQSLSSNCSALGILTALEETTGHLYVNDSTVVQRPECTEIQYTVVALDKQSKKQAKTSIIVVVEGTIMPQEQGCPSSCAVSKRRSECEECGGLGTLTGKCQWRQGDGKGITKNYSTCTPSLKTCPDGVCDTVESRYPAICPQDCTRGEIIGGHERGDRRGIKAGYGICNCFPEEKKCFCEQEDDKEALCDDVCRTVIAGAVLLSFIISVLLSSYFIHRYHKNSPKPPIASAEMTFRRPAQAYPISYSSSNVRRPSLDSLENQVSVDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLYLIVEYAKYGSLRSFLRESRKVGPSYVGSDGNRNSSYLDNPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMERPENCSEEMYNLMLRCWKQEPDKRPTFAEISKELEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNNAPLPRTLPSTWIENKLYGMSYPNWPEESPVPLTRFDGTNSVFSRYANDSVYANWMVSPSAAKFMDKFDS
97
Q59337
1.11.1.6
ACT_SITE 81; /evidence="ECO:0000250"; ACT_SITE 159; /evidence="ECO:0000250"
MSDENNKGVGTAVQGVGGPRDGRTAPGEQGTTLTTRQGHPVHDNQNSRTVGSRGPMTLENYQFIEKLSHFDRERIPERVVHARGVGAHGVFRATGKVGDEPVSKYTRAKLFQEDGKETPVFVRFSTVGHGTHSPETLRDPRGFAVKFYTEDGNWDLVGNNLKIFFIRDALKFPDLIHSQKPSPTTNIQSQERIFDFFAGSPEATHMITLLYSPWGIPASYRFMQGSGVNTYKWVNDQGEGVLVKYHWEPVQGVRNLTQMQADEVQATNFNHATQDLHDAIERGDFPQWDLFVQIMEDGEHPELDFDPLDDTKIWPREQFPWRHVGQMTLNRNPENVFAETEQAAFGTGVLVDGLDFSDDKMLQGRTFSYSDTQRYRVGPNYLQLPINAPKKHVATNQRDGQMAYRVDTFEGQDQRVNYEPSLLSGPKEAPRRAPEHTPRVEGNLVRAAIERPNPFGQAGMQYRNFADWERDELVSNLSGALAGVDKRIQDKMLEYFTAADADYGQRVREGIQAKEAEMKGQKQEAPVYGTEASSLY
13
Q8PCA4
2.2.1.2
ACT_SITE 136; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MTASPSKLAQLRDLSVVVADTGDYDAIKRLKPVDCTTNPTLVKKALDLPVYADLIERELAWGRAHGGEDRNSTINEVADRLTVGVGTMLSELVPGRVSTEVDADLAHDTQATIAKARKFIAMYAERGVSKDKILIKIAATWEGIEAARQLQQEGIDCNLTLIFNRSQALACAEAGVFLISPFVGRILDFFVAKGQTPASIDEDPGVVFVRGVYDEFKRRGSSTVVMGASFRSTAQIEALAGCDRLTISPDLLEKLDADHGDLPRKLSPLNADNAAITPINSDSFATDLAADDMATEKLASGIDTFAKDLEALRKTIADKLAG
52
B5YLI5
3.2.2.27
ACT_SITE 31; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10072"
SKTVYPPPELVFSALTITPLHKVKVVIVGQDPYHQPSQSHGLSFSVPPSIKTPPSLHNIYKELTNDHSISNFTSIPNHGNLERWARQGVLLLNNVLTVRRGEAASHKGRGWEEFTDGVIGAVVERDDDTKRTGIVFLLWGIPASKKAQTVLSKYNNTKRSKHAIIMCSHPSPLGATKTDSPFMGSRCFSRANEELVKRGWKPVDWRVDGVL
173
Q870Y1
5.3.1.8
ACT_SITE 308; /evidence="ECO:0000250"
MLPVPLIQLQCGVNSYEWGKKGNSSRAAQFAAASLDDNEFKIDEEKPYAELWMGTHPSNPSKDKHTGRTLLELIQDNQALLSPAIAERYQNKLPFLFKVLSIQKALSIQAHPNKKLAEKLHARDPKNYPDDNHKPEMAIAISDFEGLCGFRPLKEIAHFLDNVPALRQLVGEDKAKAFVETVKRNDGNESDEATAENKKVLQSAFGALMASSEADMTAAADKLVQSAKSAGADFTGTAVPSPGGAKLSELVGRLHGQFGADYGLFVLFFLNFVEMKAGEAIYLRADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDNLVNMLTYDFAPIEQQKMEPTDYTQDVKNKREAGATLNQTAIDSQSEIVEYNPPIEEFSVVRSLLKSQGSKVTFKPIDGPSIIICTQGQGKISVGPKVQEIKKGHVFFVGATAECVLESEDDKFETFKAFCVLDEQSNGN
214
P59662
3.4.21.89
ACT_SITE 38; /evidence="ECO:0000250"; ACT_SITE 76; /evidence="ECO:0000250"
MNLFKNFLKEWGLFLLILSLLALSRIFFWSNVRVEGHSMDPTLADGEILFVVKHLPIDRFDIVVAHEEDGNKDIVKRVIGMPGDTIRYENDKLYINDKETDEPYLADYIKRFKDDKLQSTYSGKGFEGNKGTFFRSIAQKAQAFTVDVNYNTNFSFTVPEGEYLLLGDDRLVSSDSRHVGTFKAKDITGEAKFRFWPITRIGTF
178
A0A8J1MTA9
2.3.2.26
ACT_SITE 1284; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MAQRLRLHFATRRSNTDPLSESSGHGLDSNIHMCFKRLSPTTSPGVIQMRLSPRQTLQNSFAPEIIPIHRGHSVSSPCKKSSSVQISLQPSRNSRCHQSGNTMPAMEDICVVNAYKDGINSSFTTSNNYNCQPAINDNCISTGTSTENGSSFSISASDNGPYSSNSSDYGSCASTASDAGSCANSILSDSSSCTYSLSDSNYLNALPNGNALFMNPEEISEFLRSKLEEPLPINKCNFHFDLDYTEKEEVKLPARKKTKIPLRRCSSLVIFPRSPSDTPPTSPTSLVPPTSRGFYQTSYQLMLSSNDFTQKEEQVASKGSLLTAVNGVRLSKNTCNVGEVRDIKPLYLNDKEDGLVPQSLETVKAGKDGPSFASDSSDFVQIPLPNICNSVAEHTKLHKDKPQLNIDSQHCRLLRSTSAYSPSKKTVECQMGRRSEQGYKNIHKCQLTHVFQRSVSEGPPQKRSSASSHKCKYPKSGSSYLHIQFAPGNKSRVSSYKKQHLRSPTIELPCKPSVKLLKTRDDFLGQVDVPLHLLPTENPRLERPYTFKDFILHPKSHKSRVKGNLRLKMTYLPKNNGSEDDAEQAEEMEPGWVILDQPDASCQPQQQQEISPLPQGWEERQDILGRTYYVSHQYRRTQWQRPTMQEDTAANESRNVQLEEQHHHAFTTRRQICEATEATESRDFPEGWEIITEDETTVYSNQNAQQRSATNSDAQAQITEELSIRLNISGNMPHSRQNSSTVHSNRRESLQSYTSEELPTLPVLLPTSSGLPPGWEEKQDDKGRSYYIDHNSRTTTWEKPIVQGPMETSQPSSIHNVPAILQLQRTTSESAQLSKTEQGFLPKGWEVRHAPSGKPFYINHVTKTTTWEDPRLKIPVQLRPKPPIDLSDLGPLPPGWEERSHTDGRVFYIDHSTKQTQWEDPRLQTVAITGPAVPYSRDYKRKYEYFRKKLKKQLDIPNRFEMKLRRTSILEDSYRRIIAVKRPEFLKARLWIEFDNEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINSNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFFIRPFYKMMLQKPIILYDMESVDSEYYNSLQWILENDPTDLDLCFTVDEELFGQTHQHELKAEGSQILVTNENKKEYIHLVIQWRFMNRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNNWREHSKYKNGYTQGHQVIQWFWKAVLMMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTVEKWGTPEKLPRAHTCFNRLDLPPYESFEDLWDKLHIAIENAQGFDGVD
65
Q8H186
2.7.11.1
ACT_SITE 197; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MGSCLSSRVLNKSSSGLDDLHLSSCKSSSSATAHKTEGEILSSTTVKSFSFNELKLATRNFRSDSVVGEGGFGCVFRGWLDETTLTPTKSSSGLVIAVKRLNPDGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEQRLLVYEFMHKGSLENHLFANGNKDFKPLSWILRIKVALDAAKGLAFLHSDPVKVIYRDIKASNILLDSDFNAKLSDFGLARDGPMGEQSYVSTRVMGTFGYAAPEYVSTGHLNARSDVYSFGVVLLELLCGRQALDHNRPAKEQNLVDWARPYLTSRRKVLLIVDTRLNSQYKPEGAVRLASIAVQCLSFEPKSRPTMDQVVRALVQLQDSVVKPANVDPLKVKDTKKLVGLKTEDKYQRNGLNKKTVGL
99
Q8PE60
