Datasets:
tamarpeleg
/
EC_exercise

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC_number
stringclasses
260 values
Active_site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
Q4JDL3
3.1.3.48
ACT_SITE 353; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044"
MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSKVFENKVNSEKVKLSLRNFPHNDYEDVFEEPSESGSDPSMWTARGPFRRDRWSSEDEEAAGPSQALSPLLSDTRKIVSEGELDQLAQIRPLIFNFHEQTAIKDCLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLLTLD
149
A0A7M7PI63
4.1.1.50
ACT_SITE 83; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 97; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 240; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 254; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MDQGSGKVNNEGGKLTHYEGTEKLLELWFEPITLENGETKRQKMCDLRVIPRDEIAEMLVKVKCEIVSFSERDEQHAYILSESSLFISKRRLILKTCGTTTVLASLDSLLALAKKYCNCKVVDIFYSRKNFMRPDLQHSLYKSFEDEVKYLDSIFDRGAAYVLGRMNGDCWYLYTLDDTSIEQPDQTLEMLMTDLDDEVMAHFQNTTGRKSEDVTKESGIADLVPDCKIDGFVFEPCGYSMNGLLKDDGYVTIHVTPEKEFSYVSFETNASMEDYSSLVDRILSTFRPGKFVMTLFTNEQAACRSSRDTLKETLLDRYTRHDRQYSEFKNYDLTFGHYVRDKKR
196
O13685
2.3.2.23
ACT_SITE 86; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
MALPKRIIKEIETLTRDPPPGIVAAPTEDNLRYFKITMEGPQQSAYEGGKFHLELFLPDEYPMMPPNVRFLTKIYHPNVDKLGRICLSTLKKDWSPALQIRTVLLSIQALMGAPNPDDPLDNDVAKIWKENEPQAIANAREWTKKYAV
64
A0A9R0JUM2
1.11.1.7
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MESFLKQWNIFMFVFLFFSLPLALAQLELGFYTSSCPDAEFIVQQVVRQHVEVDKSVPAALLRMHFHDCFIRGCDASILIDSTDSNQSEKEAGANASVREYELIDEIKNFLEQACRGIVSCADIITLATRDAIALAGGPVYNVPTGRLDGLISRASEVNLPGPASTVAQIRQTFRARGMTVRDMVLLVGGGHSIGVAHCNFFQDRLFNFQGTGAPDSTMDTTLLNELQGLCGFSSQVPNPTTFLDQNTSFVLDNEIYKQMKMNRGILQIDQELALDPLSSKIVSDFAADNGFFRRRFVDAIIKMGNLPGSGGEVRGNCRRINSATAQQSLLSSI
14
P9WHP9
5.4.99.12
ACT_SITE 72; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
MSLTRRPPKSPPQRPPRISGVVRLRLDIAYDGTDFAGWAAQVGQRTVAGDLDAALTTIFRTPVRLRAAGRTDAGVHASGQVAHVDVPADALPNAYPRAGHVGDPEFLPLLRRLGRFLPADVRILDITRAPAGFDARFSALRRHYVYRLSTAPYGVEPQQARYITAWPRELDLDAMTAASRDLMGLHDFAAFCRHREGATTIRDLQRLDWSRAGTLVTAHVTADAFCWSMVRSLVGALLAVGEHRRATTWCRELLTATGRSSDFAVAPAHGLTLIQVDYPPDDQLASRNLVTRDVRSG
217
T1FM91
1.8.1.4
ACT_SITE 484; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MISHKSTSLICKNFINCQKFSIPLGSSFQHRTYASGEHADLVVIGSGPGGYVAAIKAAQLGMKTVCVEKDPTLGGTCLNVGCIPSKSLLNNSHYWHMAKHNDFAIRGIEFNNLTLNLDKLMSQKVAAVKALTGGIAHLFKQNKVRHIEGHGTITGVNEVVVKKNDGSTESVATKNILIATGSEVMPFSGIEIDEKTVVSSTGALSLSQVPKKMIVIGAGVIGVELGSVWSRLGAEVTLIEFLGNIGGFGIDLEVAKHIQRSLTKQGLKFQLETKVLSAVKEGGGNIKVEAEDMKKKQKLQLDCDVLLVCIGRRPYTQNLGLENVKISLDNKGRVPVNKKFQTSVPNIYAIGDVIEGPMLAHKAEDEGVICVEGMVGGSGHIDYNCVPSVVYTHPEVAWVGKSEEQLKEAGIKYKVGKFPMLANSRSKCNMDTDGFVKVLGDQETDRVLGCHIISSVAGELINEAVLAMEYGASCEDVARVCHAHPTVAEALREAHLAAYCGKPINF
36
A0A804HPZ4
1.11.1.7
ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MTVDTASAPPKMAGNPIAGFLFQVAMLSSLLCSSNGHGLKMGFYKQSCPQAETIVRTTVDSFFSHDPTVSAPLLRLHFHDCFVRGCDGSVLLNSTRKNLAEKDAKPNLTLDGFYVIDAAKAALEESCPATVSCADILALAARDAVSLAAGLGKGIAMTNQSLYQVETGRRDGFVSRASEAEAHLPSSYANISALKANFGSKRLTARDLAVLSGAHAIGNSHCFSFDKRLKRYHGKGGIDPTLDPHYAIKLISKCRPGNGTTTEMVPGSSTTFDTKYYELVAKRRGLFHSDAALLHDKVTRDYVFSRLKSPESSFFADFGSAMVKMGKVGVLTGKAGEIRKNCALVNR
14
P52407
3.2.1.39
ACT_SITE 130; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 276; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317"
MAISSSTSGTSSSFPSRTTVMLLLFFFAASVGITDAQVGVCYGMQGNNLPPVSEVIALYKKSNITRMRIYDPNRAVLEALRGSNIELILGVPNSDLQSLTNPSNAKSWVQKNVRGFWSSVLFRYIAVGNEISPVNRGTAWLAQFVLPAMRNIHDAIRSAGLQDQIKVSTAIDLTLVGNSYPPSAGAFRDDVRSYLDPIIGFLSSIRSPLLANIYPYFTYAYNPRDISLPYALFTSPSVVVWDGQRGYKNLFDATLDALYSALERASGGSLEVVVSESGWPSAGAFAATFDNGRTYLSNLIQHVKGGTPKRPNRAIETYLFAMFDENKKQPEVEKHFGLFFPNKWQKYNLNFSAEKNWDISTEHNATILFLKSDM
167
P27638
2.7.11.24
ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MASATSTPTIADGNSNKESVATSRSPHTHDLNFELPEEYEMINLIGQGAYGVVCAALHKPSGLKVAVKKIHPFNHPVFCLRTLREIKLLRHFRHENIISILDILPPPSYQELEDVYIVQELMETDLYRVIRSQPLSDDHCQYFTYQILRALKAMHSAGVVHRDLKPSNLLLNANCDLKVADFGLARSTTAQGGNPGFMTEYVATRWYRAPEIMLSFREYSKAIDLWSTGCILAEMLSARPLFPGKDYHSQITLILNILGTPTMDDFSRIKSARARKYIKSLPFTPKVSFKALFPQASPDAIDLLEKLLTFNPDKRITAEEALKHPYVAAYHDASDEPTASPMPPNLVDLYCNKEDLEIPVLKALIFREVNFR
104
A0A022QC11
3.1.1.11
ACT_SITE 415; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MTRGGGKFVIVGVWVILVVGVVIGLTTGVNPEKATEEGLWTSSKAVFTVCGETDYKKTCADSLSTVANNESATPMDFLQAAINVAIQEVQAAMSLPDTIGKSANDPQQKMAVEDCKDLLQYAVAELQASFSMVGDSSLHTISDREAELKNWLSAVISYQQTCIDGFTTPELQKAISDGLLNATQLTDNALAIVTVISQIFQAFNINIPSNSILNSTAASSGRLLEEDHDHDDDGTSSSSSFPAWLPAGDRKLLASKSGGGGQPAPNAVVAQDGSGGYKTISAALAAYPKNHKGRYVIYVKAGVYDETVTITKDLVNVYMYGDGPRKSIVTGKKCFTDGVSTFQTAPFIAIGDGFIAKSMGFRNTAGPEGHQAVALRVQSDMSAFYNCRMDGYQDTLYAQTHRQFYRNCVISGTVDFIFGDSAVVIQNCLIIVRKPMDNQQNTVTAQGRTQSKETTGIVIQNCRIVPEQKLEPLRFKIPTYLGRPWKKYSKTIIMESTLADFIQPAGWMPWSGNFALDTLYYREYANKGPGAPTDKRVKWKGYSVITNRDDALQFTAAPFIQADQWLTTTGVPYFLGLKN
125
A0A251NDS7
3.1.1.11
ACT_SITE 390; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MKRSRNCIKMNMLMFFPSLTSLLLMASFFFFHLGFSFSHQIPHPTIKNACTTLLHPSLCFTALASAKTHDHFTAFHHLLEANINQTVASVESTRQSIKGLLKLQDLYLQERNALKDCLEMLDQTLYELGQAVDDLHGFRVSYGNLKTLLSAAMTNENTCIDGFFELEEFDSENQIGLNGHLQGLLAPISELMSDCLAMIRYQEQALNEQKRLVTKKPKKRFPVWMLPGDRNLMQREPTMKADIVVAADGNGDYETIGEALKMAPNMSRTRFVIKIKAGVYNETVEISREKANIMLVGDGMNTTIITGSKSFADGFSTFATATLTVIGDRFLARDLTITNTAGSKKFQAVAARVTSNSAFYHCNFSSYQDTLYVHSLRQFYRDCIIEGTIDFIFGNAAAVFQNCTVIVRKPIPGQKLMITAQGRTDPNQNTGISLQNCTIVAAPDFNKTERQNFTTFLGRPWRNYSRTIVMKSYLGDMINPQGWSKWDDYSTVETVEYIEYLNFGPGSDTRHRVKWGGYKKNCSEEIARQFTVGLFLHGAGHWLKTTGIPLSYGS
125
Q54CX4
2.3.2.31
ACT_SITE 795; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221"
MASVELEQQVDDLTVSKVTPFVEKNIDELNSLVQLMFTPSAPDIHCTQKLSKSQNTKLIQYKIRLEKTRSRILVLIDNYITHEEKLSHFLGLLDRIDDILTTIKIMSGEDEELNFTLPPTTNNNNNNTTNVLESSSDSDYDIIQPREFLKKSKPNLILSTKNSLSSLLKRKKSKNQITTTTTTTTTTANNNNTRRNRNNNNNNNNNANGANRTIDTSSEDDDESISSSDDDIVIGSRRSRAATISYLPNVPRANPTPINGRTPTPSHNFEPFTINTFLNSVNGVNKTSTTSTTTTTTTTTTAAGRTNKTVNRNNNNNNNNNNNKRFEIESEEESETDISSEEEENNNNNNNNSNNNNNSNNNNNLKLKTKSMSFTKNGIPLKIRSRINSESESEPENQLAESYELGKCQRKHISTPSLRLSSAHLPNTTTTTTTTTTTTTTTTSPKSVNNNDDDESSDSDSSDSEIENIKQTIKKNNGPPSPMTTEIIIGYSGHSKRLCNRYSLPTVQKSFTKQQLHEEIINFGRTPSRIKQSFLKPVNGDAELVFEYDDSEEEEEEEEEEEGEESDSESSSGSEGEVIVESFGIEKKVLRQYIKLKKEMEDRKKVSTKLEEPVECKICYMEYDQSNEVFTLECDHVYCFDCITEHLRILITEGRVLDISCPHPQCKKEIKESEIYMLTNEKNWLKYQKFSMIASLKTEPIKWCPTPDCDTPVRGGSERNPILNCPKCSNDFCWICGEYSHEGAKCGTEAMELQGRKNKSIESAATAYIDFLESNKHFVKPCPTCKSHIEKHDGCNHMTCINCQHQFCWLCMNPYQSGHYSSNEYPECFDRQYYSPFVPDTYTPPPPRRRHRKLKMAKKITLYTAAFTVGAPLLLIGGAVLLCVKIHKHRKNRARRNRNVGLY
67
P09624
1.8.1.4
ACT_SITE 478; /note="Proton acceptor"; /evidence="ECO:0000269|PubMed:9538259"
MLRIRSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC
36
T1FP07
2.7.1.11
ACT_SITE 185; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
MDDSAALGKIQKSQSICVTAGTEGKKIEKDCYSGCVIGVFTSGGDSQGMNAATRAIVRMGIYVGCKVYLIKEGYQGMVDGGSNIVLADWKSVSNIIQSGGTIIGSARCADFRERPGRLQAAYNLLERGITNLVCIGGDGSLTGANLFRIEWSSLLEELVKTGRITSQKAQECAHLNVVGLVGSIDNDFCGTDMTIGTDSALHRIIEAIDNINTTASSHQRCFVMEVMGRHCGYLALVAALASEADWVFIPESPPEKGWEDKLCEKLAQERSLGQRLNIIIVSEGAIDEEGRPITADQIKDLISKRLKYDTRVTILGHVQRGGNPSAFDRLLGCRMGAEAVLALMEATPFTPACVISLNGNQIVRVPLMECVARTKEVQAAMDKKEFQKAVELRGRDFVANLESFRTLARARAPKKAFCTAFNLAVVFVGAPACGMNAAVRSFVRIGITKGFRILGIKNGFEGLVNNEVVSLSWTDVHGWSGSGGARLKTNRTTPSKVGLDRVADKLRHFSIHGLLIIGGFEAFESILQLTEARSAYREFCIPMSMVPATISNNIPGTDFSLGSDTSLNAIVEIADRIKQSASGTRNRVFVLETMGGHCGYLATLSALASGADAAYIFEEPFNITDLQGDVNHLASKIRGGVKRGMVMRNEKANENYTSDFITRLYQEEGRNIFQCRLNVLGHMQQGGQPSPFDRNMGTKMAAKCAELLAKQVEENKTPEGSVFTNSSDTATLLGLQKKRSLFTPVLELKEKTDFQHRISKEVWWCKLRPLLRILAMHNSIYEVEGQENDGFDDLDKLYL
84
P48460
3.1.3.16