3.1.1.11
ACT_SITE 189; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MQEHRRRVLRSIAASAVLAMSALGSTAAFAADPVYTVAKQGNAGYRTVQAAVDAAVQGGKRAQISVGAGVYQELLVVPANAPALKMVGAGTTQTVITYDNYAARINPATGKEYGTSGSSSVIIAGNDFTAEQLSFGNHAGPVGQAVAVRVDGDRAAFRNVRFLGYQDTLYLRGAKLSYFLDCYVEGTVDFVFGAGTALFENVQLHSLGDGYLTAASTPQESARGFVFRNARITAASGVSRVFLGRPWRPYASVSFITSQLGAHIVPEGWNNWGNAANEATARYSEYQNTGAGANPSRRVKWSRQLTAAQAAALDRSTVLGSWRPF
125
A0A3B6FPE6
3.1.1.11
ACT_SITE 485; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MLYLLTFLPLQTIPCLLLRQGRLLAYLRQQCLHNIYARTTNGHAHTLLTAMTSTWMARGKGTPLQVLLLLLALLIVPRGGDGAAVFSGYTFKGQGEAEAFEEALLRQACFNVTSSSSGAGRGKGDCVSRIDTARGGPSSGPVPVLRAALRDTLGEAVSAVGAVAGLASLSNHAREEMAVRDCIELLGYSVDELGWSLDAMAESLDGVEPEMETQHGAASGSVRSGARAEDDLHAWLSAALGNQDTCTEGFRGTDGRLLRRVEASVAQLTQLVSNLLAMHKRLRSIMPLRQHGKNDTAASGAGSELPPWVMDVAGGVEGELARARGRTGRKKAMRVDVVVARDGSGRYRSVGEAVARAPNHSRRKYVIYVKRGVYYENVDVKKKKSNIVLVGEGMGETVITGSRSFSSGWTTFRSATVAVSGAGFIARDLTIRNTAGAAAHQAVALRVDSDRSAFFRVAIEGHQDTLYAHSLRQFYRDCRVSGTVDFVFGNGIAVIQRTILATLPLAPGQTGSVTAQGRKDPNQNTGFSIHNCVVEAKYPTYLGRPWKPFSRVVVMESYLGTGVRARGWLEWAGDAGLNTLFYGEYRNFGPGAGVAGRVKWPGYHVIMDPAWASHFTVRRFIDGLTWLPSAGVTFTADLIKK
125
A9UXX6
4.1.1.50
ACT_SITE 130; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 144; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 287; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 300; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MTLLLSILARRARIARLRPTGLQPSSRMTVPCPRPRSQSALASQFRCLATTARTAERNSGQPELPKVPFFEGREKLLELWFDEPARLSAAGQGLRTIPRAAWDRLLGLADCTIIEEQRTPLMDAYILSESSLFVMPEHIVIKTCGSTAPLLALPDLLEEAWALSRQDLVEVYYSRHDYLQPNLQAFPHEDFGQEVTFLESHVGPGVARQFGRPDEHQWNLFAAKRGSSVHASQTIEVIMYDADPTAMAIFYEVSSSTKEAVTLDSGIADLLPTFDIREALFSPCGYSCNGVHAGAYMTVHVTPQPECSYISFESNVLMRDYTDLVTACTRAFRPKHVQVAIVSN
196
A0A0K9NTB9
2.7.1.11
ACT_SITE 262; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MCINSPNQHSDFQTLPNSIISRKQKSSIYYSFFVLMGSLTVAIPTSPTDKKKIIHGDDGYVLEDVPHLLDYIPKLSNYPNPLQSNPAYATTKQYFVNEDDSVAQKIVVHKNSPRSIHFRRAGPRQKVYFEPIDVNACIVTCGGLCPGINTVIRELVCGLHDMYGVPKIYGIQGGYKGFYSNNYNFLEPKNVNDIHKKGGTILGTSRGGQNTTKIVDNIQDRGINQVYIIGGDGTQKGASTIFEEIQRRRLKVSVVGIPKTIDNDIMVIDKSFGFDSAVEEALRAINAAHVEAESGENGIGVVKLMGRHSGFIAMYATLASRDVDCCLIPESPFYLEGKGGLFEFIEKRLKSNGHLVLVVAEGAGQDILSANLESAKDPSGNKLLLDVGIWLSQKINDYFANVRKMLITLKYIDPTYMVRAIPSNASDNVYCTLLAHSAIHGAMAGYTGFTVGPVNGRHSYIPFDRVTESRNKVVITDRMWARLLSSTNQPSFLEPENAKAGDIKIDVF
84
Q54EG9
2.7.11.1
ACT_SITE 587; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDFKENSIYINVMDKIYAREKEVLSQNQDFQENNLSRISLILNYEDFSLKFDESLHGYSFGYVTNPFGLKLHSPFTETVRFDGAEKYIYMKRILGVPSNETQLCNYQHQNFEEKDSQKELLPSPQQLTPPTSLPSLPLLPLPQAPEQNEEQQLTQPPSPPSIPPPPPQKKQIQIFITPSGIVSQKIQNFFRDTQIKSTDPVNCSLDHSIKKNYSLEEIYENNKNYMDKNNNFLHFLFTFIDKITIKDLDHFEKEINRVHNIKKLINQQNMKGETPLHSLIINNSESCLKKLVIAKINHMGIFDYSKCDNLNKNLLAHAIEKGDIDVIRLVLIGGCPLKMSPRSKLFKKNFKIYRQQIYRVFEIKEFLTKIGFNQYIPMFLEFEFKNININYLIESFKFKLNINEDEILLWKLLTEPYKNLDFKSFCSEYQIKHQNDLISETMANHFINVCQLNPHFGYIDFHTQIGSAGNASVFEGTYKGIPIACKEMPVSGTYEQSVDSIKEIAAVGQIKKLGCATVVETIGVLKYNQKLFLVMVKEKCNLLSFLCNKSEILKMQREGIWTSIFKISKDILKGLVSLREAGMYHRDFKTANFLVSNTGKILISDFGTSRDENEKRLNTFAKTIGTMWYRCPRLGDCSEDEKTLTHYNEKSEIYSLGIILWELVCVAMTGTYISPKIPLFQNEVDFLIWIHKDYRFSFPVGTPQSFVKLITRMCLPFRDRRPTVRQVLDNVKAIKKEFLSNRGIEGEQTYSGLECWREFNFSKQNVTRISISNLHNTEYKVVNKYDYASYNNKNSLLMKRYLDNSNFVVELINPNGLFRFKSFFEKEKLLYLKLKSTYKDEYYFDMSQFLTTIIQIHQITVIYYKMLQKYRELRLLRNNNNINKNKNNNNNNNNNNNNNNNINNNNTFNNSTNNNSNDNINIPYDFNNNNNNNNNSCNNSKKFKSISESTSALGLEASSSSSSSS
99
Q83AU2
2.6.1.16
ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164"; ACT_SITE 606; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164"
MCGIVGAVAERPVADILLEGLNRLEYRGYDSAGMALLHPKTHQIQCVRVKGKVAALVDSVKKKPLLGKTGIAHTRWATHGEPSQKNAHPHCSEKTIAVVHNGIIENHDALRRKLTKAGYKFKSETDTEVIAHLIHYHLQSTPELLTAIHQATKSLKGAYALGIISTREPETLYAVRCGSPLVIGLGIGENFIASDQLALLPVTQRFIYLEEGDIVKIGLKSVAIYDKNKKAVKRTIHATKIDYNATGKGKYRHYMQKEIFEQPQAVLDTINNHFSKPQLTVQRFGSQAASIFKKIQRIQLVACGTSYHAALVGRYWLEALAGIPCQVEVASENRYRQGIVEPNTLFVALSQSGETADTLAALRQAKKAGYAATLGICNVPQSSLAREADLIFLTRAGAEIGVAATKTFTTQLVALLLLTFLFHQNNQKLIRKFTSILPQLKQLPALLQKTLELDRQIKQLSKRFNDKEHALFLGRGAMFPIALEGALKLKEISYMHAEAYPAGELKHGPLALVDKGMPVIVIAPNDHLIEKLASNMQEVQARGGELYAFVDHRINWQQENGTTLIKMPPTPDFAAPIAYTIPLQLLAYHIAVLKGTDVDQPRNLAKSVTVE
81
G1K894
3.1.3.48
ACT_SITE 456; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR608356-50"
MEPLNDADGEQDQLSKAEEPHKCTGGTLQQSWVAWWNGLTTGGIVYLFALSQILVFFFMFWCGGSETIPTLVNALDVFPNLLIPFGQLVIDSTKDLIRNGGLTMSYFLLSLISFGLLLIGILVWYLVNPPPDPPFPLQEDRRQSVSRQPSFTYSEWTEDKNEDDFLDLDPVPETPVFDCVMDMKVETDPITLTVKSVGLQERRGSNVSLTLDMCTPGCTEQGFGYVMSPREESAREYLQTASNVLTEEELHEKALDSFVLQTEFFEIPMNFIDPKEYDIPGLVRKNRYKTILPNSHSRVCLTSDDQDDPLSSYINANYIRGYGGEEKVYIATQGPIVNTVSDFWRMVWQEHSPIIVMITNIEEMNEKCTEYWPEEQVTYEGIEITVNQVIQADDYRLRLITLKKDEETRVLKHFWYTSWPDQKTPDQAPPLLQLVQEVEEAMQCTEAKSGPIIVHCSAGIGRTGCFIATSICCKQWKNEGVVDILRTTCQLRLDRGGMIQTSEQYQFVHHVMSLYEKQFSRAAAEE
149
Q03407
2.7.11.1
ACT_SITE 249; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MGNRSLTEADHALLSKPLVPTSAEHTQTQEYPRPFVDGSNSQSGSELQASPQGQFGEKALTSTNRFIPLANDDPGMQHEMGLDPSMRRRREEWAERGAAKIVKDVVDPATGELTKHVVKMGIKDFKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKYGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKAANEYLTFQKVMKIQYAFTAGFPQIVKDLVKKLLVRDPNDRLTIKQIKAHLFFHEVNFEDGSVWDDNPPEIQPYKINAEAMKPLQKVSESDTTVKMANLQLAGNGHADTPLQAPAATSQEHSVISMTAATAAFNKDYTSQPKLGSKSSTSVRSASNNTDREVIQKKVSKNRASVSSPSISTTSRGKDNRSRSSDAFWSRYLQNMDERVLLMKEVALSTRNLEDSPVGLENVALDYKNPLDIEPPTDSAGKFYKKMFLITNLGRALVFVKRRSLSMWEEQEFELQFELELNDVEKIRFISDQVLEIDGSRTIFIGCKERAVLMKLWKLIHNGMTAKPKVVSPKSDHKMFDKFILQKRQNTKKKNQAPPVPQSNRLINGLPDRCILKTPEEGALHTKRPTSLQTRSSSNYSKLLARSTQMRKNMTRTDEK
99
I1GYJ3
1.11.1.7
ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MARLTVAMLFFVLALALAPRNMDAVVVESLQPGFYNQSCPEVEQVVRDVVDSEVGMDHTLAPGLIRIFFHDCFITGCDASILLDESPAGDVPEKQSSANGFTLHGLRTIDIAKSTLEAMCPRTVSCSDIVAFAARDAAVAAGLPTYEVAAGRRDGEHSRMDDLPGNFPVPGHTVPRLTELFQKRGLSQEDLVVLSGAHSIGGAHCFMFSNRIYGFSKTADIDPSLDPAFAKLLREMCPRPKPDDNPEEAPKIDFDQRTAQKLDNSYYNELLARRSLLTSDSALVQDPATRPIVESFAKDDALWQKKFGEAMQKVGKLDVLTRPEEGQIRRNCRMVNRPKSEMRTHMGRISWPKPRHPMLQMMNWFIRGFQQPA
14
B6JZ75
2.3.2.26
ACT_SITE 1403; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MNTNEHDMATELDNDMFSNPEDESHDVSYRSAGAQLNGNGDDFDIHVIDSDAPAHEHMTSSVDDHDEGVSDEEEDEEEEEEEEEDEAVDEDMSGEDDHRYNNYYSESYESDESEVDMRRQLRRGQSNNPTQDSSTFPLDEFENSVRRFFTFSRQEGSQLGSTLGRFAPFGNLPIQFRQILIGLTDDSDPSAQMVALQELSEILVISTEDILQGLFSVEPFVREFNHILANSSSMELMLMCMTCLSNMLEAFPSSIAVVANSPIVSTLCVKMFDMQYIDMTEQALNILLRISEKFGDRIVTNRGLLAALQYLDFFYTGVQRVAISMAANCCKFLREKDVDHVKEAYPHLITALQMADTTVRDKAYECVENIMIAFEDNHDIMKSFVNTDLISSIVASLETSQFSKMQTTSQPRLFSILTCICSVSENYVQPLLEMHLSDIIYELLCGIPPPESFSHNSMVAMQSLFHCPNELISNVLSLICSLLQNCPEVSKTGENSAGTTNALVRTLLPVVMDIYSTTTDKHNRELAVIAALRMINSVDNECLQATVKSLPISAFLASILTLKSKEYALLENALLMAIALLERMPEIYKDLFIREGVVQEVSYMSSALSAELKKLRRDSSGSYENVFQLGMLQKWEKSFLSFYRDDELVNPTLEKLTKFAKSLVYENDYERVFAHLVEVYEQRLPVTSYELLQSGLIPSLLKLLSKGSVSVVRKFFQAFNKGDEHHVLDFTSGSLSRFITSLQELLSRIEKFEISIIPTSSPSQNLGFLSKQYRLKLVPSPTVNESLGLRSFMVSINGLDSLSTLEDYMKGKLFSRRTLENRLSSLHEGTATPIGNTSLTNRIANEEDSASNRSPSVNHDASPTDSQSSSSDTHLSFYFDGKPVNKNFTIFKVILESLKPKGKCSMDDVLNACITLNYNICTSADEPEVTPTVEAFQCNPDLTNVLQLLKTIYDYLSDLESVFPSRHLIGSLENLLTEFNNWKLSAKLNRQLEEPLIVLHQCLPRWCLHIASNYPFLFPFETRYILLQFTAFGMGRAINYWLSVHPVQTNDENSTVLQLVKLNRQKLRISRNQIFEYAKQVLFSFGSSKNIIEIEYEDEVGSGLGPTQEFYTTVSREFTRKHHHMWRDDNQTSNYVHSATGLFPAPMSHAIGANEKICSLFKMLGQFIARSLYDSRLISVQLNPLIFEETIPLTLSSVSKVDKELGKSLRFLERLLARQQAGFTAVPTETKIEDLCLDFTLPGYPSVELIPNGRNVQVSHKNASKYISSIIDFTVGKGVQLQIQNFREGFSTVFNYESLRIITSHELSMLFGKVEEDWSFETIAKSIVADHGYNMENTTIHNLIEVMSNFSFSEQRDFLQFITGSRKLPIGGFSSLHPALTVVRKLNEPPYVPDDYLPSVMTCVNYLKLPEYSSKEILKQKLMLAMKEGQGSFHLS
65
Q5A1W9
2.3.1.286
ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
MISIDLLDNSGTSMPADTSIKLHEVIKFISKSKKMTVLTGAGISCNAGIPDFRSSDGLYNMVKAKHPKAVVRGQDLFDISLFRDEMSLSVFCTFMESLYKSSLNAKPTETHKFIKILKDKNKLLRCYTQNIDCIEQHINLKLGINLQEFDNNKFKQVWNQLDVVQLHGNLHKLSCTNCFSQFNWNEEFQTLLANGLNPECSKCMDKYQQRLYSGKRLTGQTIGLLRPDIVLYGEHHPQMEILTQGLNSDLKSRPDCLIIMGTSLKVAGVKSLVKSLSKIIHNKGGKVIYVNKTKLSASSWKNYIDYEVVSDCDEFVRMLKTEIPDLFLTQEQLDSEKLNQVAVKGSSLNKPIVKPEAKVKIEPGIKQEDAIQYSPEREVTIKQEVNIKQEPIVKREVESVSVKEEPIPTPPTTPHKPKQATKLKRKSPDEISANEVHSRVKRLRPRNDQLSSPASSINGSEEEEEEDEPVAKVLFENARKGITLDQH
58
P06959
2.3.1.12
ACT_SITE 547; /evidence="ECO:0000255"; ACT_SITE 603; ACT_SITE 607; /evidence="ECO:0000255"
MAIEIKVPDIGADEVEITEILVKVGDKVEAEQSLITVEGDKASMEVPSPQAGIVKEIKVSVGDKTQTGALIMIFDSADGAADAAPAQAEEKKEAAPAAAPAAAAAKDVNVPDIGSDEVEVTEILVKVGDKVEAEQSLITVEGDKASMEVPAPFAGTVKEIKVNVGDKVSTGSLIMVFEVAGEAGAAAPAAKQEAAPAAAPAPAAGVKEVNVPDIGGDEVEVTEVMVKVGDKVAAEQSLITVEGDKASMEVPAPFAGVVKELKVNVGDKVKTGSLIMIFEVEGAAPAAAPAKQEAAAPAPAAKAEAPAAAPAAKAEGKSEFAENDAYVHATPLIRRLAREFGVNLAKVKGTGRKGRILREDVQAYVKEAIKRAEAAPAATGGGIPGMLPWPKVDFSKFGEIEEVELGRIQKISGANLSRNWVMIPHVTHFDKTDITELEAFRKQQNEEAAKRKLDVKITPVVFIMKAVAAALEQMPRFNSSLSEDGQRLTLKKYINIGVAVDTPNGLVVPVFKDVNKKGIIELSRELMTISKKARDGKLTAGEMQGGCFTISSIGGLGTTHFAPIVNAPEVAILGVSKSAMEPVWNGKEFVPRLMLPISLSFDHRVIDGADGARFITIINNTLSDIRRLVM
54
A0A0D1CW52
5.1.3.15
ACT_SITE 168; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 292; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
MPVTLINNNKAVKLELPKSQASAEVLFFGATVTSWKVAGGSERLFLSSKAALDGSAAVRGGIPLVFPVFGSPKDHDDVPELITKLNKHGFARDHDWALSTHVASVDQEDKASVTLELRTNDKPDIKAVWPFETVLQYTVTLLPHQLKCELKVNYVDGEGDMPFHALLHNYFLVPDSTKASVQGLNGMFYIDKVLGGEEVQLNTDNFTLDAQPIDRVHVGKHKTIPAGEKPRDVKLVYNASLLQDPLGRMGKGVEVTRSKQLKDTVVWNCADEGNKLIKDLEDGDWKKYVCVEPGSVHGFETLPKGSKWIAEQTLTAW
210
A0A3B3HRL0
3.1.3.48
ACT_SITE 1175; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