ACT_SITE 126; /note="Proton donor"; /evidence="ECO:0000250"
MLETEHANTEVHELCRQMIARIEKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDCEHGLIVDLIWSDPNRKDDTIQFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNKGYDRSKLDKRTLHDFEKNFQPLDENPRKNISCQFNVPPNGQKMSPFLGEYSMFAHETQFCKKDNETPVKKPYSSNQDEDHSVLDMIRKTQKGYGVEVSLKDKVMSLESIRKKLGMTTSTTPPPPRTPSPDAPLAQSPPIPRSPPSSTENA
144
C5YLR7
3.1.1.11
ACT_SITE 461; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSTAFSDFGPLTERRRVERQRQQRRRVMLAAGAASIVLILIVMGGAAVAYNASVQDESSSSSSSPSSSSSSGGGGGGSGSKSNLISASKSVKMMCSQTDYKDACEKSLSKAAAAANASASSPKDMVRAAVAVIGDALADAFNRSEVIKSDDPRVKAAVADCKEIYQNAKDDLGRTLHGIDAGGMNGVAKHNYELRVLLSAVIAHMETCIDGFPDGGHLKKQMTATMESGKELTSNALAIIEKASSVLVALHIPGFTAHRRLLGDNDEAENMENQPEVKHSGMSLGELEDEAMAADKRRLLKGNNFQAKLRPNVVVAKDGSGKFKTINDALNAMPKQYTGRYLIYVKQGVYQEYVTITRAMENVTMYGDGAMKTVITGSRNFADGLTTYKTATFNVQGDGFIAIALGFRNTAGAAKHQAVALLVQSDRSIFLNCRMDAYQDTLYAHSKAQFYRNCVISGTIDFVFGDAAAVFQNCILLLRRPLDSQQNIATAQGRADGRESTGFVFQYCRFAAEAGLRDASRPPIRSYLARPWREFSRTLIMESEIPAFIDKAGYLPWNGDFGLKTLWYAEYGNRGPGADTAGRVAWPGYKKVISKEEADKFTVQNFLHAEPWLKPTGTPVKYGFWA
125
A0A2C9WPN3
3.1.1.11
ACT_SITE 194; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MKNLYLFFIGGMVLLLHCSSRGCKASDCQPNTISTITVDISGHGNFTSVQSAIDFVPEGNTQWIRIQISPGKYSEKVAIPVNKSCIFLDGAGRELTSIEWGDHEETHTSATFTSYPDNIVAKGIKFKNTYNLPDGLNKIDIMKEELIWKQAVAARILGDKCAFYECGFVGLQDTLWDEEGRHYFNSCYIEGSVDFIFGQGQSIYEGCEISVNIGRFAPGVTGYITAQRKQQPQDSNGFVFKNCNISGTGTVDLGRAWGPYSTVVFYNSTMSDVIAPEGWNAWNFVNHEANFTYVEEDNKGPGADTSKRVPWEKKLDPNELQKFLNMSYVDEDGWLSKTPDLTFYY
125
Q7L8S5
3.4.19.12
ACT_SITE 149; /evidence="ECO:0000250"; ACT_SITE 152; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 268; /evidence="ECO:0000250"
MDDPKSEQQRILRRHQRERQELQAQIRSLKNSVPKTDKTKRKQLLQDVARMEAEMAQKHRQELEKFQDDSSIESVVEDLAKMNLENRPPRSSKAHRKRERMESEERERQESIFQAEMSEHLAGFKREEEEKLAAILGARGLEMKAIPADGHCMYRAIQDQLVFSVSVEMLRCRTASYMKKHVDEFLPFFSNPETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQADSPTLIIGEEYVKKPIILVYLRYAYSLGEHYNSVTPLEAGAAGGVLPRLL
175
Q2NS88
1.3.3.3
ACT_SITE 108; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333"
MDQPDIEHINAYLLALQETICAALTAADGGAVFHEDLWQRDEGGGGRTRVLRQGRVFEQAGVNFSRVYGGALPASATAHRPELAGRSYQAMGVSLVVHPENPYIPTSHANVRFFIAEKPGAEPIWWFGGGFDLTPFYGFHEDAVHWHRTAQALCQPFGDTVYPRYKRWCDDYFFLKHRNEARGIGGLFFDDLSAPNFNEAFAFCRAVSQGYLDAYLPIVERRKSHPWGERERQFQLYRRGRYVEFNLVWDRGTLFGLQSGGRTESVLMSMPPLARWQYHYDPAHDSPEAALYRDFLPARDWLKE
27
K4A4T6
2.1.1.37
ACT_SITE 522; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MAPSSPSSAAPTRASGRKRAAKAEEIHRNQEEEEEVAAASSAKRRRGASSGKKPKPPPKQAKTAKAGRKKKAEAERAEPVEDDVCAEEPDEEEMAMGEEEAAAEAEEQEAAAAAAGSPGKKRVAQPRKRGTAAAGDHEPEFVGEPVPAAEARANWPKRYDRSAAARRPEEDEEVKARCHYRSAKVDNIVYTLGDDVYVKAEENEADYIGRITEFFEGTDRCQYFTCRWFFRPEDTVINSLVCIDVDGKKHDPRRVFLSEEKNDNVLDCIISKVKIVHVDPNMDPKAKAQLIEHCDLYYDMSYSVAYSTFANIPSENGASGSETASGISSDDMDLETSSGAPVRTATLLDLYSGCGGMSTGLCLGAALAGLKLETRWAVDLNSYACQSLKYNHPQTEVRNEKADEFLALLKEWAVLCDKYVHKDVGSDSAGSEDQEDDGSPLDKDEFVVEKLIGICYGGSGRENGLYFKVQWAGYGPEEDTWEPIDNLSDCPLKIKEFVQEGYRRKILPLPGDVDVICGGPPCQGISGFNRFRNRNEPLKDEKNKQMVTFMDIVAYLKPKYVLMENVVDILKFADGYLGRYALSCLVAMNYQARLGMMVAGCYGLPQFRMRVFLWGALSSMVLPKYPLPTHDVVVRGGAPNAFSQSIVAYDETQRPSLKKALLLGDAISDLPQVENYQPHDVMEYTSSPKTEFQRYIRLGRKDMLDWSFGEEAGPDEGKLLDHQPLRLNNDDYERVKQIPVKKGANFRDLKGVKVGANNIVEWDPEIERVYLSSGKPLVPDYAMSFIKGRSPKPFGRLWWDETVPTVVTRAEPHNQIILHPTQARVLTVRENARLQGFPDYYRLFGPIKEKYIQVGNAVAVPVARALGYCLGQAFLGESEGSQPLYELPASFTSVARVAQVGASSVSTPAGEMASAPQSSPSSGNSTQSPPPSPSPPPPSPPPSQASISPPKVESSSFPAAKLSPPPPAPRKSGGSGNGGETSYSSSKDGKKKSSSSPSAPDHVGAVITGVVLGVVGFALLMAIVACLCCSRKKKKRPPPMNMPFYTDEKGNVYYPNAGLPPMWQQYGSNGSIPPPPGWHQHGGGNPLSQSPGSMAAPLSGEIYSSGPHGPALPPPSPNVALGFSKSSFSYEELAAATSGFSAGNMLGQGGFGYVHKGVLAGSGKEVAVKQLKSGSGQGEREFQAEVEIISRVHHRHLVSLVGYCIAGNQRMLVYEFVPNNTLEHHLYSKQGPVMDWPTRMKIALGSAKGLAYLHEDCHPRIIHRDIKASNILLDANFEAMVADFGLAKLTTDTNTHVSTRVMGTFGYLAPEYASSGKLTDRSDVFSFGVMLLELLTGRRPIDTANYMEDSLVDWARPLLAAALAGEAGFEELVDARLGGEYSAVEVERMAACAAASTRHSAKRRPKMSQIVRALEGDASLDDLHQDGVKPGQSMLFSAGGSENISRLRQLAFDSGEHDDYTTDYSTDSSAATTGRPPRRP
47
A0A804KQJ9
1.11.1.7
ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSFRGPTILVFLGFLSCVHADLKLGFYDDSCPKAEKMILDFVEEHIPNAPTVAASLLRMHFHDCFVRGCDGSVLINSTSTNQAEKAATPNQTLRGFDFIDRLKSVVEEECPGIVSCADILALATRDAVGVIGGPIWRVPTGRRDGLISNLTEALSEIPAPTSNLSSLQTSFANKGLNAADLVLLSGAHTIGVAHCESFSDRLYNFTGNGDQDPSLDGFYATNLKKNKCRDATDETTLVEMDPGSFRTFDVGYYRNLLKRRGLFESDAALTTDAAAKAAIVDLVDSPPQTFFAGFAMSMEKMGSIGVKTGSSGEIRRNCAVINS
14
A2EDM1
3.2.1.52
ACT_SITE 273; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MLYSIKPQLQFQAQLLSDYITQQTLMPVKYSGVISDKCSIILDIGYPDANEEAYKPTITSDSISINGSTEKGSFYGIQSLRKMIPVQKTPKKIKILTQEIIDRPRFSYRGLLLDVARYFRTVEEVKKFMDIMALHNMNFLHFHLTDDQGWRIEIPKYPDLTRIGSRRRQTKGDGIPISGFFTRKDILDLIEYGQSRQITIIPEIDLPGHAQSALTAYPKLGCTGGPYEVSERFEVHSDMLCYGNPESMVFIKDVLSYVMDLFPSKYVHIGGDEAEKSQWKACQKCQAKIRELGFVDDQISTKEDKLQRHLTIELSKIISSKGKEMIGWSEIAHGEKVENSIVMSWLRNKNNEMPEKDNYTVILTPTNPMYLDYLQEKRSNLNTLDKVYNYEPITENHNDNDVSRFMGIEACMWTEYTPTFESVMTKVLPRAAAVSVAQWSFPNLKNYQSFLGDLENLKKIYELNNYVYYADY
170
H9G588
3.1.4.11
ACT_SITE 400; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 447; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MVLLSLCVCVCVCFPAQEEEEEEKKGGGKERRRERRPRLAPPSPSRQPRQGKGRQRRQKNWGFPGGAMAGGRPGVHALQLEPLRVHETLLKGSKFMKWDEEPTSRALVTLRVDPQGFFLYWTGPNMEVDILDISSIRDTRTGRYAKLPKDLKIREILGFGGPEQRPEEKLLTVIHGPDMVNVSFLNFMAVVQDDTAKLWTEELFKLATNILAQNASRNTFLQKAYTRLKIQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIKPDEFTLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLSLDQLMDFINQKQRDPRLNEVLYPPLTQAQVRQLIDKYEPNQQFQQRDQMSMEGFGRYLGGEENAIVPPEKLDLSDDMTQPLSGYFINSSHNTYLTAGQLTGNSSVEMYRQVLLSGCRCIELDCWKGRPQDEEPFITHGFTMTTEIPFKEVIEAIAESAFKASPFPVILSFENHVDSAKQQAKMAEYCRNIFGDALLIDPFEKYPLQPGVPLPNPQELLGRILVKNKKRRTHSKASEGSVRKRVLEQMPSTYSDSSGVGEPGSPALGSPFADASEVLSPVMTNGEEKSSDRVTKLGEPRKSIDREAESEEEEEQQDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEVASKRNKSYEMSSFVETKGLEQLTNSPMEFVEYNKKQLSRIYPKGTRVDSSNYMPQVFWNAGCQMVALNFQSLDLPMQLNLGIFEYNRRSGYLLKPEFMRRQDKLFDPFTEDIIDGIVANTVKVKIISGQFLSDKRVGIYVEVDMFGLPVDTKRKFRTRTSQGNSFNPVWDEEPFVFHKVVLPTLASLRIAVFEEGGKFVGHRILPVSAIRSGYHYICLRSESNQPLCLPALLVYTEAYDYIPDDHQNYAEALINPIRHVNLMDQRAKQLAALIGESEQENAERPRESLSRSSSSATPGPTEEAHKPPPVLLSPTRSPSVVPSQVQRDDLIASILAEISPQSIEELRQQKAFVKLLKKQYRELKELRRKHMKKICSLNKKQNSNFTLAERSRILRSREGSQSSVEAVRQGQEQDGTRRKLDLQEWQMQGLLQLRESQHQLERDCKREHLHQAQQRLRDIARECQAAQLKKLKETNEKEKKELQKILDRKRHNSITEAKSRERNKKDVELTEINRRHITESVNSIRRLEEAQKRRQEKLLGGHQGILQLIDEEEPRLLAQLEGECDLEALALRQEIGRYLQEELDGGVSNGHPPPGSGASPAPTEEEEFTVL
153
Q9N2N1
2.7.11.1
ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MTTEVGPDDNVVNNFIITPSSPKSEWTIHDFELLHKLGGGNYGDVYLASVRKSNYVVAIKKLSIKKLAEFDIVNQLRREIEIAFNTRHKYLLRTYAYFFDEHDIYLILEPCSNGMLYSELNRVKLFPPPTAARYVAQLAEALLYLHQHHILHRDIKPENILLDHHQNIKLADFGWSVHDPLNRRKTSCGTPEYFPPEIVSRQMYDMSADLWCLGIFCFELLVGHTPFVSKDNDQIYKKIHAMQYTIPDSVPPEAKDLISNLLIREGSKRLALHRVLSHPFLLKYYYVPNGITPPTGKRPRS
99
B3S269
2.7.11.1
ACT_SITE 251; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 268; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MEDTYKLERNDHQQDDERFQAEHEDDYEQWDEEEDEDFEIDWTRSSDLTKKLNTSTNFKPKQKSYGKYANRICLDKLDVTLSKEAANLVLETEKRNSSSRLREKDKADRATVEQVLDPRTRMILFKLLDRNIISSINGCVSTGKEANVYHASVNNGEERAIKIYKTSILVFKDRDKYVSGEFRLYTAEIPCPKPLLLKSHVLLMEFIGTNGWASPRLKDVQISESKARELYMQCINIMRRMYWKCKLVHADLSEFNILYHKGSLIIIDVSQSVEHDHPHALEFLRKDCSNITDYFRKRQVCTMTVKELFDFITDPNITDDNIDDYLEKAQEIAAARGFSEAHPEDAVNEEVFMRTFIPNRLDEVADFESDIMKVQSGDTEDIHYQTITGLRKDLSGPSQEPSILTEQAIEDDSEDSSSTESSDDSDTETVRSAKEEKGPKCKRNEDKDSKRERKKLAKEAQREKRKNKTPKHVKKRKEKVARMKKGK
99
F6TQ56
2.7.10.1