MPLPFGLKLKRTRRYTVSSKSCLVTRIQLLNGEFVEFTLSVESTGQECLEAVAQRLELREITFFSLWYFNKQNQQRWIDLDKALKKQLDKYGLEPTVYFGVVFYVPTVTQLQQEITRYQYYLQVKKDILEGRVSCSLDQAIRLASLAVQADFGDFNQYDSQEFLQKFALFPIDWIQDDRVLEEATQKVALFYQSFRGLPAPDAEMLYMQEVEKMEGYAQENYPAKDNTGTDVTLGSCLDGIFVKYKSARPPLLYRWHEINNMSHNRSFFALELANREESVQFQTEDMETSKYVCRMCLARLKFYKINKSSLEECDTQTSEGSQKSLLTLSFPRFPMLSRTSLLSNKGQTQSTALNTVRRRSSTRISLSKPQAFMMPPPQMHYNGHFTEPYSSSQDNLYLNTQNGLYYHSQTSLDRSPLEYGSGGRLRNGSVYSAHSTSSLTNPQHYLQPSPMSSNPSITSDITRPDYVPSHRHSALIPPSYRATPDYETVMRQKTRGTGGGMLLSQEHRQSHSMRNLNIGNSYAYSRPDPLVYSQPEIRGEHGEMSQSHHYPFHLGSSFHSPSPYPYPPERRPVVGAVSVPELTNVQLQQAQEYPAPNIMRTQVYRPPPPYPYAYPRPANSTPDLSRHLYVSSSNPDLIITRRVHHSVQTFQEDSLPIAHSLQEVSEPLYSGPPPRQPYHSHKRNSIEIAGLAQSLEGVRFQERTLPSSAAETNTPPPAPHGGPSQGSQLNVFLEHSNTEERGDVKQEVRYGHKKSLSDATMLVHSSGEEEEFEDDGGRHTPLSEEAISAIVPEQQPQPRHSLPSPSPLPPQHQTHIEPPPAYPIGSALDPSMTSSITYKVHPRIQESEPLYLLQDLRQPRIMPSVSEGNLSDQAKMKPKKELKKRPVSDVPSGKNTVEGLPPAGMKKGLRSEVRNMGPLKMAHLNGLSVSRQPVYEEAKDDPERASNDDRCKLLEQHMERGELLREFENIPKRRPGGECTIALQPDNGDKNRFQDVLPYDDTRVELVPTKENNTGYINASHIRVTVGGQDWNYIAAQGPLSNTCQDFWQMVWEQGISIIAMVTAEEESGREKSFRYWPRIGSRHTTLTFGRLKITTRFRTESGCYATTGLKIKHLLTGQERTVWHLQYTDWPDHGCPEDFKGFLTYLEEIQSVRRHTNSISDPKQTIPPVLVHCSAGVGRSGVVILSEIMIACLEHNETLDVPKVLMALRAQRMLMVQTLSQYTFIYKVLIQYLRNSRLI
149
A0A067DZT7
1.1.1.37
ACT_SITE 204; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MRSSVLRSVKTLAKPAGARGYSSESVPDRKVAVLGAAGGIGQPLALLMKLNPLVSRLALYDIANTPGVAADVGHINTRSEVAGYMGNDQLGQALEDSDVVIIPAGVPRKPGMTRDDLFNINAGIVKDLCSAIAKYCPNAIVNMISNPVNSTVPIAAEVFKKAGTYNEKKLFGVTTLDVVRAKTFYAGKANVNVAEVNVPVVGGHAGITILPLFSQATPKANLADEDIKALTKRTQDGGTEVVEAKAGKGSATLSMAYAGAIFADACLKGLNGVPDVVECSFVQSTVTELPFFASKVRLGKNGVEEVLGLGPLSDFEQEGLEKLNPTFHIRKLFQILQFFRKCCTCCSWHQLFGCFSLE
5
M5VW91
1.11.1.7
ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MNVNILLVAFVVCGLLGACQGGQLRKNFYRSTCPSAEEIVRNVTWNHVSSNPNLPAKLLRMHFHDCFVRGCDGSVLLNSTANNTAEKDAAPNLSLAGFNVIDDIKENLENKCPGIVSCADILALAARDSVSFQFKRSLWKVLTGRRDGTISRTREALINIPPPAFNFTQLKQRFASKNLTVHDLVVLSGSHTIGVGHCPTFSNRLYNFTGKGDQDPSLNATYAAFLKTKCPSLNDTTTTVEMDPGSSLKFDTGYYATLKQHKGLFQSDAALLTNKGAANIVQELGDNDKFFAEFAQSMVRMGAIEVLTGTSGEIRSKCWAVNSN
14
A0A2C9WFV6
3.1.1.11
ACT_SITE 223; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MARGHYVDATHCVLIAILVVATTVSSDDTTPIPADDSKVSNWFQTNVKPWKSRKGTLDPALEAAEAKSKIITVSKDGKGKFKTVTDAIKSIPSQNKERVIIKIGPGVHTEKIEIEKTKPFITFLGDPKAMPTLAFGGTARKYGTHYSGTVTIDSDYFMGVNIIFQNTAPKPQSNKPGGQAVALRINGDKAAFYNCKFLGFQDTLCDDRGHHFYRNCYIEGTVDFIFGRGRSLYLESQLNVVDNKDLTFITAQGKEQKSENFGYSFVQCKITGSGSGSFLGRAWRKMPEVTFSYTEMGAVVNPLGWSDNRQPDRDSTVFFAEYKNSGPGSNPKGRVKFTKQLKDAQAKNFLSLGYIQGSKWLLPPPK
125
M0WUX2
1.11.1.7
ACT_SITE 90; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASSRTAAMLVLVAAVLCPAAFSKTSSAFISMPTDHVGGSIPPVSPAEGLAFDFHADSCPQLQDVVRSAVQTALQSEIALAAGLLRIFFHDCFPQGCDASVLLTGDGSELQLAPNLTLQPRALQLIESIRAMVHAACGPVVSCADITALATRDAVAFSGGQGYDVPLGRLDSLAPAPSSAVFNLPQASSNAATLIDVFQTRNLDNVDLVALSGGHTIGKGHCSSFSNRFSEDSGFVRSLASNCSTDFNRLQDLDVTTPDVFDNKYFTNLQEGKGVFTSDQKLTADWRTEWVVNGFAGNHWWFFGQFAASMTKLGNLQGPQGNVGEIRRNSCFVRNAQSILTTTSDEGLSASV
14
A0A059AD64
4.1.1.50
ACT_SITE 71; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 85; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 234; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 247; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MALSVSAIGFEGYEKRLELTFYEPGIFADPEGMGLRSLSKSQLDEFLKLAECTIVSSLSNDFVDSYVLSESSLFVYPYKLIIKTCGTTKLLLSIPAILRLADSLSLSVKSVRYTRGSFIFPGAQHFPHRNFSEEVAVLDTYFGNLGAGSKAYLMGSPERAQKWHVYSASAEKTSLSDSVFTLEMCMTGLGKQRASVFFKENSPSAAAMTEESGIRKILPKSDICDFDFDPCGYSMNAIEGSGISTIHVTPEDGFSYASFEAVGYDFKAADLSQLIQRVLVCFEPTEFSVALHSDLAGEDLVSRFPLDLKGYSAGETSCEALGKGGSIMYMSFAGTGSCGSPRSILKCCWSEDEKDEEVEEK
196
Q4QD53
1.1.1.205
ACT_SITE 327; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 425; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"
MATNNANYRIKTIKDGCTAEELFRGDGLTYNDFIILPGFIDFGAADVNISGQFTKRIRLHIPIVSSPMDTITENEMAKTMALMGGVGVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVPPNTPISNIIRIKEEKGISGILVTENGDPHGKLLGIVCTKDIDYVKNKDTPVSAVMTRREKMTVERAPIQLEEAMDVLNRSRYGYLPIVNENGEVVNLCSRRDAVRARDYPHSTLDKSGRLICAAATSTRPEDKRRVAALADVGVDVLVLDSSQGNTIYQIAFIKWVKSTYPHLEVVAGNVVTQDQAKNLIDAGADGIRIGMGSGSICITQEVLACGRPQGTAVYKVAQYCASRGVPCTADGGLRQVGDICKALAIGANCAMLGGMLSGTTETPGEYFFKGGVRLKVYRGMGSLEAMSQGKESGKRYLSENEVIQVAQGVSGNVVDKGSAAKLIAYVSKGLQQAAQDIGEISFDAIREKMYAGQVLFNRRSPTAQGEGGVHSLHSYEKKLFAAKM
3
Q8DQN1
3.1.26.11
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01818"
MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLEGTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTGASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHVVKDLEEVEI
137
K7MD49
3.1.1.11
ACT_SITE 529; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSTPPMPFLFLFLFSLIVPLLLAQAPSPSPTHSPPPPSPSPSPKHTPPPPPSTTTPPSPKHVPPPPPSSPSPSPKHAPPPPHSSPLPSPKHAPSSPPPSQAHAPPLPSSQSPPPTHSPPPSSPSPPSPTHAPPPSPTPPPARAPSPPPPPPPSSPSSACKSTLYPKLCRSIVSSIRSSPSDPYNLGKFSIKQSLKQAKKLVLVFKDFLTKYKSSSSLNAAEIAALEDCSELNQLNVNYLESVSEELKSADSSNDTELVEKIETYLSAVATNHYTCYDGLVVIKSNIANAIAVPLKNVTQLYSVSLGLVTQALKKNLKTHKTRKHGLPTKDYKVRQPLKKLIKLLHTKYSCTASSNCSTRSERILKESENQGVLLKEFAIVSLDGTENFTSIGDAIAAAPDNLRAEDGYFLIYVREGNYEEYVTVPIQKKNILLIGDGINKTCITGNHSVVDGWTTYNSSTFAVSGERFVAVDVTFRNTAGPQKHQAVALRNNADLSTFYRCSFEGYQDTLYVHSLRQFYRECDIYGTVDFIFGNAAVVFQSCNIYARKPMPNQKNAVTAQGRTDPNQNTGISIQNCKIDAAPDLAEDLKSTNSYLGRPWKVYSRTVFMQSYIGELIQSAGWLEWNGTDGLNTLFYGEFKNFGPGSDTSKRVQWSGYNLLSATQARNFTVHNFTLGYTWLPDTDIPYSEGL
125
P27636
2.7.11.1
ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNSMADTDRVNLTPIQRASEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWINSTENVKVDKLNKFKEDFTDADYHWDADFQEEKLNISPSKFSLAAAPAAWAENNQELDLMPPTESQLLSQLKSSSKPLTDLHVLFSVCSLENIADTIIECLSRTTVDKRLITAFGSIFVYDTQHNHSRLRLKFIAMGGIPLIIKFEHLAKEFVIDYPQTLIECGIMYPPNFASLKTPKYILELVYRFYDLTSTAFWCRWCFKHLDISLLLNNIHERRAQSILLKLSSYAPWSFEKILPSLIDSKLKKKILISPQITYVVFKSINYMITTNDDKIHKSAIPSSSSLPLSSSPTRNSPVNSVQSPSRSPVHSLMATRPSSPMRHKSISNFPHLTISSKSRLLIELPEGFFTWLTSFFVDMAQIKDLSVLKYFTKLCYLTVHINSTFLNDLLDNDAFFAFIRNIDTIIPFIDDAKTAAFIWKQITAICVEMSLDMDQMSASLFSTAMNFIRKKNNTSISGLEIILNCLHFTLRNVNDDVAPTVGSSESHSVFLIKVNNDAAIELPIDQLVDLFYALNDDDVNLSKLISIFTKICSLPGFENLTINIIFHPNFYEKIVSFFDTYFNSLLIQIDLLKFIKLIFSKSLLKLYDYTGQPDPIKQTEPNRRNKATVFKLRAILVQITEFLNNNWNKDVPKRNSNQVGGDSVLICQLCEDIRSLSKKGSLQKVSSVTAAIGSSPTKDERSNLRSSKDKSDGFSVPITTFQT
99
Q7UK67
3.4.21.92
ACT_SITE 124; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 149; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
MSDPFGSPFPSLHDQNLNAQHAMASDHRLANAASYQSYQRQRQMTLGDLLLENRIVFMQGEIHYANANEIVMKLLYLQSENRRKDIHLYINSPGGSVTATLAIYDTMQMLSCPVATYCVGEACSGAAVLLIGGAKGKRFCLPNSRVMMHQPLGGVSGQVSDIEIQAAEMFRYRDKLNEIISSHCGKSVEQIAKDTDRDFFLDAQQAKEYGLVDDLLLGTPASEEDED
179
Q5BE04
2.3.1.286
ACT_SITE 253; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
MAPRKTKPATKPAAKPTPASTATTSSCPSPKSFPIPMEVDDFSFSDSELSDAQSLIEPEGFSLLSPDESSGGRSQDELPPARKKRRVAGPKERRTQHLDLTPRLGFSDYGDQEPQLNLLVNTIRNHKKIVVIAGAGISTSAGIPDFRSDDGLFKTLQKKHNLKASGKLMFDAAVYQDEALTASFQEMVRSLSEEAEKSSPTAFHHMLARLGSDNRLTRLYTQNIDGIETSMPPLATQIPLNVKAPWPRTIQLHGSLEKMVCQKCRHMSTFDRVMFDRPDAPECPECVLTNQFRMETGQRSHGIGKMRPRIVLYNEHNPDEEAITSVMNADIRSRPDALIVVGTSLKIPGVRRLVKSLCSVIRSRRNGVTMWINNEPPSGKEFEDCFDLLVKGDCEEVARLAQLKRWDDDSKPIFDECQSADVERVKNEQGPLSVVITTPKKEKVQAQTGMLTPSSSYDGDVENASTTTLSNPASKGRKLTEILKASKKDAPKTESAGVKKPAPRKRTKKEPVKNAKITTFSKVTKAQKVTPEEKSVKLEEHKAMHPLPPGAARTNAPMLPGLAKDDSKSTPSGKRGQLETISPDRIPKGMGKLLD
58
Q9I5G7
3.4.21.89
ACT_SITE 90; /evidence="ECO:0000250"; ACT_SITE 145; /evidence="ECO:0000250"
MTLNFPLLLVIAVAVCGALALVDLVLFAPRRRAAISSYEGQVNEPDPAVLEKLNKEPLLVEYGKSFFPVLFIVLVLRSFLVEPFQIPSGSMKPTLEVGDFILVNKFAYGIRLPVLDTKVIPIGDPQRGDVMVFRYPSEPNINYIKRVVGLPGDTVRYTKEKRLYVNGELVAEKLVGEEPGTLGSVTLYQEKLGQAEHLIRKEMSRYRIEPDRQWTIPAGHYFMMGDNRDNSNDSRYWNDPKIPKDLLGMVPDRNIVGKAFAVWMSWPDPKMSNLPNFSRVGVIH
178
A0A2K1KK22
2.3.2.26
ACT_SITE 1379; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MTIASRAEEGGGGVGVETSAREILLRNQPELLEQFGNDLFPVLVQVYGSSVNPPVRHKCLAAIIKLVHFTAPEMLRSLLQESNISSFLAGVLASKDMSLLTKALQIAEMLMQKLPDVFAKMFVKEGVVHALDTLITSEQVGALSPPGGSRSADLAANAVVTASGGILPPPRPRRGGASRRKSMGSTDEEAGLSTSAPLSTTMASPPSGGEPLRTIRSGLRASAIARAKKIRNTYFPGDAGAADEGVTESLRKLKKLCAQLNGEASGGEGKGKGLGGGRGAGLSEEQLGAVVGVLLGELGAGDGVSTFEFVGSGVVGGLINYFTCGNTAKENVEDPGLREQALKRMKQFIEVALPRETGVSGSDAPLTLLVRKLQNALASLERFPVVLSHAPRSNSWTVSIAAGLSALTQPFKLRLCRATGDKTLRDYSNNIVLIEPLATLIAVEDFLWPRVKRHERAGTAATGAASTSEASAPIPVPNAERRPSTRSRSAAAAAGMGSGRSSESWGGASGAKGKGKAVSRSLGASPGGDESRGPETRNAAARRRAAAASASTEKAASEGESEEDVEVSPVELEEAVAMDEDDLSEEEDEDEDDDHDDVFGDDPVAPCKRDQVHDVQLGDAEGGAVASSSEASQPSGGASVVSRTGALTSGAESSGTRTGGSRGALSYAAAALASAGVNGSRGGGRERKSVGAAAAAAANSPPKLVFCLGGKQLNRMLTIFQAIQRQAVAEEDEEERYGGSEHGGGSGRRLWDEVYTITYQRADANGEATASAVGKSASASPRGKGCGSAMEGSWQQASLLDSTLQGELPCDLDRSNNSYSILLLLRVLEGLNKLAPRLRAQGALEAFAAGEVDRVDESPGAGPLVPREDFLSSKLTPKLARQMQDALALCSGGLPSWCGQLTRACPFLFPFETRRQYFHSTAFGLSRALQRLQQQQSADGAAASNDRELRVGRLQRQKVRVSRQRILESAAKVMELYSGHKAVLEVEYFGEVGTGLGPTLEFYTLLSHELQKEKLDMWRSETMMKSEAMAGVESAEVEAVDADVEMVEEEVAEVEALSMGEGDRGSAEGGAISGEYVTAPQGLFPRPWHPDTDPGSNKKYWKVLEHFRLLGRVMAKALQDGRLLDVPMSTAFYKIILGQELDLYDIQTLDPELGRTLFEMQGLIRRKQLLETHGGKREEVEALTFRGSRLEDLCLDFTLPGYPEYELRSNGREVAVDLDNLEEYVSLVVEATVKVGVGPQIEAFRSGFNQVFQLSSLQIFSEDELDYLLCGRRELWAPESLPDIMKFDHGYTASSPPIRNLLDIMCELSPEEQRAFLRFVTGAPRLPPGGLAALNPKLTIVRKHPTGGSGVALGSTPPGAAAGMGTTLADRDLPSVMTCANYLKLPPYSCKEIMRERLLYAIHEGQGSFDLS
65
A0A2C9U7U4
1.11.1.7
ACT_SITE 100; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MNESAGRIHYKRMPSTTTAFISKVKLNFLIEMSAAKSFSALLLQITIVLLLVFNPANAQLKVGFYSNTCPKAEAIVKDVIDGVLSVAPSLAGPLLRMHFHDCFVRGCDGSVLLNSTTQQAEKDGPPNLTLRGYQVIDRVKSALEKACPGVVSCADIVAIVARDVTVASKGLRWEVETGRRDGRVSIAAETLTNLIAPNANITTIITRFQAKGLSVKDAVVLSEKNPHAVDVILIPLCYTGSHTIGTSHCSSFNSRLYNFTGKGTDNDFDPTLDSEYVKELKSKCKPGDQNSLVEMDPGSFRTFDADYYTLVSKRRGLFQSDAALLDNSITKAYVNLQVATQGSTFLKDFGDSMVKMGRVDVLTGTAGEIRKVCSKVN
14
A0A9R0K4I6
3.1.1.11