ACT_SITE 1022; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MCPDPRRAALAALAAGLLQGLFWIPGLADEDFPMKPELSLPGEQVVIEAGTAFDVTCRGSAPVAWAWAGDSSPRRVRRRERPCPDDLRLTCSRLTVYGMAADDTGYFTCTYRDGAVADDPDLRAAVYVFVRDRSQPFVQPFSVYPMVINILRGTQEVVVPCRVSSPDLQVKLDLYGTNPAYKFTSVSKDWDPKKGFTVTRPSYHFFSSMLQCVTEVGGETFRTFYIPQKVETEKKNLVISANHQKMLVGALLSLRCVAETTYNGRNELRWEYKKKRPDCCEVKKNIDQGDPVYKTYSTLTIRNVTVEDNGLYTCREHKASGLEANITITVYERAFINVLSRNISTIEGTVGQKGLKLVVKVAAFPRPSVAWFKDSRPIEENNTCCQSDPVRYKLTVRDVSLRSAGLYAVVLSDPQHGLSETHSVRLVVNERPKIYEKETDLDEMEPVLLGSEHVLRCTASGVPAPSIAWSWESCLPDDPLCRRRSKRVSISDHSLTTGPYSANTIKSVEETTLSHEERNKTLSILTVTSSNVSGVYFCVASNKIGGDERGMKFFISDVPDQLETEPQVSAIAGHDAVLRCRAARVIFDHLLWLDPSGGVVPGTSTQNQSDSYSISLSLVIHNASREHEGKYSCRARSRYNATLEQERSTRLQIRERVAPYVLETLASLTVNSSGKIVLECKVGGTPAPGITWTKNGYSVLPASGISLENRTLVIERAKKDDEGTYECQATNEVGQASTSAVITVEGLEERSNIEVIILVCTGLAATLFWLLLTLFIRKLRKPNVSDIKTGYLSIIMDPEEVPLDEQCERLPYDSSRWEFPRDRLRLGKTLGHGAFGKVVEASAFGIDKSSTCKTVAVKMLKECATTNECKALMSELKILIHIGHHLNVVNLLGACTKSGGPLMVIVEFCKYGNLSNYLRGKRGDFIAFKSQEGSEPGEKSLEDSSGDLTELIKRRLESVASTGSSASSGFIEDKSYSDSEEEEEDSEDLYKRLLTLEDLICYSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPEAIFDKIYTTQSDVWSFGVLLWEIFSLGASPYPGVQIDEEFCRRLKEGTRMRSPEYSTPEIYQTMLDCWRGPCSERPNFTELVERLGDLLQASVQQEGKEYIPLNITDGGLNPKSHPLEETNRGKRWSALETGSKKRPLSVKTFDEVPVEQEKPEESGSDSGMVLTSDEIKSLKRLEIRSWPHGIMALALRAVSKSKESVLSESGREGMKFQPPPAPLEAGGALDFGLEDSALLSLDPALECHSPPPDYNSVVHYSAPPV
97
I3T5V1
3.4.21.89
ACT_SITE 48; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 92; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MPFMNYIAQWKSVAKEALDRSAIIAKFLCYLHFTGNYLCSPTHAYGPSMLPTLNIAGDVVLVEHVSPRIGKVGHGDLVLVKSPLNPNRNLTKRVVAMEGDTVTYFDPLNSEDSRIAVVPKGHVWIQGDNVYASRDSRHFGPVPYGLIRGKVFFRVWPPSSFGRLDN
178
M1C4R5
2.3.2.26
ACT_SITE 322; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MAYQLPHETSTKRKFNDYAAASTARMRHNEILFNSSLKTPIQFFVRMFSGGKTLVIQAYSSDTVTSAYYRLLVRFALKMLLEGRHKNEELYEMLICRSRLFEDSFEYIGHASPRSLRGQLFIQFENEEATGPGVLREWFSLWLQEDTEDILGLTFVCEDEELGSRKVVELYPNGKNMIVNSQNRDNYVNLLVKHRFVTSITRQVAHFAQGFGDIIIDQRLRESFYRILDHEDLNRILHGSKTAVSVEDWEEHTNYNGYKKDDPQISWFWELEVCRLSRDMCFYFFWTSIKSLPVEGFGGLDSKLHIYRTSDSHDCLPSSHTCFYRLCFPPYPSVDVMQNRLNIITQNYVGCSFGAE
65
Q10364
2.7.11.1
ACT_SITE 392; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MMNKWAKNWFGLSKKSVSTNSAKGSLPRSPLASIQTNQPVEEGEGGSLPSVSNLGPSSIDHPMEEFASDQSTVGNRNSNDILPEVDHEPSGYLKLQIGSLVLGGPHTDAALAMECSRLNQLFVVVQFGTTEFVSPPLKWESPGRDIGTSSRDSANVSRSSSMMSSHPIPTPAIQRTSSIPNPLTPSYVVFDVAKPVPIDVNIYDHGNNNEFVGRTYIHPSYNYGQFEQFCNSVEVSPAYNRMVDLRLSLNTVFQPLSQHSYGPDDFVPLKLIGKGTFGQVYLVRKKDTERVYAMKVLSKKVIVRRKEVAHTVGERDILVQTSAADSPFIVALRFSFQTPKDLYLVTDYMAGGELFWHLQKSVRFPEERAKFYIAELLLALQALHKRGIVYRDLKPENILLDVQGHIALCDFGLSKANLSVGTTTRTFCGTTDYLAPEVILDEAGYDMMVDFWSLGVLLYEMTCGWSPFYADNTQQLYKNIVFGKVRFPRGLLSVEARDLIKLLLNRNPKHRLGAHGDVEEVMKHPFFDGIDWKKLAAKEISPPFKPIVEGEIDVSNFDVEFTNKAIDRDFSSTDEMSTSAPLSSTVQNGFKGFTYIDASAMDEAFGYHNSNDSASSISSQDDYSKDNSDMDLNRANDEVFMGQIDP
99
M4FAJ8
1.1.1.37
ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MFRSMLVRSSSSAKQSLIRRNLSSGSVPERKVAILGAAGGIGQPLALLMKLNPLVSSLSLYDIANTPGVAADVGHINTRSEPGMTRDDLFNINAGIVKNLCSAIAKYCPHALVNMISNPVNSTVPIAAEIFKKAGMYDEKKLFGVTTLDVVRAKTFYAGKANVPVAEVNVPVIGGHAGVTILPLFSQATPQANLSGDVLTALTKRTQDGGTEVVEAKAGKGSATLSMAYAGALFADACLKGLNGVPDVVECSYVQSTITELPFFASKVRLGKNGVEEVLDLGPLSDFEKEGLEALKPELKSSIEKGVKFANQ
5
B3SC97
3.1.4.11
ACT_SITE 295; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 342; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MTVIKTNFKVDSDGFFVSWTENKEGMCLDMFMINEAKNGTLPKDQRVRDLIEKECGPNVSEARLLTIVYGYSLVDMKEIRLIASDAKSREIWKGGINKIIHDVISMNAPSDHFIKRSWVKLCCTGDADGNIQVKNIYKLVPSKLEDRVVDSLKALNLPNKKNAVIDPSKFPFSTFMSLYNKLCPRKDIEDIVMNRTGGKAPYLSIEQLRTFHNEEQRDPRLNELLYPFMKALQSKAIIDQYEPLEVLKGRGLITPEGLQYYFYSADSLIVPLEKLQLKAKDMDEPIAHYFINSSHNTYLVGKQFGGKSVVDMYRNVLLAGCRCIELDCWDGKGQDEEPIITHGKAMCSDILFKDVIEVIKEAAFIATDYPVILSFENHCSIKQQRKLAQYCLESFGDLLLTKPIDGYPTEPGKRLPPPSKLRGKILIKNKKLIKTEQDTEKENAAASKDTANSPTKDSNGTITTNSQNGIKSDSAASDTKKDGTDDAKPKINGSTTTKTTKGDSSEDPPAKKNLDPDVVAAVANYRYTGSTGNIDELLSSVVIYTQPVPFPGFEEAKQRNLHYNMSSFNESTGFGHFKASPTDYVNYNKRQLSRIYPKGSRVESSNFIPQIFWNAGSQMVSLNFQTPDLGFQLNQCKFEYNGMCGYLLKPEFMRRDDKQFDPFAENPVDGIIAADLAVQVISGQFVSDRKVNTYVEVDMYGLPVDTVRKKFKTKTVYGNSINPYYDSESFRFRKVIFPDLALVRFTVNDENGKMIAQRVIPFNAIQAGYRHVVLRNEWCNPIGLAQLFCHFKMKTYVPEGLDEMVEMLSQPLKFLSILDERSKKMQVYDVDEDEDVSAVVDETIEKAPSKDDSKPQTPAKPNAKATPKKSDSGSSSSNDSSSNESKAQMVRQTSAVGGMLDREPIKPVDIDELLKSKAFSKFFKKHQKEYHLVHKKHDKERFSAISQNLKQVNDLSMETFGKKSFIENKTKEKKSRQKTGNPEADLKSKYIARVKSLKGSPSKDKINALVTKHISESTDIAKRHEEDLQKFKNKASGIIWDQIKSLIINAFGDQIKNLEEQQKRDFAELRKGQAKRSMDDTKKIVIDRSENTDKEDRTRRHRELSQYNVKQFMEERKKLCGRHDREKKQLEKKQEEEMRSFESRKDEVNANQILYLNINR
153
M3VVQ0
1.1.1.205
ACT_SITE 444; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156"; ACT_SITE 542; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156"
MPHPRHSRTAPDSQAPPPEAQSPPRHPPGRRSLPSGGPGSLQAERLPPARSSGLRMEGPLAPLAGSGLLPLPLQGGGAAAVPEPGARQHPGHETAAQRYSARLLQAGYEPESSMADYLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTTRNELVVAPAGVTLKEANEILQRSKKGKLPIVNDRDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPQLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYTFLPFTRSGCTEDGVGSRGSGGGAPQDAPLSTASLHN
3
A0A9R0JLT8
3.1.1.11
ACT_SITE 428; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MALYHPPSFLITLSSILLLLQLATTHTNSLPLTPSQPQGSNNASASMPASAVCQSTLYPSYCKDVLQSANKTANVYEYGRFSFKRSVSQAARFLKVVNKYLHDSRKLKLTPSAVAALQDCQFLAELNVDFLADSFNAAVNTQENKTLALTTVEDVQTFLSGILTNQQTCLDGLKSAESAWSFDRGITSPLSTDTKLYSIALSLFTKAWIPKKKKGSKPPRGKKHPGFFGNNGGRLPGLKMSDNARAVFEASLSRRHERLLGSDNEGDDQVLIYDVVTVSKDGSGNFSTINDAIAAAPNKTEASDGYYLVYVSAGVYEENVSIDKKKRYIMMIGDGINQTIITGNRSVADKVFSTFQSATFAVTGTGFVGMNMTIRNTAGAINHQAVALRSGSDLSAFYNCSFEGYQDTLYAHSLRQFYRECDIYGTVDFIFGNANVVFQNCNIYPRLPLDNQFNAITAQGRTDPNQNTGISIENCVIRASDDLANSNSTTKTYLGRPWKEYSRTVYLESFIDNVVDPSGWREWNGSFALDTLYYGEFNNTGPGSNVTDRVSWAGYHVMNATDASSFTVSTFVFGDEWLPQTGVPYTSGLL
125
A0A7M7N2Y7
2.7.10.1
ACT_SITE 937; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
MWLTSLHEILKGDVYFHQNNQLCYVETIAWDDMQPGLVANISMWDEHAQRNCSEHRCHESCNGHCWGPGEEHCQILTLKDCSSTCDYRCRGPTQADCCHRSCAGGCTNSSNAGCLACRQFSLDNTCVETCPRRYEYDRNTFTNVENPNFRYSYGSRCLKDCPNNVLVDGDNCVKVCGPGKKEQDNQCIPCEGVCPSTCDGIGDDGALSSKHIRSKQFDNCTQINGNLIITSHTFTGDAFAGTTPIDPSALEIFRTVKQITGYLSVQGLHQHFTNLSMFSNLERIDGRNLYGEPPFASLAILDNQHLEALSLISLNELKLGGAYVQNNRLLCYSEETAFDAVINPEYSVSFVNNKDRATCIAENKTCDPQCADIGCWGPGPRQCAKCKNAIIGDTCIEACDLDNGQYVETEASASEAAVCEHCDTQCSAGCSGPEPDQCDCQSDSTGTNCRRMCRNVQDGPFCRAECPEPKFANAQKNCTDCHSNCLKGCNGPENNLGEDGCLECPQVMLDYNRKVMECMLINTPCSDDYFYDRISHSEKSDPLAGSVICQQCDPMCIGCDGAGPRRCKQCKLFRQDDECVDECRSGFYPDVDDMCQPCHPQCRQCFNGTVHDCLDCESYTVQTGENTFFCALSCPAEYPNELSPYVCGKTCPTLFFPNAMSKCEGCHTECKDGCHNGTRSGCYACKNVVVNLECRAECPAAYKNTNGTCLYIHGPDQKATPKPGAAKYLPLNSGGMSIGLLAGIVTSSLIIFIVIIVFVIWFKQRIKNDMYIDIPPNIDLHDMKSCDYTGAPLTPSNVEPNQAQLKIIKDTELKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVSPHAAEELLEEAKVMASVDHPCLLRLLCVCIAQNMTLITQLMPLGAILDYVRQHKEQIGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNEYKAQGGKMPIKWLALECIQFRRFSHKSDVWSFGVTLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQEELERMTKDPQRYLVIQNDGAMSLPSPTPSDFYKTLMQDTESGADPDLLMDAEDYLQPMSLTANNMTYESQQGFFPVNGAGPRSPTGKPSGPLRKDSSLLRYCQDPTFKGNFDRQNSNTSGNDPNLNDDYLIPNDKLEGFSPLMEEEHDYQNDPRRPTDLGDNYLPLNDGTGSQPTSPSAGMLDNLEYHAIMDQASQGPKSPRTPTIHTGDPWTPMQQQHPHLVARQHSTPSQPRTPPAYAPLAPTMSSSTPLLGDVSFEGPVPPGGAPVMNGQNGGPKGMYRSPPPSNSSGSLGRHSTRGSESDYVNSDVVTDRGESTV
97
P32282
1.17.4.1
ACT_SITE 435; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 437; /note="Cysteine radical intermediate"; /evidence="ECO:0000250"; ACT_SITE 439; /note="Proton acceptor"; /evidence="ECO:0000250"