ACT_SITE 191; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGKTSGVCLILVIVVALICGAYLLLKYHEKFHKPKSSSNYKFDAIVCSMGDETFTTVSEAIISAPSYSSTRFFIRVCSGVYNEVVVVPQNKTNIVLIGDGAETTKITANRHISDFSTSETATFSVLGDGFMAQDITFENDAGSESGQAVALLCSANHTIFYRCKFIGYHDTLYAKQGSQYYRECDIYGTVDFIFGFATAVFQKCNLYGRVSKYQKVTFTAQGRQSLDEKSGFTLQGCYFTAAPEAGMGANISGFLGRPWFPYSTVMVMESFLDTIITSSGWREWSDTPETNAIYLEYNNWGPGADTSGRVHWSGFKVVTDAKEAMPYTASHFIQGDEWIPPTKVPYDAGFLS
125
Q4V8J2
2.3.2.23
ACT_SITE 86; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
MTASKRVAKELDDLSKELPPYLRHLSSDDANVLVWHMLLLPDQLPYRLKAFGLRIDFPREYPLKPPTLRFTTKIYHPNISEDGLVCLPLISTENWKPYTKAYQVLEALNILVSRPNLEEPVRLELADLLTQDPEMFRKKAEEFTLQYGVDRPS
64
Q76HM9
3.2.1.35
ACT_SITE 129; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q12794"
MITQLGLTLVVGLTLCLVHVQALLQVPEFPFSVLWNVPSARCKTRFGVHLPLDALGIIANHGQRFHGQNITIFYKNQFGLYPYFGPRGTAHNGGIPQAVSLDHHLAQAAHQILHNLGSSFAGLAVLDWEEWYPLWAGNWGTHRQVYQAASWAWAQQMFPDLNPQEQLHKAQTGFEQAARALMEHTLRLGQMLRPHGLWGFYRYPVCGNGWHNMASNYTGHCHPAIITRNTQLRWLWAASSALFPSIYLPPRLPPAYHQTFVRHRLEEAFRVALTGHAHPLPVLAYVRLTHRSSGRFLSLDDLMQTIGVSAALGAAGVVLWGDLSVSSSEEECWRLHDYLVGTLGPYVINVTKAATACSHQRCHGHGRCSWKDPGQMEAFLHLQPDDNLGAWKSFRCRCYLGWSGPTCLEPKP
166
W1PQY8
4.2.1.11
ACT_SITE 252; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 386; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"
MSVQEYLDKHKLSRKIEDAVNAAVRAKSSDPVLFISNHMKKAVPSVITKVTARQVLDSRGIPTVEVDLYTNKGMFRAAVPSGASPGMYEAVELRDGDKSKYLGKGVSKAVRNINEKISEALIGMNPTSQSEIDRAMIDLDKTENKGELGANAMLAASMAACKAGAAEKEIPLYQHIADLSGKTKLILPVPAFSMISGGKHAGNNLAVQEIMIIPIGANTFEEAMQMGSETYQHLKAVITEKYGQTGCNVGDEGGFAPNISSSIEGLDLIKEAINRAGYSDKIKLAMDVAASQFCIGKKYDLDFKAPNKSGQNFKTGQEMTEMYTQICGDYPIVSIEEPFDKDDWENTKAFSALGLCQVVGADLLMNNPKRIERAIHESTCHALLLKLNQIGTITEAIEVAKQASDAEWGVVISHRSGETEDPFIADLAVGLAAGRIKAGAPCRGERVAKYNQVS
200
A2DE79
3.5.1.98
ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MNQRAVYFYDDDIGKFYYAPNHAMKPHRVRMAHTLITAYGLDKKMRCLRPKRATANDMMRFHSADYISFLERVQPENIDQLNGLAEKFNLNTDTPIFEGVFEFCQISAGGTLSAAEELIKGKADIAINWAGGLHHAKMTQASGFCYVADCVLGILKLLERYKRVMYIDIDVHHGDGVEEAFYTTDRVLTVSFHKYGHYFPGSGNSNDVGAGRGKYYSINVPLKDGIDDNTYTMLFKNIITTAFEWYRPEAILLQCGADSLTGDRLGTFNLTISGHAECIRICKSFGVPLLLTGGGGYTVRNVARCWTYETALVLGEELENQIPYNQYLPYFGPDYNLHIQPSNKPNQNAEEYLKKKEAEIMDHMRHLPCAPSIRLWNSKDELSRMLEDSDESDDNFYDSRLTDSCIHTDYHFSYLPQ
184
P15202
1.11.1.6
ACT_SITE 70; /evidence="ECO:0000269|PubMed:9931255"; ACT_SITE 143; /evidence="ECO:0000269|PubMed:9931255"
MSKLGQEKNEVNYSDVREDRVVTNSTGNPINEPFVTQRIGEHGPLLLQDYNLIDSLAHFNRENIPQRNPHAHGSGAFGYFEVTDDITDICGSAMFSKIGKRTKCLTRFSTVGGDKGSADTVRDPRGFATKFYTEEGNLDWVYNNTPVFFIRDPSKFPHFIHTQKRNPQTNLRDADMFWDFLTTPENQVAIHQVMILFSDRGTPANYRSMHGYSGHTYKWSNKNGDWHYVQVHIKTDQGIKNLTIEEATKIAGSNPDYCQQDLFEAIQNGNYPSWTVYIQTMTERDAKKLPFSVFDLTKVWPQGQFPLRRVGKIVLNENPLNFFAQVEQAAFAPSTTVPYQEASADPVLQARLFSYADAHRYRLGPNFHQIPVNCPYASKFFNPAIRDGPMNVNGNFGSEPTYLANDKSYTYIQQDRPIQQHQEVWNGPAIPYHWATSPGDVDFVQARNLYRVLGKQPGQQKNLAYNIGIHVEGACPQIQQRVYDMFARVDKGLSEAIKKVAEAKHASELSSNSKF
13
A0A1U7Z6I7
3.2.1.21
ACT_SITE 182; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 386; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"
MATANDNGETISKEVSRSDFPPDFVFGVATSAYQIEGANNEGGRGDSIWDIFSHTEGKILDGSNGDIAVDHYHRYREDIELMAKLGFDAYRFSISWSRIFPDGLGTKANEEGIAYYNNVINALLEKGIEPYITLYHWDLPSNLHESISGWLSEKIVKYFAIYAETCFASFGDRVKHWITINEPLQTSVNGYCTGIFAPGRTENSLTEPYLATHYQLLAHAAAVSVYRNKFKANQGGEIGITVDCEWAEAFSDKTEDKVAAARRLDFQLGWFLDPIFYGDYPEVMREKLGDQIPKFSEEDKELLKNSVDFLGLNHYTSRFIAHVSKSPEVNGYYQVQQIERIVEWPNGERIGERAASEWLYIVPWGFRKVLNYISQRYRNTPIYITENGMDDEDSETSPLHEVLDDKKRLGYYKGYLDAVAQSIRDGVDVRGYFAWSLLDNFEWAQGYTKRFGLVYVDYKNGLSRHPKSSALWFSRFLRTGEGKHGKVD
161
A0A078FHG5
5.3.1.8
ACT_SITE 318; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MGADAIQTNGGDPAKLTVVEGIKRLRCAVKNYEWGKLGHESLVARLHEANSGNRVDPAVPHAELWMGTHESGPSHVVKEEELGSGHGGSDCMVTLKSWVSDNPDVLGSRAVDKWGCDLPFLFKVLSVTKALSIQAHPNKALAEKLHREEPLLYRDANRKPEIALAITPFQALCGFVSLKELKEVIANVPEIPELVGSKAADQIFTVNEKDGEESVKSVVRLIFTQLMSATNNETKRVISEMKMRLITETNHRELSEKEKLVLELEKQYPGDVGVISAFFFNYVKLNPGEALYLDADQPHAYISGDCVECMAASDNVVRAGLTPKHRDVQTLCSMLTYKLGYPEILKGFPLTPYITRYLPPFDEFEVDHCDLPTGKSTIFPAIPGPSVYLVIEGTGKLQTGSSQLLVNRGDVLFVPAHNEIQVTGESDVIKLYRAGVSSRFFQTL
214
Q9HR24
3.5.4.5
ACT_SITE 55; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MDTDDLLAAARDATAAAHVPYSEYKVGAALDTASGAVYTGCNIENANYSNSLHAEEVAVGKAVSAGDTDFQRLAVTSSQRDAVTPCGMCRQTLAEFAADDLTILCDSGDDTAGVVTYTLGELLPDTITASNLDA
187
Q504U8
2.7.10.1
ACT_SITE 792; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPGEWLVWKQSCSSTSSTHSAAASLQCPSQVLPPASPEGETVADLQTQ
97
A0A078J5S8
3.2.1.143
ACT_SITE 280; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 299; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"