MQLINVIKSSGVSQSFDPQKIIKVLSWAAEGTSVDPYELYENIKSYLRDGMTTDDIQTIVIKAAANSISVEEPDYQYVAARCLMFALRKHVYGQYEPRSFIDHISYCVNAGKYDPELLSKYSAEEITFLESKIKHERDMEFTYSGAMQLKEKYLVKDKTTGQIYETPQFAFMTIGMALHQDEPVDRLKHVIRFYEAVSTRQISLPTPIMAGCRTPTRQFSSCVVIEAGDSLKSINKASASIVEYISKRAGIGINVGMIRAEGSKIGMGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVENLLVLKNNKGVEENRIRHMDYGVQLNDLMMERFGKNDYITLFSPHEMGGELYYSYFKDQDRFRELYEAAEKDPNIRKKRIKARELFELLMTERSGTARIYVQFIDNTNNYTPFIREKAPIRQSNLCCEIAIPTNDVNSPDAEIGLCTLSAFVLDNFDWQDQDKINELAEVQVRALDNLLDYQGYPVPEAEKAKKRRNLGVGVTNYAAWLASNFASYEDANDLTHELFERLQYGLIKASIKLAKEKGPSEYYSDTRWSRGELPIDWYNKKIDQIAAPKYVCDWSALREDLKLFGIRNSTLSALMPCESSSQVSNSTNGYEPPRGPVSVKESKEGSFNQVVPNIEHNIDLYDYTWKLAKKGNKPYLTQVAIMLKWVCQSASANTYYDPQIFPKGKVPMSIMIDDMLYGWYYGIKNFYYHNTRDGSGTDDYEIETPKADDCAACKL
21
F1R2A7
2.7.11.1
ACT_SITE 192; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 508; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
MPLAQLVDPWRKMAIGSAASETEPHHVLEDSMGEDENLSCQEEVSVKEINITHLVKEGSEKADPQQFELRKVLGQGSFGKVFLVKKTTGPDAGQLYAMKVLKKATLKVRDQVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEDGHIKLTDFGLSKESIDHENKAYSFCGTVEYMAPEVVNRRGHTYSADWWSYGVLMYEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSSEAQSLLRSLFKRNPTNRLGAGPDGVEEIKRHPFYVSIDWNKLFRRESHPPFKPATGRPDDTFYFDPEFTAKTPKDSPGVPPSANANRLFRGFSFVAITSEEESQSLPSNSMSSIVQQLHRNVSQFSDAYEVKEDIGIGAYSICKRCIQKSTMMEYAVKVYDDGRTVYLVTELLKGGELLDKILRQKFFSEREACAVLHTITKTVAYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGQFSLTGGFWNSVSCQAKDLVSKMLHVDPHQRLTAAQVLKHPWITHKDKLPNYQLNRQDAPHLVKGAMAATFSALNRNIPPVLEPVGCSILAQRRGVKKLTSTAL
99
A0A061ACK7
3.1.3.3
ACT_SITE 68; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 70; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MAVFFHFHRILYSHNVFQLNFRMIRVALPTTASAIPRSISTSPGETISKNHEEEVKRVWRKADAVCFDVDSTVCQDEGIDELAAYLGVGEAVANVTRTAMNGNARFRYRDALAARLQVMKPNHEQLEQFVNISKPKLTVGIRELVSRLHARGTHVYLVSGGFRRLILPVAELLGIEKSRIYANEILFDKFGKYHGFDTSELTSDSGSKETGKPAVIALLKKMYNYKTVVMVGDGATDVEASPPADAFIGFGGNVIREGVKARAKWYVTDFDVLRKDLDHDESDIDDE
147
A0A7M7MY35
2.7.11.13
ACT_SITE 494; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50"
MVFLRVRVLQVDSKEIELPGSVLFDPFVAVNVKESVKDANGQTQLRQKRKTAFVEWNKCFDSHLYDGRVIQVIVYNRPESYLAEANYKVNELAAMCGMDGRIETKWLDLMPYGRLQVQLRCFPEEGGGGDPMNSVRSTVSHHNSDMDKKDDTTGLLTKRRVAIRKAKVHEHRGHKFTPHYFRTPAYCSYCNEFIWGLVGTQGYRCMECELSVHKRCFNQVLGKCPGTGVNSTETKKLKERFNINMPHRFKVNNYKSPTFCDHCGTMLYGLFRQGVKCEVCNVNVHHKCKNNVPNLCGVNQRLLSEALSSIEITKSMKDKKLPPGAGNGKHGYVPDDDEDLDEAVYEPLWTTDGGPPDRPVAVQKYSIDDFMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEEKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGEDEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGVKGDVRAHQFFKSIDFEKLERRELPPPFKPKIKSDGDASNFDPEFTMEKVALSPTDTSMLSSINQRQFRGFSFTNPTMAEK
100
F7GAE4
5.4.99.12
ACT_SITE 66; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001430-1"
MGSVQAAGSVRARYLVYFQYVGTDFNGVAAVRGTQRAIGVQNYLEEAAERLNSVVPVRFTISSRTDAGVHALSNAAHLDVQRRSGRPPFPPEVLAEALNTHLRHPAIRVLRAFRVPSDFHARHAATSRTYLYRLVTGCHRLAELPVFERNLCWTLQADCLDVAAMQEAAQHLLGTHDFSAFQSAGSPVPSPVRTLRRVSVSPGQASPLVTPEESRKLRFWSLEFESQSFLYRQVRRMTAVLVAVGLGALAPAQVKTILESQDPLGKHQARVAPAHGLFLKSVLYGSLGAASCTLQGPQFGSHK
217
A0A8M1NJV4
3.2.1.35
ACT_SITE 140; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
MLLESNVLHPFLTLALSIMLSPSNPFLNMVEGVESVIGRRGFQVIWNVPTARCQRRYGVSLPLQQYNIIHNSHQRFQGQNMSIFYQRRLGLYPYISREGVKVNGGLPQEGYLKAHLSLAGVEIREKLRSSFSGLAVLDWEAWEPVWKWNFGTRIVYRKLSKKLVRWEHPDMSEEEVKSKAKLDFELAARQFMEETLRLGLRLCPEGLWGFYGFPSCYNNNGQGQSGYTGKCHNGTEILNDRLGFLWQQSTALYPSIYLWRKLAGHTHAQLMVRHRILEALRVASQHSPGSEPLPVFPYTRVAFIHSLTFLNQTDLEHTLGESAALGAAGVVLWGELSFAKSKHQCTLLRDYLSSVLGEYITALRAGVTNCSERLCNAQGRCSRWDPHSHHMIPLLGPHDALSLSDMRSKFKCVCYEGWSGEKCEHRIS
166
Q00055
1.1.1.8
ACT_SITE 245; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P21695"
MSAAADRLNLTSGHLNAGRKRSSSSVSLKAAEKPFKVTVIGSGNWGTTIAKVVAENCKGYPEVFAPIVQMWVFEEEINGEKLTEIINTRHQNVKYLPGITLPDNLVANPDLIDSVKDVDIIVFNIPHQFLPRICSQLKGHVDSHVRAISCLKGFEVGAKGVQLLSSYITEELGIQCGALSGANIATEVAQEHWSETTVAYHIPKDFRGEGKDVDHKVLKALFHRPYFHVSVIEDVAGISICGALKNVVALGCGFVEGLGWGNNASAAIQRVGLGEIIRFGQMFFPESREETYYQESAGVADLITTCAGGRNVKVARLMATSGKDAWECEKELLNGQSAQGLITCKEVHEWLETCGSVEDFPLFEAVYQIVYNNYPMKNLPDMIEELDLHED
7
Q9HR35
6.5.1.1
ACT_SITE 255; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00407"
MKFGSFATFAADIEATDADLDVVALVAELFDAADSDLDVVARFVQGRVFPAHSETKLDIGPQLCYTALSRAAGRNVDADDIEARLAETGDIGAVAGSLDLGGQTGLAAFGGGDDHADGLTVSGVADELAALAAAAGDGSQSEKVTLLFGLFNQCTSREARYLARLVLGEMRIGVGEGAVRDAIAEAFDVPTAAVQRALQVSNDYGLVAETARDSGTDALDAMGLEVGRPVQAMLAQAGTVTDALDEWHEAAVETKFDGARVQVHYDGDDVVLYSRNMENVTGALPELVEFVENNVTAPVIIDGEAVAADEDGDPLPFQEILKRFRRKHDVAAMREEISVELHAFDCLHAPSADGGEDLLDAPFSDRHRRLRSVVDDASAVSEVLVTDDADEIAAFEATALEGGHEGIMLKNPAAPYTPGDRGKDWLKRKPDVETLDLVVTGAEWGEGRRASVLGTFLLSARDAAGDGFETIGKVATGLTDEELAALSDRLEPHVRSEDGQTVDIEPAVVLEVGYEEIQASPTYSSGYALRFPRFVSVREDKTPTTADTIERVERLAAQQQQ
254
A0A9J7L7D9
2.1.1.33
ACT_SITE 151; /evidence="ECO:0000256|HAMAP-Rule:MF_03055"
MASLPQKKFYRQRAHSNPMADHSFDYPVKPDVMDWSPYYPAFFESPSQAERHDDDKEAEERLPSRVEFADIGCGYGGLLVALSPMFPDTLMLGMEIRVKVSDYVTDRIKALRDKHPGEYQNVSCIRTNAMKYLPNFFRKGQLKKMFFLFPDPHFKKTKHKWRIISSTLLAEYAYVLAVGAIVYTITDVEEVHEWMKQHFVQHPLFQQMTAEEYKDDPIVEKLYESTEEGQKVTRNKGDKFLAIFRRIKDPLLPN
45
A0A2K1L722
3.1.1.11
ACT_SITE 249; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MEKKAPRRDAACVVVIMYMTAVLVFCSPGLVQGRSPLKNRALKSDIKVPATKDEVAAEFLSWVASVVTDYENKTSSQTNSPSRLPNLGIKAEPPIYYVDQAGYGNFRTVQEAVNAVPEGNSMRVIILVKPGIYRERVNIPKSKGYITLQGSGKESTSIDYNENAASAGSTYDSATVAVFSDYFVARDISFRNSAPAPPSGAVNMQAVALRITGDCAAFYGCGFYGSQDTLNDDMGRHYYKNCEIVGSIDFIFGDAQSLYKDCALNVNAATYGSVTAQKRESSSRRTGFSFVGGSLLGSGQVYLGRAWGPYSRVVFAFTFMQDIVIREGWHNWNDPNRQRTAYYGQYKCLGPGATENGRVEWSHELTDAEAAPFLSLAFIDGQDWVTEP
125
P37159
3.2.1.17
ACT_SITE 50; /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"; ACT_SITE 68; /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
MKAFIVLVALAMAAPALGRTLDRCSLAREMSNLGVPRDQLARWACIAEHESSYRTGVVGPENYNGSNDYGIFQINNYYWCAPPSGRFSYNECGLSCNALLTDDITHSVRCAQKVLSQQGWSAWSTWHYCSGWLPSIDGCF
160
P12965
2.7.11.1
ACT_SITE 189; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MPSPIPVERFLPRDLSPSIDLRPCSSPLELSHRKLPGGLPACSGRPRLLPPRLAWCSIDWEQVLLLEPLGSGGFGSVYRATYRGETVALKKVKRSTKNSLASRQSFWAELNAARLRHPHVVRVVAASASCPGDPGCPGTIIMEYTGTGTLHQRIYGRSPPLGAEICMRYARHVADGLRFLHRDGVVHLDLKPANVLLAPGDLCKIGDFGCSQRLREGDEAAGGEPCCTQLRHVGGTYTHRAPELLKGEPVTAKADIYSFAITLWQMVSRELPYTGDRQCVLYAVVAYDLRPEMGPLFSHTEEGRAARTIVQSCWAARPQERPNAEQLLERLEQECAMCTGGPPSCSPESNAPPPLGTGL
99
A0A2R6XAG6
3.4.19.12
ACT_SITE 50; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 162; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 177; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
MRASSGIEEEGPVLVRAKSLREHLQMADESAVHSRDTGGVYHERQRLQLCLLHALNNLLQGENAFTRKELDDIADRLPAMTSSSERWRPWSLILKRHRNSLTGDYDVNVLIAALASRQKDVKWYDRRKGVQGLNVDEYGSQLVGIIVNVPSKRFWNLWTGRHWVALRAVNGRWYNLDSDFPTPRAFAHGEADLKKYLEAVFAESGEVLIVTEGKADGA
175
Q9RSZ7
3.4.21.92
ACT_SITE 101; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 126; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
MEVMSVIPYVIEQTGRGERSYDIYSRLLKDRIIFVGTPVESQMANSIVAQLLLLDSQNPEQEIQMYINCPGGEVYAGLAIYDTMRYIKAPVSTICVGMAMSMGSVLLMAGDKGKRMALPNSRIMIHQGSAGFRGNTPDLEVQAKEVLKLRDTLVDIYHKHTDLPQEKLLRDMERDYFMSPEEALKYGLIDQVIDQTRENRGGEE
179
A0A3Q1LJ39
2.3.2.26
ACT_SITE 760; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MHVCEVTSAVFHSLRPRGQEPSRLLCPGFSRQEYWSGLPGPPSGDLPDPGIEPASLTPLSLAVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDTTGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE
65
A0A8I6G1H3
2.7.11.1
ACT_SITE 313; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038189-1"
MSKPLTPSTYVRSLNVGILRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTCELLFDWGTTNCTVGDLVDLLIQIELFAPATLLLPDAVPQAVHSLPPREAATVAQAHRPCQEKNRTTVTPALAQKLEPSCELPDSSSPGHQSVEFSDTRFHSFSFYELKSITNDFDERPVSIGGNRMGEGGFGVVYKGCVNNTTVAVKKLGAMVEISTEELKQQFDQEIKVMAKCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHMRCKIARGAANGIRFLHENHHIHRDIKSANILLDQDFTAKISDFGLARASAKLAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLELITGLAAVDENREPQLLLDIKEEIEDKEKTIEDCTDEKMSDADPASVEAMYSVASQCLHEKKNRRPDIAKVQQLLQETSA
99
A0A2R6W0W7
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MMYTKMSSQWLLWTFAAFLLALTVDAQLSTTFYSSSCRNLTARVDEIIRGHIRRDRTLAPSLLRLHFHDCFVRGCDASVLLNSPRGAQGEKDAIGNKDSLRGFEIIDDVKTKIETMCPGVVSCADLLALSARDSMRAFGNITWSVPLGRRDGTVTSASEANNDLPPPFGTFSSLSAIFRRKGLTVKDMVILSGAHTVGTARCASMQTRLYSFSSANPTDPTLDPTFASRLKRQCPQGDNTTLIRNDQTKPTDTWDFNYYSNVLRSKGLFGSDDAMKRNPAARKIVLSQNKPGSPFSAEFAKAMEKMGRIGVLTSRQGQIRRTCTRTN
14
P74696
5.4.99.25
ACT_SITE 38; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080"
MFGFLNLHKPLHLTSHDCVAKVRRLLRQKRVGHGGTLDPLAEGVLPLAVGSATRLLPYLPGAKQYQALIRFGVRTDSDDLAGEVLESKNVSYLTLAAVEQILPTFLGEIEQIPPQYSAIQVNGKRLYELARAGIPQAVPSRMVTINDLKILGWRSGNQPELDLQVTCGEGTYIRALARDLGDRLGTGATLAGLVRQQSGGMALDNSVGLTALEKIVAEEEHIPLIPPQEALSHLPTVQLNSELEKRWFHGQRLLLPDLPVGVVLITSELGPVKCLGVALVTPEDHGTVLRPKVVLN
218
Q9VUL1
6.3.4.2
ACT_SITE 399; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 526; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 528; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"
MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGAEVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQTPVQGSSKPQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTKPTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQNGVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVVKALQHAALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWARENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRLGKRITVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKTRMEIIELSGHPYFVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQRGCRLSPRQLSDASSDEEDSVVGLAGATKSLSSLKIPITPTNGISKSCNGSISTSDSEGACGGVDPTNGHK
252
P50908
4.2.1.20
ACT_SITE 34; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 45; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"
MKGFIAYIPAGFPDLETTRKILIALNELGITGVEIGVPFSDPVADGPVIQLAHSVALRNGVTIKKILEMLSEISVDYDLYLMSYLNPIVNYPEGKEKLLDELKKLGVKGLIIPDLPLREVKNVDIAYPIVPFVAPNTKDEEIDLINSVQAPFVYYISRYGVTGEREDLPFADHIKRVKERIKLPLFVGFGISRHEQVKKVWEIADGVIVGSALVRIMEENPKDEIPRKVVEKVKELLGK
202
Q8R601
5.4.99.12
ACT_SITE 56; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
MLMRRKNIKIEFRYDGSSYYGFQRQPNKITVQGEIEKVLRIVTKEEINLISAGRTDRGVHANHQVSNFYTSSNIPIEKYKYLLTRALPNDIDILSVEEVDENFNARHNAKMREYIYIISWEKNPFEARYCKFVKEKIVAEKLEKIFSDFIGVHDFKNFRLSDCVSKVTVREIYQIEVKYFGENKIKIYIKGSAFLKSQVRIMVGTALEIYYGRLLENHIRLMLNDFTKEYKKNLVEAEGLYLNKIEY
217
A0A9R1UK63
3.4.19.9
ACT_SITE 226; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 337; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MITLLPAIVHSHFSHVKTQNTTNHRLRTPPSPMTPSHQPPPPPPPPSSPVSTASKHITTSNSASTSSPTPSDVWNYVWIPFLISLCKEVSSAKPSSESTNVLTSDSVSRLSSTCPTTDSKLNFRPIIGILSHPGDGASGRLNNAANASYIAASYVKFVESAGARVIPLIYNEAPEILQSKLNLVNGVLFTGGWAKSGLYAEVVEGIFKQVLKKNDEGDHFPLLAICLGFELLTMIVSKNNKILEQFSASDQASTLQFMTNIEGTVFQRFPADLLAKLSTDCLVMQNHKYGISPETFQENTKLCNFFKILTTSIDQDNKVYVSTVQSQRYPITAVQWHPEKNAFEWGLSKIPHSDDAVQVTQHVANFFVSEARKSLNRPPVRKVLDNLIYNYSPTYCGKAGKGYDEVYIFTENLARI
176
Q6K8B0
3.1.1.11
ACT_SITE 385; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGHAVARRLILLLVFLPCFLLPLSGAHAFPASALEAEAVAARHHRLRIALNATAVHVGKALEALSGAAVAPASAVMTTPFSAGSSSSSPLAAAARDDCAELLEDSLDLLAGAGEPSAAHDDAVTWLSAALTNHDTCADSLNEAGIPHGADAAPHLAAARAMVRDCLTMYAEAASAAMATSNKDGLAGVPVRNGGGKSKKQRKRGRRRRRSLFPRWLSARDRRLLLVPAAPLVESADMVVAKDGTGTHRTISDAVKAAPERSGRRTVIHVKAGRYDENVKVGRKKTNLVFVGDGKGVTVVSAGRSVADNFTTFHTATFAASGSGFMMRDMTVENWAGPERHQAVALRVSADRAAVYRCSIIGYQDTLYAHSNRHFYRDCDVYGTVDFVFGNAAAVLQRCNLWSRSPLPGQKNTVTAQNRRDPGQSTGLVIHACRVVPSPPPPSTAPAVAAPLAPTYLGRPWKLYSRVVVMMSYIGGHVPPEGWLAWNATFALDTLYYGEYMNYGPGAGVAGRVAWPGHRVINDSAEAERFTVARFISGASWLPATGVSFLSGLSL
125
A0A251Q011
5.3.1.8
ACT_SITE 315; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MESIGKSMKHHNQRSIRLQRLRCSVQNYDWGKRGTDSLVARLSALNSSSEIDPEKPYAEIWMGTHESGPSFLIQNGDENNGFLSIGSESLSLKDWVLENPKVLGEKVVQKWGSDLPFLFKVLSVGKALSIQAHPDKELAKVLHKFMPNLYKDANHKPEMALAVTHFEALCGFISLEELKVVLDNVPEIEELVGSEDANKVFDITDRDDENKVTSVLRSIFTHLMSASKEMITTIITKMKNRLHIESQGRLLTEKEQLVLQLERQYPADVGVISAFFLNHVNLKPGEALYIGANEPHAYIFGECIECMATSDNVVRAGLTPKHMDVNTLCSMLTYKQGYPKILQGVALGPYVTRYLPPFDEFEVDCCQLPQGESAEFPAVPGPSIFVVTFGEGIIYSIDLKGDVITEGDVLFAPANTQISITSASQLQIYRAGVNSMFFQAS
214
Q8D1X3
2.2.1.2
ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MNQLDYIKKFTNVVIDSGNIKYIKKYSPKDVTTNPSLILRESKSKHYYPLLMDAISYAKKKGGNLNSYIINANDKLLVNIGREILKIIDGRISIEIDVRLSFSYLDLIIRAKKIISLYNSYGIENNRILIKIAATWEGIQAAKFLEKSGINCNLTLIFSLVQAIACAESNVYLISPFVGRVNDWYIKNFKLNKNSKIDPGVKLVYKIFYFYQKYGYKTFVMGASFRNIDQIISIIGCDAITISPDFVNKLNNLKLKKIKNFIRVNLESKIKKNKLLEKEFRWKFNQNFMAVEKLSEGIRLFLRDQKKIDSFFLKKFKSG
52
W5M0F9
2.7.11.1
ACT_SITE 305; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038189-1"
MSKTITPSTYVRNLNHGMFRKLADFLDPQEDWKKIAVNIQKPSGEPRYNQFHLRRFEQQAAIGKSPTSELLYDWGTTNCTVGDLVDILVQNQLLSSASLLLPGKWNLVIAVLQYAVKEAPVAIRDSQEAQTIPVGRTVESYAPDSTTQPEEEDFDGQGFSRFSFQELRKLTCNFDERPVSEGGNKLGEGGFGVVYRACIDKKVVAVKKLTMISDLSLEELKLQFKQEIQAMKMLKHENLVEMIGFSYDGDHPCLVFDYMSNGSLLDRLACLDGTPPLPWSKRCSIAVGTARGIEYLHTNHHIHRDIKSGNILLDKMFVAKISDFGLSRASAKLTSTVMTETIVGTTAYMSPEALRGEITPKSDIFSFGVVLLEIISGHPPVDENRDPKFLVSWKDEIEDEEISLEEFVDKKIKDWDFSSVENMYFLASQCLNERKNKRPEMKEVHEQLEDIQNCTSAL
99
Q07794
2.3.1.48
ACT_SITE 288; /note="Proton donor/acceptor"; /evidence="ECO:0000269|PubMed:18707894"
MSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKSTIKTQHFFSLFHQGKVFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIILEFILSIDPNYYLQKVKPAIRSYKKISPELISAASTPARTLRILARRLKQSGSTVLKEIESPRFQQDLYLSFTCPREILTKICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLLIECFQNDTQAKLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFIHQLAEEDRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLATPSLFPSSADVIVPKSRKQFRAIKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATNLQSLTGKREHRERNQPVPASNINTLAITMLKPRKKAKALPKT
61
P75960
2.3.1.286
ACT_SITE 147; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01121"
MLSRRGHRLSRFRKNKRRLRERLRQRIFFRDKVVPEAMEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGSIA
58
Q5QMT0
3.2.1.21
ACT_SITE 215; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 424; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"
MGHRLVVVLLLALLVAGAARAAEQAAGEDGIRGGAGADHQEAAGITGGLSRRSFPAGFVFGTAASAYQVEGMALKDGRGPSIWDAFVKTPGEIANNATADVTVDEYHRYKEDVNIMKSMGFDAYRFSISWSRIFPTGTGKVNWKGVAYYNRLINYMLKIGITPYANLYHYDLPEALEVQYGGLLNRKIVEAFADYAEFCFKTFGDRVKNWMTFNEPRVVAALGYDDGNFAPGRCTKCTAGNSATEPYIVAHHLILSHASAVQRYRHKYQHIQKGKIGILLDFVWYEGLTNSTADQAAAQRSRDFHVGWFLHPIIYGEYPKSLQVIVKERLPKFTADEVHMVKGSIDYVGINQYTAYYVRDQQPNATTLPSYSSDWHAAPIYERDGVPIGPRANSDWLYIVPWGLYKAVTYVKEKYGNPTMFLSENGMDDPGNVTIAQGVHDTTRVAYYRSYITKLKEAIDDGANCIGYFAWSLLDNFEWKLGYTSRFGLVYVDFRTLRRYPKMSAYWFRDLVSSKN
161
B3SDG7
3.2.1.143
ACT_SITE 200; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 218; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 219; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"
LFNVLHTRVLKEAILSYNEQYRDYWSFDGLHAYFQAIGPSESYDFFYQTLPKMIDLALRLPKLITKSIPLLRQGYRGSVTMSQEQAACILANAFFCTFPERSGSFTKGSHDFGYPAFNFNSLFEIKSNRVLQKLQCLVHYFGRVTKTSKLKPMPRGIITYERRQVYDIDKAIESSRSQFCKICVDSSGLIEDATGMSQIDFANKRIGGGVLRSGCVQEEILFLISPELIVSLLITQVLDDNECLIIRGSERFSHYSGYSNSFRWTGNYVDKTPRDSEGKLYSEVVAIDALVFSSFRAQLKQASLRREFMKAYCGFNLPRSYSGPKYAIATGNWGCGAFGGLIQMMAAAEAGRPVCYYTFGDKVKFVELKIWKNIRTS
159
A0A3B6TSM9
3.2.1.14
ACT_SITE 142; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
MRALAVVAMLATAAMAIACARAAQCGSQAGGATCPNCLCCSQFGWCGSTPEYCGDGCQSHCSGCGSTPVTPYPFGGVSSIVSPSLFNQILLHRNDPACQAKGFYTYDAFIAAATAFPGFGTTGSIAIRKREIAAFLAQTSHETTGGYCTPSEQWPCAPGRLYYGRGPIQLTHNYNYGQAGRAIGADLLGNPNLVVVNPTVSFETAMWFWMTEQPPKPSSHAVITGQWNPSATDRAAGRVPGFGVITNIINGGMECFHGYDERVQDRIGFYKRYCKIFGISYGDNLDCYKQRPFA
158
A0A1D5Q008
5.3.1.8
ACT_SITE 295; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MAEPRVFPLRCPVRNYAWGQRGLRSAVAQLVASGDPAASVEPERPYAELWMGAHPSGDAEVLDGRDPPRSLGSWLAEHPACLGPKVRDAFGGRLPFLFKVLSVRTALSIQAHPNKELAAKLHAQFPQHYPDANHKPEMAIALTPFEGLCGFRPVEEIAAFLRAVPELRALVGEVAAEQLERSASHDPRGVSAALRVCFTCLMKSEKEVFGKQLGLLVERISQQAAKGQDTSASNGELLLRLHAQFPGDIGCFSIYFLNVVRLEPGEAMFLAANEPHAYLQGDCVECMACSDNTVRAGLTPKFIDVLTLCEMLNYTPAPSSSKIFPAVQSPLDPCVFIYDPPVPDFTLMRIEIPSSIKLYLISALDSASILLVIQGTAMGTSTAAASEMTLRRGSVIFISANESISLHLSSSEGMLLFRACCLL
214
A0A078GUZ4
3.1.1.11
ACT_SITE 220; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAPQLRSFTCSLSYLLSVSLLFFIFHCLCFRFSFVAACSNSTEEQHHPHRKWVGPSGHKVITVSLNGHAQFRSVQGAVDSIPKNNNMSIVIKIAPGYYREKVVVPATKPYITFKGAGRDVTVIEWHDRASDRGPDGQQLRTYQTASVTVYANHFSARNISFTNTAPAPMPGMQGWQAVAFRISGDKAYFSGCGFYGAQDTLCDDAGRHYFKECYIEGSIDFIFGNGRSMYKDCELHSIASRFGSIAAHGRTCPEEKTGFTFVGCRVTGTGPLYVGRAMGQYSRIVYAYTYFDALVAHGGWDDWDHKSNKSKTAFFGVYNCYGPGAAATTGVSWARALDYESAHPFIAKSFVNGRHWIAPRDA
125
A0A1U7ZW74
3.1.1.11
ACT_SITE 414; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MQNNEGTNKRIAIISASSLILVAMVVAVTVGVNQHPTAGSDGTKTVSNDDEQIQTSMKAIKAICQPTDYKETCIKSLSSAAGNTTDPKDLVKIAFKIATKQIKEAVNRSVVLKELEKDPRASKALANCRELMDYAIDELNSSFDELGSIDIDDIDDALENLKIWLSASLTYQETCLDGFQNTTGNAGESMRKALKTAGELTQNGLAMVTEVASILTSLQMPSKRRLLSSEQQSQCPFAMEDEFPTWTSAAKRRLLAASRANIKPNITVAKDGSGKYKTISEALRHVPKNSNETFVIHIKAGVYHEQVQINRSMTHLMIIGDGPTKTKITGNKNFVDGTPTFKTATVAVIGDGFMAKDIGFENSAGPEKHQAVALRVQSDMSIFYNCQIDGYQDTLYAHTHRQFYRNCTISGTIDFIFGNSAVVLQKCRIVVRKPLENQQNIVTAHGRKDRREPTAIILQSCRIVADPLLFPVRNTTRSYLGRPWKEYSRTIIMQTLIDDLINPDGWLPWSGDFALKTCFYAEYNNRGPGAVLTQRVKWRGIKTSIMTPEKAQQFTAGRFIRGDSWIKPTGVPYDSGLSSM
125
Q9XGV6
1.11.1.7
ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASTIPIVTLLIVMLSCHAANAQLSPNFYASSCPNLQTIVRNAMSRAVNRETRIGASILRLFFHDCFVNGCDGSILLDDTATFTGEKNAVPNRNSARGFEVIDTIKTNVEAACSATVSCADILALAARDGVALLGGPTWQVPLGRRDARTASQSAANNQIPSPFANLATLTSSFAAKGLSTRDLTALSGGHTIGLARCTTFRGRIYNDTNIDANFAATRRANCPASGGDNNLAPLDIQTPTRFDNDYFRNLVARRGLLHSDQELFNGGSQDALVRTYSNNPATFSADFAAAMVKMGNISPLTGTQGEIRRNCRVVN
14
Q8PDD1
2.4.1.18
ACT_SITE 408; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 461; /note="Proton donor"; /evidence="ECO:0000250"
MAEGGGGSAVALQDLQAIAAGLPGDAFAVLGPHVQADGRLRVRVLAPGAEALGLIDGRGKLLARMQASPIDGVFEGELPADAAYRLRIVWPDVVQEIEDPYAFAPQIDESALLQIGAGDGQALRANLGARHVQVGELPAVRFAVWAPHAQRVAVVGDFNGWEPRRHPMRQRSGGIWELVLPRVETGARYKYAIITADGRVLLKADPVARQSELPPATASVVASADAFAWTDAEWMARRSAAAEPAPLSIYEVHAASWRRDGHDQPLDWVSLAAQLIPYVQELGFTHIELLPITEHPFGGSWGYQPLGLYAPTARHGSPDGFAQFVDACHRAGIGVILDWVSAHFPDDAHGLSQFDGSATYEHADPREGMHRDWNTLIYNYGRPEVTAYLLGSAMEWIAHYHLDGLRVDAVASMLYRDYGRAEGEWVPNAHGGRENLEAVAFLRQLTGEIASQFPGVLTIAEESTAWPGVTAPISEGGLGFTHKWNMGWMHDTLHYMQRDPAARAQHHSQLTFGLVYAFSERFVLPLSHDEVVHGTGGLLGQMPGDDWRRFANLRAYLALMWAHPGDKLLFMGAEFGQWADWNHDRSLDWHLLDHAPHRGMQQLVRDLNRALRRVPALYRGNHRADGFEWSVADDARNSVLAFIRHDPDGGAPLLAVSNLTPQPHHDYRVGVPRAGGWREILNTDSAHYGGSNLGNGGRLLTEPTGMHGHAQSLRLTLPPLATIYLQAEK
73
O80397
2.7.12.2
ACT_SITE 196; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MRPIQSPPGVSVPVKSRPRRRPDLTLPLPQRDVSLAVPLPLPPTSGGSGGSSGSAPSSGGSASSTNTNSSIEAKNYSDLVRGNRIGSGAGGTVYKVIHRPSSRLYALKVIYGNHEETVRRQICREIEILRDVNHPNVVKCHEMFDQNGEIQVLLEFMDKGSLEGAHVWKEQQLADLSRQILSGLAYLHSRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGKYDGYAGDIWSLGVSILEFYLGRFPFPVSRQGDWASLMCAICMSQPPEAPATASPEFRHFISCCLQREPGKRRSAMQLLQHPFILRASPSQNRSPQNLHQLLPPPRPLSSSSSPTT
108
A0A251SM41
3.1.1.11
ACT_SITE 263; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MCEKGFEMKNITTDLLPKVTTNLTQLLLNSLATSVVIKGGNPPGLHELNFGNELYNFLGLETVQPNVVVAKDGSGNFTTVQEAVNSRGQGASGQRYTIYVKSGVYEEYVVIPQEAPLITMYGDGIGNTVITGNRHFNGSDLKGTATFNSISNMLNFKLEITLGKFRLLTRIDHEQFSKKINNKIIVKLLWFTWIVEVWSKRFIAVNMTFRNTAGPEAQQAVAFLSGSDKSAYYQCSFEGYQDTLYTFHSRQFYKQCQIFGTVDFIFGASPAVFQDCDILLRKPLPEGGLVVTANGQKFSNLSGGYSLQGCKIHAADDLKPVVGQFAKAFLGRPWFQYSETVYMESFIDDLVDPQGWLDSWGYKETAYCGEYKNSGPGSSTDQRVDWPSFHVITDPNTANQFTVAEFINGTEWLPTYGVPFVSGLETL
125
A0A251NHS5
3.2.1.143
ACT_SITE 270; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 288; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 289; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"
MEGREDLKSILEYLPVVVRTWSLFWPSQVVEALKALARGPEHSGVHSGELLFSAISDLRCSLSLSSHPLPPSAPHGYALFFDELMSRAEARKWFGEVVPALANLLLRLPSLLELHYQNADALINGGRDGVKTGLRLLHSQEAGIVFLSQELISALLGCSLFCLFPINNRGAKHLPTINFDHLFTTLYDSYNEKQENKIRCIIHYFERISFHMPKGYVSFERKVLPLEHGPLSISYPKASFWSNSAIPLCRFEVHSSGFIENQSSGALEVDFANKYIGGGVLHRGCVQEEIRFMINPELIASMLFMPSMADNEAIEIIGAERFSNYTGYASSFRFSGDYVDKRDTDSLRRRKIRIIAIDALCSPGMRQYKQKLLLRENNKAFCGFFHQSKYQQYKRLFRESGCSGIQPHSDVKDSNDVFSNNLLSHGASITSVETCGGKSVHKVIRDSEEILSLDNEDDVGIATGNWGCGAFGGDPEVKTIIQWLAASQVALRPFISYYTFGMKALQNLDQVTQWILSHEWTVGDLWNLLVEYSLQRLKGETNDGFFTWLLPSLLYP
159
A0E455
1.8.1.4
ACT_SITE 467; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MFKTRYLITNQFTHFQRSSFSSQPFDLVVIGGGPGGYVAAIKAAQLGLKTACVEKRGSLGGTCLNVGCIPSKALLNISHKYEDAHKNFKGLGIKVDNLGVDWAQVQKKKGDIVGSLTKGIEGLFAKNKVSYYKGWGKFTSKNEIAIDLNDGKKETITTKNTLIATGSEPTPFPGLDFDEKIIISSTGALALQQIPKKLVVIGGGVIGVEMASVYQRLGTEVTVVEYLDNICGAIDLEVSKAFQKILTKQGMKFLIGHKVLGGKNLGNAAEVVIEPVKGGDKITLTADHVLVSTGRRPYTQGLNAESIGVKLDNRGRIQIGHNFTTGVDGVYAIGDVVEGPMLAHKAEEEGIAVAEILSGKVGHVNYDAIPGVIYTNPEVATVGKTEEELKKAGVQYSKGSFPFLANSRAKANDEIEGFIKVLTDKKTDKLLGVHIVGPNAGEMIAEAVLGIEYGAASEDLARTCHAHPTLSEALKEACMSAHFKPIHM
36
A0A022RTI0
3.2.1.52
ACT_SITE 338; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MGYFSNLLISTILLSCTIWSISILQISAVRFPINVWPKPTTFHWPHPQAIPLSPKFIISAPRHHRHLSAAVHRYLRQILTEHHRPLVSPPLNLTSSPPLKTLKITVADTAAALAHGVNESYTLEIPSTGAAAVLTAETPWGAMRGLETFSQLVYSKPSVVACGLRISDAPLFAHRGVLLDTSRNYFELDDLLRLIRAIGMNKLNVFHWHITDSHSFPLVTPSEPELAAKGAYGEAMKYTAADVKKVVQYGMEHGVRVVPEIDMPAHTGSWAEAYPEIVTCANEFWWPIESEWSDRLAAEPGTGQLNPLNPKTYQVVKNVIKDVVSVFPDKFFHAGADEITPNCWKTDPSIQEFLSKKGTLSQVLEIFVNSTLPYILSLNRTVVYWEDVLLDENVRVDPTFLPRENVILQTWNNGPNNTKKIVSLGYRAIVSSSDYYYLDCGHGGFLGNDSQYNQLPGFEQGKGGSWCAPFKTWQTIYNYDITSGLSGVEAELVVGGEVALWSEQADSTVMDSRVWPRGSAMAEALWSGNRDEFGKKRFAEATDRLSEWRYRMVCRGIGAEPIQPLWCVKNPGMCNTVHPF
170
A0A022RFV7
2.1.1.37
ACT_SITE 460; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MAIKRKSRSVKTDPAAMEEDSRSNKRISSAAVESDGDFEGEDQVESAAAPVVDQTVEKVKSPVQEVKPDDEEEEEDDEGDAEFLGEPVPADEARKRWPHRYQKINMEVVQARCHFLKAEVDGQIYFLEDDAYVMGEPGKPNYIGKIIEIFEALDGSKNFTAQWFYRGGDTVRHSKKMPFKMFNTKCVFFSDIKDDNPLSCLVKKLKIEILPLKADIDVKEALKSTCEYYCDKKYLLPFSSFVSLPSDTSTSSDESGSTISSDTDGEVPELNNERTLLDLYSGCGAMSTGLCLGANSCGVKLVTKWAVDINEYACESLRLNHPETQVRNESADDFLHLLKEWEKLSSREYGVLNDTEDDDDDDDDDDDEDEEDEAGAEDSEVFEVDEILAVCYGDPNKTGNPKLHFKIRWLGYGPDYDTWEPLEGLSGCPEKLKEYVAKGNQSKMLPLPGTVDVLCGGPPCQGISGFNRFRNTKNPLADQKNEQLSIFMDIVAFLRPKFVLMENVVDIVRFAGGFLGRYALGRLLSMDYQARMGMMAAGAYGLPQFRMRMFMWGALPTERLPQYPLPTHNVVARGNAPTEFEGNVVGFEASREVKLAKELFLEDAISDLPPVDNDESRDERPYDLQPQSEFQRFIRLRRDEMPGSLLFNLEVVKHDLYDHRPLQLNQDDYERVCRIPKKKGANFRDLPGVRVRADNKVEWDPDVEREKVTSGKPLVPDYAMTFVRGTSSKPFGRLWWDQTVPTVVTRAEPHNQAILHPLQDRVLTIRENARLQGFPDYYKLLGPIKERYIQVGNAVAVPVARALGFSLALALRGLSGNEPLLTLPEDYPLMRDVPVPNIVTL
47
A0A7M7RBW2
3.1.3.48
ACT_SITE 155; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR037322-1"
MGVPTENSQAKRDTTAVRDDAACSSGFDSSDDDQEPVDKSPFQIDWLDLSEYGIAEKLGISGLPGCRFDDTWRSMESDINGLISQGVEDVFVLCTRGELNKYRVRRLMQEYTTAGLSVHHYPFPAGLVPSPANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDDYMEWKDAIAKVRQLKGSRAIQTVKQYNFVSDFRKMREEYEATRPDGDRRSISR
149
Q81BY0
1.11.1.6