MSFWKFGKAKRMEKKEYLGSFLKYLPLVAQSSSLAWPPSVEQELQTISEGPTKSMVNSGEVLASHITNMRKSLSLDACDLSPNPLLQGYATFFDKKISREESAKFFGEVVPALCGLLLQLPSMLETHYQNADHVLDGVTSGLRLLAPQEAGVVFLSQELIAALLACSFFCLFPEADRRSKHLQSINFDDLIWFPFMSYCSKRENKIRCLLHYFERVCQCMPTGFVSFERKVLPRGHKHNPHYVSYPDAEYWAKSTTPLCSVEIHTSGAIEDQPGEALEVDFADEYIGGLTLSYDTLQEEIRFVINPELIAGMIFLPRMDVNEAIEIVGVERFSRYTGYGPSFQYAGDYTDEKDFDAFKRRKTRVIAIDALPNPGSTQYKPERLLREINKAFSGYLHQCKHQAGPPPSSAVESSKRWCMDDHEEKIGVATGNWGCGVFGGDPEVKIMLQWLAISQSGRPFMSYYTFGLQALQNVNQVIERIGLQEMKVGELWSKLVEYSAERLSRSTRLGFFSWFMASLSATN
159
Q54L00
2.7.11.1
ACT_SITE 509; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDTNNCGVCKTIVNPGSERVKAGTSVFHAKCFVCKECKNELESFIRSKDGSLICDECDIKLNARKCFKCQLPIQSTIVTARGKSFHNDCFNCASCEKIIKGGFFFVEGEFYCSTCDAKPSDKTKTTTPPPSEIPLPGKSGVSLANGVEIQVPNNSTNIIYVLNTNESSNGLSSSGGSGNSISGSGGTNTGSSTSSFMIHKRNNSNELNVVTPTATTTVDLLTSSTTTTPTLSPSTLSPPISTARFSNDYLISLQDDIYAKQQQQLLLLQQQQIQIQQQLQQQQLEILQKNQSLLNSSSPSPSTSSTSSTSSISQSQNLNTSQPNITQQLSNLNISNQKNGEIEKYIPKINGKTLTELLKHQSFDDILGEVLSKKISIYKELSKEEVAFGDVIASGASGKVYKGIYKGRDVAIKVYSSENFCFNIEEFDREVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKEKPLAYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKQMTLNLGTSCYMSPELFKGNGYDETCDVYAFGIVLWEIIARKEPYENINSWSIPVLVAKGERPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTLKKISESLTLKRNKK
99
A0A2R6WG03
1.11.1.7
ACT_SITE 166; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASALNRGNSLKVPLPKASLLTRTASFPTDSSQRVSGAFQGPAATAPLMRGDTFKAGASTDSASVRWGSMKGAGKMAASTLKLAVLLFIGVYLYGAVSYARSIRYPSRVVTTEMLYRRLEEAGDTVPEHFHLYSCPQATFVVSELVNKFVTTDPNLAGGLEVLQFHDCFVRGCDASILLNSTSATTPEKDASPKADQESLRGFEQIDKIRAALEEACPDIVTCADILALVARDPTLKAGGPSWSVVLGRREGFVFLEAEAKISLPSPLSNFSSLVQNFELVKCTMDETSSY
14
O69886
3.4.21.89
ACT_SITE 114; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 184; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MGDVAVGARSGHDGEENRGRPEERSGPAAVGAPDSGHGSGTEDGRVTNGQRGQDGHNGGTEDEGVGGTPPATPPAAKKQRSFWKELPILVGIALVLALLIKTFLVQAFSIPSSSMENTLQIGDRVLVDKLTPWFGSEPERGEVVVFHDPADWLAGEPTPDPNALQTVLSWIGLMPSAEEKDLIKRVIGVAGDTVECNKTGPLKVNGKALNEPYVYPGNTPCSDDDQGGRFKVTVPEGKIWVMGDHRQNSRDSRYNQSDKNGGMVPVDEVVGRAIVVAWPMNRWGTLPVPDTFDQDGLQARSSAAAALSVAPQGLAVAGVVPFVWWRRRRTAPAETR
178
U5CQZ8
2.1.1.37
ACT_SITE 799; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MEDRKVLRRSPGMASSSAMLRRSPRMVSSSANMGQTLPSSSFGGSVKETHLPSLGHGSSMEGKKDLRRSPRMASSSANMWRPVLSSSTDNSVKETSSPNVGHGSSRVDCKLLRRSPRMVSSSANMGQTMPSSRTDGLVKEASLPNVGSGSSMEGKKELRRSPRMVSWSANIGQTMASLSTDVSVEETSLPNVSCGSSMEGKKELRRSPRMLSRSLNIGQTKPSLSTDGSIKETSLPNVGHGSSMESKKELRRSPRMLSRSLNIGQTKPSLSTDGSVKETSLPNVGHGSSMESKKELRRSPRNASYFENFGQNKLSSSIEHSGTALSLPNLGHVSSMDYKKALRRSPRIVLCSEKSGKNRRSLSTDSSVKVDSSPDSVCEVYQRRVKKQKVGEKVTNEECRLIGAPVDLEEAHNRWPWRYNVEKSGRNSKKNWSMDSDELILDVRCHYLQADICGHKFNLGDTAYVKGQKGGPNYIGRILEFFETMDGIQYFNAQWFFRAADTVIQGLASQHDKKRIFYSDLKNDNLLDCIVSKIKIVQVTPNVNLAKRKSIPPCDFYYDMSYSIPYSTFSNILSETSNGNSDSLSSVCTETGCVSDIASKSSTRKASRSNEPERTELTLLDLFCGCGGMSTGLSLGAKLSGVNLVTRWALDLNESACQSLKLNHPETEVRNESAEEFFELLKAWEKLCKQYCPSGVEKAPSRGLQSDGNPKEDSKIPSGEYEVSHFVGIRYGDHIESGKRGLMFKVRWKGYGSSEDTWEPIGSLGKCQERTREFVQEGIKANILPLPGDVGIVCGGPPCQGISGYNRFRNEEAPLDDPKNHQLVVFMDIVNFLQPRYVLMENVLDILKFAGGFLGRYALSRLINMNYQARLGIMAAGCYGLPQFRLRVFLWGAHPHEKLPQYPLPTHDVVLRGVIPCEFEPNTVAYDEDQPRNLKDAVLLGDAISDLPTVTNFETRDEMPYGKPPQTEFQRYIRATKHEMMGTAPSSVKRSSHKPMLYDHRPLLLNEDDHQRVCQIPKRKGANFRDLPGVVVGADNKVEWDPKIKRVLLPSGKPLVPDYAMSHLNGKSSKPFARLWWDETVPTVLTRAPPHNQAILHPVQDRVLTVRESGRLQGFPDYYKLCGSVRDRYMQVGNAVAVPVAMALGYAMGLAYRGLSSNDPLITLPTDFPLRRPPSSSSSSEVE
47
Q59S66
2.7.11.1
ACT_SITE 365; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MMLPRNSPHRTESTLAYNNNNSNNNNNNNGSSLFQRKPLAPINSEFKISKPQHIKPTTHSHTFTTPTPKTRNTATTTTNNNNRNNHQYRNPNLNTSLVFTPTKNSSSSSSSHSSSLLSSSPFVEEPENQPESNHTRATSHYRTTSTSQYKSSANKDASHSLITSSKRKTSTKQTSESTNPKRRTTTTATQNTNNNKILNPSLSSSTIRFSTVSSSTSSSTTSSSSSSHTSPKPQQQLTLDDFEFGKILGKGKLGRVYCVKHKQSGLIFALKVMSKSEIMNLKLEKSLRREIEIQSNLYHINITRLYSWFHDSINIYLLLEYSIEGELYTHLKKLKRFDNIMASNYIFQITQALIFLHQRGIIHRDLKPENIMVSLDNQLKLSDFGWSVQINQNQNQNQIHNQTQTQKTPHQKKQKQKRLTICGTLDYLPPEMIESKSHDFSVDIWALGILCYELLVGKPPFEAINRNITYEKIAKVDIKYPSNLDVDAIDLISKLVVKDPNKRLSLKEVLNHNWIIKNKPKWPKNIYK
99
H3G9S9
3.1.1.11
ACT_SITE 205; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MHSFALPLVALASLATSTAAAIDAPCNGPNARTQPPAGAIVVDITGTYNGSYQSVAEGMAYLPNTTEEHTVFLFPGVYQEQVIVPKLAGPLVLQGYTCDSMSYAENKVTITHTMAQRDLAPEIKNNRNALVSTMRLKSSSGVKMYNLNVANPTGKIDQLGQAIAAYVDAPNYGFYACNFTGYQDTVCAHKGPELFARSYISGAVDFIFGMRAQAWFESCDIETVGEGWITANGNVNSSNLSEYVFNRARVFGSSGNGSTYLGRPWQPYARVVWQNSELGDVVHPQGWSTWDDKTSTENVYFKEFNNSGPGAAIEQRVPFSGQLNASVDIKEILGEGFESAWWVDTKYL
125
A0A3Q7EVV1
2.2.1.1
ACT_SITE 505; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MAISNFIVKPFPPLFHIQTNNYRYDYHTKKLALKSNIVCLKTNNISTTSPLFDQSRPSLFKDKDYKLSWQEEVKRAYPLEISNQNLNDDEKLQELVDKRCIDNFRMLIVDSVQHAKAGHAGMALGMAEVAYFLYRHAMRYSLTSPKWFNRDRFVLSAGHGCLLQYVCLHLASFRSVQIEDLKCLCKLGSRTPGHPENVVAQGIEVTTGPLGQGVANAVGLALAEANLNARYNKPDVAVVDHRTYCIMGDGCSMEGISNEAASLAAHWKLHKLTLIYDDNHNTIDGSTDLALSEDTSARFEALGWNTITIDNSQGNLDAFKNALISAHCETRKPTFIRVKTIIGKLSKKEGTSKAHHGTFDDDDVKQMKQKVKWEDREPFHVIPMVYREMQAQTNLGGRLEQEWHSKLNYYQNKYPEEAAEFKLLLPDGMIPGWESSLPKCSMSDPVDSTRGYSGKCLNALAKVLPGLIGGSADLASSNQAYLHNLGDFKQPDSPWGQNIRYGVREHAMGGISNGLALHGGGLIPFAATFLVFSDYMKNSVRLSALSHAGVIYILTHDSVGIGEDGPTHQPIEHLAGLRAIPHLLLFRPADGKETAGAYKVAIENRSVPSLVALSRQKVAANVEGTLADAVGKGGYIVSDNSEKELPEIILIGTGSELCLCEASANVLRKEGTRVRVVSLVCWRLFDRQPRDYKECVLPSSVSKRVSVEAGSPLGWKEYVGDEGIVMGIDDFGSSGPYSEVFNKYGFTEENVTKTAKSLLTKRSSITTQTYYIYIEIGISHSPFSSIL