ACT_SITE 65; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 138; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MNEKYDKHRKELLEEDFNKHRELTEPAKFHSQTVGSRGPVLEQDSVLHESLQQFIHEKILERPVHVKGFGAFGYFQTIYSMSEHTKLSFLQNSNEKVPVMVRFSLAVSTKGTPDTARNVRGFSTKFYTKEGIFDLLCNHIPVFSVRDPMRFPETIQALLPSPKNNLIDPNRFWSFVAKAPESIHFVVRLYSNNGTAKSLRHIPGHSVNTYVWRNAEGNRKYVKYHWYPFEGVQYITSKEAIKLAAENPDYSGKDLYDAIENGKPVEYGLYVQLMDPKDETHLSYDPLDDTKVWDEQTYPLIPVGKMVLNKNPENFMEQVEKVAFSPSNLLEGAELSDDKMLQGRANIYSDSQRRRIGPEFRKLTINQQQDWTPANQITTGEGRYVEGKLERASITKQDDFTQAGEFYTKLQPIEKEHLAENLASDLKVISDDIREIVLGYFNQVSTDLKTSIETKMKEH
13
P78619
1.11.1.6
ACT_SITE 100; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 173; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
MRALGLVGLVGVANAVCPYMTGELGRRDTNPDATEATEEFLSEYYLDDTDSYLTTDVGGPIEDQQSLKAGARGSTLLEDFIFRQKIQRFDHERVPERAVHARGAGAHGVFTSYGDFSNITAASFLSAEGKETPVFVRFSTVAGSRGSSDLARDVHGFATRFYTDEGNFDIVGNNIPVFFIQDAIQFPDLIHAVKPKGDREIPQAATAHDAAWDFFSQQPSTLHTLLWAMAGHGIPRSFRHVDGFGVHTFRLVTEDGSTKLVKFHWKTLQGLASMVWEEAQQISGKNPDYMRQDLFESIEAGRYPEWELNVQIMDEEDQLRFGFDLFDPTKIVPEEYVPLTPLGKMTLNRNPRNYFAETEQVMFQPGHVVRGVDFTEDPLLQQGRLFSYLDTQLNRNGGPNFEQLPINQPRVAIHNNNRDGAGQMFIPLNPDAYSPNTLKGSTLKQANQTAGRGFFTAPDRTANGNLVRAKSSTFDDAWSQPRLFWNSLLPAEKQFVVNAIRFENANVKSDVVKNNVIVQLNRISNDLATRVAKAIGVDAPEPDNTYYHDNTTSNIGAFGHRLQSLAGLKIAVLASVDAEESFSAATALKAELSNDNLDVIVVAERFSNGVNQTYSASDAIQFDAVVVAPGAEKLFGAKSAANSSSTLYPAGRPLEILVDAFRFGKPVAALGSGSTAFDNAGINTAVEGVYVADAVDESFANNLEEGLTVFKFLDRFALDSDE
13
Q5K6Y3
2.7.11.1
ACT_SITE 330; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 347; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MSRRPDLGYIDQASEDPVNTVSTPIGGLEPNADKGVEAEAPEEDSGSSIEEESEGEPFEDVDGGDFDFGALDVGGSGEEDEEEDDGDWDVDDEDWELANGDFTKQYNRVRQQHAATSGSAPLPARNLSQQTKSKLSKSNPTAGSGVVTNPKAAQDKHDKDKSDRATQEQVLDSRTRLVLAGLVNRGVIGMIERCISTGKEANVYYSSPGRAVKIYRTSILVFRARQNYIVGEQRFRGEYTSSRNPRKMIRVWAEKELRNLRRLVQGGVRAPVVHECKENVLVMDFLGKGEVASPRLKDAEIPEDRLPDLYAEMVIATRRMYQHCHLVHADLSEYNILLHDNHLYIIDVSQSVEHDHPRAFDFLRSDISNIEEFFSRRGVATLGIRKSWEFIVTENIGLSPTGSASSSLEMEKGDDGERRLVGVLEEWLKEPSDKTDDAVFMESYIPRTLAEVYDPERDVDVLKSGGGDELIYAGVTGLKLAHESANAKVKEKEKEKQSASAGAGAGADDANKREEVDADENVEKGERVKGKCKDEGKNDKTSKSVRFEDEVDEHDEEDDAQEAEEQGEEEGMDKKSRGFRHEDRESKKERKKAVKEEQREKRKTKMPKAEKQKLIKKSASRH
99
Q9VQ67
2.3.2.26
ACT_SITE 944; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MGQMHCSPEDASLRSDLVLIRSFVVYKGRPPDHATRFDISMLVSHINVGGVMHAATGGKTFPTLKVKLCFGESMGISSLSSCGDPERLPELPPLDEQRLQRAALHLQQKLILREWLKDHRLQHHYQRLLAVEVASLEDVYWLEDSRASKILGKDWQLWSGARQNLPTSKAQLDALKAQLWSTVVKSSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV
65
Q69RP3
1.11.1.7
ACT_SITE 90; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MTRTPASLSLAVVAVSVAAAALLLAALVAADGQKQQGYVQPAYRRPAAGLKADYYHQSCPDMEGIVQRAVKKAIAADSTLAPALLRLFFHDFAVGGIDASVLVDSPGSERYAKASKTLRGFELIESIKAELEAKCPKTVSCADILAAAARDASTEVKVDYWPLMYGRKDGRRSSMVDADQYVPMGRESVTDLIAFFESRGLTVLDLAVLSGAHTIGRATCAAVKPRLWDYAGTGRPDASMSPRYGDFLRRKCAAAGDGGYVYLDADTPTEFDNGYYKNLLRDMGLLETDQKLLPDSRTGEFVRELAGARPELIRHQFADSMRRLGAAQVLTGDEGEVRLKCSAINSNSY
14
A2DKE7
2.3.2.26
ACT_SITE 1136; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MEIAINNPVECNESLPIPGKDEENYLFKLAYARATFTDSNWQVSENICKIRTEHKDKILEKIEANDDENVSLGAMIALGAEIFDSEVTRYIKIKGKTELANNHDVDVQRNSQACFQIDPPKFNVTAKLTAKMIEFIDKVDLDIQATPSQKPADNSQKPLDTPQKIAEKAIKNCIILSFLSKLFDAVSDKNKFAEKFPKMKEICKKFKDTVVPNYTNSKYSYFIRQQLKRVCEKNGIKDKFIPLTHCGECKDSMFNGSPDTSSFFVHTKMIDVNNAIEISFTDMKTQLKYIGFISENWDCTFLSLLDRNIYMDKKFVPYTGSLSNITLWMDNNYLCFGNVKIDSGETKKRWAFVITVCDDSLVEYKFVQPRSTSLKANAPPTKQHRFDLNMIFPKVCLGMQVKIENHSDVNISRLEANYGYTITGCNFENRSTETYIVPANQITTQYTPFDTVMICAEIENRIGDPTQLLNDLLQTCKNYSISLIKTMLPYYLPEINSEMALNMITKLSDTSSKQELDQIKALMKGKENDIKAKLENTVMEGEKDPKFTAGRDINQLYNSTYGASQIGIFQAWNHGIFYEKTFVQGLKLFFKYKKVCLGFIPMILKTFNKNLPNDLESAKMILNFFNNPTYEGYFSNMSEKDYTEYFNNLVTFVFERDPNTIVAKQAHSSLINKCAQSLIGDLFTLGKNVSNKAKRMPPLLLFSDKGATFSKCVVKNNNYYPVEILLPNGTTKIITSNSYSSCEANKGYRYHFGTDGKQVLSDWKNYIEKDFSGVYKPLLVDYMLKNKICDAKIGDYPSIVLFFANIGLSTLTEVSDDYFDYSTPELNPIDNYFNDDANIKVGWLNNFRDWAAEGTIGYLKIDITRTHSHGVDYDSPNLIRIIDYLARDEAHFPSKIIAFRAKENKLMYFAEYEGTTGQDVGGMFRDSFFLMVNELMDVNIRYFIKPPSTLHCEKNRLVPASNLPIKVASTIGSLIASAIATRNAHKAWNLPRFIWDSFVTNSDLSLLVDCDDESYFNSLKNIVNAMRKGFWKVIPLDKVKNFSGRFIEGLTCGVKKELDFNSFIAYFNPPSRNCVVWPVFTQAISKFTSQEFSKLMGFITGNETPKNAKDFCLKLADKSTSYQDENSFALPFAHTCFNLIEIMPYKTPELLRQKLIICFSFQAEFND
65
B3S8Y0
3.2.1.52
ACT_SITE 298; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MPQTMSTTSSYLRIRPQQFQFESDSQSSLLRRAFQRYMKIAFLQPLPPNEPAAAVDPSAPKPHVIGNLTSLFFQIDNPNTDLRLGMDESYSLSIRATPQPVAFVHTKEIWGALRALETFSQLIDARADGFFISEAKIIDFPRFSHRGILVDTARHYLTMDTLLQHLDAMAYNKFNVLHWHIVDDQSFPFVSLTFPNMSLFGAYTQRHIYTPEDVSKVIEYARDRGIRVIPEFDTPGHASSWKSIPNLLTPCYGPNNIPNGNFGPINPIVDSNYEFLAVFFSEIKKRFPDAYVHLGGDEVSFSCWASNPDIQDFMVQKGFGKNFALLEQYYETRLLQLVEKVGLRYIIWQDVIDNKVKVNPNTVVQVWRSSPSYKSELKRVTSLNLKTILSSCWYLDLIGYGRDWEGYYRCDPQNFKGTTAEKNLVFGGEACLWGEYVDSTNFLERMWPRASAIGERLWSSAKVNNVDAALPRIDYHRCQHHIRRGIRAQPVNGYSFCQAEYNTVMRYMKKDEL
170
Q5KQL9
2.1.1.37
ACT_SITE 941; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016"
METPPPDPVSPPPPAADEGSPGGDDGAEDAGGFSAGLDSLWTALFGSPEELEPMWSPPRGFGVGAEFAAAEVEPEIMDVAGGPWDGAPWRSSGVVAGEGAATALVPPTAAAGFAEFEPAAPIDSYPAGAAAASLGDVPEVSALDSGVDCSPDPPPSSSPPVDFDARGFDPVADSAPAMESPLPPSVASSEANLDGRMLDCTLNSVPSPPLASPYEVGLGAEDPIKDSSPSVAWGTTMDAKDPEVDATCANGTALRRSRRIMKIKSAASSMPLNQNGDSSRASKRRVADSRKSRSSEGSKLPAFTGPISVNTVDLINGVKVQGLQEIVAVENVSSSYDNNQKAGGLYNQVVVALPAASNSLLKDKGASVLPRRKTRLASKVLVNSDRVSAISPVVNGGPPVQKSDVCIPTKKHKLAVEECLTSLDGVDGGGIVLCNSKLKSAKSRVVSKTPQGRGRRSPQPPKTQRARTLSVKYLEKLKRAENNNNNGSMSKSPRVPMIPENNGSMSKSPRVPIIPELSTKHELVLDKHMVDSVMLETDDGSCFFVGDAVPDDEARKQWPHRYEINDQIMKKDKRTSSQTFANAGKAVLDVKCHYLQAKVSRYTFCIGECAFVKGPEGKPNYIGRLLEFFETKTGECYFRVQWFFTAEDTVIGEQAQSHDPRRLFYSDLTDDNLLDCIVSKVTIVQVPPSVDGKSKSVPSSDYYYDMKYSIDYSTFSTIEMEDTDDLMQSCYTSRINDKMKKIDVNKKHKSPVLEKMELSLLDLYCGCGGMSTGLCLGARGGGVNLSARWAIDDDEIACESFRNNHPETRVRNETTDDFLELLKEWEKLCKTYVKHSRTKACVDSTTESNNETPDCSTVPPEEFEVWKLVDICFGDPNKVSKHGLYFKVRWKGYGPHHDTWEPVEGLRNCKEAIRDFVIEGHRQRILPRPGDVDVVCGGPPCQGISGYNRNREFEAPFKCEKNKQIIVFMDVVQFLKPKYVYMENVLDILKFADATLARYALSRLVAMHYQARLGIMAAGCYGLPQFRMRVFLLGCHSKEKLPPFPLPTHEAIVKNGCPLAFERNLVGWPNDTPMQLARPIVLEDILSDLPEVANGESRDEMLYVKGPQTEFQRYIRSFNVEVHGPRAHVTKDSKSSKLYDHRPLVLDNDNYQRILQIPKRKGANFRDLSGVIVGPDNVARLDPTKERVLLPSGRPLVLDCILAYENGKSLRPFGRVWWDEVVGTVLTVPNARMQALIHPAQDRLLTIRESARLQGFPDNYRFRGTVKDRYRQIGNAVAVPVGRALGYALAMAYLKKSGDDPLMLLPPNFAFSHDLRGFA
47
A9UZ45
2.3.2.26
ACT_SITE 1109; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MSRVQLESDDSDSSAGSPERQAVSRTSSQSVIESVDPRALRSQTSASLRSATHQAARAPAQLEASSDDWDAPDSEDDVDLYGRPVARTASSSSEHENADLEEAGTLASGHGAPREQQEQRRRRTRAASGSVRALQSLAAARRRRADVQNATVEHARSPTSPQRKRVHRDQSTSAELAEPKHSKLWKYREAHSTLNRTSRFIPEHSAYNHDLREVEDLAGFIASDDEEARARPHRLLLPDSDSENEAAPGPNINASQPPVPGMPSFSTDSDSDQGSDDPAMMTILLQRNLNLAVPSLCLVFGAGSSNVKDSNPRQIERVRRSLQGPLASDDDASSSSSTVAAISDDEDAACVAAARLFDEPRRGSQSQAVPHADQRVSEEDFFVNSDEEGEGDGTHRHFECPCQHDAPYMGRRLFCRQELCRRMQHAACFNRPERRDRSLPPHICHVCTKVVPEVPADRTALWTAVEHDDLNEVTKLLNQQRVPADICSYDHDGMTAVMLAARRDNWPISRVSRVDLNNWTILHHVIATDADRVLQHLLDVVMAGREPLNQPQFKERLDGSNLLHHCAAYNALQCWAVMLRYARLKQAMGAWVDKPDHEGMTPLFTALRAGHLTMAQKLWPRSVATRDSTDAHRRTALHLAAEGGNAECVRLVLDASSSDVLESRDAMGFTPLMVAAQVGAEAALECLIAAGAQVEAFDHEGTSALHVAALGGHTAAPLRERAIAILKTISTTERYFRFLNDLVRQHPAMLDTDLHFLLYQRGLLDLDVKTAWLRRKVQNEMPRSLAQVQAARLSPTKHPKNIHLKVAFVGEAGICLGPLRELFSVLPDSILTDTKLLTAATENNPRLVPTYFLNEHGACEAARPDSNARTAQFRALGTLLGLAILHQQTVNLPLALHVLAEMLSDPVEPNIDSLETLDGDLGRNLRWLLNRSIDDLDLDLGYSVSVPPCAGAAPIEIELSRDHASVTDANKKGYVQAVAQFHLVDKTSCEVRDLREGFQSVLPPDLLMPFTAGELALTLEGVATIDVQAWQRHTSYSNEYDANHQVIRWFWQLVTTLSDAEKSLLLQFVTGVTRLPPGGFADLRALGGGSGMTITRGGDVRHLPGASTCFNLLKLPPYPTPAILRQKVLIAIRHGAHGFSFS
65
Q5SIL4
5.6.2.2
ACT_SITE 118; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897"
MAQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHVKSAKIVGEVMGKYHPHGDAAIYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTEARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIPNLLVNGASGIAVGMATSLPPHNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAKVRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIELKRGANPQVVLNQLYKHTALQTSFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSLFELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKARIALMERFGLSEAQAQAILDMRLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLITEFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHVFVADAHDDLLLFTNRGRVYRLKVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLDQEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDRLVGVALSDPEDEAILATQEGQAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPLSEYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRATAGVRVMNLPEDDEVASAFVVEEEK
222
P47686
1.8.4.12
ACT_SITE 121; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01126"
MSKYQKKSEAELKRTLTKLQFDVTQNAHTEPPYINEYNRNFEKGIYVDITSGEPLFISTDKFKSGCGWPAFSKPIDKNLIANYRDESHGMIRTEVRAKNSDSHLGHVFNDGPSELGGLRYCINSAALKFIPFEEMEKLGYKDYIHLFKNK
40
P9WPC5
3.4.21.92
ACT_SITE 98; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 123; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
MSQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDISLYINSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQPIERIEADSDRDRWFTAAEALEYGFVDHIITRAHVNGEAQ
179
A0A2C9V465
3.1.1.11
ACT_SITE 180; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASLQIQLVASLIFLLILLSWTVQGQPKTTFDLVVAKDGNGNYSTIMDAIAAAPKHSARKFIIKIEKGIYTENVLVEDDKTNIIFIGDGIDKTIISGSRSAGGGYKTYKTATLGIRGDGFMAMDITIENTAGAANKQAVALRSSAQSVFYRCKFSGYQDTLYTNQKKQFYRQCEIYGTIDFIFGDATVVLQNCAIYARLPPKGESNTITITAQGRNKSTENSGIVIQNCTITAADDLKRSGSSLIKSYLGRPWKEYSTTIVMQSFIDNIIDPAGWLEWENNKTNLATIFYAEYENRGPGAATNRRVKWTSYHKINRREAMKFTVRNFISGNAWLPSLGIPFFLDLM
125
Q5AVP1
3.2.1.78
ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q99036"; ACT_SITE 299; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q99036"
MKHLLSLVCTLGAATLAASAAAEAGSMPSANGLDFVIDGEASYFAGSNAYWLSFLTNNADVDLALDHFAESGLKILRIWGFSDVTAEPSDNKVYFQLHQNGSSTVNTGPNGLERLDYIISGAEKRGIKLVIPLVNYWDDFGGMNAYISAYGGDKPGWYTNDKIQAAYHAYVKAVVSRYVDSPAIFAWELANEPRCSGCDTSIINQWATKTSSFIKSLDPNHMVAMGDEGMGLPGDSNYPYSYYEGNDFALNLAIPDIDFGTLHLYTTDWGVSNNSWGNKWVQDHAAVCKSAGKPCLFEEYGMKGNHCTYELAWQKTALATPGMAADLFWQFGENLSSGQTHNDKYTVYYGSNEWKCVVSDHVAAVAVRRYRLPVGGGQHGP
172
A0A251URT2
3.2.1.1
ACT_SITE 204; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 229; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MSPIVLIRCVIFVTCFLVTMLSAAPTLLFQGFNWESCNKQGGLYNSLVNSIDDLAAAGVTHVWLPPPSQSAAPQGYMPGRLYDLNASSYGNEEELKSLIKSFKNKGIKAIADIVINHRTAEKQDERGVWCIFEGGTPDERLDWGPSLICKDDIEYSNGMGNADTGEPFPPAPDIDHLNPRVQNELSDWMNWLKIDIGFDGWRFDYARGYSSSITKVYMTNTSPDFAVGEYWNSVAIGPDGKPEYNQDKHRNEIMNWVQESGGGSLTAFDFTTKFILQAAVEGELWRLIDPNGKPPGLIGILPGSAVTFIDNHDTGSTQKISPFPSDKVMQGYAYILTHPGIPSLFYDHFFDWGLKDELTKLSAVRARNEITATSQVKILAYEAELYVAVIDEKVIVKIGPKMDLGNLIPENFKLATSGDQYAVWEKLP
157
A7RNH5
2.7.11.1
ACT_SITE 114; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1"
MVYAGTRVRDGKPVAIKVIPKNNVYFFEEVGGISVPMEVYLHRVLDHPNVVRLYDYFEYNQAYVLVLERPTHYRDLFDYITEKKLLSEREAKDIFKQVVHAVAYCEGKGVFHRDIKDENLLLDTKTGQVKLFDFGSGTVLENTLYTDYEGTRAYCPPEWFRFHRYHARPCTVWSLGILLFNMLSGDVPFANQIEIVRGELNFAENVSKEAQSLVRWLLAKHPSYRPTLENILKHPWLGSVKYRRSKSPQARCHTFPENYFPEPDEYPHSPTIIAFNRNRRHSST
99
A0A022PN84
5.1.3.15
ACT_SITE 173; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 276; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
MASSPSVELSNGINGLSSVILHQLANGFTYSAEILLYGGQVISWMNQRGEELLYQSERAVFEPPHPVRGGIPICFPRFFGFGDVEDHGFARTRMWRLENLIDDMDFPPPGPDKAFADFILDNMPDDFPHWPYNHRFELRLRVILAPCGDLTMISRVKNVNTNGEPFSFKFVYHTYFAVSNIRATQVEGLEGVGYVDCLEMHERFVQDDDPITFVNELDRIYLNTPDEVTVRDRQYRRTYTITKNAGLPDIVVYNPWDSRNLADLGNYEYTWMVCVEAAAVDKEITLNPDEEWTGMQRLSFMEF
210
P34948
5.3.1.8
ACT_SITE 304; /evidence="ECO:0000269|PubMed:8180205"
MSSEKLFRIQCGYQNYDWGKIGSSSAVAQFVHNSDPSITIDETKPYAELWMGTHPSVPSKAIDLNNQTLRDLVTAKPQEYLGESIITKFGSSKELPFLFKVLSIEKVLSIQAHPDKKLGAQLHAADPKNYPDDNHKPEMAIAVTDFEGFCGFKPLDQLAKTLATVPELNEIIGQELVDEFISGIKLPAEVGSQDDVNNRKLLQKVFGKLMNTDDDVIKQQTAKLLERTDREPQVFKDIDSRLPELIQRLNKQFPNDIGLFCGCLLLNHVGLNKGEAMFLQAKDPHAYISGDIIECMAASDNVVRAGFTPKFKDVKNLVEMLTYSYESVEKQKMPLQEFPRSKGDAVKSVLYDPPIAEFSVLQTIFDKSKGGKQVIEGLNGPSIVIATNGKGTIQITGDDSTKQKIDTGYVFFVAPGSSIELTADSANQDQDFTTYRAFVEA
214
A0A8V1AB34
3.1.3.16
ACT_SITE 176; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 178; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"
GRGPLTGCERWRRAVAQRGPFPLPSSPRTAFPSSAELGGTTGGGGRGGGGGPGAGRGGRGDEISGRRAWRQRGGCAGGRAEGGGGRGGEGGGGGEAPRGGSVSQCNISLKKQRSRSIFSTLFCCFRDYNVEPPSTNSTSALPPLVEENGGLQKPPAKYLLPELTASDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSKEEEVYSMLHKLCNR
144
B6K0G7
2.3.2.26
ACT_SITE 631; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MENIRFELQLTISHLEGVWRRNVFRVRRPFVSFSIDGGQVQSTHDVSGRLIYRWDEQFTVILHPKSVIVFQLFDKLKTNNATDGFLGIGAIPINNVIPAQSSILEATTKIPIHDSNGYFYGKLVCHFESKHFSPQQLAAGDIAISTSPDINLSVWEPRVDEYGKLYYYNRNHLSQQQLVSKNHVPCQLSSSSSSVPDEQTKHESRCSKIFARIKLDKATVAHLSQNPVLAHSIFDELALNKGPLPKGWEMRLTDDFHVYFVDHETKTTTWEDPREQCSIPSSSSKLQLLRRKQAYLYQELAKQVKEGQCHIKVERKNILHNAFDIILRLPPEDLKMKLLIRFKGEDGLDYGGVSREFFYLLSHQMFDPSTCLFEYSNAGDYSLRISIHSCINEEHLSWFRFIGRVIGLAIFHRRYLDVCFVRTLYKTLLGQSPEFEDLQYVDKDLYHSLSWIRDNHVDETLCLTFSTTVDHFGEAVIYDFKPNGRNISVTEENKHEFLKLASEWHMYKNTEEQFQSLKRGLNEIISDKDLRIFDVDELGVLIGGTSTIDVEDWKRYTDYRSYSESDLTIKLFWRLVSEWPEEKRARLLQFTTGTSRIPLNGFKDIHGSDGPRKFVIEKVGTVDQLPHAHTCFNRLDLPPYQTKQQLDRKLTLAIEETAGFGTK
65
Q54GE6
1.1.1.37
ACT_SITE 244; /note="Proton acceptor"; /evidence="ECO:0000250"
MEQAILRINNISSQLTGKCPFKAHGGGAGKCPYKLGGGQILDQSKAWSLVNVTANVDQVTPIKVLVTGAAGQIAYSLMFMIASGQMFGPHQPVILHLLDIPKMADALKGVVMELQDCSYPLLQSVVATTDIQTAFLHINVAILVGAFPRGPGMQRKDLLKVNVSIFKEQGEALNKYASRGVKVLVVGNPANTNALTALMKASDLPTSNFSALTRLDQNRAQSMISEKVGTNVDNVHNVIIWGNHSQTQVPDVNHGYILNYPNRGLIEPIPSSVNDDKWLNEQFIPLVQNRGATVIAARKLSSAASAANAIVGHVRDWLLGTKDGEHVSMAVYSDGSYNVPKGLIFSFPVTCHNGQWTIVQGLKINSSTQQKIDATIKELQEEKETAMSFLN
5
A0A1Y1IEE3
6.3.4.4
ACT_SITE 113; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 141; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 241; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"
MAAAMHCVAGTAGAWLPGHTAALDHATTTPPASFSPFPLSASHQTRFHSQLASVSILSHQQAFSPVEKKRKFVAAGGVRAQTVSAPQAEIEKAADEFGKLTQVAAVLGTQWGDEGKGKLVDILAQRYDVVARCQGGANAGHTIYNEKGQKFALHGVPSGVLNPKATCLVGNGVVVHLPSFFDELDKLQSQGVNTEGRVLVSDRAHLLFDLHREIDGLREEELAGGKIGTTKRGIGPAYASKVVRNGIRVGELRRPETFKEKLRVMYEDAKARFPGLNYTEEILSAEAARYVELGKRLEPYITDTVYYVNKAHAEKKKILIEGGQATLLDVDFGTYPFVTSSNPSIGGVIVGLGLAPQKLGAVIGVAKAYTTRVGAGPYPTELHDETGDRLRANGFEFGTTTGRPRRCGWLDMVALRFACDINGFTHINLTKLDVLSGFSEIKLGVGYRAPDGEVVPAFPADLELLEQIKVDYEVLPGWEEDISGMRKWSQLPKNAQAYVLRIEEIVGVEVKWIGVGPGRDAIITKE
253
A0A139WMZ3
2.7.11.1
ACT_SITE 188; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 530; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
MANSTRRYRAFGVSRSLRIVSSQSGDADEAVGVEEAGPTEGEHEIELGELVRNGHDKADPSQFELLKVLGEGSFGKVFLVRKVVGADNGRLYAMKVLRKATLKVRDRHRTKMERNILVDVEHPFIVKLHYAFQTAGKLYLILDFLRGGDLFSRLSKEVMFTEEDVKFYLAELALALNHLHTIGIIYRDLKPENVLLDADGHIALTDFGLSKLPLEEGKAYSFCGTVEYMAPEVVNRKGHSFAADWWSFGVLMFEMLTGSLPFQGANRRDTMTQILKAKLGMPANLSSEAQSLLRALFKRNPANRLGAGPGGVEDLKKHEFFATIDFDALLAKKIRPPFQPAVCGPDDAYFDSEFTSKTPRDSPGVPASANAHELFRGFSFVAPCLLENGNVSKKSETPLKIMRTMERNFNDDYLLMDTLGTGSYSICKLARHKATGQQFAVKIIKKSLCDCREEIEILMRYGHHPGIVTMKSVYEEAGKIYMVLQLLRGGDLLDYMIAKKHLAEQEAAAILKTLATTVAYLHENGVVHRDLKPANILFASEERTPDSVTICDMGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVILYIMLSGRCPFSTAPSDSPHRILQRISSGKLDLHNGHWSGVSQEAKMLVTDMLHIAPQRRPTAAQLVKHPWLAAAAPSLYQVQANTSQVSTPEQDAHLKETVAATFRAIATSPQVAHLGPVAMSELARRRFRDKALSRVQQNS
99