51
Q61RA2
2.7.11.1
ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSADVSTKPRGSLPIPTAPGESNECYRVIRTLGEGAFGEVLLIVNNKNPDMAVAMKKMQITTQANTNNIRKEFLIQQKLSKVGHDNFIRAIGMRTENGFHFLFLEYADGGELFDKIEPDHGMPTAIAQFYFRQLIEGLKYIHDCDIVHRDIKPENLLLTTSHVLKISDFGMATLYRNEGKERLLDLSCGTIPYAAPEVCAGGKYRGPPIDVWSSGIVLIAMLTGELPWDRASDSSYAYLQWLGNNNLDENPWRKMDVRALCMLRRILTDNVHRRATIEQIKTDPWFTHNYGKLEMTYGRPLKRARYADENSPDCNISSTQQADAVSTAKRRHLETPDKVAHVERQNASFSQPTRTEDLLLTQNIDMSQNNTNLLERMVCRMTRFCTKFDVPTSYRQLIHASEHAGYEVRQTADNRLLVTFREVSMMVTLYSLKTESRVMVDFRRSRGDGIQFKKMFLEVRNRMNDSICVDGQNFLEDCGYVPRKPQFVREANA
99
B7P9S3
2.3.2.26
ACT_SITE 801; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MFNAQTKATSKEQFLEQAKAARIERAYERRRDQAATSIQEYAVLWIQQLKNILWNCCIYLKDLKPESPQDAKPLMLHLHVLVTFTSTSSWRVLKDKSCEPLRPVLMQLCANVASHLVGKGGLYGALQALLLRGLARARPALKRAPLMAATNLALRPMISGQFSEDLMNLFLLHILSVPALVHHLLNIAPESVAVFNSHGVFRRSLDILTVEQNMRILFNALEGNYALCLLANLVHLAYLNIEVTAPAELFDVPAFFFLLESCQKYVVNKRSNLTHWHPILGWFAQSIDHGVQYRRLGGPETTTVALTCALFETALSSLTQLRLDILTGLCYQDLVLAHLWKLVRSLGPGHGVKAFLDLLALTTKASSPEFMILVLFCDCATHLITDMKVSTFMGDLEKGKKAAQVLMQKVPHIIPHKERVVLFRKYVNNEKTVLGLTESACALSQSTLITVHRTRIVEDGYQQLAMLPTQALKGVIRVRFINEQGLDEAGIDQDGVFKEFLEETIKRVFDPSLNLFRATSEQRLYPSPTSYIHENHLSLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHQHSALYSSIDELPSLDADLYRSLTLIKHYEGDVQDLDLTFSLNEDCMGKLVTHELVPGGKAVPVTNVNKISYIHLMAHFRMHMQIHDQTGAFLKGFRSIINPDWLTMFSTPELQRLISGDNTPIDLQDLRRHTKYFGGFHNNHRLVNWLWDILERDFNSEEHRLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDQDTGDTIASVIRGFFTIRKRDPVNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAITSNTGFELS
65
A0A9J7KSQ2
2.7.10.1
ACT_SITE 774; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MDFLNSWFRTGFLHRTGLRRLPRLSQMNWTGTLFLLATLWTLGSTQEPLSSTTVVLVGYPAVLSCGYASEQPPASVDWYRLEGLDADQERTHLLYHDSNSGTFAFGNYSDRATVVDDANLRLDTVYMSDNGDYECEVPTTEDYDTFLSKVRLQVLESPDGPRITGYSPPLLAGQTLHLRCESQIVGDVRPTLVWYNGSQELSRVEPSVWQPDTTTAVLNYVLDVSKYDNAKPYRCQAMYRGPVGVREQKVTLDIRYAPTTHMTYPLGTQVREGDDVLLRCGVDSNPPSTVSWERLEGAMPPNHKLYEEHHLLRIVGITRQFHGTYQCKAENSLGISTTSVRLDILYAPSIARQVWNTAEALVGENFTRTCVADGNPTPSVRWSRDGSEEVYDDPLFFSSINFTDDGSYICRARSSIPNFPDSTAKFRLDVKGPPQIVKQNTIFSAKENGSVTLECEVESDPPATRVAWKWESNSIESGTVGRYSVRQKETPTSILSTLTIKSVQASDFRSYQCLAVNVHGEETQVIVLERATAPPPQPIPLVAIVLPVILVFFMVVLGLLYYLRKYWQRKLPWTPKYLKNKDMEMRAIEDDYLPPIAQDSASPMPLLPGDDPSNYYQEPDLIRDLEFPRDKLSLERVLGRGNFGQVIKAKAQGVGGADKPMTVAVKTTKDGSSADAKEDLLKELKMMKLIPPHPNVVMLIGYCTKTEPVYVIVEYCALGNLQNFLRKCRSKRDSTYANIQVDERLLTPRDLASFIWQIARGMAHVASLKIVHRDLASRNVLIDKNKVCKISDFGLSRDVYDTDNEEYEQKTQGRLPLRWMAPESLFDHVYSVKSDVWSFGITMWEVLTLACTPYPGLSPPAMMERLRNGFRMSKPVHCNDEVYDIMRKCWEDDPEDRPTFIDLVRLLEDVITKAEDFIKIDEIPAAMYDESNSKKSKQEKC
97
A0A8J1MWT3
1.11.1.6
ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 143; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MADTGRYTQQQKKTYEPEPSLLTTSSGVPIGDKKNSLTVGIRGPLLIQDSVFTEEIAHFNRERIPERVVHARGAGAFGYFEVTNDITQYCKAKVFSHVGKRTPIAVRFSTTTGELGSNDTVREPRGFAIKFYTEEGNWDLVGNHTPVFFIRDPILFPSLSHAQKKNPQTHLKDPNMFWDFVSLCPQSLHKITHLFTDRGIPDGYRHMHGFGNHVFKMVNAQAKPLYCKFHYKTDQGIKNLTREEAKVVAGKDPDYSLRDLFEAIKKGDYPSWTLSIQVMTFEQAEKMSFNPFDITKVWYQSEFPLIPVGKLVLNKNPTNYFAQVEQIAFEPKNLVPGIEPSPDKILHGRIFAYSDALRYRLGVNYAQIPVNRPQGVKVANYQRDGAMAIDNQGNAPSYYPNSFGGPKDKAEYKELVYHVSGDVDKFDDKEADDTFQVREFYQKTLNDKERQDLCENIASSLIGAQQFIQDRSVKNFAAIDPDYGARVQKELDKLRAASLKKEEPKKTEPKPLFYQQKNY
13
Q9XI87
2.7.11.1
ACT_SITE 285; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MSSDSPAAGDGGEQAAAGTSVPSPSYDKQKEKARVSRTSLILWHAHQNDAAAVRKLLEEDPTLVHARDYDKRTPLHVASLHGWIDVVKCLLEFGADVNAQDRWKNTPLADAEGARKQKMIELLKSHGGLSYGQNGSHFEPKPVPPPIPKKCDWEIEPAELDFSNAAMIGKGSFGEIVKAYWRGTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHQYLKEKGGLTPTTAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRRYDKKVDVFSFAMILYEMLEGEPPFANHEPYEAAKHVSDGHRPTFRSKGCTPDLRELIVKCWDADMNQRPSFLDILKRLEKIKETLPSDHHWGLFTS
99
A0A0G2K612
2.3.2.26
ACT_SITE 725; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
65
O49353
3.2.1.39
ACT_SITE 137; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 276; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317"
MLYLPKKLFLFFFSCIVVIVNYNNSDFVNAANSIGFVNAANSIGLNYGLLGDNLPSPSKVITLYKSIDITKIRIFDPNTEVLNALRGHRDIAVTVGVRDQDLAALSASEEAVKGWFATNIEPYLSDINIAFITVGNEVIPGPIGPQVLPVMQSLTNLVKSRNLPISISTVVAMWNLEQSYPPSAGMFTSQAREQLVPVLKLLSQTNSPILVKIYPYFSYASDPSSIRLDYATFNTEAIVVQDGSLGYSNMFDAIFDAFVWAMEKEGVKDLPMVVSETGWPSAGNGNITTPDIAGTYNRNFVKHIASGKGTPKRPNKGIDGFLFATFNENQKPVGTEQNFGLYNPNDMKPIYNLF
167